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Schaefer Juergen R - - 2012
Familial hypercholesterolemia (FH) is an autosomal dominant inherited disorder caused by mutations in the low density lipoprotein receptor (LDLR) gene. FH is characterized by elevated plasma LDL cholesterol, premature atherosclerosis, and a high risk of premature myocardial infarction. In general, mutations within LDLR gene can cause five different classes of ...
Zucker Deborah D Tufts University, Boston, MA, USA. - - 2012
In scientific teams as in life, conflicts arise. This paper aims to provide an introduction to tools and skills to help in managing conflicts in practice. Using a structured approach enables the concerns and interests of all involved to be identified and clarified. It also permits a better understanding of ...
Marmotti Antonio - - 2012
Peroneal tendoscopy is an innovative technique that allows visualization of the tendons from the myotendinous junction to the peroneal tubercle, together with adjacent anatomic structures such as the recently unveiled vincula. Through a minimally invasive approach, it is possible to diagnose and treat several disorders, such as common tenosynovitis, accessory ...
Braido F - - 2012
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, with the involvement of many inflammatory cells and mediators. Traditionally, this inflammation is thought to spread to a systemic level, thus inducing damage of different organs. However, other pathogenetic mechanisms could take part to the above-described process, ...
Felder Tisha M TM South Carolina Statewide Cancer Prevention and Control Program, University of South Carolina, 915 Greene Street, Suite 200, Columbia, SC, 29208, - - 2012
Community-based participatory research (CBPR) initiatives such as the National Cancer Institute's Community Networks Program (CNP) (2005-2010) often emphasize training of junior investigators from underrepresented backgrounds to address health disparities. From July to October 2010, a convenience sample of 80 participants from the 25 CNP national sites completed our 45-item, web-based ...
Jamesdaniel Samson - - 2012
S-nitrosylation is a redox-sensitive protein modification, which is a highly specific, but reversible mechanism that regulates several signal transduction cascades. Oxidative stress plays a causal role in the ototoxic effects of an anti-neoplastic drug, cisplatin. Despite emerging evidence implicating nitroxidative stress as a critical factor in cisplatin toxicity, the significance ...
Gervasi Maria-Teresa - - 2012
The prevalence of viral infections in the amniotic fluid (AF) has not yet been ascertained. The aim of this study was to determine the prevalence of specific viral nucleic acids in the AF and its relationship to pregnancy outcome. From a cohort of 847 consecutive women undergoing midtrimester amniocentesis, 729 ...
Zaretzki Jed - - 2012
RS-Predictor is a tool for creating pathway-independent, isozyme-specific, site of metabolism (SOM) prediction models using any set of known cytochrome P450 (CYP) substrates and metabolites. Until now, the RS-Predictor method was only trained and validated on CYP 3A4 data, but in the present study, we report on the versatility the ...
Collet Tinh-Hai TH Department of Ambulatory Care and Community Medicine, University of Lausanne, Lausanne, - - 2012
Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting.We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts. Individual data on 52 ...
Razvi Salman - - 2012
BACKGROUND Subclinical hypothyroidism (SCH) has been associated with ischemic heart disease (IHD); however, it is unknown whether treatment of SCH with levothyroxine sodium will reduce the risk of IHD. The aim of this study was to investigate the association between levothyroxine treatment of SCH with IHD morbidity and mortality. METHODS ...
Foye Ondulla T OT Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, - - 2012
Immaturity of gut-associated immunity may contribute to pediatric mortality associated with enteric infections. A murine model to parallel infantile enteric disease was used to determine the effects of probiotic, Lactobacillus acidophilus (La), prebiotic, inulin, or both (synbiotic, syn) on pathogen-induced inflammatory responses, NF-κB, and Smad 7 signaling. Newborn mice were ...
Grinberg Yelena Y - - 2012
Spreading depression (SD), the likely cause of migraine aura and perhaps migraine, is triggered by widespread and unfettered neuronal hyperexcitability. Migraine and the initiating hyperexcitability of seizure, which involve oxidative stress (OS), are likely interrelated. Environmental enrichment (EE) decreases seizure and can reduce migraine. EE's well-characterized neuroprotective effect involves insulin-like ...
Oron Galia G Perinatal Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, - - 2012
To identify risk factors for adverse pregnancy outcome in women with inflammatory bowel disease (IBD) and to assess the effect of maternal pre-pregnancy weight and weight gain during pregnancy on pregnancy outcome. A retrospective, matched control study of all gravid women with IBD treated in a single tertiary center. Data ...
Fahlbusch Fabian B FB Department of Pediatrics and Adolescent Medicine, Erlangen, Germany. - - 2012
The F-box protein Fbxw8 is a cofactor of Cullin 7 (Cul7), which regulates protein transfer to the proteasome and cell growth. Cul7 or Fbxw8 deficiency is associated with intrauterine growth restriction (IUGR) due to abnormal placental development leading to poor oxygen supply to the fetus. We studied the role of ...
Goblirsch Brandon R - - 2012
OleA is a thiolase superfamily enzyme that has been shown to catalyze the condensation of two long-chain fatty acyl-coenzyme A (CoA) substrates. The enzyme is part of a larger gene cluster responsible for generating long-chain olefin products, a potential biofuel precursor. In thiolase superfamily enzymes, catalysis is achieved via a ...
Laskov Ido I Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, - - 2012
To investigate prematurity rate in women aged ≥ 45 carrying a singleton pregnancy. Other maternal and neonatal outcomes are also described. Retrospective cohort study. Women delivering a singleton pregnancy at a single tertiary medical center. The study included all women aged 45 years and over who delivered at 20 weeks ...
Curreli Francesca - - 2012
The CD4 binding site on HIV-1 gp120 has been validated as a drug target to prevent HIV-1 entry to cells. Previously, we identified two small molecule inhibitors consisting of a 2,2,6,6-tetramethylpiperidine ring linked by an oxalamide to a p-halide-substituted phenyl group, which target this site, specifically, a cavity termed "Phe43 ...
Grujić Jelena - - 2012
Recent experimental evidence [Grujić Fosco, Araujo, Cuesta, Sánchez, 2010. Social experiments in the mesoscale: humans playing a spatial Prisoner's dilemma. PLoS ONE 5, e13749] on the spatial Prisoner's Dilemma suggests that players choosing to cooperate or not on the basis of their previous action and the actions of their neighbors ...
Dahan Arik - - 2012
The drug intestinal permeability (P(eff)) measure has been widely used as one of the main factors governing both the rate and/or extent of drug absorption (F(abs)) in humans following oral administration. In this communication we emphasize the complexity behind and the care that must be taken with this in vivo ...
Saeidi Nima N Center for Engineering in Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, - - 2012
Many tissue engineering applications require the remodeling of a degradable scaffold either in vitro or in situ. Although inefficient remodeling or failure to fully remodel the temporary matrix can result in a poor clinical outcome, very few investigations have examined in detail, the interaction of regenerative cells with temporary scaffoldings. ...
Ellis Christopher R CR Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United - - 2012
Glycosylation regulates vital cellular processes and dramatically influences protein folding and stability. In particular, experiments have demonstrated that asparagine (N)-linked disaccharides drive a "conformational switch" in a model peptide. The present work investigates this conformational switch via extensive atomically detailed replica exchange molecular dynamics simulations in explicit solvent. To distinguish ...
Liu Jun - - 2012
The image features a polymer solar cell with a graphene oxide (GO) hole-extraction layer and a GO-Cs electron-extraction layer to efficiently convert solar light into electricity at low cost. By tuning the GO work function through charge neutralization of its carboxylic acid groups to afford GO-Cs, a single material system ...
Lin Hao-Wu - - 2012
Highly efficient top-illuminated organic solar cells with microcavity structures are numerically simulated and fabricated by H.-W. Lin, K.-T. Wong, and co-workers on page 2269. The high efficiencies are primarily attributed to the thin, electrically optimized active layers and the panchromatic simulation programdesigned in-cell and out-of-cell optical resonance structures, incorporating favorable ...
Hu Linfeng - - 2012
A novel 1D/1D semiconductor/semiconductor nanocomposite-based photodetector is fabricated by X. S. Fang and co-workers on page 2305 from highly crystalline ZnS/ZnO biaxial nanobelts. Optimized performance of the ZnS/ZnO nanobelt photodetector is better than that of pure ZnS or ZnO nanostructures, as it combines UV-A photoresponsivity, high sensitivity, and a fast ...
Culver James C - - 2012
On page 2344, J. L. West, M. E. Dickinson, and co-workers demonstrate an image-guided method for engineering complex biomimetic materials. Using laser scanning microscopes and twophoton photolithography, they use this method to create patterned poly(ethylene glycol) diacrylate hydrogels that recreate 3D structural and biochemical features of endogenous vascular microenvironments, as ...
La Rocca Vieira Renata - - 2012
The purpose of our study was to determine the frequency and imaging features of atypical femoral fractures in a consecutive asymptomatic patient population on long-term bisphosphonate treatment and search for distinguishing clinical and laboratory parameters in the subset of patients with fractures. Two hundred femoral radiographs in 100 asymptomatic patients ...
Jeong Su Jin - - 2012
The objective of our study was to describe the MRI findings of medullary carcinoma of the breast and to correlate those findings with the histopathologic findings. From January 2005 to June 2010, MR images of 15 patients (age range, 32-73 years; mean age, 50 years) with pathologically confirmed medullary carcinoma ...
Olds William J - - 2012
In this paper, spatially offset Raman spectroscopy (SORS) is demonstrated for noninvasively investigating the composition of drug mixtures inside an opaque plastic container. The mixtures consisted of three components including a target drug (acetaminophen or phenylephrine hydrochloride) and two diluents (glucose and caffeine). The target drug concentrations ranged from 5% ...
Smith C D - - 2012
The outcome of an anatomical shoulder replacement depends on an intact rotator cuff. In 1981 Grammont designed a novel large-head reverse shoulder replacement for patients with cuff deficiency. Such has been the success of this replacement that it has led to a rapid expansion of the indications. We performed a ...
Eiras Carmen - - 2012
The aim of the present study was to establish a relationship between the results obtained using the enzyme-linked immunosorbent assay (ELISA) technique for antibodies in blood serum and milk at herd level. For this purpose, 325 samples of bulk tank milk were analyzed with 4 antibody ELISAs from dairy herds ...
Harris Jenine K - - 2012
Public Health Services and Systems Research (PHSSR) is concerned with evaluating the organization, financing, and delivery of public health services and their impact on public health. The strength of the current PHSSR evidence is somewhat dependent on the methods used to examine the field. Methods used in PHSSR articles, reports, ...
Diamond Michael P MP Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University, Detroit, MI 48201, USA. - - 2012
To estimate whether progestin-induced endometrial shedding, before ovulation induction with clomiphene citrate, metformin, or a combination of both, affects ovulation, conception, and live birth rates in women with polycystic ovary syndrome (PCOS). A secondary analysis of the data from 626 women with PCOS from the Eunice Kennedy Shriver National Institute ...
Gu Y P - - 2012
We describe a new surgical technique for the treatment of lacerations of the extensor tendon in zone I, which involves a tenodesis using a length of palmaris longus tendon one-quarter of its width. After exposing the dorsal aspect of the distal interphalangeal joint and harvesting the tendon, a 1.5 mm drill ...
Bollo Enrico - - 2012
During the years 2009-2011, 7 Siberian tigers (Panthera tigris altaica), aged between 2 and 14 years, from the Safaripark of Pombia were referred for necropsy to the Department of Animal Pathology of the University of Turin (Italy). Three tigers, aged 10 (2 animals) and 14 years, had multifocal, irregularly distributed, ...
Kamholz Karen L - - 2012
Initiating a pasteurized human donor milk (PDM) program in a level III neonatal intensive care unit (NICU) can be a difficult process that requires commitment by a multidisciplinary team, education, sufficient funding, and "buy-in" from NICU staff, families, and hospital administration. We began planning for our program in February 2011 ...
Aldridge S E - - 2012
Incomplete avulsion of the proximal hamstrings can be a severely debilitating injury that causes weakness, pain while sitting and inability to run. The results of the surgical treatment of 23 consecutive patients with such injuries at least two years after surgery are described. The surgery consisted of the repair of ...
Horch K - - 2012
The growing citizen and patient orientation of the German healthcare system reflects a health policy process which aims to achieve more individual and social responsibility as well as more autonomy on the part of healthcare users. At the same time the process is regarded as an essential component of a ...
Banco Barbara - - 2012
In the present study, a case of a spontaneously metastasizing seminoma in 9-year-old pet lionhead rabbit is described. The rabbit was presented with unilateral testicular enlargement and a palpable abdominal mass. Spiral computed tomography revealed the presence of an abdominal-pelvic mass in the region of the sublumbar lymph nodes. Testes ...
Pérez-Escamilla Rafael - - 2012
Background: Strong evidence-based advocacy efforts have now translated into high level political support and concrete goals for improving breastfeeding outcomes among women in the United States. In spite of this, major challenge remain for promoting, supporting and especially for protecting breastfeeding in the country. Objectives: The goals of this commentary ...
Ploss Alexander - - 2012
Hepatitis C virus (HCV) causes chronic infection in almost 2% of the world's population. If untreated, chronic carriers can develop severe liver disease including fibrosis, cirrhosis and hepatocellular carcinoma. Until recently, hepatitis C was treated with a combination of pegylated interferon and ribavirin, a treatment which was only partially effective ...
Park Jae Berm - - 2012
To evaluate retrospectively the role of radiofrequency (RF) ablation for liver metastases arising from pancreatic ductal adenocarcinoma simultaneously with pancreatic resection or after curative resection in patient survival. RF ablation of liver metastases was performed on 34 patients with pancreatic ductal adenocarcinoma postoperatively after pancreatectomy or intraoperatively at pancreatectomy between ...
Tochetto Sandra M - - 2012
The purpose of this study was to investigate whether changes in attenuation and size of liver metastatic lesions of colorectal cancer at MDCT 1 month after (90)Y radioembolization treatment are predictive of response at FDG PET 3 months after treatment. Twenty patients with colorectal liver metastasis consecutively treated with (90)Y ...
Anthony Evelyn Y - - 2012
This article reviews the range of adnexal masses that present in pediatric females. The preferred imaging modalities, the appearance of the normal ovaries, and the epidemiology of ovarian diseases and abnormalities are discussed. The illustrated abnormalities include simple and complex ovarian and paraovarian cysts, neoplasms, ovarian torsion, ectopic pregnancy, and ...
Schouest Jonathan M - - 2012
A three month, open-label, single center study was conducted to determine whether a uniquely derived serum containing barley bioengineered, human-like epidermal growth factor protein could improve visible signs of photodamage and aging in facial skin. Twenty-nine females, aged 39 to 75 years, with mild to severe, fine and course rhytids, ...
Ditomassi Marianne - - 2012
This study identified organizational characteristics that are highly correlated with the work satisfaction of RNs using 2 practice environment measurement tools. In the sample, the organizational characteristics of autonomy, control over practice, and internal work motivation are critical to RNs' sense of work satisfaction. As care redesign efforts ensue, the ...
Mutimer David J - - 2012
Hepatitis B and hepatitis C infections are important causes of end-stage liver disease and primary liver cancer. Successful antiviral treatment prior to the development of cirrhosis will prevent most of the morbidity and mortality associated with those infections. This can be achieved for a high proportion of patients. However, many ...
Lessne Mark L - - 2012
Reperfusion injury after venous thrombolysis for phlegmasia cerulea dolens (PCD), despite its potentially rapid, fatal course, has not been well described in the literature. Two cases of fatal reperfusion injury after venous thrombolysis are reported, and the clinical manifestations and treatment strategies of PCD and the aspects of reperfusion injury ...
Jacob K A - - 2012
Arrhythmogenic cardiomyopathy (AC) is characterised by myocardial fibrofatty tissue infiltration and presents with palpitations, ventricular arrhythmias, syncope and sudden cardiac death. AC is associated with mutations in genes encoding the desmosomal proteins plakophilin-2 (PKP2), desmoplakin (DSP), desmoglein-2 (DSG2), desmocollin-2 (DSC2) and junctional plakoglobin (JUP). In the present study we compared ...
Oda Seitaro - - 2012
We investigated whether a hybrid iterative reconstruction (HIR) algorithm improves image quality at low-tube-voltage coronary CT angiography (CTA) compared with filtered back projection (FBP). Eighteen patients (seven men, 11 women; mean age, 67.8 years) underwent retrospectively gated coronary CTA at 80 kV with a volume CT dose index (CTDI(vol)) of ...
Thapa Mahesh M - - 2012
The purpose of this article is to discuss MRI of the pediatric knee and familiarize the reader with conditions encountered in the pediatric population. Clinical scenarios are included to convey important concepts and to orient the learner to normal variants and abnormalities of the pediatric knee. The conditions discussed include, ...
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