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Crowson Cynthia S CS Mayo Clinic, Rochester, MN 55905, - - 2013
Obesity is an underrecognized risk factor for rheumatoid arthritis (RA). In recent years, both the prevalence of obesity and the incidence of RA have been rising. Our objective was to determine whether the "obesity epidemic" could explain the recent rise in the incidence of RA. An inception cohort of Olmsted ...
di Minno Matteo Nicola Dario - - 2013
We prospectively evaluated whether obesity impacts achievement of minimal disease activity (MDA) in subjects with psoriatic arthritis (PsA). Among PsA subjects with an active disease and who were starting a treatment with tumor necrosis factor α blockers, 135 obese (body mass index [BMI] >30 kg/m(2) ) patients and 135 patients ...
El-Zaatari Mohamad M Department of Internal Medicine-Gastroenterology, University of Michigan, Ann Arbor, MI 48109-2200, - - 2012
Normally, sonic hedgehog (Shh) is expressed in the pancreas during fetal development and transiently after tissue injury. Although pancreatic cancers express Shh, it is not known if the protein is secreted into the blood and whether its plasma levels change with pancreatic transformation. The goal of this study was to ...
Ahn Dong-Won - - 2012
Guggulsterone is a dietary plant sterone possessing therapeutic potential against cancers. However, the antitumor effect of this natural compound on pancreatic cancer has not been determined yet. This study was designed to investigate the therapeutic efficacy of guggulsterone in pancreatic cancer. In this study, we examined the effect of guggulsterone ...
Wolfe Frederick - - 2012
To study the relative risk (RR) of all-cause and cause-specific mortality in rheumatoid arthritis (RA) associated with body mass index (BMI), and to quantify the clinical and outcome consequences of abnormal BMI. We studied mortality in 24,535 patients over 12.3 years, dividing patients into 3 age groups, <50, 50-70, and ...
Koutras Angelos K - - 2012
Current evidence indicates that angiogenesis plays an important role in the pathogenesis of several malignancies, including breast cancer. Bevacizumab is a monoclonal antibody that targets the vascular endothelial growth factor (VEGF). Recent clinical data have demonstrated that the addition of bevacizumab to first-line chemotherapy improves the progression-free survival of patients ...
Gunda Venugopal V Cell Signaling, Retinal and Tumor Angiogenesis Laboratory, Department of Genetics, Boys Town National Research Hospital, Omaha, NE 68131, - - 2012
The anti-angiogenic, carboxy terminal non-collagenous domain (NC1) derived from human Collagen type IV alpha 6 chain, [α6(IV)NC1] or hexastatin, was earlier obtained using different recombinant methods of expression in bacterial systems. However, the effect of L-arginine mediated renaturation in enhancing the relative yields of this protein from bacterial inclusion bodies ...
Hancock Adam T AT Arthritis UK Primary Care Centre, Keele University, Stoke-on-Trent, UK. - - 2012
To systematically identify and appraise the existing literature on the association between polymyalgia rheumatica (PMR) and vascular disease. The Medline, Embase, CINAHL, and Cochrane databases were searched from inception to September 2010. Search criteria included observational studies containing patients with isolated PMR reporting on a vascular outcome. Data were extracted ...
Jhun Joo-Yeon - - 2012
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-α. Rheumatoid arthritis (RA) is a prototype of inflammatory arthritis, but the relationship between RA and obesity is controversial. We made an obese ...
Ku Min-Sho MS Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, - - 2012
Epidemiological research underpins the importance of effective health-care strategies for adolescents. This descriptive study compares the 10 most common diseases among Taiwanese adolescents for 2000 and 2009. Data for a total of 69,594 visits in 2000 and 65,802 visits in 2009 by adolescents aged between 10 and 20 years were ...
Kakizaki Yusuke - - 2012
Symplocarpus renifolius and Arum maculatum are known to produce significant heat during the course of their floral development, but they use different regulatory mechanisms, i.e. homoeothermic compared with transient thermogenesis. To further clarify the molecular basis of species-specific thermogenesis in plants, in the present study we have analysed the native ...
McBride David J DJ Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. - - 2012
The application of paired-end next generation sequencing approaches has made it possible to systematically characterize rearrangements of the cancer genome to base-pair level. Utilizing this approach, we report the first detailed analysis of ovarian cancer rearrangements, comparing high-grade serous and clear cell cancers, and these histotypes with other solid cancers. ...
Liu Wen W Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, - - 2012
Aspirin (ASA), a major antiplatelet and cancer-preventing drug, irreversibly blocks the cyclooxygenase (COX) activity of prostaglandin H synthase-1 (PGHS-1). Considerable differences in ASA effectiveness are observed between individuals, and some of this variability may be due to PGHS-1 protein variants. Our overall aim is to determine which, if any, of ...
Burki Vincent V Paris Descartes University, Medicine Faculty, APHP, Cochin Hospital, Rheumatology B Department, Paris, France. - - 2012
Hip involvement is a classic feature of spondyloarthritis (SpA). The aim of the present paper is to study the prevalence, clinical and radiological features of hip involvement, and the association with criteria for severity, in a cohort of patients with SpA in a tertiary care centre. retrospective single centre observational ...
Ala-Houhala M J - - 2012
A short course of narrowband ultraviolet B (NB-UVB) exposures increases the serum 25-hydroxyvitamin D [25(OH)D] concentration in patients with psoriasis and healthy subjects. To compare the effects of NB-UVB and oral vitamin D substitution in healthy subjects in winter. Healthy adult hospital employees and medical students were screened for serum ...
Tee Jin-Ming JM Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The - - 2012
The specific molecular determinants that govern progenitor expansion and final compartment size in the myogenic lineage, either during gestation or during regenerative myogenesis, remain largely obscure. Recently, we retrieved d-asb11 from a zebrafish screen designed to identify gene products that are downregulated during embryogenesis upon terminal differentiation and identified it ...
Uzhachenko Roman R Department of Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, - - 2012
Fus1, encoded by a 3p21.3 tumour suppressor gene, is down-regulated, mutated or lost in the majority of inflammatory thoracic malignancies. The mitochondrial localization of Fus1 stimulated us to investigate how Fus1 modulates inflammatory response and mitochondrial function in a mouse model of asbestos-induced peritoneal inflammation. Asbestos treatment resulted in a ...
Hill Gerhard W GW - - 2012
Stem cell therapy holds great promise for treating neurodegenerative disease, but major barriers to effective therapeutic strategies remain. A complete understanding of the derived phenotype is required for predicting cell response once introduced into the host tissue. We sought to identify major axonal guidance cues present in neurons derived from ...
- - 2012
Cover Picture: A word cloud was generated using key words from the abstracts of the CHO Cell Genomics Special Section and arranged around a chromosome spread. Top panels represent important aspects of CHOmics (left to right): transcriptomics, CHO cells; genomics; bioprocessing; microRNAs. Image courtesy of Vaibhav Jadhav, Matthias Hackl and ...
Jeon Kilsoo - - 2012
The nonobese diabetic (NOD) mouse is a classical animal model for autoimmune type 1 diabetes (T1D), closely mimicking features of human T1D. Thus, the NOD mouse presents an opportunity to test the effectiveness of induced pluripotent stem cells (iPSCs) as a therapeutic modality for T1D. Here, we demonstrate a proof ...
Romanos Georgios E - - 2012
The mandibular incisive canal (MIC) is the anterior extension of the mandibular canal and its presence is of interest in surgical procedures in the chin region. The aim of this study was to investigate the presence of a MIC in panoramic radiographs (OPGs). One thousand forty-five OPGs were randomly chosen ...
McCann Mary Ellen ME Department of Anaesthesia (Pediatrics), Harvard Medical School, Senior Associate in Anesthesiology, Children’s Hospital Boston, Massachusetts, USA 02115. - - 2012
Millions of newborn and infants receive anesthetic, sedative and analgesic drugs for surgery and painful procedures on a daily basis. However, recent laboratory reports clearly demonstrate that anesthetic and sedative drugs induced both neuroapoptosis and neurocognitive deficits in laboratory models. This issue is of paramount interest to pediatric anesthesiologists and ...
Pringle Daphne R - - 2012
Thyroid cancer is the most common endocrine malignancy in the population, and the incidence of this cancer is increasing at a rapid rate. Although genetic analysis of papillary thyroid cancer (PTC) has identified mutations in a large percentage of patients, the genetic basis of follicular thyroid cancer (FTC) is less ...
Li Deyu D Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2012
The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidation can be the alkyl carbon adjacent to N1. Such may be the ...
Boyle Joseph P - - 2012
The innate immune response provides our first line of defence against infection. Over the course of evolution, pathogens have evolved numerous strategies to either avoid activating or to limit the effectiveness of the innate immune system. The Kaposi's sarcoma-associated herpesvirus (KSHV) contains tegument proteins in the virion that contribute to ...
Takahashi Yusuke - - 2012
The efficient recycling of the chromophore of visual pigments, 11-cis-retinal, through the retinoid visual cycle is an essential process for maintaining normal vision. RPE65 is the isomerohydrolase in retinal pigment epithelium and generates predominantly 11-cis-retinol (11cROL) and a minor amount of 13-cis-retinol (13cROL), from all-trans-retinyl ester (atRE). We recently identified ...
Wang Q Tian - - 2012
Heart disease is a leading cause of death and disability in developed countries. Heart disease includes a broad range of diseases that affect the development and/or function of the cardiovascular system. Some of these diseases, such as congenital heart defects, are present at birth. Others develop over time and may ...
Demir Özlem - - 2012
The causative agent of African sleeping sickness, Trypanosoma brucei , undergoes an unusual mitochondrial RNA editing process that is essential for its survival. RNA editing terminal uridylyl transferase 2 of T. brucei (TbRET2) is an indispensable component of the editosome machinery that performs this editing. TbRET2 is required to maintain ...
Holley Sandra M SM Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, - - 2012
Ligand-gated ion channels undergo conformational changes that transfer the energy of agonist binding to channel opening. Within ionotropic glutamate receptor (iGluR) subunits, this process is initiated in their bilobate ligand binding domain (LBD) where agonist binding to lobe 1 favors closure of lobe 2 around the agonist and allows formation ...
Pauker S G - - 2012
Although clinical trials often provide "best evidence" comparing the effectiveness of alternative management strategies, such evidence can be limited in duration or in the results reported, causing clinicians and policy analysts to wonder "what if?" Models of the clinical prognosis-often spanning patients' lifetimes (the "long haul")-are perhaps weaker evidence, but ...
Michalopoulos Argyris S - - 2012
Inhaled antibiotics, such as TOBI (a tobramycin solution), gentamicin, colistin and aztreonam lysine (Cayston) have been effectively administered with safety and efficacy in patients with cystic fibrosis and bronchiectasis. In addition, inhaled antibiotics have been administered with safety and efficacy for the prevention and treatment of patients with ventilator-associated tracheobronchitis ...
Pressler Jana L - - 2012
Many new nursing leaders assuming deanships, assistant, or interim deanships have limited education, experience, or background to prepare them for the job. To assist new deans and those aspiring to be deans, the authors of this department, 2 deans, offer survival tips based on their personal experiences and insights. They ...
Ahmed Ali Usama - - 2012
: Anastomotic sinus is a relatively uncommon complication after an IPAA. Disease course is poorly defined, and management can be challenging. : The purpose of this study was to evaluate the frequency, management, and outcome of anastomotic pouch sinus. : This research is a retrospective cohort study from a prospectively ...
Mulder Sanna A - - 2012
Patients with colorectal cancer are at risk for developing metachronous colorectal cancer. The purpose of posttreatment surveillance is to detect and remove premalignant lesions to prevent metachronous colorectal cancer. The aim of this study was to investigate the incidence of and predictive factors for metachronous colorectal cancer in patients with ...
Roessler Gernot F - - 2012
Citation information: Roessler GF, Dietlein TS, Plange N, Roepke A-K, Dinslage S, Walter P, Mazinani BAE. Accuracy of intraocular lens power calculation using partial coherence interferometry in patients with high myopia. Ophthalmic Physiol Opt 2012, 32, 228-233. doi: 10.1111/j.1475-1313.2012.00903.x ABSTRACT: Purpose:  Ultrasound-A-scan-biometry intraocular lens power calculation for cataract surgery sometimes ...
Tzivanakis A - - 2012
Ileocecal resection is the most commonly performed operation in patients with Crohn's disease. Anastomotic-associated complications, with their associated morbidity, are the most feared risks of surgery. This study aimed to assess the influence of a variety of putative risk factors in a homogenous group of patients undergoing first or subsequent ...
Engberg Elina - - 2012
The global epidemic of chronic non-communicable diseases is closely related to changes in lifestyle, including decreasing leisure time physical activity (PA). Physical inactivity is a major public health challenge. To respond to that challenge, it is essential to know which personal and environmental factors affect PA behaviour. Certain life events ...
Memari Amirhossein - - 2012
PROBLEM:  Individuals with autism spectrum disorders (ASDs) have at least as many comorbidities as individuals with typical development may show, but sometimes with different presentations. METHODS:  The study used a school-based health survey related to children diagnosed with ASD in Tehran to determine the possibility of comorbid conditions. Ninety-one children ...
Valencia S J - - 2012
Circadian clocks allow organisms to predict environmental changes of the day/night cycle. In the cyanobacterial circadian clock machinery, the phosphorylation level and ATPase activity of the clock protein KaiC oscillate with a period of approximately 24 h. The time information is transmitted from KaiC to the histidine kinase SasA through the ...
Chung Duc M - - 2012
This study aimed to determine the predictors of discharge to acute care after inpatient rehabilitation in severely affected stroke patients. This was a retrospective study using data from the Uniform Data System for Medical Rehabilitation (UDSMR) between 2008 and 2009. The main outcome variable was discharge location, which included discharge ...
Siddiqui Muhammed R S - - 2012
: Imaging modalities such as endoanal ultrasound or MRI can be useful preoperative adjuncts before the appropriate surgical intervention for perianal fistulas. : We present a systematic review of published literature comparing endoanal ultrasound with MRI for the assessment of idiopathic and Crohn's perianal fistulas. : A meta-analysis was performed ...
Ishiuchi Takashi - - 2012
Willin is a FERM-domain protein, which is related to the Drosophila Expanded, a protein known to be a component of the Hippo signaling pathway. We recently showed that Willin localizes at the apical junctional complex (AJC) in epithelial cells together with Par3 and regulates the contractility of the circumferential actomyosin ...
Bergström Tobias - - 2012
Neural stem cells are the origins of neurons and glia and generate all the differentiated neural cells of the mammalian central nervous system via the formation of intermediate precursors. Although less frequent, neural stem cells persevere in the postnatal brain where they generate neurons and glia. Adult neurogenesis occurs throughout ...
White Evan C - - 2012
: Steroids, immunomodulators, and biologics, often in combination with one another, are frequently used in the treatment of Crohn's disease. Retrospective studies have yielded conflicting results regarding the influence of preoperative immunosuppressive therapy on postoperative complications after surgery in Crohn's disease. Unplanned hospital readmission is considered to be an index ...
Blauvelt Margaret J - - 2012
Student evaluations are relied on heavily to provide feedback for teaching improvement and professional growth. However, their use as the primary source of performance feedback may be limiting. To add another dimension to faculty evaluation, a peer-review process for both clinical and didactic teaching was implemented. The authors describe the ...
Brainard Annie M - - 2012
In 1916, when Annie Brainard published this paper, there was an ongoing discussion in the journal about specialization versus generalization of public health nursing (PHN) work. This discussion revolved around issues such as the size of communities (rural versus urban), population density, and cost effectiveness. For geographically large rural communities ...
Xing Weirong W Musculoskeletal Disease Center, Loma Linda VA HealthCare System, Loma Linda, CA 92357, - - 2012
Understanding how bone growth is regulated by hormonal and mechanical factors during early growth periods is important for optimizing the attainment of peak bone mass to prevent or postpone the occurrence of fragility fractures later in life. Using genetic mouse models that are deficient in thyroid hormone (TH) (Tshr(-/-) and ...
Murala Subrahmanyam - - 2012
In this paper, we propose a novel image indexing and retrieval algorithm using local tetra patterns (LTrPs) for content-based image retrieval (CBIR). The standard local binary pattern (LBP) and local ternary pattern (LTP) encode the relationship between the referenced pixel and its surrounding neighbors by computing gray-level difference. The proposed ...
King Michalene A - - 2012
Simulation activities have been developed for many areas of nursing, but there are minimal nursing simulation activities in the area of mental health nursing. In this article, the authors describe development of mental health simulation activities for junior BSN students using clinical faculty as the standardized patients. Faculty who want ...
Banerjee A - - 2012
Background:  Exercise stress testing offers a non-invasive, less expensive way of risk stratification prior to coronary angiography, and a negative stress test may actually avoid angiography. However, previous meta-analyses have not included all exercise test modalities, or patients without known Coronary artery disease (CAD). Methods and Results:  We systematically reviewed ...
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