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Results 351 - 400 of 2632
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Whelan Jane - - 2012
The hexavalent vaccine Infanrix hexa was introduced into the national childhood vaccination schedule in the Netherlands in 2006. It is offered, concomitantly with pneumococcal vaccine (Prevenar), to children at increased risk of hepatitis B, administered in a 4-dose schedule at 2, 3, 4 and 11 months of age. We assessed ...
Hassanian-Moghaddam Hossein - - 2012
Phosphine is absorbed rapidly across mucous membranes causing systemic poisoning including functional cellular hypoxia. Following ingestion of metal phosphides, continuous absorption of phosphine could contribute to the intractable systemic manifestations. A 16-year-old male was admitted to hospital 1-hour post-ingestion of two fresh 3 g tablets of aluminum phosphide 56%. He ...
Cohen Steven P - - 2012
Perineural inhibitors of tumor necrosis factor have recently generated intense interest as an alternative to epidural steroid injections for lumbosacral radiculopathy. To evaluate whether epidural steroids, etanercept, or saline better improves pain and function in adults with lumbosacral radiculopathy. A multicenter, 3-group, randomized, placebo-controlled trial conducted from 2008 to 2011. ...
Fink Howard A - - 2012
Screening and monitoring for chronic kidney disease (CKD) could lead to earlier interventions that improve clinical outcomes. To summarize evidence about the benefits and harms of screening for and monitoring and treatment of CKD stages 1 to 3 in adults. MEDLINE (1985 through November 2011), reference lists, and expert suggestions. ...
Wendler David - - 2012
This analysis suggests that one-time general consent is better than a gift model for addressing 5 central challenges that arise in the context of obtaining and storing human biological samples for future research. This conclusion supports the suggestion made in a recent Advance Notice of Proposed Rulemaking to incorporate one-time ...
Zhao Ying Y - - 2012
Fibric acid derivatives (fibrates) have been shown to increase serum creatinine level in randomized trials. To assess renal outcomes in elderly adults within 90 days of a new fibrate prescription. Population-based cohort study. Ontario, Canada. Patients aged 66 years or older with a new outpatient prescription for a fibrate or ...
Fan Mingzhu - - 2012
The remarkable regeneration capability of plant tissues or organs under culture conditions has underlain an extensive practice for decades. The initial step in plant in vitro regeneration often involves the induction of a pluripotent cell mass termed callus, which is driven by the phytohormone auxin and occurs via a root ...
Usmani S Z - - 2012
To determine whether primary plasma cell leukemia (PPCL) remains a high-risk multiple myeloma feature in the context of contemporary therapy and gene-expression profiling (GEP), we reviewed records of 1474 patients with myeloma, who were enrolled in Total Therapy protocols or treated identically off protocol. A total of 27 patients (1.8%) ...
Juusola Jessie L - - 2012
A recent randomized, controlled trial showed that daily oral preexposure chemoprophylaxis (PrEP) was effective for HIV prevention in men who have sex with men (MSM). The Centers for Disease Control and Prevention recently provided interim guidance for PrEP in MSM at high risk for HIV. Previous studies did not reach ...
Sweet Michael - - 2012
White Syndrome (WS) and Brown Band Disease (BrB) are important causes of reef coral mortality for which causal agents have not been definitively identified. Here we use culture-independent molecular techniques (DGGE and clone libraries) to characterize ciliate and bacterial communities in these diseases. Bacterial (16S rRNA gene) and ciliate (18S ...
Wallace Lindsay M - - 2012
No treatment exists for facioscapulohumeral muscular dystrophy (FSHD), one of the most common inherited muscle diseases. Although FSHD can be debilitating, little effort has been made to develop targeted therapies. This lack of focus on targeted FSHD therapy perpetuated because the genes and pathways involved in the disorder were not ...
Liao Chen-Yu - - 2012
Initial studies linking Sirtuins to longevity in yeast initiated what is now a rich vein of aging research that is full of promise and fraught with controversy. Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals. Now Kanfi et al. provide the evidence but with an interesting ...
Gao D - - 2012
Background:Adipose tissue expansion during obesity is associated with a state of low-grade inflammation and an increase in macrophage infiltration, which predisposes to insulin resistance and vascular malfunction. Growing evidence suggests that vitamin D(3) has immunoregulatory effects and adipose tissue could be a target for vitamin D(3) action. Preadipocytes, one of ...
Wu Qixi - - 2012
Formation of a bipolar spindle is indispensable for faithful chromosome segregation and cell division. Spindle integrity is largely dependent on the centrosome and the microtubule network. Centrosome protein Cep57 can bundle microtubules in mammalian cells. Its related protein (Cep57R) in Xenopus was characterized as a stabilization factor for microtubule-kinetochore attachment. ...
Song Jae-Min - - 2012
In this study, we tested the hypothesis that DNA vaccination in the skin using microneedles improves protective immunity compared to conventional intramuscular (i.m.) injection of a plasmid DNA vaccine encoding the influenza hemagglutinin (HA). In vivo fluorescence imaging demonstrated the expression of a reporter gene delivered to the skin using ...
Moskowitz Richard R American Institute of Homeopathy, USA. - - 2012
This article is a rebuttal to Kevin Smith's 'Against Homeopathy,' which was posted on 14 February 2011.(1) It contends that his argument rests entirely on the assumption that homeopathic remedies are nothing but placebos. His argumentation is good, but his assumption is false. Evidence is presented to show that the ...
Milgrom Lionel L Programme for Advanced Homeopathic Studies, London. - - 2012
In this short response we show that Kevin Smith's moral and ethical rejections of homeopathy(1) are fallacious and rest on questionable epistemology. Further, we suggest Smith's presumption of a utilitarian stance is an example of scientism encroaching into medicine.
Spencer Brian B Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0624, - - 2013
Neurosin is a predominant serine protease in the central nervous system (CNS) and has been shown to play a role in the clearance of α-synuclein (α-syn) which is centrally involved in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Although it has been previously shown that ...
Vrlinic Tjasa T LUNAM Université, UMR Université du Maine-CNRS n° 6283, Institut des Molécules et Matériaux du Mans-Département, Av. O. Messiaen, 72085 Le Mans, - - 2012
New non-fouling tubes are developed and their influence on the adhesion of neuroproteins is studied. Recombinant prion proteins are considered as a single component representative of hydrophobic proteins. Samples are stored for 24 h at 4 °C in tubes coated with two different coatings: poly(N-isopropylacrylamide) as a hydrophilic surface and a plasma-fluorinated ...
Sharma S S Department of Nutrition, CRCHUM and Montreal Diabetes Research Center, Faculty of Medicine, University of Montreal, Montreal, Quebec, - - 2013
The biological mechanisms that link the development of depression to metabolic disorders such as obesity and diabetes remain obscure. Dopamine- and plasticity-related signalling in mesolimbic reward circuitry is implicated in the pathophysiology and aetiology of depression. To determine the impact of a palatable high-fat diet (HFD) on depressive-like behaviour and ...
Tentler John J JJ Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, 12801 East 17th Avenue, Aurora, CO 80045, - - 2012
Progress in oncology drug development has been hampered by a lack of preclinical models that reliably predict clinical activity of novel compounds in cancer patients. In an effort to address these shortcomings, there has been a recent increase in the use of patient-derived tumour xenografts (PDTX) engrafted into immune-compromised rodents ...
McGlynn Katherine A KA Division of Hormonal and Reproductive Epidemiology, National Cancer Institute, Suite 550 6120 Executive Boulevard, Rockville, MD 20852, USA. - - 2012
The incidence of testicular cancer has been increasing over the past several decades in many developed countries. The reasons for the increases are unknown because the risk factors for the disease are poorly understood. Some research suggests that in utero exposures, or those in early childhood, are likely to be ...
Singh Pankaj K PK The Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, 987696 Nebraska Medical Center, Omaha, NE 68198, USA. - - 2012
Advances in understanding the biology of tumour progression and metastasis have clearly highlighted the importance of aberrant tumour metabolism, which supports not only the energy requirements but also the enormous biosynthetic needs of tumour cells. Such metabolic alterations modulate glucose, amino acid and fatty-acid-dependent metabolite biosynthesis and energy production. Although ...
Grangeon M M Université de Lyon, Université Claude Bernard Lyon1-CRIS EA 647-Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) Villeurbanne, - - 2012
A case study. The aim was to investigate whether motor imagery (MI) could be successfully incorporated into conventional therapy among individuals with spinal cord injury (SCI) to improve upper limb (UL) function. The Physical Medicine and Rehabilitation Unit at the Henry Gabrielle Hospital in Lyon, France. The participant was an ...
Serra-Añó P P Department of Physiotherapy, University of Valencia, Valencia, - - 2012
Time series design. To determine the effects of a shoulder resistance training programme on isokinetic and isometric strength, body composition, pain and functionality in paraplegic subjects. University of Valencia, Valencia, Spain. A total of 15 subjects with thoracic spinal cord injury (SCI) performed three testing sessions with an 8-week period ...
Bangasser D A DA Department of Anesthesiology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. - - 2013
Stress-related psychiatric disorders are more prevalent in women than men. As hypersecretion of the stress neuromediator, corticotropin-releasing factor (CRF) has been implicated in these disorders, sex differences in CRF sensitivity could underlie this disparity. Hyperarousal is a core symptom that is shared by stress-related disorders and this has been attributed ...
Patel Vaibhav B - - 2012
Loss of angiotensin (Ang)-converting enzyme 2 (ACE2) and inability to metabolize Ang II to Ang 1-7 perpetuate the actions of Ang II after biomechanical stress and exacerbate early adverse myocardial remodeling. Ang receptor blockers are known to antagonize the effect of Ang II by blocking Ang II type 1 receptor ...
Pino C J - - 2012
BACKGROUND: Systemic inflammatory response syndrome (SIRS) can occur in association with cardiopulmonary bypass (CPB) surgery, resulting in multiple organ dysfunction (MOD). Activated neutrophils have been implicated as major inciting factors in this process. Neutrophil-depleting filters incorporated within the extracorporeal blood circuit during CPB have been developed and evaluated, with inconsistent ...
Poljsak Borut - - 2012
Abstract The study addressed the influence of sleep as an important but overlooked contributory factor to the formation and progression of facial wrinkles and an alternative pillow was designed to reduce them. Materials and Methods Fifteen healthy young participants of both sexes (aged 26-42 years) volunteered for this study. We ...
Cheng Lung-I - - 2012
OBJECTIVE: To evaluate the impact of Medicare Part D on medication utilization, drug expenditures, and medical expenditures in patients with arthritis. METHODS: This was a retrospective study using a national sample of 2,484 Medicare-eligible beneficiaries with arthritis from the pooled Medical Expenditure Panel Survey 2005-2008 data. Quantile regression was used ...
Lamontagne Mario - - 2012
While the effect of total hip arthroplasty on the operated limb mechanics is well documented, little is known on its effect on the contralateral limb. The purpose of this study was to measure the joint mechanics of both lower limbs during the tasks of sit-to-stand and stand-to-sit. Twenty total hip ...
Berges Ivonne-M - - 2012
Purpose: To examine the association between positive affect and social participation in adults with first-time stroke after in-patient medical rehabilitation. Methods: A prospective cohort design using information from the Stroke Recovery in Underserved Populations database (SRUP) for the years 2005-2006. Data were collected at discharge from in-patient medical rehabilitation and ...
Kuller Andrew M - - 2012
Insight has emerged as a potential predictor variable in cognitive behavioral therapy for psychosis (CBTp). However, previous research has produced mixed results. The present study aimed to clarify whether symptom type is a moderating variable. A group of psychotic patients (n = 44) were assessed through pre- and post-treatment in a CBTp ...
Singh Kamal Nain - - 2012
A novel approach for the direct C-4 arylation of N-methyl-1,2,3,4-tetrahydroisoquinolines by nucleophilic addition of β-aminocarbanions to benzynes is described which provides a one-pot procedure for synthesis of the title compounds.
Liu Jun-Hong - - 2012
Six new quassinoids (1-6) and eight known compounds of this type (7-14) were isolated from the seeds of Brucea javanica. Their structures were elucidated by analysis of their spectroscopic data and from chemical evidence. Compounds 1-5 were found to be unusual quassinoids with a 2,3-seco A ring. The configurations at ...
Ko Chia-Yun - - 2012
The <italic>Arabidopsis thaliana At1g68290</italic> gene encoding an endonuclease was isolated and designated ENDO2, which was cloned into a binary vector to overexpress ENDO2 with a C-terminal 6×His-tag in <italic>A. thaliana</italic>. Our <italic>Arabidopsis</italic> transgenic lines harboring <italic>35SP::ENDO2</italic> produced stable active enzyme with high yield. The protein was affinity purified from transgenic ...
Donegan Eleanor - - 2012
Objective: Generalized anxiety disorder (GAD) is characterized by excessive worry and somatic symptoms of anxiety (e.g., restlessness, muscle tension). Several psychological treatments lead to significant reductions in GAD symptoms by posttreatment. However, little is known about how GAD symptoms change over time. Our main goal was to examine how GAD ...
Gilmore Stephen J - - 2012
High throughput molecular biology began around the mid-1990s with the introduction of microarrays - a technology that enabled investigators to quantify the cellular expression levels of tens of thousands of mRNA transcripts simultaneously. To date, a large number of microarray experiments have been performed in the investigation of RNA expression ...
Li Xiaoxia - - 2012
Objective:  Liver X receptors (LXRs) are key regulators of cholesterol homeostasis. Synthetic LXR agonists are anti-atherogenic and anti-inflammatory. However, the effect of LXR agonists on endothelial progenitor cell (EPC) function is largely unknown. Here, we explored the effect of the LXR agonist TO901317 (TO) on EPC biology and the underlying ...
Branagan Sean P - - 2012
Electroosmotic flow (EOF) is used to enhance the delivery of Fe(CN)64-/Fe(CN)63- to an annular nanoband electrode embedded in a nanocapillary array membrane, as a route to high efficiency electrochemical conversions. Multilayer Au/polymer/Au/polymer membranes are perforated with 102-103 cylindrical nanochannels by focused ion beam (FIB) milling and subsequently sandwiched between two ...
Dakhilalian Mansoor - - 2012
Abstract Background: Implant supported overlay dentures (ISODs) have been widely accepted among patients using conventional removable complete dentures (CRCDs). The present study aimed to comparatively study conventional and ISODs in terms of function and coordination of masticatory muscles using electromyograms.Materials and methods: Included were 10 patients with ISODs (each with ...
Torkildsen Oivind - - 2012
OBJECTIVE: To investigate whether ω-3 fatty acids reduce magnetic resonance imaging (MRI) and clinical disease activity in patients with multiple sclerosis, both as monotherapy and in combination with interferon beta-1a treatment. DESIGN: Multicenter, randomized, double-blind, placebo-controlled clinical trial conducted from 2004 to 2008. SETTING: Thirteen public neurology departments in Norway. ...
Tonks Ian - - 2012
ABSTRACT: Colorful terminal hydrazido(2-) complexes of the type (dme)MCl3(NNR2) (dme = 1,2-dimethoxyethane; M = Nb, Ta; R = alkyl or aryl) or (MeCN)WCl4(NNR2) have been synthesized. Perturbing the electronic environment of the β (NR2) nitrogen affects the energy of the lowest-energy charge transition in these complexes. This effect is caused ...
Lampugnani Edwin R - - 2012
Flower primordia are partitioned by boundaries during their early development. Such boundaries occur between whorls of organs, and also between organs within whorls. PETAL LOSS (PTL) is a trihelix transcription factor gene that is expressed in boundaries between sepal primordia in the outer whorl. Over-expression of PTL results in growth ...
Munirama S - - 2012
Ultrasound guidance is now common in regional anaesthesia practice, but remains limited by poor visibility of the needle tip and poor quantification of local anaesthetic spread. Sonoelastography based on tissue compression is a technique depicting tissue strain. Hitherto used largely for tumour diagnosis, we used it in both Thiel embalmed ...
Brugaletta Salvatore - - 2012
AimsTo analyse the vasoreactivity of a coronary segment, previously scaffolded by the ABSORB bioresorbable vascular scaffold (BVS) device, in relationship to its intravascular ultrasound-virtual histology (IVUS-VH) composition and reduction in greyscale echogenicity of the struts. Coronary segments, transiently scaffolded by a polymeric device, may in the long-term recover a normal ...
Roussel Mikael - - 2012
BACKGROUND: We sought to evaluate, on a model of sepsis, the clinical relevance of new parameters obtained on a WBC differential by flow cytometry, implemented in the routine workflow of our hematology laboratory. METHODS: A WBC with differential by flow cytometry was done on 459 patients at admission in Intensive ...
Kaneku Hugo - - 2012
In our previous study, 92% of patients with chronic rejection had donor-specific HLA antibodies (DSA), but surprisingly 61% of comparator patients without rejection also had DSA. We hypothesized there are differentially distributed IgG subclasses between the two groups. A modified single antigen bead assay was used to detect the presence ...
Xiao Kai - - 2012
The deterministic growth of oriented crystalline organic nanowires (CONs) from the vapor-solid chemical reaction (VSCR) between small-molecule reactants and metal nanoparticles has been demonstrated in several studies to date, however the growth mechanism has not yet been conclusively understood. Here, the VSCR growth of M-TCNQF4 (where M is Cu- or ...
Wasko Piotr - - 2012
Amphotericin B (AmB) is a lifesaving polyene antibiotic used widely to treat deep-seated mycoses. Both the pharmaceutical effectiveness as well as toxic side effects depend on molecular organization of the drug. In the present study we analyzed steady-state fluorescence, fluorescence anisotropy spectra, fluorescence lifetimes and fluorescence anisotropy decays of AmB ...
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