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Kennedy J L JL University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA, - - 2012
The classification of asthma to identify forms which have different contributing causes is useful for all cases in which the disease requires regular treatment, but it is essential for the management of severe asthma. Many forms of the disease can occur, and complex mixtures are not uncommon; here we artificially ...
Jenkins Marc K MK Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. - - 2012
Recent advances in technology have led to the realization that the populations of naive T cells specific for different foreign peptide:MHC (p:MHC) ligands vary in size. This variability is due, in part, to the fact that certain peptides contain amino acids that engage in particularly favorable interactions with TCRs. In ...
Saelens Brian E BE Seattle Children's Research Institute, Washington 98145-5005, USA. - - 2012
Identifying neighborhood environment attributes related to childhood obesity can inform environmental changes for obesity prevention. To evaluate child and parent weight status across neighborhoods in King County (Seattle metropolitan area) and San Diego County differing in GIS-defined physical activity environment (PAE) and nutrition environment (NE) characteristics. Neighborhoods were selected to ...
Marnett Lawrence J - - 2012
The inflammatory response represents a first line of defense against invading pathogens and is important to human health. Chronic inflammation contributes to the etiology of multiple diseases, especially those associated with aging, such as cancer and cardiovascular disease. The chemistry of the inflammatory response is complex and involves the generation ...
Querejeta-Fernández Ana - - 2012
A lot of interesting and sophisticated examples of nanoparticle (NP) self-assembly (SA) are known. From both fundamental and technological standpoints, this field requires advancements in three principle directions: (a) understanding the mechanism and driving forces of three-dimensional (3D) SA with both nano- and microlevels of organization; (b) understanding disassembly/deconstruction processes; ...
Zhang Yan - - 2012
Ag(2)S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0-1.4 μm) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for the first time. Highly selective in vitro targeting and imaging of different cell lines are achieved using biocompatible NIR-II Ag(2)S QDs with ...
Xue Yi - - 2012
Rhomboid protease conducts proteolysis inside the hydrophobic environment of the membrane. The conformational flexibility of the protease is essential for the enzyme mechanism, but the nature of this flexibility is not completely understood. Here we describe the crystal structure of rhomboid protease GlpG in complex with a phosphonofluoridate inhibitor, which ...
Lin Jiusheng - - 2012
DJ-1 is a conserved, disease-associated protein that protects against oxidative stress and mitochondrial damage in multiple organisms. Human DJ-1 contains a functionally essential cysteine residue (Cys106) whose oxidation is important for regulating protein function by an unknown mechanism. This residue is well-conserved in other DJ-1 homologues, including two (DJ-1α and ...
Dweck Marc R MR Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom. - - 2012
With combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of active plaque calcification and inflammation, respectively. The noninvasive assessment of coronary artery plaque biology would be a major advance particularly in the identification of vulnerable plaques, ...
Frankel David S DS Cardiovascular Division, Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2012
The goal of this study was to evaluate the ability of noninvasive programmed stimulation (NIPS) after ventricular tachycardia (VT) ablation to identify patients at high risk of recurrence. Optimal endpoints for VT ablation are not well defined. Of 200 consecutive patients with VT and structural heart disease undergoing ablation, 11 ...
Mora Samia S Center for Cardiovascular Disease Prevention, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA. - - 2012
The goal of this study was to determine whether residual risk after high-dose statin therapy for primary prevention individuals with reduced levels of low-density lipoprotein cholesterol (LDL-C) is related to on-treatment apolipoprotein B, non-high-density lipoprotein cholesterol (non-HDL-C), trigylcerides, or lipid ratios, and how they compare with on-treatment LDL-C. Guidelines focus ...
Baker Aaron B AB Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA. - - 2012
The purpose of this study was to examine the role of heparanase in controlling thrombosis following vascular injury or endovascular stenting. The use of endovascular stents are a common clinical intervention for the treatment of arteries occluded due to vascular disease. Both heparin and heparan sulfate are known to be ...
Ramey Sandra L - - 2012
Police officers are prone to cardiovascular disease, overweight, and obesity. Because night-shift work affects sleep, a modifiable risk factor linked to chronic disease, the researchers explored the relationship among shift work, sleep, and wellness for police officers. Sleep, C-reactive protein (CRP) levels, stress, fatigue, and body mass index were used ...
Chan Yang-Hsiang - - 2012
This communication describes a new class of semiconducting polymer nanoparticle-quantum dot hybrid with high brightness, narrow emission, near-IR fluorescence, and excellent cellular targeting capability. Using this approach, we circumvented the current difficulty with obtaining narrow-band-emitting and near-IR-fluorescing semiconducting polymer nanoparticles while combining the advantages of both semiconducting polymer nanoparticles and ...
Nagornova Natalia S - - 2012
Studying solvation of a large molecule on an atomic level is challenging because of the transient character and inhomogeneity of hydrogen bonding in liquid water. We studied water clusters of a protonated macrocyclic decapeptide, gramicidin S, which were prepared in the gas phase and then cooled to cryogenic temperatures. The ...
Chai Wei-Ming - - 2012
The structures of the condensed tannins isolated from leaf, fruit and stem bark of Delonix regia have been investigated with 13C nuclear magnetic resonance (13C-NMR), high performance liquid chromatography electrospray ionization mass spectrometry (HPLC-ESI-MS) coupled with thiolysis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analyses. The results showed ...
Gittleson Forrest S - - 2012
While inhomogeneous thin conductive films have been sought after for their flexibility, transparency, and strength, poor control in the processing of these materials has restricted their application. The versatile technique of layer-by-layer assembly allows greater control over film deposition but even this has been hampered by the traditional dip-coating method. ...
Sathira-Angkura Vera - - 2012
STUDY DESIGN.: Cross-sectional observational study to investigate psychometric properties of an adapted Thai version of the refined Scoliosis Research Society-22 (SRS-22) questionnaire. OBJECTIVE.: To evaluate the reliability and validity of the adapted Thai version of the refined SRS-22 questionnaire. SUMMARY OF BACKGROUND DATA.: The SRS-22 questionnaire is a valid instrument ...
Vilchez-Vargas Ramiro - - 2012
Despite various efforts to develop tools to detect and compare the catabolic potential and activity for pollutant degradation in environmental samples, there is still a need for an open-source, curated and reliable array method. We developed a custom array system including a novel normalization strategy that can be applied to ...
Barnett A L - - 2012
Background  Despite their movement difficulties, youngsters with Developmental Co-ordination Disorder (DCD) generally have sufficient capability for physical activity. However, they tend to be less physically active and less physically fit than their well co-ordinated age peers. The aim of this study was to use qualitative research methods to understand which ...
Zabidi Z - - 2012
Objective: To determine the potential antiulcer activity of methanol extract of Melastoma malabathricum leaves (MEMM) using various established rat models. Materials and Methods: Ten groups of rats were used and orally administered 10% DMSO (negative control), 100 mg/kg ranitidine (positive control) or MEMM (50, 250 and 500 mg/kg) followed by ...
Heleno Sandrina - - 2012
Mushrooms do not constitute a significant portion of the human diet, but their consumption continues to increase due to their functional benefits and presence of bioactive compounds. Some of those compounds can be found in the phenolic, polysaccharidic and lipidic fractions of edible and inedible species. Herein, those fractions of ...
Moen M H - - 2012
In medial tibial stress syndrome (MTSS) bone marrow and periosteal edema of the tibia on the magnetic resonance imaging (MRI) is frequently reported. The relationship between these MRI findings and recovery has not been previously studied. This prospective study describes MRI findings of 52 athletes with MTSS. Baseline characteristics were ...
Romano-Trujillo R - - 2012
Lead selenide nanoparticles (PbSe NPs) have been obtained through an easy and low cost route using colloidal synthesis in aqueous solution. The synthesis was carried out at room temperature using Extran (Na(5)P(3)O(10), NaOH and H(2)O) as surfactant. Hydrochloric acid (HCl) was used to eliminate the generated by-products. The size of ...
Cole Martin G - - 2012
OBJECTIVE: The purpose of this study was to determine the course of delirium in older long-term care (LTC) residents. METHODS: A prospective cohort study of 279 residents in seven LTC facilities in Montreal and Quebec City, Canada, was conducted. The Mini Mental State Examination (MMSE), Confusion Assessment Method (CAM), Delirium ...
Farla Robert J M - - 2012
Crystal defects form during tectonic deformation and are reactivated by the shear stress associated with passing seismic waves. Although these defects, known as dislocations, potentially contribute to the attenuation of seismic waves in Earth's upper mantle, evidence for dislocation damping from laboratory studies has been circumstantial. We experimentally determined the ...
Nuraje Nurxat - - 2012
A synthetic method of using genetically engineered M13 virus to mineralize perovskite nanomaterials, particularly strontium titanate (STO) and bismuth ferrite (BFO), is presented. Genetically engineered viruses provide effective templates for perovskite nanomaterials. The virus-templated nanocrystals are small in size, highly crystalline, and show photocatalytic and photovoltaic properties.
Phipps Kathy R - - 2012
Objectives: To describe the Indian Health Service (IHS) oral health surveillance system and the oral health status of American Indian and Alaska Native (AI/AN) children aged 1-5 years. Methods: A stratified probability sample of IHS/tribal sites was selected. Children were screened by trained examiners at community-based locations including medical clinics, ...
Sutter Peter - - 2012
Epitaxial transition metal films have recently been introduced as substrates for the scalable synthesis of transferable graphene. Here, real-time microscopy is used to study graphene growth on epitaxial Ru films on sapphire. At high temperatures, high-quality graphene grows in macroscopic (>100 μm) domains to full surface coverage. Graphene nucleation and ...
Shi Xin-Wei - - 2012
Secoscabronine M (1) is a hemiacetal cyathane diterpenoid that was isolated from the fruiting bodies of the basidiomycete Sarcodon scabrosus (Fr.) Karst. Compound 1 possesses a novel structure with a bond cleavage between C-3 and C-4. The structure of the new compound was elucidated by means of spectroscopic methods, including ...
Gibbs Michelle M - - 2012
We used the World Health Organization's recommended procedures to establish desirable fortificant levels for three problem micronutrients in children's diets, based on dietary data collected earlier from Filipino (n = 1374; 6-36 months), Mongolian (n = 179; 12-36 months) and Cambodian (n = 177; 12-36 months) children. Prevalence of inadequate and excessive intakes of calcium and ...
Zwicker J G - - 2012
The quality of life (QOL) of children with developmental coordination disorder (DCD) is largely unknown, but evidence suggests that multiple QOL domains are affected by the disorder. While DCD is primarily considered a motor disorder, multiple studies have reported psychological and social concerns in children with this condition. Our primary ...
Shi Yugang - - 2012
A bicyclic imidazolium ionic liquid (), [b-4C-im][Br], was found to be highly effective not only for promoting PCR of GC-rich DNA by minimizing non-specific amplification, but also for facilitating PCR of normal-GC DNA under mild conditions.
Wedlake L J - - 2012
Wedlake L.J., McGough C., Shaw C., Klopper T., Thomas K., Lalji A., Dearnaley D.P., Blake P., Tait D., Khoo V.S. & Andreyev H.J.N. (2012) Clinical trial: efficacy of a low or modified fat diet for the prevention of gastrointestinal toxicity in patients receiving radiotherapy treatment for pelvic malignancies. J Hum ...
Suzuki Genjiro - - 2012
Prion conversion from a soluble protein to an aggregated state may be involved in the cellular adaptation of yeast to the environment. However, it remains unclear whether and how cells actively use prion conversion to acquire a fitness advantage in response to environmental stress. We identified Mod5, a yeast transfer ...
Choudhary Amir F - - 2012
Complex odours often possess perceptual qualities that are distinct from their components. Previous studies in humans, rodents, and insects indicate that the perception of complex odour blends depends on the concentration of the components and the mixture's complexity. However, we know relatively little about the way that an odour mixture ...
Ketola T - - 2012
It has frequently been suggested that trait heritabilities are environmentally sensitive, and there are genetic trade-offs between tolerating different environments such as hot and cold or constant and fluctuating temperatures. Future climate predictions suggest an increase in both temperatures and their fluctuations. How species will respond to these changes is ...
Haik Melina N - - 2012
This study evaluated joint position sense (JPS) during medial and lateral rotations of the shoulder in female workers with and without shoulder impingement syndrome (SIS). Three groups were assessed. The case group consisted of 15 female assembly line workers (35.5, SD 5.8 years) with unilateral SIS. Control group 1 consisted ...
Tedja Roslyn - - 2012
Accurate assessment of nanoparticle safety in vitro requires a comprehensive understanding of the interaction between the nanoparticles and the biological environment they encounter prior to cell contact. Exposure to fetal bovine serum (FBS), a common supplement in cell culture media, is shown herein to reduce the aggregate size of titanium ...
Coker V S - - 2012
A combination of scanning transmission X-ray microscopy and X-ray magnetic circular dichroism was used to spatially resolve the distribution of different carbon and iron species associated with Shewanella oneidensis MR-1 cells. S. oneidensis MR-1 couples the reduction of Fe(III)-oxyhydroxides to the oxidation of organic matter in order to conserve energy for ...
Gebru Elias - - 2012
The in vitro activity of 15 antimicrobial agents against clinical isolates of Staphylococcus pseudintermedius, Staphylococcus aureus, Escherichia coli, Pasteurella spp. and Streptococcus canis from dogs was investigated. For Staphylococcus spp., the highest frequency of resistance was observed for penicillin, followed by ampicillin, tetracycline, and chloramphenicol. The highest frequency of resistance ...
Koriat Asher - - 2012
A recent study, using a perceptual task, indicated that two heads were better than one provided that the members could communicate freely, presumably sharing their confidence in their judgments. Capitalizing on recent work on subjective confidence, I replicated this effect in the absence of any dyadic interaction by selecting on ...
van Kesteren Z - - 2012
To evaluate in an objective way the effect of leaf interdigitation and leaf width on volumetric modulated arc therapy plans in Pinnacle. Three multileaf collimators (MLCs) were modeled: two 10 mm leaf width MLCs, with and without interdigitating leafs, and a 5 mm leaf width MLC with interdigitating leafs. Three rectum patients ...
Kim Songhui - - 2012
We study the opto-electrical properties of Natronomonas pharaonis sensory rhodopsin II (NpSRII) by using a near-field microwave microprobe (NFMM) under external light illumination. To investigate the possibility of application of NFMM to biological macromolecules, we used time dependent properties of NPSRII before/after light activation which has three distinct states - ...
Braun Douglas C - - 2012
Ilonidis et al. (Reports, 19 August 2011, p. 993) report acoustic travel-time decreases associated with emerging sunspot regions before their appearance on the solar surface. An independent analysis using helioseismic holography does not confirm these travel-time anomalies for the four regions illustrated by Ilonidis et al. This negative finding is ...
Wang Renjie - - 2012
A series of bis(2-phenylbenzothiozolato-N,C(2'))iridium(acetylacetonate) [(bt)(2)Ir(acac)] derivatives, , were synthesized. Different substituents (CF(3), F, CH(3), OCH(3)) were introduced in the benzothiazole ring to study the substituent effect on the photophysical, electrochemical properties and electroluminescent performance of the complexes, and finally to select high-performance phosphors for use in organic light-emitting diodes (OLEDs). ...
Burdack-Freitag Andrea - - 2012
The concentrations of nineteen odorants, recently characterized by GC-olfactometry and aroma extract dilution analysis as the most odor-active compounds in raw hazelnuts, were quantitated by stable isotope dilution assays (SIDA). Calculation of odor activity values (OAV) on the basis of odor thresholds in oil revealed high OAVs, in particular for ...
Crespo Olga - - 2012
[6]-Azaosmahelicenes, the first d(4)-heterometallahelicenes, have been synthesised and fully characterised. Their optical properties (UV-Vis absorption and luminescence) are reported.
Hamed Arafa I - - 2012
INTRODUCTION: Tribulus is a well-known pharmaceutical herb that has been used for a long time in the traditional Chinese and Indian systems of medicine for the treatment of various diseases. It has been found that the genus Tribulus is rich in biologically active furostane-, cholestane- and spirostane-type steroidal saponins. OBJECTIVE: ...
Fogari Roberto - - 2012
Objective: The objective of this study was to compare valsartan or ramipril addition to amlodipine + hydrochlorothiazide (HCTZ) on blood pressure (BP) and left ventricular hypertrophy (LVH) in hypertensive diabetic patients with LVH. Research design and methods: 293 patients were treated with amlodipine 10 mg + HCTZ 12.5 combination and ...
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