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Mischak Harald - - 2012
While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implementation. Some of the problems lie in ...
Tongsai Sasima - - 2012
Early ambulation after percutaneous coronary intervention (PCI) could increase patient comfort, decrease length of hospital stay, and reduce the costs. However, this approach may increase the risk of vascular complications and has not been well assessed. This study was conducted to assess the safety of early ambulation versus late ambulation ...
Pradka Sarah P - - 2012
We report the 44-year follow-up of a 9-year-old girl who underwent a saphenous vein interposition graft in 1964 after suffering extensive pelvic trauma with complete disruption of the right common femoral artery. The patient recovered from this injury and experienced no disability or pain until 2008, when she suddenly developed ...
Abah Udo - - 2012
This article addresses the main risk factors for stroke in cardiac surgery and discusses the role of carotid artery intervention and peri-operative epi-aortic scanning in the prevention of stroke. In great Britain and Northern Ireland, there were ∼2789 new strokes following the 105,558 cases of cardiac surgery from 2004 to ...
An Gyeong-Ju - - 2012
Abstract The purpose of this study was to understand the relationship between powerlessness, social support, and glycemic control in Korean adults with type 2 diabetes, taking into consideration their demographic characteristics. A total of 124 adults with type 2 diabetes answered the questionnaires of powerlessness and social support. Glycemic control ...
Hayashi Yuya - - 2012
RNA interference (RNAi) is a sequence-specific gene-silencing mechanism triggered by double-stranded RNA and powerful tools for a gene function study and RNAi therapy. Although siRNAs offer several advantages as potential new drugs to treat various diseases, the efficient delivery system of siRNAs in vivo remains a crucial challenge for achieving ...
Dunk Paul William - - 2012
The smallest fullerene to form in condensing carbon vapor has received considerable interest since the discovery of Buckminsterfullerene, C60. Smaller fullerenes remain a largely unexplored class of all carbon molecules that are predicted to exhibit fascinating properties due to the large degree of curvature and resulting highly pyramidalized carbon atoms ...
Dogan Mustafa - - 2012
Perioperative vasospasm during cardiovascular surgery is a challenging problem. Several vasodilator agents are frequently utilized for its prevention in surgical practice. Magnesium and diltiazem both have known potential vasorelaxant effects. We planned to compare the efficacy of diltiazem and magnesium in relieving phenylephrine-precontracted rat aortic rings. Ten young adult female ...
Hong Sung-Yong - - 2012
Aims:  Isoprene (2-methyl-1,3-butadiene; C(5) H(8) ) is naturally produced by photosynthesis and emitted in the atmosphere by the leaves of many herbaceous, deciduous, and woody plants. Fermentative yeast and fungi (Ascomycota) are not genetically endowed with the isoprene production process. The work investigated whether Ascomycota can be genetically modified and ...
Goodman Michael - - 2012
Cancer clusters garner considerable public and legislative attention, and there is often an expectation that cluster investigations in a community will reveal a causal link to an environmental exposure. At a 1989 national conference on disease clusters, it was reported that cluster studies conducted in the 1970s and 1980s rarely, ...
Ghali Shadi S Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, - - 2012
Minimally invasive component separation (CS) with inlay bioprosthetic mesh (MICSIB) is a recently developed technique for abdominal wall reconstruction that preserves the rectus abdominis perforators and minimizes subcutaneous dead space using limited-access tunneled incisions. We hypothesized that MICSIB would result in better surgical outcomes than conventional open CS. All consecutive ...
Hamazaki T - - 2012
Cartilage contains high levels of n-9 eicosatrienoic acid (20:3n-9) but no blood vessels. 20:3n-9 might inhibit angiogenesis. Angiogenesis was measured in human umbilical vein endothelial cells and diploid fibroblasts. Co-culture was performed with vascular endothelial growth factor-A (VEGF-A, 10 ng/mL) and fatty acids (0.1-10 μmol/L). After 10 days of incubation ...
Pitters Jason L - - 2012
Tungsten single atom tips have been prepared from a single crystal W(111) oriented wire using the chemical assisted field evaporation and etching method. Etching to a single atom tip occurs through a symmetric structure and leads to a predictable last atom unlike etching with polycrystalline tips. The single atom tip ...
Day Rusty Davis - - 2012
Elevated mercury concentrations ([Hg]) were found in Alaskan murre (<italic>Uria spp.</italic>) eggs from the coastal embayment of Norton Sound relative to insular colonies in the northern Bering Sea-Bering Strait region. Stable isotopes of Hg, carbon, and nitrogen were measured in the eggs to investigate the source of this enrichment. Lower ...
Kowaka Yasuyuki - - 2012
Electronic and vibrational structures in the S(0) (1)A(1) and S(1) (1)A(1) states of jet-cooled phenanthrene-h(10) and phenanthrene-d(10) were analyzed by high-resolution spectroscopy using a tunable nanosecond pulsed laser. The normal vibrational energies and molecular structures were estimated by ab initio calculations with geometry optimization in order to carry out a ...
Kawakami Norito N Department of Mental Health, School of Public Health, the University of Tokyo, Tokyo, - - 2012
Better information on the human capital costs of early-onset mental disorders could increase sensitivity of policy makers to the value of expanding initiatives for early detection and treatment. Data are presented on one important aspect of these costs: the associations of early-onset mental disorders with adult household income. Data come ...
Talpur Rakhshandra - - 2012
Better treatment and survival outcomes are needed for the rare primary cutaneous peripheral T-cell lymphomas.Five (62.5%) of 8 patients with peripheral T-cell lymphomas enrolled in a pilot study of denileukin diftitoxat 18 μg/kg per day for 5 days followed by once weekly for 24 weeks responded, including 2 complete responses, ...
Moseler Michael - - 2012
Combining temperature-programmed reaction measurements, isotopic labeling experiments, and first-principles density functional theory, the dependence of the reaction temperature of catalyzed carbon monoxide oxidation on the oxidation state of Pd13 clusters deposited on MgO surfaces grown on Mo(100) is explored. It is shown that molecular oxygen dissociates easily on the supported ...
Young E L EL Department of Anaesthetics, Royal Surrey County Hospital, Guildford, - - 2012
To perform a systematic review of cardiopulmonary exercise testing (CPET) in the pre-operative evaluation of patients with abdominal aortic aneurysm or peripheral vascular disease requiring surgery. Review methods and reporting were according to the PRISMA guidelines. Studies were eligible if they reported CPET-derived physiological parameters in patients undergoing abdominal aortic ...
Zheng Wenjun - - 2012
This study aims to model a minimal dynein motor domain capable of motor function, which consists of the linker domain, six AAA+ modules (AAA1-AAA6), coiled coil stalk, and C-terminus domain. To this end, we have used the newly solved X-ray structures of dynein motor domain to perform a coarse-grained modeling ...
Marino Tiziana - - 2012
A theoretical investigation at MP2/6-311++G(2d,2p)//MP2/6-31+G(d,p) level was employed in order to study the one-electron oxidation mechanism of methionine in aqueous solution. Three reaction paths corresponding to the HO•, O2 attack and hydrolysis were considered. Results show that all the processes are exothermic and that the rate determining step can be ...
Jaquet Ralph - - 2012
Based on different ab initio electronic structure calculations (CI-R12 and Gaussian Geminals) of the Born-Oppenheimer electronic energy E(BO) of H(3) (+) from high to highest quality, we build up a potential energy surface which represents a highly reliable form of the topology of the whole potential region, locally and globally. ...
de Haan Hendrick W - - 2012
Through a detailed Langevin dynamics simulation study, the role of memory effects during unbiased translocation is explored. Tests are devised to uncover the presence of memory effects by directly measuring forward/backward-correlated motion as well as the associated change in the dynamics. Conducting these tests at low and high viscosities, a ...
Saadeldin Islam M - - 2012
The temporal progressive increase of interferon tau (IFNτ) secretion from the bovine trophoblast is a major embryonic signal of establishing pregnancy. Here, we cultured and isolated bovine trophoblast cells (BTs) from IVM/IVF oocytes and in vitro produced blastocysts, used them, for the first time, as donor cells for nuclear transfer ...
Tseng Ming-Tsung - - 2012
Persistent neuropathic pain due to peripheral nerve degeneration in diabetes is a stressful symptom; however, the underlying neural substrates remain elusive. This study attempted to explore neuroanatomical substrates of thermal hyperalgesia and burning pain in a diabetic cohort due to pathologically proven cutaneous nerve degeneration (the painful group). By applying ...
Ulzi Gianna G Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, - - 2012
Myotonia congenita is an autosomal dominantly or recessively inherited muscle disorder causing impaired muscle relaxation and variable degrees of permanent muscle weakness, abnormal currents linked to the chloride channel gene (CLCN1) encoding the chloride channel on skeletal muscle membrane. We describe 12 novel mutations: c.1606G>C (p.Val536Leu), c.2533G>A (p.Gly845Ser), c.2434C>T (p.Gln812X), ...
Sacramento R L - - 2012
We have studied, via laser absorption spectroscopy, the velocity distribution of (7)Li atoms released from cryogenic matrices of solid neon or molecular hydrogen. The Li atoms are implanted into the Ne or H(2) matrices - grown onto a sapphire substrate - by laser ablation of a solid Li or LiH ...
de Oliveira G G G - - 2012
Nevirapine is the first antiretroviral member of non-nucleoside reverse transcriptase inhibitor used in active antiretroviral therapy (HAART). The aim of this work was the evaluation of the dissolution profile of nevirapine tablets by means of the Disk Intrinsic Dissolution Rate (DIDR) using a 2(3) factorial design. This study used a ...
Abu-Abied Mohamad - - 2012
The loss of rooting capability following the transition from the juvenile to the mature phase is a known phenomenon in woody plant development. Eucalyptus grandis was used here as a model system to study the differences in gene expression between juvenile and mature cuttings. RNA was prepared from the base ...
Decloedt A - - 2012
BACKGROUND: Horses are extremely susceptible to ionophore intoxication. Although numerous reports are available regarding monensin, little is known about lasalocid toxicity. OBJECTIVES: To describe accidental lasalocid poisoning on a farm in Belgium. ANIMALS: Eighty-one horses, of which 14 demonstrated clinical signs from day 0-21 after being fed a new concentrate ...
Zeb Irfan I Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA. - - 2012
Fatty liver disease is a common clinical entity in hepatology practice. This study evaluates the prevalence and reproducibility of computed tomography (CT) measures for diagnosis of fatty liver and compares commonly used CT criteria for the diagnosis of liver fat. The study includes 6814 asymptomatic participants from a population-based sample. ...
Jones Reese E - - 2012
We present a rigorous Green-Kubo methodology for calculating transport coefficients based on on-the-fly estimates of: (a) statistical stationarity of the relevant process, and (b) error in the resulting coefficient. The methodology uses time samples efficiently across an ensemble of parallel replicas to yield accurate estimates, which is particularly useful for ...
Ngo N H - - 2012
It is well known that the Voigt profile does not well describe the (measured) shapes of isolated lines. This is due to the neglect of the intermolecular collision-induced velocity changes and of the speed dependence of the collisional parameters. In this paper, we present a new line profile model for ...
Puibasset Joël - - 2012
The exact bridge function of the Lennard-Jones dipolar (Stockmayer) fluid is extracted from Monte Carlo simulation data. The projections g(mnl)(r) onto rotational invariants of the non-spherically symmetric pair distribution function g(r, Ω) are accumulated during simulation. Making intensive use of anisotropic integral equation techniques, the molecular Ornstein-Zernike equation is then ...
Kawachi Miki - - 2012
Arabidopsis thaliana MTP1 is a vacuolar membrane Zn(2+) /H(+) antiporter of the cation diffusion facilitator family. Here we present a structure-function analysis of AtMTP1-mediated transport and remarkable Zn(2+) selectivity through functional complementation tests of more than 50 mutant variants in metal-sensitive yeast strains. This was combined with homology modeling of ...
Zhao Jing - - 2012
The dynamics of glass forming liquids as the glass transition temperature (T(g)) is traversed has become of special interest because of the continuing question as to whether or not the dynamics diverge towards an ideal glass transition/Kauzmann temperature or if the apparent Vogel-Fulcher-Tammann (VFT) divergence is lost as one goes ...
Magata Fumie - - 2012
Persistence of the corpus luteum (CL) in cattle usually occurs during the puerperium and is associated with interference of prostaglandin (PG) F(2α) release from the uterus. The objective of the present study was to determine for the first time the gene expressions in the persistent CL compared with the CL ...
Warren Cortney S - - 2012
Although body dissatisfaction and drive for thinness are commonplace in college-aged women, their relationships with fat talk and stress are understudied. This study examined (a) whether fat talk predicts body dissatisfaction and drive for thinness and (b) whether stress moderates these relationships. Results from self-report questionnaires completed by 121 female ...
Celik Hale Goksever - - 2012
To investigate the effect of laparoscopic endometrioma stripping on serum antimüllerian hormone (AMH) and the correlation between the clinicopathologic factors. Prospective study. University hospital. Sixty-five women with endometriomas. All patients underwent laparoscopic cystectomy. Serum AMH, FSH, LH, E(2), and antral follicle count (AFC) were measured preoperatively, at 6 weeks, and ...
Soltanizadeh Nafiseh - - 2012
In this study, the role of the globin moiety in the structure of this pigment has been evaluated, using myoglobin and hemin as model systems. After the synthesis of the cured pigment from the compounds used in this study, the absorption spectra, Fourier Transform Infrared Spectroscopy (FTIR) and ESI/MS spectroscopy ...
Autschbach Jochen - - 2012
This perspective article discusses some broadly-known and some less broadly-known consequences of Einstein's special relativity in quantum chemistry, and provides a brief outline of the theoretical methods currently in use, along with a discussion of recent developments and selected applications. The treatment of the electron correlation problem in relativistic quantum ...
Manca Fabio - - 2012
Stretching experiments on single molecules of arbitrary length opened the way for studying the statistical mechanics of small systems. In many cases in which the thermodynamic limit is not satisfied, different macroscopic boundary conditions, corresponding to different statistical mechanics ensembles, yield different force-displacement curves. We formulate analytical expressions and develop ...
Sun Wenfang - - 2012
The photophysics of six bipyridyl platinum(II) bisstilbenylacetylide complexes with different auxiliary substituents are reported. These photophysical properties have been investigated in details by UV-Vis, photoluminescence (both at room temperature and at 77 K), and transient absorption (ns and fs) spectroscopies, as well as by linear response time dependent density functional ...
Lederle Amy - - 2012
Vocal tremor is an acoustical phenomenon characterized by relatively periodic modulations in fundamental frequency and intensity. Although vocal tremor is considered easier to perceive during sustained phonation than during connected speech, systematic comparison between these speech contexts has not been investigated. This investigation compared vocal tremor perception during sustained phonation ...
Lin You-Sheng - - 2012
We propose a long-range corrected hybrid meta-generalized-gradient approximation (GGA) functional, based on a global hybrid meta-GGA functional, M05 [Y. Zhao, N. E. Schultz, and D. G. Truhlar, J. Chem. Phys. 123, 161103 (2005)], and empirical atom-atom dispersion corrections. Our resulting functional, ωM05-D, is shown to be accurate for a very ...
Gupta Bhaskar Sen - - 2012
The nonequilibrium dynamics and aging behavior of a supercooled liquid is investigated from an analysis of the correlation of density fluctuations at two different times. The dynamic correlation functions are computed by solving numerically the equations of nonlinear fluctuating hydrodynamics. The aging time dependence follows a modified stretched exponential form ...
Ho Man Yi - - 2012
Electrochemical impedance spectroscopy (EIS) is used to detect TNT in a novel sandwiched structure which relies on the specific interactions between i) primary amine with TNT; ii) TNT and anti-TNT aptamer. With pure targets, the assay has a sensitivity of 10e-14 M, a dynamic range 10e-14 to 10e-3 M and ...
Loginov Evgeniy - - 2012
Excitation spectra up to the ionization threshold are reported for barium atoms located on the surface of helium nanodroplets. For states with low principal quantum number, the resonances are substantially broadened and shifted towards higher energy with respect to the gas phase. This has been attributed to the repulsive interaction ...
Huang Enmin - - 2012
BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common congenital malformation associated with genetic and environmental risk factors. A recent genome-wide association study identified two novel susceptibility loci on chromosomes 1p22 and 20q12; however, conflicting results, especially for 1p22, have been reported in Han Chinese population. ...
Chai Jeng-Da - - 2012
In contrast to the original Kohn-Sham (KS) formalism, we propose a density functional theory (DFT) with fractional orbital occupations for the study of ground states of many-electron systems, wherein strong static correlation is shown to be described. Even at the simplest level represented by the local density approximation (LDA), our ...
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