Search Results
Results 451 - 500 of 1952
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Bellows Brandon K - - 2012
The objective of the current study was to determine the cost-utility of pregabalin versus duloxetine for treating painful diabetic neuropathy (PDN) using a decision tree analysis. Literature searches identified clinical trials and real-world studies reporting the efficacy, tolerability, safety, adherence, opioid usage, health care utilization, and costs of pregabalin and ...
Lacau Harlette - - 2012
Central Asia has served as a corridor for human migrations providing trading routes since ancient times. It has functioned as a conduit connecting Europe and the Middle East with South Asia and far Eastern civilizations. Therefore, the study of populations in this region is essential for a comprehensive understanding of ...
Ishmukhametova Aliya - - 2012
We report on the effectiveness of a custom-designed oligonucleotide-based comparative genomic hybridization microarray (array-CGH) to interrogate copy number across the entire 2.2-Mb genomic region of the DMD gene and its applicability in diagnosis. The high-resolution array-CGH, we developed, successfully detected a series of 42 previously characterized large rearrangements of various ...
Ouyang Fengxiu - - 2012
Elevated pre-pregnancy body mass index (BMI), excessive gestational weight gain (GWG), and gestational diabetes (GDM) are known determinants of fetal growth. The role of placental weight is unclear. We aimed to examine the extent to which placental weight mediates the associations of pre-pregnancy BMI, GWG, and GDM with birthweight-for-gestational age, ...
Zöllner Sebastian - - 2012
Advances in sequencing technology allow assessing the impact of rare variation on common disorders. For this purpose, methods combine rare variants across a gene and compare an aggregate statistic between cases and controls. However, sequencing many individuals is costly. Hence, it is necessary to identify case samples that are most ...
Ferreira Anderson J - - 2012
The renin-angiotensin system (RAS) is a main therapeutic target for cardiovascular diseases. Within the last two decades, novel components of the RAS have been discovered, opening new opportunities to interfere with its activity. Angiotensin(Ang)-(1-7) is synthesized by angiotensin-converting enzyme 2 (ACE2), and interacts with the G-protein-coupled receptor Mas. The axis ...
Lai Yurong - - 2012
Drug transporter proteins are expressed on the cell membrane, regulating substrate exposure in systemic circulation and/or peripheral tissues. Genetic polymorphism of drug transporter genes encoding these proteins could alter the functional activity and/or protein expression, having effects on absorption, distribution, metabolism and excretion (ADME), efficacy and adverse effects. The authors ...
Hutson Janine R - - 2012
There is a lack of high-quality data regarding optimal chemotherapy dosage regimens among infants. Dosing regimens for chemotherapy during the first year of life are commonly based on empiric recommendations extrapolated from older children; however, balancing efficacy and toxicity is critical as severe adverse drug reactions may lead to treatment ...
Yang Chung S - - 2012
Tea, made from the dried leaves of the plant Camellia sinensis Theaceae, is a very popular beverage consumed worldwide. Recently, green tea extract-based dietary supplements have also been widely consumed for the acclaimed beneficial health effects, such as weight reduction. Although tea consumption is considered to be innocuous, the potential ...
García-Olmo Dolores C - - 2012
Most cancer deaths are due to the development of metastases and this phenomenon is still a hard challenge for researchers. A number of theories have tried to unravel the metastatic machinery, but definitive results that link the evidence with conventional concepts of metastatic disease remain to be reported. Considerable evidence ...
Koczor Christopher A - - 2012
Two families of nucleoside analogs have been developed to treat viral infections and cancer, but these compounds can cause tissue- and cell-specific toxicity related to their uptake and subcellular activity, which are dictated by host enzymes and transporters. Cellular uptake of these compounds requires nucleoside transporters that share functional similarities ...
Subramanian Sankar S Environmental Futures Centre and Australian Rivers Institute, School of Environment, Griffith University, Nathan, Qld, Australia. - - 2012
A number of previous studies suggested the presence of deleterious amino acid altering nonsynonymous single-nucleotide polymorphisms (nSNPs) in human populations. However, the proportions of deleterious nSNPs among rare and common variants are not known. To estimate these, >77,000 SNPs from human protein-coding genes were analyzed. Based on two independent methods, ...
Kohannim Omid O Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1769, - - 2012
Several common genetic variants have recently been discovered that appear to influence white matter microstructure, as measured by diffusion tensor imaging (DTI). Each genetic variant explains only a small proportion of the variance in brain microstructure, so we set out to explore their combined effect on the white matter integrity ...
VanVeller Brett B Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, - - 2012
The cyclization and planarization of polycyclic aromatic hydrocarbons with concomitant oxygen substitution was achieved through acid catalyzed transetherification and oxygen-radical reactions. The triptycene scaffold enforces proximity of the alcohol and arene reacting partners and confers significant rigidity to the resulting π-system, expanding the tool set of iptycenes for materials applications.
Tan Hung-Jui HJ Dow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, MI 48109-2800, - - 2012
Although partial nephrectomy is the preferred treatment for many patients with early-stage kidney cancer, recent clinical trial data, which demonstrate better survival for patients treated with radical nephrectomy, have generated new uncertainty regarding the comparative effectiveness of these treatment options. To compare long-term survival after partial vs radical nephrectomy among ...
Economidou Daina D Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, - - 2012
Impulsive behavior is a hallmark of several neuropsychiatric disorders (eg, attention-deficit/hyperactivity disorder, ADHD). Although dopamine (DA) and norepinephrine (NE) have a significant role in the modulation of impulsivity their neural loci of action is not well understood. Here, we investigated the effects of the selective NE re-uptake inhibitor atomoxetine (ATO) ...
Mittelbrunn Maria M Centro Nacional de Investigaciones Cardiovasculares, Melchor Fernández Almagro, 3, 28029 Madrid, - - 2012
An emerging concept is that cellular communication in mammals can be mediated by the exchange of genetic information, mainly in the form of microRNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are taken up by an acceptor cell. Transfer of genetic material can ...
White Heather M HM Division of Endocrinology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, - - 2012
The angiogenic inhibitor TNP-470 attenuates high-fat diet-induced obesity; however, it is not clear how the compound alters energy balance to prevent weight gain. Five-week-old C57BL/6J mice were fed high-fat diet (45% energy from fat) for 6.5 weeks and treated with TNP-470 (20 mg/kg body weight; n = 7) or vehicle ...
Ye Shengfa S Max-Plank Institute for Bioinorganic Chemistry, Stiftstrasse 34-36, 45470 Mülheim an der Ruhr, - - 2012
α-Ketoglutarate (αKG)-dependent nonheme iron enzymes utilize a high-spin (HS) ferrous center to couple the activation of oxygen to the decarboxylation of the cosubstrate αKG to yield succinate and CO(2), and to generate a high-valent ferryl species that then acts as an oxidant to functionalize the target C-H bond. Herein a ...
de las Fuentes Lisa L Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, - - 2012
Genome-wide association (GWA) studies of complex diseases including coronary heart disease (CHD) challenge investigators attempting to identify relevant genetic variants among hundreds of thousands of markers being tested. A selection strategy based purely on statistical significance will result in many false negative findings after adjustment for multiple testing. Thus, an ...
Porter Lee B - - 2012
A procedure has been developed for calculating permeability (k) from the Kozeny-Carman equation, a procedure that links ideas from percolation theory with the ideas of Koltermann and Gorelick (1995) and Esselburn et al. (2011). The approach focuses on the proportion of coarser pores that are occupied by finer sediments relative ...
Guéguen Nicolas - - 2012
OBJECTIVE: Previous studies have found a link between body tattoos or piercings and risky behavior. However, these studies only examined survey data but not real behavior. METHODS: Young men (mean = 20.6 years) and women (mean = 20.2 years) leaving a bar were asked whether they wore tattoos and piercings or not and were requested to ...
Jacobsen Magnus W - - 2012
The advent of second-generation sequencing has made it possible to quickly and economically generate whole mitochondrial genome (mitogenome) sequences. To date, mitogenome studies of nonmodel organisms have demonstrated increased power for resolving interspecies relationships. We explored an alternate use of such data to recover relationships and population history of closely ...
Byeon Jeong Hoon - - 2012
Several novel nanoparticle composites were conveniently obtained by appropriately reacting freshly produced aerosol metal nanoparticles with soluble organic components. A serial reactor consisting of a spark particle generator coupled to a collison atomizer was used to fabricate the new materials, which included nanomagnetosols (comprising iron nanoparticles, the drug ketoprofen, and ...
Isoda Susumu - - 2012
Background: Residual shunting and mortality are problems associated with current surgical repair techniques for post-infarction ventricular septal defects.Methods: We describe the mid-term results of the "sandwich technique" to repair a post-infarction ventricular septal defect (VSD), performed via a right ventricle incision. Application of direct ultrasonography to the right ventricular wall ...
Mekheimer Ramadan Ahmed - - 2012
ABSTRACT: In this paper we report the synthesis of some novel 1,2,4- triazolo[1,5-a]pyridines and azolotriazolopyridines ring systems. The products were screened for various types of activity like antibacterial, anti-fungal and antioxidative activity. Compound 13 was found to pose an antioxidative activity. In addition, this compound was found to extend the ...
Muroya Takahiro - - 2012
Treatment options for chronic renal artery dissection, which is a rare cause of renal artery stenosis and renovascular hypertension, such as medical management, percutaneous intervention, and open surgical repair remain controversial. We describe a 55-year-old man with a chronic dissecting aneurysm of a renal artery complicated with renovascular hypertension that ...
Heianza Y - - 2012
Aim  To evaluate various screening criteria for pre-diabetes to identify which combination of impaired fasting glucose and elevated HbA(1c) values performs most effectively in predicting future diabetes in a large cohort of Japanese individuals. Methods  The study included 4670 men and 1571 women without diabetes (diabetes: fasting plasma glucose ≥ 7.0 mmol/l, ...
Flynn Linda - - 2012
Purpose: Medication errors remain a threat to patient safety. Therefore, the purpose of this study was to determine the relationships among characteristics of the nursing practice environment, nurse staffing levels, nurses' error interception practices, and rates of nonintercepted medication errors in acute care hospitals. Design: This study, using a nonexperimental ...
Hanson Niklas - - 2012
Ecological risk assessments (ERA) of chemicals are often based on mortality and reproduction of individuals. To protect populations, fixed safety factors are applied to the data. However, the relationship between individuals and populations cannot easily be described by pre-defined numbers. The use of population models may reduce uncertainty and, hence, ...
Pratsch A L - - 2012
Background: With respect to survival and local disease control, the adequate extent of lymph node dissection for melanoma metastasis to the groin is controversial. Since the methods for accurate quantification of leg oedemas are not well standardised, it remains also unclear whether the iliac part of a radical ilioinguinal lymph ...
De Volder Michaël F L - - 2012
New developments in digital mirror devices (DMDs) require suspension hinges with a good damping and high temperature stability. Carbon nanotubes (CNTs) offer these unique properties. Herein it is shown how CNT hinges can be integrated in micromirrors. The image illustrates a micromirror with a CNT suspension, and a typical overdamped ...
Ren Guifang - - 2012
Dry eye is one of the most prevalent eye diseases and dry eye disease (DED) is associated with ocular surface inflammation. The interaction between killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens (HLAs) regulates the activation of natural killer (NK) cells and certain T cell subsets in response to ...
Marion Vincent - - 2012
BackgroundBardet-Biedl Syndrome (BBS) is an emblematic recessive genetically highly heterogeneous ciliopathy characterised mainly by polydactyly, retinitis pigmentosa, obesity, cognitive impairment, and kidney dysfunction. The 16 BBS genes known to date are implied in the primary cilia related cellular pathways.Methods and resultsSingle nucleotide polymorphism (SNP) array analysis followed by exome sequencing ...
Wu Bei - - 2012
Revealing the uptake, transport, localization and speciation of both essential and toxic elements in plants is important for understanding plant homeostasis and metabolism, subsequently, providing information for food and nutrient studies, agriculture activities, as well as environmental research. In the last decade, emerging techniques for elemental imaging and speciation analysis ...
Mainz Verena - - 2012
ObjectiveThe neurobiological mechanisms of structural brain abnormalities in patients with anorexia nervosa (AN) remain poorly understood. In particular, little is known about the changes in and the recovery of gray matter (GM) volumes after weight gain and the relation to hormonal normalization in adolescent patients with AN.MethodsNineteen female patients aged ...
Jung Ju - - 2012
Surfactin is a biological surfactant with numerous potential applications. In this study, Bacillus subtilis was engineered to improve surfactin production by the activation of two competence-stimulating pheromones, ComX and competence and sporulation factor (CSF) to stimulate the transcription of srfA operon. Both signaling factors, encoded by comX and phrC, were ...
Boggess Kim A - - 2012
Background: Maternal periodontal disease diagnosed by a detailed oral health examination is associated with preeclampsia. Our objective was to measure the association between maternal self-report of oral symptoms/problems, oral hygiene practices, and/or dental service utilization prior to or during pregnancy and severe preeclampsia. Methods: A written questionnaire was administered to ...
Hegde Ganapati V - - 2012
Mantle cell lymphoma (MCL) is one of the most aggressive B-cell lymphomas with a median patient survival of only five to seven years. The failure of existing therapies is mainly due to disease relapse when therapy-resistant tumor cells remain after chemotherapy. Therefore, development and testing of novel therapeutic strategies to ...
Zou Weibin - - 2012
Bone marrow-derived mesenchymal stem cells (MSCs) have been shown to home to tumor tissues, where they promote tumor growth and suppress immune rejection. In this study, we tested whether MSCs engineered to express the immune stimulating factor LIGHT, a member of the tumor-necrosis factor superfamily, could induce tumor regression. Using ...
Adeyemi Joseph A - - 2012
The sheepshead minnow (Cyprinodon variegatus) is able to withstand a wide range of salinities. Salinity acclimation involves physiological and biochemical changes, which may influence how organisms then respond to a stressor. The present study investigated effects of salinity acclimation on subsequent Cu toxicity. In experiment 1, fish were acclimated to ...
Lardy Matthew - - 2012
In modern day drug discovery campaigns, computational chemists have to be concerned not only about improving the potency of molecules but also reducing any off-target ADMET activity. There are a plethora of anti-targets that computational chemists may have to consider. Fortunately many anti-targets have crystal structures deposited in the PDB. ...
Grünberger Alexander - - 2012
In the continuously growing field of industrial biotechnology the scale-up from lab to industrial scale is still a major hurdle to develop competitive bioprocesses. During scale-up the productivity of single cells might be affected by bioreactor inhomogeneity and population heterogeneity. Currently, these complex interactions are difficult to investigate. In this ...
Hoff Jana Midelfart - - 2012
Background. Pressure ulcers are a serious and frequently occurring complication in patients with a traumatic spinal cord injury. The purpose of the article is to consider the causes of pressure ulcers and how to prevent them. Method. The article is based on a non-systematic search in the PubMed database and ...
Kosoglu Mehmet A - - 2012
BACKGROUND AND OBJECTIVES: Microneedles made from silica fiberoptics permit transmission and collection of light, which is an important functional advantage over metal or silicon microneedles. This added functionality may enhance or even enable new percutaneous light-based clinical diagnostic and therapeutic procedures. Micron-diameter fiberoptic microneedles, created from solid fibers capable of ...
Duncanson Wynter J - - 2012
We describe droplet microfluidic strategies used to fabricate advanced microparticles that are useful structures for the encapsulation and release of actives; these strategies can be further developed to produce microparticles for advanced drug delivery applications. Microfluidics enables exquisite control in the fabrication of polymer vesicles and thermosensitive microgels from single ...
Dong Haifeng - - 2012
A simple, highly sensitive and selective multiple (microRNA) miRNA detection method based on the graphene oxide (GO) fluorescence quenching and isothermal strand-displacement polymerase reaction (ISDPR) was proposed. The capability to discriminate ssDNA and double-stranded nucleic acid structure, coupling with the extraordinary fluorescence quenching of GO on multiple organic dye allows ...
Fischer Hans-Georg - - 2012
The human brain has been proposed to represent a genetic mosaic, containing a small but constant number of neurons with an amount of DNA exceeding the diploid level that appear to be generated through various chromosome segregation defects initially. While a portion of these cells apparently die during development, neurons ...
Walters Sherry L - - 2012
The ideal animal model would contribute no confounding variables in experimental science. Variables affect experimental design resulting in increased animal use or repeated studies. We demonstrated a simple refinement which may reduce the number of animals used experimentally while simultaneously improving animal welfare. The objective of this study was to ...
Olah George A - - 2012
Structures of octahydriodo diborane (B(2)H(8)) 1 and its protonated 3, diprotonated 5, triprotonated 6, and tetraprotonated 7 ions were found to be calculationally viable minima at the MP2/cc-pVTZ level of theory. Each structure contains two-electron three-center (2e-3c) bonds. The protonation of 1 to form 3 was found to be strongly ...
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