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Atlas Ronald M - - 2012
One Health is an emerging concept that aims to bring together human, animal, and environmental health. Achieving harmonized approaches for disease detection and prevention is difficult because traditional boundaries of medical and veterinary practice must be crossed. In the nineteenth and early twentieth centuries, this was not the case-then researchers ...
Biocanin Vladimir - - 2012
OBJECTIVES: The main purpose of this study was to evaluate the dose-dependent anesthetic efficacy of the intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA) obtained with different volumes of 4 % articaine and 1:100,000 epinephrine (Ar + Ep) in human mandibular premolars, using a computer-controlled local anesthetic delivery system (CCLADS). The ...
Im Wan-Taek - - 2012
Strain Gsoil 348(T) was isolated from a ginseng field soil sample by selecting micro-colonies from one-fifth strength modified R2A agar medium after a long incubation period. 16S rRNA gene sequence analysis indicated that the strain is related to members of the phylum Armatimonadetes (formerly called candidate phylum OP10). Strain Gsoil ...
Ekino Shigeo - - 2012
The bursa of Fabricius of the chicken is known as a primary lymphoid organ for B-cell development. Morphologically, the origin of IgG-containing cells in the bursa has not been clear until now, because abundant maternal IgG (MIgG) is transported to the chick embryo and distributed to the bursal tissue around ...
Fiorillo Chiara C Neuromuscular Unit, IRCCS Stella Maris, Via dei Giacinti 2, 56028 Pisa, Italy. - - 2012
Inherited disorders characterized by motor neuron loss and muscle weakness are genetically heterogeneous. The recent identification of mutations in the gene encoding transient receptor potential vanilloid 4 (TRPV4) in distal spinal muscular atrophy (dSMA) prompted us to screen for TRPV4 mutations in a small group of children with compatible phenotype. ...
Schlötzer-Schrehardt Ursula - - 2012
OBJECTIVES: To characterize the localization profiles of seven adhesion/growth-regulatory galectins in the normal human eye using immunodetection of endogenous galectins and binding of labeled galectins to sections, useful as a basis to detect disease-associated alterations. METHODS: Non-cross-reactive anti-galectin antibodies and biotinylated galectins were tested on acetone-fixed cryosections of normal human ...
Sisakhtnezhad Sajjad - - 2012
Evidence has emerged recently indicating that differentiation is not entirely a one-way process, and that it is possible to convert one cell type to another, both in vitro and in vivo. This phenomenon is called transdifferentiation, and is generally defined as the stable switch of one cell type to another. ...
Iatan Iulia - - 2012
Plasma levels of high-density lipoprotein cholesterol (HDL-C) show an inverse association with coronary heart disease (CHD). As a biological trait, HDL-C is strongly genetically determined, with a heritability index ranging from 40 % to 60 %. HDL represents an appealing therapeutic target due to its beneficial pleiotropic effects in preventing CHD. This ...
Cretoiu Mariana Silvia - - 2012
The main objective of this study was to assess the abundance and diversity of chitin-degrading microbial communities in ten terrestrial and aquatic habitats in order to provide guidance to the subsequent exploration of such environments for novel chitinolytic enzymes. A combined protocol which encompassed (1) classical overall enzymatic assays, (2) ...
Cao Bingzhen - - 2012
The objective of this study is to elucidate the primary action of methylmercury chloride (MMC) intoxication on peripheral nervous system. We chronologically observed the pathological changes of sciatic nerve, dorsal root ganglion (DRG) neurons, ventral and dorsal roots in rats given 4 mg/kg/day of MMC on consecutive days and killed on ...
Hasegawa Yuh - - 2013
The influence of the third molars on mandibular incisor crowding has been extensively studied but remains controversial. The purpose of this study was to ascertain whether, in Mongolian subjects, the lower third molar can affect anterior crowding and/or the inclination of teeth in the lower lateral segments. Panoramic radiographs, 45° ...
Ohue Shiro - - 2012
Various surgical approaches to the infratemporal fossa (ITF) have been reported. Among them, the preauricular transzygomatic anterior ITF approach (anterior ITF approach) has been used for exposure of the antero-superior part of the ITF. The purpose of this article is to show anatomical dissections using the anterior ITF approach and ...
Timpson Leanne M - - 2012
Haloarchaeal alcohol dehydrogenases are exciting biocatalysts with potential industrial applications. In this study, two alcohol dehydrogenase enzymes from the extremely halophilic archaeon Haloferax volcanii (HvADH1 and HvADH2) were homologously expressed and subsequently purified by immobilized metal-affinity chromatography. The proteins appeared to copurify with endogenous alcohol dehydrogenases, and a double Δadh2 ...
Roguska Agata - - 2012
The new generation of medical implants made by titanium is functionalized with different coatings to improve their bioactivity and reduce a risk of infection. This article describes how these goals can be achieved via deposition of silver nanoparticles and calcium phosphate coating. TiO(2) nanotubes were grown on a Ti substrate ...
Moylan S - - 2012
In some patients with major depressive disorder (MDD), individual illness characteristics appear consistent with those of a neuroprogressive illness. Features of neuroprogression include poorer symptomatic, treatment and functional outcomes in patients with earlier disease onset and increased number and length of depressive episodes. In such patients, longer and more frequent ...
Poersch Karla - - 2012
Introduction:  Cardiopulmonary exercise testing (CPET) is increasingly used to evaluate the overall impact of the illness on patients with COPD.While laboratory tests of exercise performance are costly, the six-minute walk test (6-MWT) can be more easily performed. Although the main outcome commonly used in this field test is the distance ...
Yee Helen S - - 2012
Chronic hepatitis C virus (HCV) infection affects approximately 1.3% of the United States population and 4% of veterans who use Department of Veterans Affairs medical services. Chronic HCV is the primary cause of cirrhosis, hepatocellular carcinoma (HCC), and end-stage liver disease requiring liver transplantation in the United States. Management of ...
Chen Jui-Tse - - 2012
Well-defined cationic polymers were synthesized via the reversible addition fragmentation chain transfer polymerization and were subsequently used as stabilizer for the synthesis of cationic iron-oxide magnetic nanoparticles via the coprecipitation method. The surface-coated iron-oxide nanoparticles made stable suspension in water and were characterized by a range of techniques such as ...
Lopez-Poveda Enrique A - - 2012
Differentiating the relative importance of the various contributors to the audiometric loss (HL(TOTAL)) of a given hearing impaired listener and frequency region is becoming critical as more specific treatments are being developed. The aim of the present study was to assess the relative contribution of inner (IHC) and outer hair ...
Lee Young-Kyun - - 2012
BACKGROUND: The Oxford hip score (OHS) is one of the most widely used scoring systems to assess clinical outcome for patients with total hip arthroplasty (THA). Few studies have evaluated the OHS in non-Western patients with other cultural backgrounds, particularly Asians. Translation and transcultural adaptation of the OHS into the ...
Iorio R - - 2012
PURPOSE: The aim of this study was to evaluate the accuracy of conventional instrumentation for tibial resection in total knee arthroplasty (TKA) as assessed by a computer-based navigation system during each phase of the surgical procedure. The hypothesis is that conventional instrumentation fails to achieve optimal accuracy in final implant ...
Baig Arshiya A - - 2012
Churches provide an innovative and underutilized setting for diabetes self-management programs for Latinos. This study sought to formulate a conceptual framework for designing church-based programs that are tailored to the needs of the Latino community and that utilize church strengths and resources. To inform this model, we conducted six focus ...
Bal Bikram S - - 2012
Lifestyle intervention programmes often produce insufficient weight loss and poor weight loss maintenance. As a result, an increasing number of patients with obesity and related comorbidities undergo bariatric surgery, which includes approaches such as the adjustable gastric band or the 'divided' Roux-en-Y gastric bypass (RYGB). This Review summarizes the current ...
Zheng Bin - - 2012
BACKGROUND: Blinks are known as an indicator of visual attention and mental stress. In this study, surgeons' mental workload was evaluated utilizing a paper assessment instrument (National Aeronautics and Space Administration Task Load Index, NASA TLX) and by examining their eye blinks. Correlation between these two assessments was reported. METHODS: ...
Luo F - - 2012
BACKGROUND: Hypertension has been associated with hypoalgesia. This prospective study was designed to test the effects of untreated preoperative essential hypertension on post-operative pain intensity and morphine requirement after major abdominal surgery. METHODS: Sixty subjects (30 untreated essential hypertensives and 30 normotensives) scheduled for abdominal surgery were included in this ...
Cao Xinwang - - 2012
The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo ...
Galbete Cecilia - - 2013
Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk and to examine their interaction with lifestyle factors in an elderly population. Subjects (n = 978; ...
Phillips Melissa S - - 2012
INTRODUCTION: Flank hernias represent a challenging problem to reconstructive surgeons. Their anatomic proximity to the bony prominence and major neurovascular structures limits fixation options and restricts mesh overlap. We present our technique and outcomes of a preperitoneal repair with wide mesh overlap. METHODS: This study is a retrospective analysis of ...
Nardozza Luciano Marcondes Machado - - 2012
BACKGROUND: Fetal growth restriction (FGR) is a condition that affects 5-10 % of gestations, and it is the second primary cause of perinatal mortality. In this review the most recent knowledge about FGR is presented focusing on its concept, etiology, classification, diagnosis, management, and prognosis. METHODS: Searches were conducted in Pubmed, ...
Liu Jie J Department of Psychiatry, Yale School of Medicine, New Haven , CT 06511, - - 2012
Convergent evidence supports limbic, anterior paralimbic, and prefrontal cortex (PFC) abnormalities in emotional processing in bipolar disorder (BD) and suggests that some abnormalities are mood-state dependent and others persist into euthymia. However, few studies have assessed elevated, depressed, and euthymic mood states while individuals processed emotional stimuli of varying valence ...
Lu Yang - - 2012
Enzyme-linked immunosorbent assays (ELISAs) are investigated in this work for the detection of bisphenol-A (BPA), a plastic monomer and a critical contaminant in food and environment. A series of polyclonal antibodies generated in vivo using BPA-butyrate-protein conjugate and BPA-valerate-protein conjugate were evaluated on direct and indirect competitive assay formats with ...
Ní Lochlainn M - - 2012
BACKGROUND: In the absence of reliable, objective and direct measures of awareness, the diagnosis and prognosis of the vegetative and minimally conscious states are greatly complicated. This has led to an unacceptably high level of misdiagnosis. Although diagnosis and prognosis have typically relied on bedside behavioural measures, a number of ...
Kuhne F - - 2012
The castration of dogs is an amputation covered by Section 6 (1) of the Animal Protection Law in Germany. Apart from the general indications given by veterinary medicine, castration of an animal is a potential method of animal behaviour therapy. However, the highly variable, individual effects of castration on behaviour ...
Liu Jia-Ming - - 2012
Under the condition of 60 °C and 20 min at pH 6.12, chlorpromazine hydrochloride (CPZ) could react with fluorescein isothiocyanate (FITC) to produce FITC-CPZ, which increased the π-electron density (δ) of carbon atom in FITC conjugated system and the room temperature phosphorescence (RTP) intensity of FITC. Thus, a new solid substrate room ...
Reisenauer Christl - - 2012
Diagnoses of complications in women who underwent pelvic floor surgery using meshes and the multidisciplinary management of these cases at two national referral urogynecological centers between January and June 2011, are presented in a series of cases of mesh complications, which provide an indication of the wide range of symptoms ...
Li Zhixia - - 2012
Poly(methylmethacrylate) (PMMA)-based cements containing magnetite (C-PMMA/Fe(3) O(4) ) is useful in hyperthermia treatment for bone tumor. We have prepared C-PMMA/Fe(3) O(4) by incorporating Fe(3) O(4) powders of different diameters (means of 300, 35, and 11 nm) into the polymerization reaction of methyl methacrylate monomer to develop a new bone cement ...
Martin Robert C G RC - - 2012
The primary objective of this study is to evaluate the safety, tolerance, and pharmacokinetic profile of liver-directed therapy with drug-eluting beads irinotecan (DEBIRI) in combination with systemic modified FOLFOX in the treatment of unresectable liver metastases in chemotherapy-naive patients with colorectal cancer. DEBIRI, loaded with 100 mg irinotecan (100-300 μm beads), was ...
Hernández Antonio - - 2012
Bone regeneration and vascularization with porous PLGA scaffolds loaded with VEGF (0.35 and 1.75 μg) and BMP-2 (3.5 and 17.5 μg), incorporated in PLGA microspheres, or the combination of either dose of BMP-2 with the low dose of VEGF were investigated in an intramedullary femur defect in rabbits. The system ...
Asano Satoru - - 2012
We report the successful management of a female patient who developed postoperative thrombotic thrombocytopenic purpura (TTP) after an uneventful laparoscopic oophorocystectomy. The patient underwent uneventful laparoscopic surgery for ovarian cystoma. One hour after completion of surgery, the patient suddenly went into shock, with her blood pressure dropping to 60/40 mmHg. Hemorrhage ...
Morecroft Ian I Institute of Cardiovascular and Medical Sciences, University of Glasgow, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, Glasgow, - - 2012
Serotonin is produced by pulmonary arterial endothelial cells (PAEC) via tryptophan hydroxylase-1 (Tph1). Pathologically, serotonin acts on underlying pulmonary arterial cells, contributing to vascular remodeling associated with pulmonary arterial hypertension (PAH). The effects of hypoxia on PAEC-Tph1 activity are unknown. We investigated the potential of a gene therapy approach to ...
Chabrot Pascal - - 2012
PURPOSE: To evaluate cisplatin (CDDP) pharmacokinetics after its intravenous (IV) or intrahepatic arterial administration (IHA) in healthy pigs with or without embolization by absorbable gelatine. MATERIAL AND METHODS: We analysed plasmatic and hepatic drug concentration in four groups of six mini-pigs each according to the modality of administration of CDDP ...
Avdonin Sergei - - 2012
Dendrites of nerve cells have membranes with spatially distributed densities of ionic channels and hence non-uniform conductances. These conductances are usually represented as constant parameters in neural models because of the difficulty in experimentally estimating them locally. In this paper we investigate the inverse problem of recovering a single spatially ...
Niedojadło Janusz - - 2012
The spatial organisation of the splicing system in plant cells containing either reticular (Allium cepa) or chromocentric (Lupinus luteus) nuclei was studied by immunolabelling of SR proteins, snRNA, and the PANA antigen, known markers for interchromatin granule clusters in mammalian cells. Electron microscope results allowed us to determine the distribution ...
Simor Péter - - 2012
Nightmares are intense, emotionally negative mental experiences that usually occur during late-night sleep and result in abrupt awakenings. Questionnaire-based studies have shown that nightmares are related to impaired sleep quality; however, the polysomnographic profile of nightmare subjects has been only scarcely investigated. We investigated the sleep architecture of 17 individuals ...
Cao Bianmei - - 2012
Sustained release of copper (Cu) ions from Cu-containing intrauterine devices (CuIUD) is quite efficient for contraception. However, the tissue surrounding the CuIUD is exposed to toxic Cu ion levels. The objective for this study was to quantify the concentration dependent cytotoxic effects of Cu ions and correlate the toxicity due ...
Li Yun - - 2012
Highly sensitive detection of proteins offers the possibility of early and rapid diagnosis of various diseases. Microchip-based immunoassay integrates the benefits from both immunoassays (high specificity of target sample) and microfluidics (fast analysis and low sample consumption). However, direct capture of proteins on bare microchannel surface suffers from low sensitivity ...
Benegiamo Giorgia - - 2012
BACKGROUND: Hepatitis C virus infects ~3 % of the population and it is a risk factor for hepatocarcinogenesis. The epigenetic mechanisms of HCV-induced hepatocyte transformation towards malignancy in this context are unclear. AIMS: The purpose of this study was to evaluate the effect of HCV core proteins of different genotypes on ...
Akagi Hideko - - 2012
BACKGROUND: Myeloid cell leukemia-1 (Mcl-1) is an anti-apoptotic protein that regulates apoptosis sensitivity in a variety of cell types. Here we evaluate the roles of Mcl-1 in chemotherapy-associated apoptosis in gastric cancer cells. In addition, our study examined whether Mcl-1 contributed to apoptosis resistance in so-called cancer stem cell (CSC)-like ...
Wray Curtis J - - 2012
BACKGROUND: Racial disparities exist for patients with pancreatic cancer. This observation has primarily been noted in the Surveillance, Epidemiology, and End Results database and has focused primarily on whites and African Americans. We sought to determine if these disparities exist in a local, racially diverse patient population. METHODS: Retrospective review ...
Pinheiro M C N - - 2012
Our objective was to evaluate the temporal evolution of mercury exposure in two riverside communities, Barreiras and São Luiz do Tapajós, downstream of gold mining areas in the Tapajós basin, Brazilian Amazon. The quantification of mercury in hair sample was made by atomic absorption spectrophotometry in the period between 1994 ...
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