Search Results
Results 251 - 300 of 2824
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McBride Ali - - 2012
Purpose The pharmacology, pharmacokinetics, clinical efficacy, safety, and administration of eribulin in patients with metastatic breast cancer are reviewed. Summary Classical chemotherapeutic agents for breast cancer have dominated treatment regimens even in the era of targeted therapy. Disease progression through these agents is often due to the development of resistance ...
Tozoglu U - - 2012
The foramen of Huschke (foramen tympanicum) represents a developmental defect in the antero-inferior aspect of the bony external auditory meatus. The foramen is located at the antero-inferior aspect of the external auditory canal, posteromedial to the temporomandibular joint. The aim of this study is to define the prevalence and location ...
Fasano Alfonso A Istituto di Neurologia, Università Cattolica del Sacro Cuore, Rome, Italy. - - 2012
Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide range of effects on the motor and non-motor symptoms of Parkinson's disease. Long-term, high-quality evidence is available for stimulation of the subthalamic nucleus and globus ...
Marnett Lawrence J - - 2012
The inflammatory response represents a first line of defense against invading pathogens and is important to human health. Chronic inflammation contributes to the etiology of multiple diseases, especially those associated with aging, such as cancer and cardiovascular disease. The chemistry of the inflammatory response is complex and involves the generation ...
Zhang Yan - - 2012
Ag(2)S quantum dots (QDs) emitting in the second near-infrared region (NIR-II, 1.0-1.4 μm) are demonstrated as a promising fluorescent probe with both bright photoluminescence and high biocompatibility for the first time. Highly selective in vitro targeting and imaging of different cell lines are achieved using biocompatible NIR-II Ag(2)S QDs with ...
Querejeta-Fernández Ana - - 2012
A lot of interesting and sophisticated examples of nanoparticle (NP) self-assembly (SA) are known. From both fundamental and technological standpoints, this field requires advancements in three principle directions: (a) understanding the mechanism and driving forces of three-dimensional (3D) SA with both nano- and microlevels of organization; (b) understanding disassembly/deconstruction processes; ...
Mora Samia S Center for Cardiovascular Disease Prevention, Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA. - - 2012
The goal of this study was to determine whether residual risk after high-dose statin therapy for primary prevention individuals with reduced levels of low-density lipoprotein cholesterol (LDL-C) is related to on-treatment apolipoprotein B, non-high-density lipoprotein cholesterol (non-HDL-C), trigylcerides, or lipid ratios, and how they compare with on-treatment LDL-C. Guidelines focus ...
Dweck Marc R MR Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom. - - 2012
With combined positron emission tomography and computed tomography (CT), we investigated coronary arterial uptake of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) as markers of active plaque calcification and inflammation, respectively. The noninvasive assessment of coronary artery plaque biology would be a major advance particularly in the identification of vulnerable plaques, ...
Lin Jiusheng - - 2012
DJ-1 is a conserved, disease-associated protein that protects against oxidative stress and mitochondrial damage in multiple organisms. Human DJ-1 contains a functionally essential cysteine residue (Cys106) whose oxidation is important for regulating protein function by an unknown mechanism. This residue is well-conserved in other DJ-1 homologues, including two (DJ-1α and ...
Frankel David S DS Cardiovascular Division, Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2012
The goal of this study was to evaluate the ability of noninvasive programmed stimulation (NIPS) after ventricular tachycardia (VT) ablation to identify patients at high risk of recurrence. Optimal endpoints for VT ablation are not well defined. Of 200 consecutive patients with VT and structural heart disease undergoing ablation, 11 ...
Baker Aaron B AB Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA. - - 2012
The purpose of this study was to examine the role of heparanase in controlling thrombosis following vascular injury or endovascular stenting. The use of endovascular stents are a common clinical intervention for the treatment of arteries occluded due to vascular disease. Both heparin and heparan sulfate are known to be ...
Xue Yi - - 2012
Rhomboid protease conducts proteolysis inside the hydrophobic environment of the membrane. The conformational flexibility of the protease is essential for the enzyme mechanism, but the nature of this flexibility is not completely understood. Here we describe the crystal structure of rhomboid protease GlpG in complex with a phosphonofluoridate inhibitor, which ...
Ramey Sandra L - - 2012
Police officers are prone to cardiovascular disease, overweight, and obesity. Because night-shift work affects sleep, a modifiable risk factor linked to chronic disease, the researchers explored the relationship among shift work, sleep, and wellness for police officers. Sleep, C-reactive protein (CRP) levels, stress, fatigue, and body mass index were used ...
Chan Yang-Hsiang - - 2012
This communication describes a new class of semiconducting polymer nanoparticle-quantum dot hybrid with high brightness, narrow emission, near-IR fluorescence, and excellent cellular targeting capability. Using this approach, we circumvented the current difficulty with obtaining narrow-band-emitting and near-IR-fluorescing semiconducting polymer nanoparticles while combining the advantages of both semiconducting polymer nanoparticles and ...
Crespo Olga - - 2012
[6]-Azaosmahelicenes, the first d(4)-heterometallahelicenes, have been synthesised and fully characterised. Their optical properties (UV-Vis absorption and luminescence) are reported.
Hamed Arafa I - - 2012
INTRODUCTION: Tribulus is a well-known pharmaceutical herb that has been used for a long time in the traditional Chinese and Indian systems of medicine for the treatment of various diseases. It has been found that the genus Tribulus is rich in biologically active furostane-, cholestane- and spirostane-type steroidal saponins. OBJECTIVE: ...
Fogari Roberto - - 2012
Objective: The objective of this study was to compare valsartan or ramipril addition to amlodipine + hydrochlorothiazide (HCTZ) on blood pressure (BP) and left ventricular hypertrophy (LVH) in hypertensive diabetic patients with LVH. Research design and methods: 293 patients were treated with amlodipine 10 mg + HCTZ 12.5 combination and ...
Miller Daniel J - - 2012
STUDY DESIGN.: Randomized controlled trial. OBJECTIVE.: To assess whether monitoring increases brace-wearing compliance in patients with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA.: Noncompliance is a barrier to brace treatment of AIS. Studies have demonstrated that monitoring improves medication compliance; however, this has not been investigated in spinal braces. ...
Lim Yeong-Dae - - 2012
We report a novel cleaning technique for graphene by using inductively coupled plasma (ICP) of Ar with an extremely low plasma density of 3.5108 cm-3. It is known that conventional capacitively coupled plasma (CCP) treatments destroy the planar symmetry of graphene, giving rise to the generation of defects. However, ICP ...
Mase Masaji - - 2012
Nine fowl adenoviruses (FAdVs) isolated from chickens with inclusion body hepatitis (IBH) in Japan from 2009 to 2010 were characterized serologically and genetically. These isolates were all neutralized by antisera against the SR-48 strain (FAdV-2). Phylogenetic analysis based on the part of the hexon gene that included the L1 region ...
Pauli Harald - - 2012
In mountainous regions, climate warming is expected to shift species' ranges to higher altitudes. Evidence for such shifts is still mostly from revisitations of historical sites. We present recent (2001 to 2008) changes in vascular plant species richness observed in a standardized monitoring network across Europe's major mountain ranges. Species ...
Rauschenbach Stephan - - 2012
Crystalline inverted membranes of the nonvolatile surfactant sodium dodecylsulfate are found on solid surfaces after electrospray ion beam deposition (ES-IBD) of large SDS clusters in vacuum. This demonstrates the equivalence of ES-IBD to conventional molecular beam epitaxy.
Eisa Fabian - - 2012
One of the biggest challenges in dynamic contrast-enhanced CT is the optimal synchronization of scan start and duration with contrast medium administration in order to optimize image contrast and to reduce the amount of contrast medium. We present a new optically based approach, which was developed to investigate and optimize ...
Wei Qingshuo - - 2012
The fabrication of low voltage flexible organic thin film transistors using zirconia (ZrO<sub>2</sub>) dielectric layers prepared via supercritical fluid deposition was studied. Continuous, single phase films of approximately 30 nm thick ZrO<sub>2</sub> were grown on polyimide (PI)/aluminum (Al) substrates at 250 ºC via hydrolysis of tetrakis(2,2,6,6-tetramethyl-3,5-heptane-dionato) zirconium in supercritical carbon ...
Meier-Davis Susan R - - 2012
Background/Aims: Transdermal patch administration results in a locally high concentration of drug that induce local toxicity, including tumorogenicity. As a worst-case scenario for consequences of repeated application on neoplastic growth, the melanin-binding drug, rasagiline, was used in a transdermal formulation applied directly to a human-derived melanoma to determine the effects ...
Joo Jinmyoung - - 2012
We developed a novel gravimetric immunoassay for sensitive detection of multiple protein biomarkers using silicon microcantilever arrays and multifunctional hybrid nanoparticles. Magnetic-photocatalytic hybrid nanoparticles with a highly crystalline TiO2 shell were synthesized using a solvothermal reaction without a calcination process. After functionalizing the hybrid nanoparticles and silicon cantilevers with antibodies, ...
Fang H Z - - 2012
The interfacial energies of three twin boundaries with low-index boundary planes: prismatic [Formula: see text], basal O-terminated (0001), and basal Cr-terminated (0001), and the segregation energies of five doping elements (Ce, Hf, La, Y and Zr) have been calculated as a function of temperature. The static energies at 0 K were ...
Billiard S - - 2012
Variability in the way organisms reproduce raises numerous, and still unsolved, questions in evolutionary biology. In this study, we emphasize that fungi deserve a much greater emphasis in efforts to address these questions because of their multiple advantages as model eukaryotes. A tremendous diversity of reproductive modes and mating systems ...
Ribeiro Sandra - - 2012
Chronic kidney disease (CKD) has been associated with an abnormal lipid profile. Our aim was to study the interplay between oxidized low-density lipoprotein (ox-LDL), adiponectin, and blood lipids and lipoproteins in Portuguese patients with CKD under hemodialysis (HD); the influence of the pentanucleotide repeat polymorphism in the apolipoprotein(a) (apo [a]) ...
Cavalli Silvia - - 2012
Aniline-catalyzed oxime chemistry was employed to conjugate a γ-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT-SPION conjugate.
Toh Shigeo - - 2012
Strigolactones (SLs) function as plant hormones that mediate a myriad of developmental responses in higher plants. SLs also act as an environmental signal to stimulate seed germination of parasitic plant species of genera Striga and Orobanche. In contrast to their hormonal roles, genetic mechanisms of how SLs stimulate parasitic seed ...
Tuma Tomas - - 2012
A novel scan trajectory for high-speed scanning probe microscopy is presented in which the probe follows a two-dimensional Lissajous pattern. The Lissajous pattern is generated by actuating the scanner with two single-tone harmonic waveforms of constant frequency and amplitude. Owing to the extremely narrow frequency spectrum, high imaging speeds can ...
Riley James R - - 2012
GaN nanowires oriented along the nonpolar a-axis were analyzed using pulsed laser atom probe tomography (APT). Stoichiometric mass spectra were achieved by optimizing the temperature, applied dc voltage, and laser pulse energy. Local variations in the measured stoichiometry were observed and correlated with facet polarity using scanning electron microscopy. Fewer ...
Auboiroux Vincent - - 2012
Magnetic resonance imaging (MRI) and ultrasonography have been used simultaneously in this ex vivo study for the image-guidance of high intensity focused ultrasound (HIFU) treatment in moving tissue. A ventilator-driven balloon produced periodic and non-rigid (i.e. breathing-like) motion patterns in phantoms. MR-compatible ultrasound (US) imaging enabled near real-time 2D motion ...
Han Yejee - - 2012
The phosphorescence double ratiometric sensor detects Cr(III) ions by taking advantages of the reversible coordination binding and the biomimetic oxidation reaction.
Ye Lili - - 2012
Polyols, as a typical type of alcohols containing multiple hydroxyl groups, are becoming a new generation of green energy platform. In this paper, the decomposition mechanisms for three polyol molecules i.e. 1,2-propanediol, 1,3-propanediol, and glycerol have been investigated by quantum chemistry calculations. The potential energy surfaces of propanediols and glycerol ...
Wegner K - - 2012
The fabrication of functional thin films and devices by direct deposition of nanoparticles from the gas phase is a promising approach enabling, for instance, the integration of complex analytical and sensing capabilities on microfabricated platforms. Aerosol-based techniques ensure large-scale nanoparticle production and they are potentially suited for this goal. However, ...
Boller Simone - - 2012
Abstract The insulin receptor (IR) recruits adaptor proteins, so-called insulin receptor substrates (IRS), to connect with downstream signalling pathways. A family of IRS proteins was defined based on three major common structural elements: Amino-terminal PH and PTB domains that mediate protein-lipid or protein-protein interactions, mostly carboxy-terminal multiple tyrosine residues that ...
Kardhashi Anila - - 2012
Granular cell tumors (GCTs) are uncommon soft tissue tumors of neural derivation, as supported by immunohistochemical and ultrastructural evidence. Vulvar involvement has been reported in 7-16%. This paper presents the cases of a 60-year-old woman and her 32-year-old niece with a strong family history of cancer, both presenting with an ...
Chang Chirn-Bin - - 2012
BACKGROUND: Explicit criteria for potentially inappropriate medications (PIMs) developed from other regions were often difficult to apply to a specific territory without significant modifications. PURPOSE: To describe a process of developing a country-specific explicit PIM criteria from quality review of several published PIM criteria, followed by consensus among regional experts ...
Crocker James K - - 2012
The dose for image-based motion monitoring of prostate tumours during radiotherapy delivery has not been established. This study aimed to provide quantitative analysis and optimization of the fluoroscopic patient imaging dose during radiotherapy for IMRT and VMAT treatments using standard and hypofractionated treatment schedules. Twenty-two patients with type T1c N0/M0 ...
Bortolini Z - - 2012
In this study, we associated imaging modalities, such as computed tomography (CT) and standard radiography, with anatomical specimens to describe the anatomy of the appendicular skeleton of red-footed tortoises ( Chelonoidis carbonaria), using animals of different sizes, ages, sexes and weights. Manus and pes bones were described from conventional radiography ...
Tian Lingmin - - 2012
This study was designed to investigate the antioxidant activity, hepatoprotective effect and phenolic composition of ethyl acetate fraction (EAF) extracted from H. cordata tea. EAF was shown to exhibit strong ferric-reducing antioxidant power (FRAP) and scavenging activity against DPPH radical in vitro, and the antioxidant effects were further verified by ...
Tao Xiao-Yuan - - 2012
Cotton plants accumulate phytotoxins, including gossypol and related sesquiterpene aldehydes, to resist insect herbivores and pathogens. To counteract these defensive plant secondary metabolites, cotton bollworms (Helicoverpa armigera) elevate their production of detoxification enzymes, including cytochrome P450 monooxygenases (P450s). Besides their tolerance to phytotoxin, cotton bollworms have quickly developed resistance to ...
Aluwihare-Samaranayake Dilmi - - 2012
ALUWIHARE-SAMARANAYAKE D and PAUL P. Nursing Inquiry 2012 [Epub ahead of print] The influence of gender, ethnicity, class, race, the women's and labour movements on the development of nursing in Sri Lanka The paper reveals that historically various socio-political factors, including gender, class, ethnicity, race, waves of colonization, decolonization, the ...
Evangelio Emi - - 2012
The studies described herein focus on the 1,3-dipolar cycloaddition reaction between first-row transition metal-azide complexes and alkyne reagents, i.e. an inorganic variant of the extensively used "click reaction". The reaction between the azide complexes of biologically-relevant metals (e.g., Fe, Co and Ni) found in metalloenzyme active sites and alkyne reagents ...
Lisso Janina - - 2012
Loss of the Arabidopsis NFX1-LIKE2 (NFXL2) gene (At5g05660) results in elevated ABA levels, elevated hydrogen peroxide levels, reduced stomatal aperture, and enhanced drought stress tolerance. Introduction of the NFXL2-78 isoform into the nfxl2-1 mutant is largely sufficient for complementation of the phenotype. We show here that cuticular properties are altered ...
Shih Hong-Mou - - 2012
Acute kidney injury is a common complication following cardiac surgery. Even small increases in creatinine levels are associated with increases in morbidity and mortality. Numerous factors such as hemolysis can contribute to the development of acute kidney injury after cardiac surgery. We present a rare case of severe hemolysis related ...
Phylipsen Marion - - 2012
OBJECTIVE: The aim of this study was to develop a pyrophosphorolysis-activated polymerization (PAP) assay for non-invasive prenatal diagnosis (NIPD) of β-thalassemia major and sickle-cell disease (SCD). PAP is able to detect mutations in free fetal DNA in a highly contaminating environment of maternal plasma DNA. METHODS: Pyrophosphorolysis-activated polymerization primers were ...
Tavernor L - - 2012
Background  Compared with other conditions there has been a lack of focus on quality of life (QoL) as an outcome measure for children and young people with Autism Spectrum Disorder (ASD). This pilot study aimed to evaluate the validity of existing QoL questionnaires for use with children with ASD aged ...
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