Search Results
Results 1 - 50 of 2309
1 2 3 4 5 6 7 8 9 10 >
di Minno Matteo Nicola Dario - - 2013
We prospectively evaluated whether obesity impacts achievement of minimal disease activity (MDA) in subjects with psoriatic arthritis (PsA). Among PsA subjects with an active disease and who were starting a treatment with tumor necrosis factor α blockers, 135 obese (body mass index [BMI] >30 kg/m(2) ) patients and 135 patients ...
Crowson Cynthia S CS Mayo Clinic, Rochester, MN 55905, - - 2013
Obesity is an underrecognized risk factor for rheumatoid arthritis (RA). In recent years, both the prevalence of obesity and the incidence of RA have been rising. Our objective was to determine whether the "obesity epidemic" could explain the recent rise in the incidence of RA. An inception cohort of Olmsted ...
Koutras Angelos K - - 2012
Current evidence indicates that angiogenesis plays an important role in the pathogenesis of several malignancies, including breast cancer. Bevacizumab is a monoclonal antibody that targets the vascular endothelial growth factor (VEGF). Recent clinical data have demonstrated that the addition of bevacizumab to first-line chemotherapy improves the progression-free survival of patients ...
Ahn Dong-Won - - 2012
Guggulsterone is a dietary plant sterone possessing therapeutic potential against cancers. However, the antitumor effect of this natural compound on pancreatic cancer has not been determined yet. This study was designed to investigate the therapeutic efficacy of guggulsterone in pancreatic cancer. In this study, we examined the effect of guggulsterone ...
Wolfe Frederick - - 2012
To study the relative risk (RR) of all-cause and cause-specific mortality in rheumatoid arthritis (RA) associated with body mass index (BMI), and to quantify the clinical and outcome consequences of abnormal BMI. We studied mortality in 24,535 patients over 12.3 years, dividing patients into 3 age groups, <50, 50-70, and ...
El-Zaatari Mohamad - - 2012
Normally, sonic hedgehog (Shh) is expressed in the pancreas during fetal development and transiently after tissue injury. Although pancreatic cancers express Shh, it is not known if the protein is secreted into the blood and whether its plasma levels change with pancreatic transformation. The goal of this study was to ...
Gunda Venugopal V Cell Signaling, Retinal and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, - - 2012
The anti-angiogenic, carboxy terminal non-collagenous domain (NC1) derived from human Collagen type IV alpha 6 chain, [α6(IV)NC1] or hexastatin, was earlier obtained using different recombinant methods of expression in bacterial systems. However, the effect of L-arginine mediated renaturation in enhancing the relative yields of this protein from bacterial inclusion bodies ...
Hancock Adam T AT Arthritis UK Primary Care Centre, Keele University, Stoke-on-Trent, UK. - - 2012
To systematically identify and appraise the existing literature on the association between polymyalgia rheumatica (PMR) and vascular disease. The Medline, Embase, CINAHL, and Cochrane databases were searched from inception to September 2010. Search criteria included observational studies containing patients with isolated PMR reporting on a vascular outcome. Data were extracted ...
Jhun Joo-Yeon - - 2012
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-α. Rheumatoid arthritis (RA) is a prototype of inflammatory arthritis, but the relationship between RA and obesity is controversial. We made an obese ...
Kakizaki Yusuke - - 2012
Symplocarpus renifolius and Arum maculatum are known to produce significant heat during the course of their floral development, but they use different regulatory mechanisms, i.e. homoeothermic compared with transient thermogenesis. To further clarify the molecular basis of species-specific thermogenesis in plants, in the present study we have analysed the native ...
McBride David J DJ Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. - - 2012
The application of paired-end next generation sequencing approaches has made it possible to systematically characterize rearrangements of the cancer genome to base-pair level. Utilizing this approach, we report the first detailed analysis of ovarian cancer rearrangements, comparing high-grade serous and clear cell cancers, and these histotypes with other solid cancers. ...
Ala-Houhala M J - - 2012
A short course of narrowband ultraviolet B (NB-UVB) exposures increases the serum 25-hydroxyvitamin D [25(OH)D] concentration in patients with psoriasis and healthy subjects. To compare the effects of NB-UVB and oral vitamin D substitution in healthy subjects in winter. Healthy adult hospital employees and medical students were screened for serum ...
Liu Wen - - 2012
Aspirin (ASA), a major antiplatelet and cancer-preventing drug, irreversibly blocks the cyclooxygenase (COX) activity of prostaglandin H synthase-1 (PGHS-1). Considerable differences in ASA effectiveness are observed between individuals, and some of this variability may be due to PGHS-1 protein variants. Our overall aim is to determine which, if any, of ...
Tee Jin-Ming JM Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The - - 2012
The specific molecular determinants that govern progenitor expansion and final compartment size in the myogenic lineage, either during gestation or during regenerative myogenesis, remain largely obscure. Recently, we retrieved d-asb11 from a zebrafish screen designed to identify gene products that are downregulated during embryogenesis upon terminal differentiation and identified it ...
Hill Gerhard W GW - - 2012
Stem cell therapy holds great promise for treating neurodegenerative disease, but major barriers to effective therapeutic strategies remain. A complete understanding of the derived phenotype is required for predicting cell response once introduced into the host tissue. We sought to identify major axonal guidance cues present in neurons derived from ...
Romanos Georgios E - - 2012
The mandibular incisive canal (MIC) is the anterior extension of the mandibular canal and its presence is of interest in surgical procedures in the chin region. The aim of this study was to investigate the presence of a MIC in panoramic radiographs (OPGs). One thousand forty-five OPGs were randomly chosen ...
- - 2012
Cover Picture: A word cloud was generated using key words from the abstracts of the CHO Cell Genomics Special Section and arranged around a chromosome spread. Top panels represent important aspects of CHOmics (left to right): transcriptomics, CHO cells; genomics; bioprocessing; microRNAs. Image courtesy of Vaibhav Jadhav, Matthias Hackl and ...
Jeon Kilsoo - - 2012
The nonobese diabetic (NOD) mouse is a classical animal model for autoimmune type 1 diabetes (T1D), closely mimicking features of human T1D. Thus, the NOD mouse presents an opportunity to test the effectiveness of induced pluripotent stem cells (iPSCs) as a therapeutic modality for T1D. Here, we demonstrate a proof ...
McCann Mary Ellen ME Department of Anaesthesia (Pediatrics), Harvard Medical School, Senior Associate in Anesthesiology, Children’s Hospital Boston, Massachusetts, USA 02115. - - 2012
Millions of newborn and infants receive anesthetic, sedative and analgesic drugs for surgery and painful procedures on a daily basis. However, recent laboratory reports clearly demonstrate that anesthetic and sedative drugs induced both neuroapoptosis and neurocognitive deficits in laboratory models. This issue is of paramount interest to pediatric anesthesiologists and ...
Pringle Daphne R - - 2012
Thyroid cancer is the most common endocrine malignancy in the population, and the incidence of this cancer is increasing at a rapid rate. Although genetic analysis of papillary thyroid cancer (PTC) has identified mutations in a large percentage of patients, the genetic basis of follicular thyroid cancer (FTC) is less ...
Li Deyu D Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2012
The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidation can be the alkyl carbon adjacent to N1. Such may be the ...
Boyle Joseph P - - 2012
The innate immune response provides our first line of defence against infection. Over the course of evolution, pathogens have evolved numerous strategies to either avoid activating or to limit the effectiveness of the innate immune system. The Kaposi's sarcoma-associated herpesvirus (KSHV) contains tegument proteins in the virion that contribute to ...
Takahashi Yusuke - - 2012
The efficient recycling of the chromophore of visual pigments, 11-cis-retinal, through the retinoid visual cycle is an essential process for maintaining normal vision. RPE65 is the isomerohydrolase in retinal pigment epithelium and generates predominantly 11-cis-retinol (11cROL) and a minor amount of 13-cis-retinol (13cROL), from all-trans-retinyl ester (atRE). We recently identified ...
Wang Q Tian - - 2012
Heart disease is a leading cause of death and disability in developed countries. Heart disease includes a broad range of diseases that affect the development and/or function of the cardiovascular system. Some of these diseases, such as congenital heart defects, are present at birth. Others develop over time and may ...
Demir Özlem - - 2012
The causative agent of African sleeping sickness, Trypanosoma brucei , undergoes an unusual mitochondrial RNA editing process that is essential for its survival. RNA editing terminal uridylyl transferase 2 of T. brucei (TbRET2) is an indispensable component of the editosome machinery that performs this editing. TbRET2 is required to maintain ...
Holley Sandra M SM Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, - - 2012
Ligand-gated ion channels undergo conformational changes that transfer the energy of agonist binding to channel opening. Within ionotropic glutamate receptor (iGluR) subunits, this process is initiated in their bilobate ligand binding domain (LBD) where agonist binding to lobe 1 favors closure of lobe 2 around the agonist and allows formation ...
Biswas Asok - - 2012
ABSTRACT:: Cutaneous clear cell neoplasms represent a heterogenous group of several primary and metastatic tumors with diverse histogenesis. Tumors with widespread clear cell change can seem strikingly similar under the microscope resulting in diagnostic difficulties. Although most cases are idiopathic, intracytoplasmic accumulation, artifact of tissue processing, and degenerative phenomenon have ...
Fox Justin - - 2012
: Fewer than 10% of patients with colon cancer in the United States are reportedly treated with a laparoscopic colectomy despite the benefits it has over the open approach. This estimate, however, may be artificially low because of inaccurate case identification. : The aim of this study was to estimate ...
Rudnicka Alicja R - - 2012
Citation information: Rudnicka AR & Owen CG. An introduction to systematic reviews and meta-analyses in health care. Ophthalmic Physiol Opt 2012, 32, 174-183. doi: 10.1111/j.1475-1313.2012.00901.x ABSTRACT: Important issues in medical research are often examined in a number of studies, sometimes using different study designs. Data from such studies are often ...
Batailler M - - 2012
GPR50, formerly known as melatonin-related receptor, is one of three subtypes of the melatonin receptor subfamily, together with the MT(1) and MT(2) receptors. By contrast to these two high-affinity receptor subtypes and despite its high identity with the melatonin receptor family, GPR50 does not bind melatonin or any other known ...
Riebeling Christian - - 2012
Testing for embryotoxicity in vitro is an attractive alternative to animal experimentation. The embryonic stem cell test (EST) is such a method, and it has been formally validated by the European Centre for the Validation of Alternative Methods. A number of recent studies have underscored the potential of this method. ...
Miller D - - 2012
Introduction:  Non-invasive ventilation (NIV) has revolutionised the management of hypercapnic exacerbations of chronic obstructive pulmonary disease (COPD). We wished to evaluate factors related to its overall success in the 'real-life' setting. Methods:  A retrospective analysis of patients receiving NIV for a hypercapnic exacerbation of COPD was performed. Demographics, laboratory data, ...
Evans Mary E - - 2012
  The purpose of this study was to gain an understanding of the barriers and facilitators to implementation of the five overarching recommendations of the Institute of Medicine report and to consider the implications for nursing.   Data were collected through use of a semi-structured interview of purposive sample of ...
Jinabhai Amit - - 2012
To compare monochromatic aberrations of keratoconic eyes when uncorrected, corrected with spherically-powered RGP (rigid gas-permeable) contact lenses and corrected using simulations of customised soft contact lenses for different magnitudes of rotation (up to 15°) and translation (up to 1mm) from their ideal position. The ocular aberrations of examples of mild, ...
Anschutz Doeschka J - - 2012
This study tested the direct effect of watching thin ideal children's television on body satisfaction in preadolescent girls (6-8 years old). A within-subject design was used in which girls (N = 51) were tested three times. They watched television clips in random order containing either (1) thin ideal animated characters or (2) ...
Rostgaard Tine - - 2012
Despite relatively generous coverage of the over-65 population, Danish home help services receive regular criticism in the media and public opinion polls. Perhaps as a consequence, reforms of Danish home care policy for senior citizens have placed a strong emphasis on quality since the 1990s. This reform strategy represents a ...
Leichtle Stefan W - - 2012
: Anastomotic leakage is a morbid and potentially fatal complication of colorectal surgery. Determination of pre- and intraoperative risk factors may identify patients requiring increased postoperative surveillance for this major complication. : The purpose of this study was to identify risk factors associated with anastomotic leakage after colectomy with primary ...
Saghir Shakil Ahmed - - 2012
It is well recognized that expression of enzymes varies during development and growth. However, an in-depth review of this acquired knowledge is needed to translate the understanding of enzyme expression and activity into the prediction of change in effects (e.g. kinetics and toxicity) of xenobiotics with age. Age-related changes in ...
Song Mingli - - 2012
Reconstruction of a 3-D face model from a single 2-D face image is fundamentally important for face recognition and animation because the 3-D face model is invariant to changes of viewpoint, illumination, background clutter, and occlusions. Given a coupled training set that contains pairs of 2-D faces and the corresponding ...
Michalopoulos Argyris S - - 2012
Inhaled antibiotics, such as TOBI (a tobramycin solution), gentamicin, colistin and aztreonam lysine (Cayston) have been effectively administered with safety and efficacy in patients with cystic fibrosis and bronchiectasis. In addition, inhaled antibiotics have been administered with safety and efficacy for the prevention and treatment of patients with ventilator-associated tracheobronchitis ...
Chung Duc M - - 2012
This study aimed to determine the predictors of discharge to acute care after inpatient rehabilitation in severely affected stroke patients. This was a retrospective study using data from the Uniform Data System for Medical Rehabilitation (UDSMR) between 2008 and 2009. The main outcome variable was discharge location, which included discharge ...
Siddiqui Muhammed R S - - 2012
: Imaging modalities such as endoanal ultrasound or MRI can be useful preoperative adjuncts before the appropriate surgical intervention for perianal fistulas. : We present a systematic review of published literature comparing endoanal ultrasound with MRI for the assessment of idiopathic and Crohn's perianal fistulas. : A meta-analysis was performed ...
Ishiuchi Takashi - - 2012
Willin is a FERM-domain protein, which is related to the Drosophila Expanded, a protein known to be a component of the Hippo signaling pathway. We recently showed that Willin localizes at the apical junctional complex (AJC) in epithelial cells together with Par3 and regulates the contractility of the circumferential actomyosin ...
Harashima S-I - - 2012
Aims:  To assess the efficacy and safety of combination therapy with sitagliptin and low dosage sulphonylureas on glycaemic control and insulin secretion capacity in Japanese type 2 diabetes. Methods: Eighty-two subjects were sequentially recruited for the 52-week, prospective, single arm study. Sitagliptin was added on to sulphonylureas (glimepride or gliclazide) ...
Gruber Kenneth J - - 2012
  What is the comparative impact of a second pregnancy prevention program for teen mothers on those who graduate from the program compared with a sample of young mothers of similar age and social circumstances who did not participate in the program?   Fifteen program graduates and 20 nonprogram cohorts ...
Memari Amirhossein - - 2012
PROBLEM:  Individuals with autism spectrum disorders (ASDs) have at least as many comorbidities as individuals with typical development may show, but sometimes with different presentations. METHODS:  The study used a school-based health survey related to children diagnosed with ASD in Tehran to determine the possibility of comorbid conditions. Ninety-one children ...
Brainard Annie M - - 2012
In 1916, when Annie Brainard published this paper, there was an ongoing discussion in the journal about specialization versus generalization of public health nursing (PHN) work. This discussion revolved around issues such as the size of communities (rural versus urban), population density, and cost effectiveness. For geographically large rural communities ...
Jiang Wei - - 2012
: Restorative proctocolectomy with IPAA is the surgical treatment of choice in patients with ulcerative colitis who require colectomy. Pouchitis is the most common long-term complication in patients with IPAA. While immune-mediated disorders frequently coexist with IBD, they appear to be associated with an increased risk for chronic antibiotic-refractory pouchitis. ...
Semerci Oguz - - 2012
Dual-energy computerized tomography has gained great interest because of its ability to characterize the chemical composition of a material rather than simply providing relative attenuation images as in conventional tomography. The purpose of this paper is to introduce a novel polychromatic dual-energy processing algorithm, with an emphasis on detection and ...
Parés David - - 2012
: Fecal incontinence is highly prevalent in the general population and especially in risk groups. Obesity is also common and is associated with comorbidities that impair general health and interfere with daily activities. Identifying mutable factors for fecal incontinence, such as stool consistency, is of paramount importance to improve quality ...
1 2 3 4 5 6 7 8 9 10 >