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Lee In-Seob - - 2012
BACKGROUND: Posttransplant malignancy is one of the major causes inhibiting long-term graft survival. Gastric adenocarcinoma is the most common malignancy in Korea and occurs more frequently in renal transplant recipients compared to that in Western countries. We aimed to analyze the clinical features of the post-renal-transplant gastric cancer and assess ...
Carter Timothy I - - 2012
BACKGROUND: Locally advanced breast cancer (LABC) often requires complex treatment, and the prognosis is typically poor. We hypothesize that LABC patients engage the healthcare system with a variant pattern as compared with patients diagnosed with early stage disease. METHODS: We identified all newly diagnosed breast cancer patients between 2005 and ...
Wang Xiaochun - - 2012
The levels of DDTs, HCHs and PCBs in topsoil, cereal and irrigation water from typical industrial and agricultural areas of Jilin Province in Northeastern China were evaluated by using gas chromatography coupled with an electron capture detector. The amount of ∑OCPs and ∑(7)PCBs found in topsoils ranged from 24.7 to ...
Böckler Anne - - 2012
When acting and attending together, we take each other's perceptual and intentional relations to the environment into account. The present study investigated whether people are also sensitive to a co-actor's attentional relation to jointly attended events. Two participants sat next to each other and performed a two-choice Navon task, responding ...
Huang Qiuxin - - 2012
A sensitive and reliable liquid chromatographic-tandem mass spectrometric method for enantiomeric determination of five chiral azole antifungals (econazole, ketoconazole, miconazole, tebuconazole, and propiconazole) in wastewater and sludge has been established and validated. An isotope-labeled internal standard was used for quantification. Recovery of the individual enantiomers was usually in the range ...
Oksala Niku - - 2012
Background. Apolipoprotein A-I (apoA-I) and B (apoB) and multiple lipoprotein cardiovascular risk factors can be computationally estimated with our extended Friedewald approach (EFW) from classical inputs. Their impact on cardiovascular events and mortality in the working age population is not known. Methods. The working age (≤ 65 years, n = 5956) prospective ...
Lentz Ezequiel M - - 2012
Fragments from camelid single-chain antibodies known as VHHs or nanobodies represent a valuable tool in diagnostics, investigation and passive immunity therapy. Here, we explored different strategies to improve the accumulation of a neutralizing VHH antibody against rotavirus in tobacco transplastomic plants. First, we attempted to express the VHH in the ...
Hu Feifei - - 2012
ATP-binding cassette transporters (ABC) are important detoxification proteins and were proposed to play important roles in monoterpene resistance in Saccharomyces cerevisiae. In this work, the transcriptional levels of typical ABC transporters of S. cerevisiae under 85 mg D: -limonene/l were evaluated using real-time quantitative PCR. Only the transcriptional level of PDR5, ...
Nieuwenhuis M M W - - 2012
BACKGROUND: Adherence to (non)pharmacological treatment is important in heart failure (HF) patients, since it leads to better clinical outcome. Although self-reported and objectively measured medication adherence in HF patients have been compared in previous studies, none of these studies have used an evidence-based cutpoint to differentiate between adherence and non-adherence. ...
Sims M - - 2012
Aims:  To examine whether English legislation to make virtually all indoor public places and workplaces smoke free on 1(st) July 2007 displaced smoking into the home and hence increased the proportion of children exposed to levels of second hand smoke known to be detrimental to health. Design:  Repeated cross-sectional study ...
Swarnkar Supriya - - 2012
Rotenone causes cytotoxicity in astrocytic cell culture by glial activation, which is linked to free radical generation. The present study is an investigation to explore whether rotenone could also cause cellular toxicity in mouse neuroblastoma cells (Neuro-2a) under treatment similar to astroglial cells. The effect of rotenone (0.1, 1, and ...
Kameoka Junichi - - 2012
T-cell prolymphocytic leukemia (T-PLL) is characterized by a post-thymic immunophenotype, salient chromosome abnormalities, and an aggressive clinical course. However, cases in which these features are absent have been occasionally reported in Japan. Here, clinical and biological features of 13 T-PLL cases, diagnosed between 1992 and 2009 in the Tohoku region ...
Zhao Wen-Chao - - 2012
BACKGROUND: Surgical strategies for the treatment of multiple hepatocellular carcinomas (HCC) remain controversial. This study compared the prognostic power of the University of California, San Francisco (UCSF) criteria with the Barcelona Clinic Liver Cancer (BCLC) early-stage criteria. METHODS: Clinical and survival data of 162 multiple-HCC patients in Child-Pugh class A ...
Besir Fahri Halit - - 2012
Abstract  A potential association might exist between atherosclerosis and migraine. Carotid intima-media thickness (CIMT) is a marker of generalized atherosclerosis; hence, we aimed to assess CIMT in migraine patients. This study included 30 patients and 60 healthy controls aged between 20 and 40 years. Episodic migraine diagnosis was made according to the ...
Facchiano Enrico - - 2012
PURPOSE: To evaluate laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) with neoadjuvant, adjuvant, or palliative purpose in order to discuss potential clinical implications. METHODS: A systematic search of PubMed's Medline through August 2011 using the keywords laparoscopic, hyperthermic, and chemotherapy. RESULTS: Eight studies encompassing a total of 183 patients were considered. The ...
Hartmann E M - - 2012
This critical review presents challenges and strategies in the detection of viral contaminants in food products. Adenovirus, caliciviruses, enteroviruses, and hepatitis A are emerging contaminant viruses. These viruses contaminate a variety of food products, including fruits, vegetables, shellfish, and ready-to-eat processed foods. The diversity of targets and sample matrices presents ...
Shao Ning - - 2012
PURPOSE: MKK4 has been suggested as a tumor suppressor. The functional variant (-1304T>G) in the MKK4 promoter has been implicated as a risk factor for many types of cancer. However, its role in prostate cancer (PCa) is unclear. To determine whether this SNP constitutes a risk factor for PCa susceptibility ...
He Xiuquan - - 2012
Abstract Recent evidence has suggested that microglia activation plays an important role in the pathogenesis of Parkinson's disease (PD). Activated microglia secrete various pro-inflammatory cytokines and neurotoxic mediators, which may contribute to the development of PD. Thus, the inhibition of microglia activation may have a therapeutic benefit in the treatment ...
Haliloglu Berna - - 2012
INTRODUCTION AND HYPOTHESIS: For an accurate evaluation of bladder diaries, we aim to investigate normal urinary habits and determining factors on functional bladder capacity, frequency, and 24-h volume in the bladder diaries of asymptomatic women. METHODS: One-hundred and fifteen asymptomatic women who recorded a 24-h bladder diary were included in ...
Saluja Sundeep Singh - - 2012
BACKGROUND: Leak from cervical esophagogastric anastomosis (CEGA) following esophagectomy is associated with morbidity and poor functional outcome. To address this issue, we conducted a randomized trial comparing "hand-sewn" with "stapled side-to-side" CEGA. METHODS: Of 174 patients who underwent esophageal resection and CEGA between 2004 and 2010, 87 each were randomized ...
Fujita Nobuhiro - - 2012
We report a male case of primary retroperitoneal mucinous cystadenoma (PRMC) that was at initially misdiagnosed as a complicated renal cyst. On ultrasonography, a71-year-old man was found to have an abdominal mass suspicious for right renal cyst. The initial computed tomography scan showed an unenhanced, low-density mass that deformed the ...
Buyuktiryaki Ayse Betul - - 2012
Drug reaction, eosinophilia and systemic symptoms (DRESS) is an acute and life-threatening disease, characterised by fever, rash and systemic symptoms, including lymphadenopathy, abnormal liver function, interstitial nephritis, pulmonary and cardiac infiltrates and haematological abnormalities with eosinophilia and atypical lymphocytes. The drugs mostly associated with DRESS are anticonvulsants, allopurinol, minocycline and ...
Lee Charles C - - 2012
Hemicelluloses represent a large reservoir of carbohydrates that can be utilized for renewable products. Hydrolysis of hemicellulose into simple sugars is inhibited by its various chemical substituents. The glucuronic acid substituent is removed by the enzyme α-glucuronidase. A gene (deg75-AG) encoding a putative α-glucuronidase enzyme was isolated from a culture ...
Lethaus Bernd - - 2012
OBJECTIVE: The purpose of this paper was to find a correlation between laser doppler flowmetry (LDF) and the bone mineral density quotient (BMDQ) to evaluate irradiated bone quality preoperatively. MATERIALS AND METHODS: Premolars and molars were extracted from six minipigs. After a three-month healing period, three animals received irradiation at ...
Rohrbach B W - - 2012
BACKGROUND: Pituitary pars intermedia dysfunction (PPID) is common in older horses. OBJECTIVES: To determine diagnosis frequency, prognostic factors, long-term survival, and owner satisfaction with treatment. ANIMALS: Medical records from horses diagnosed with PPID, 1993-2004. METHODS: A retrospective cohort design with data collected from the Veterinary Medical Data Base (VMDB) and ...
Desgagné-Penix Isabel - - 2012
Recent advances in DNA sequencing technology and analytical mass spectrometry are providing unprecedented opportunities to develop the functional genomics resources required to investigate complex biological processes in non-model plants. Opium poppy produces a wide variety of benzylisoquinoline alkaloids (BIAs), including the pharmaceutical compounds codeine, morphine, noscapine and papaverine. A functional ...
Kucukay Fahrettin - - 2012
PURPOSE: The purpose of this study is to analyze the outcomes of the self-expanding covered metallic stent (SECMS) therapy in the management of the postoperative anastomotic leaks that seen after total gastrectomy-esophagojejunostomy (EJ) operations. MATERIALS AND METHODS: Contrast radiography and endoscopy revealed EJ fistulas in 14 patients. SECMSs were implanted ...
Bennett Emily - - 2012
Parents of 125 children, adolescents and young adults with autism spectrum disorders completed a newly developed questionnaire aimed at identifying cognitive and behavioural characteristics associated with savant skills in this group. Factors distinguishing skilled individuals were then further investigated in case studies of three individuals with exceptional skills for music, ...
Cisarovsky Gabriel - - 2012
Laboratory experiments are often preferred over field experiments because they allow the control of confounding factors that would otherwise influence the causal effect of a particular focal experimental factor. These confounding factors can, however, significantly alter the response of an organism confronted with a particular situation, which can have great ...
Hayes Don D - - 2012
Introduction:   Humidity is commonly associated with increased airway hyperresponsiveness in asthma. Objective:  To examine mold sensitization in patients with allergic asthma or allergic rhinitis and self-reports of humidity as exacerbating factors of clinical symptoms. Methods:   A retrospective, cross-sectional study at a University hospital outpatient allergy and asthma clinic ...
Thude H - - 2012
This study was carried out to evaluate the association between 77C>G transversion (rs17612648) in exon A of the PTPRC gene and liver transplant rejection. No significant differences in genotype and allele frequencies of the 77C>G transversion were detected between recipients without rejection (n = 106) and recipients with rejection (n = 104). In conclusion, ...
Lemmens-Gruber Rosa - - 2012
Background Effective control of diabetes mellitus type 1 (DM1) and type 2 (DM2) can reduce the development and progression of diabetic complications. Therefore, patient education should be considered as an integral part of diabetes management. Objective The aim of the study was to assess DM patients' perception of knowledge for ...
Olbrich Jason M - - 2012
Polymeric controlled delivery systems hold great promise in the field of modern medicine. Such technology has already been converted into commercially viable products in a myriad of fields. Chemotherapy is an example of such an area where constant efficacious levels of drug can greatly enhance clinical outcomes. The key to ...
Suzuki Yoshi-Ichi - - 2012
The time-energy mapping of the photoionization integral cross section and laboratory-frame photoelectron angular distribution is used to study photoionization stereodynamics of a diatomic molecule. The general theoretical formalism [Y. Suzuki and T. Suzuki, Mol. Phys., 2007, 105, 1675] is simplified for application to a diatomic molecule, and a high-resolution photoelectron ...
Lin Gen - - 2012
BACKGROUND: Evidence shows a strong relationship between KRAS mutations and the NF-κB signaling pathway. In colorectal cancer, however, the study of this subject has been very limited and results are inconsistent. AIMS: To examine the relationship between KRAS mutations and NF-κB activation and their effect on chemotherapy response and survival ...
Goerigk D - - 2012
Malignant catarrhal fever (MCF) is a worldwide occurring sporadic disease of cloven-hoofed animals. For the first time, this case report describes clinical and pathological as well as histopathological findings in an alpaca suffering from MCF caused by ovine herpesvirus 2. Clinical symptoms comprised apathy, dehydration, anorexia, and emaciation. These symptoms ...
Zoladz Jerzy A - - 2012
The effect of maximal voluntary isometric strength training of knee extensor muscles on pulmonary V'O(2) on-kinetics, the O(2) cost of cycling and peak oxygen uptake (V'O(2peak)) in humans was studied. Seven healthy males (mean ± SD, age 22.3 ± 2.0 years, body weight 75.0 ± 9.2 kg, V'O(2peak) 49.5 ± 3.8 ml kg(-1) min(-1)) performed maximal isometric strength training lasting 7 weeks (4 sessions ...
Oyane Ayako - - 2012
Simple, mild, and area-specific calcium phosphate (CaP) coating techniques are useful for the production and surface modification of biomaterials. In this study, an area-specific CaP coating technique for polymer substrates was successfully developed using a liquid-phase laser process. In the proposed method, Nd-YAG laser light (355 nm, 30 Hz, and ...
Singla Neil K - - 2012
Background:  This is the first study to compare plasma and cerebrospinal fluid (CSF) pharmacokinetics of intravenous (IV), oral (PO), or rectal (PR) formulations of acetaminophen. Methods:  Healthy male subjects (N = 6) were randomized to receive a single dose of IV (OFIRMEV(®) ; Cadence) 1,000 mg (15 minute infusion), PO (2 Tylenol(®) 500 mg caplets; ...
Breer H - - 2012
Sensing potentially beneficial or harmful constituents in the luminal content by specialized cells in the gastrointestinal mucosa is an essential prerequisite for governing digestive processes, initiating protective responses and regulating food intake. Until recently, it was poorly understood how the gastrointestinal tract senses and responds to nutrients and non-nutrients in ...
Staaf Elina - - 2012
The purpose of this study was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays. Whole blood collected from one donor was exposed to different doses of alpha particles ((241)Am), X-rays and a combination of both. All exposures ...
Barrier-Battut I - - 2012
Fertility is reduced after semen cooling for a considerable number of stallions. The main hypotheses include alterations in plasma membrane following cooling and deleterious influence of seminal plasma. However, interindividual variability is controversial. We hypothesized that the removal of seminal plasma could enhance motility in some 'poor cooler' stallions, but ...
Haltrich Irén - - 2012
Cytogenetic aberrations are very important factors in risk assessment of childhood hematological malignancies. We report six childhood acute lymphoid leukemia (ALL) cases with rare cytogenetic aberrations: five with RUNX1, ABL1 or MLL proto-oncogene amplification and one case of multiple copies of ETV6/RUNX1 fusion genes. The simultaneous presence of two adverse ...
Luong Susan - - 2012
6-Monoacetylmorphine (6-MAM), being a unique metabolite of heroin, is routinely tested in urine samples to monitor heroin use. However, detection of 6-MAM-related opiates such as morphine is known to be affected by in vitro urine adulteration using oxidizing adulterants such as potassium nitrite. This study aimed to investigate the fate ...
Ashihara Hiroshi - - 2012
Pyridine compounds, including nicotinic acid and nicotinamide, are key metabolites of both the salvage pathway for NAD and the biosynthesis of related secondary compounds. We examined the in situ metabolic fate of [carbonyl-(14)C]nicotinamide, [2-(14)C]nicotinic acid and [carboxyl-(14)C]nicotinic acid riboside in tissue segments of tea (Camellia sinensis) plants, and determined the ...
O'Brien Jon - - 2012
Issue. While population wide smoking rates are falling steadily the rates remain high among the disadvantaged. The future we face is one where the differentials in smoking rates will continue to widen and will flow through to increased health inequalities. Approach. How best to reduce smoking rates among the disadvantaged? ...
Nieder M - - 2012
Four cows from North-West Germany have been diagnosed with tick-borne fever (TBF) based on the demonstration of morulae in neutrophilic granulocytes in their blood smears, positive signals in real-time PCR specific for Anaplasma phagocytophilum using DNA extracted from their buffy coats, and demonstration of specific antibodies in their sera using ...
Burkard Alexandra - - 2012
We have developed a novel technique which causes primary human hepatocytes to proliferate by transducing them with genes that upregulate their proliferation. Upcyte(®) hepatocytes did not form colonies in soft agar and are not immortalised anchorage-independent cells. Confluent cultures expressed liver-specific proteins, produced urea and stored glycogen. CYP activities were ...
Wang Lin - - 2012
Understanding the structure and formation dynamics of the solid electrolyte interphase (SEI) on the electrode/electrolyte interface is of great importance for lithium ion batteries, as the properties of the SEI remarkably affect the performances of lithium ion batteries such as power capabilities, cycling life, and safety issues. Herein, we report ...
Wagner R - - 2012
AIMS/HYPOTHESIS: Microalbuminuria represents an established surrogate marker of early diabetic nephropathy and glomerular microangiopathy. Increasing evidence is emerging of a role of perivascular adipose tissue (PVAT) as an important link between obesity, insulin resistance and both macro- and microangiopathy. It is not known whether perivascular renal sinus fat (RSF) has ...
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