Search Results
Results 351 - 400 of 2634
< 3 4 5 6 7 8 9 10 11 12 13 >
Wu Qixi - - 2012
Formation of a bipolar spindle is indispensable for faithful chromosome segregation and cell division. Spindle integrity is largely dependent on the centrosome and the microtubule network. Centrosome protein Cep57 can bundle microtubules in mammalian cells. Its related protein (Cep57R) in Xenopus was characterized as a stabilization factor for microtubule-kinetochore attachment. ...
Lin Xiaoqing - - 2012
The traditional distillation method for recovery of butanol from fermentation broth is an energy-intensive process. Separation of butanol based on adsorption methodology has advantages in terms of biocompatibility and stability, as well as economy, and therefore gains much attention. However, the application of the commercial adsorbents in the integrated acetone-butanol-ethanol ...
Nyman Tommi - - 2012
Ecology Letters (2012) ABSTRACT: The origin of species-rich insect-plant food webs has traditionally been explained by diversifying antagonistic coevolution between plant defences and herbivore counter-defences. However, recent studies combining paleoclimatic reconstructions with time-calibrated phylogenies suggest that variation in global climate determines the distribution, abundance and diversity of plant clades and, ...
Behre Ulrich U GlaxoSmithKline Pharmaceuticals, Bangalore, - - 2012
This paper presents data from two studies that evaluated 5-y and 10-y persistence of antibodies against hepatitis B (HBV) surface antigen (anti-HBs) and immune response to an HBV vaccine challenge in children and adolescents who had received three doses of a HBV vaccine in infancy as part of routine clinical ...
Piasta Shayne B - - 2012
Longitudinal results for a randomized-controlled trial (RCT) assessing the impact of increasing preschoolers' attention to print during reading are reported. Four-year-old children (N = 550) in 85 classrooms experienced a 30-week shared reading program implemented by their teachers. Children in experimental classrooms experienced shared-book readings 2 or 4 times per week during ...
Yamano Yumiko - - 2012
Stereoselective total synthesis of the C(40)-diacetylenic carotenoid alloxanthin () and the C(31)-acetylenic apocarotenoid triophaxanthin () was accomplished by Wittig condensation of C(10)-dialdehyde or C(16)-keto aldehyde , respectively, with C(15)-acetylenic tri-n-butylphosphonium salt .
Minami Atsushi - - 2012
Enantioselective epoxidation followed by regioselective epoxide opening reaction are the key processes in construction of the polyether skeleton. Recent genetic analysis of ionophore polyether biosynthetic gene clusters suggested that flavin-containing monooxygenases (FMOs) could be involved in the oxidation steps. In vivo and in vitro analyses of Lsd18, an FMO involved ...
Zandman-Goddard Gisele - - 2012
New evidence suggesting an X chromosome effect underlies the development and progression of male systemic lupus erythematosus comes from a study of sex chromosome aneuploidy in men with this disease. The description of a number of immunoregulatory mechanisms encoded on the X chromosome support this hypothesis; however, further studies are ...
Yao Ling - - 2012
The early diagnosis plays a decisive role in the outcome of colorectal cancer (CRC) therapy. The <italic>ex vivo</italic> culture of fresh CRC tissues and paired normal colorectal tissues provides a feasible way to explore potential serum biomarkers for CRC early detection at near-physiological condition. In the present work, we applied ...
Colombo Alessia - - 2012
The dipolar and octupolar contributions of the second order nonlinear optical properties of [(4'-(C(6)H(4)-p-D)-2,2':6',2''-terpyridine)-Ru-(4'-(C(6)H(4)-p-A)-2,2':6',2''-terpyridine)]Y(2) heteroleptic complexes (D and A are donor and acceptor groups, respectively), and related free terpyridines and homoleptic complexes, have been obtained by means of a comprehensive combination of Electric Field Induced Second Harmonic generation, Third Harmonic ...
Koc Yener - - 2012
Aim: The aim of this study is to investigate the mortality and the factors which may affect it in patients who were transferred to peritoneal dialysis (PD) from hemodialysis (HD), compared to patients assigned to PD as first-line therapy. Material and Methods: A total of 322 patients treated with PD ...
Shaw David - - 2012
This article provides an ethical critique of the Good Clinical Practice (GCP) and Declaration of Helsinki (DoH) documents. While the previous criticisms of GCP are entirely correct, there is much more wrong with the document than has previously been acknowledged, including a circular definition and an astonishing vagueness about ethical ...
Wendler David - - 2012
This analysis suggests that one-time general consent is better than a gift model for addressing 5 central challenges that arise in the context of obtaining and storing human biological samples for future research. This conclusion supports the suggestion made in a recent Advance Notice of Proposed Rulemaking to incorporate one-time ...
Wang Ming-Te - - 2012
This study examined the relative influence of adolescents' supportive relationships with teachers, peers, and parents on trajectories of different dimensions of school engagement from middle to high school and how these associations differed by gender and race or ethnicity. The sample consisted of 1,479 students (52% females, 56% African American). ...
Sidoroff Marianne - - 2012
Abstract Children with moderate to severe inflammatory bowel disease (IBD) are treated with systemic glucocorticoids (GCs). The majority of the patients respond to the given treatment; however, steroid resistance and dependency are significant clinical problems. Also therapy-related side effects limit the use of GCs in the control of active inflammation. ...
Richards Nicole K - - 2012
Nitrate and halide ions coexist in a number of environmental systems, including sea salt particles, the Arctic snowpack, and alkaline dry lakes. However, little is known about potential synergisms between halide and nitrate ions. The effect of sea salt on NO3- photochemistry at 311 nm was investigated at 298 K ...
Oxborough David - - 2012
Aims: To determine the intraobserver reproducibility of peak and temporal values for myocardial strain (ɛ) and strain rate (SR) using a speckle tracking technique in the left ventricle (LV), right ventricle (RV), and left atrium (LA). Methods and Results: Myocardial speckle tracking echocardiograms of the LV, RV, and LA were ...
Xin Gongbiao - - 2012
In this paper, a series of Mg-Ti-Pd trilayer films with various thicknesses of the Ti interlayer were prepared by magnetron sputtering. The trilayer films could be reversibly (de)hydrogenated at room temperature. The relationship between structure and properties of Mg-Ti-Pd trilayer films was comprehensively investigated. Our studies showed that the hydrogen ...
Culasso A C A - - 2012
Summary.  The history behind the production of clotting factor concentrates produced differences in the prevalence of Hepatitis C Virus (HCV) and other blood-borne infections in haemophilic patients. Prevalence rates of HCV infection up to 100% were reported in patients treated with concentrates before 1985. Conversely, nowadays, viral inactivation and recombinant ...
McDaniel L Patrice - - 2012
Aristolochic acid (AA) is a potent human nephrotoxin and carcinogen. We previously reported that AA treatment resulted in DNA damage and mutation in the kidney and liver of rats. In this study, we have determined the DNA adducts and mutations induced by AA in rat spleen. Big Blue® transgenic rats ...
Eskelinen Antti-Pekka - - 2012
Degradable Newkome-type and polylysine dendrons functionalized with spermine surface units are used to control the formation of DNA origami structures. The intact dendrons form polyelectrolyte complexes with the scaffold strands, therefore blocking the origami formation. Degradation of the dendron with an optical trigger or chemical reduction leads to the release ...
Ren Qing - - 2012
The purpose of this study is to evaluate the performance of an adaptive gating method, which is designed to accommodate the beam-to-beam and day-to-day variation of the internal/external correlation, as well as the real tumor position during respiratory-gated fractionated radiotherapy. We define a two-step procedure: (1) before each treatment, target ...
Zhang Pu - - 2012
OBJECTIVE.: Exploring the use of echo-tracking (ET) for evaluating changes in carotid artery wall elasticity after smoking cessation. METHODS.: Carotid artery ultrasound examination was performed in 67 male patients before and after smoking cessation treatment, for measurement of intimal media thickness (IMT), and ET measurement of wall elasticity variables, ie, ...
Tan Sinan - - 2012
Today, ultrasound is the main diagnostic tool in the prenatal detection of congenital abnormalities. Therefore, ultrasound examination should be offered to all pregnant women. A detailed sonographic examination of the fetus is usually performed between 18 and 22 weeks of pregnancy. The accurate recognition of normal fetal anatomy is very ...
Karnik Rohit - - 2012
Gerodontology 2012; doi: 10.1111/j.1741-2358.2011.00603.x Prevalence of gingival overgrowth among elderly patients under amlodipine therapy at a large Indian teaching hospital Objectives:  To determine the prevalence of amlodipine-induced gingival overgrowth (GO) among elderly subjects attending an Indian teaching hospital and find any association with demographic factors, drug variables, oral hygiene status ...
Szostak Roman - - 2012
An efficient method for the quantitative determination of acetaminophen (AAP) and diclofenac sodium (DS) in commercial suppositories based on partial least squares (PLS) treatment of FT-Raman spectra is described. The relative standard errors of prediction (RSEP) were calculated for calibration and validation data sets to evaluate the quality of the constructed ...
Siddiq Danish M - - 2012
Catheter-associated urinary tract infection (CAUTI) is the most common health-care-associated infection worldwide. Although not all cases of bacteriuria result in clinical infection, several hundred thousand episodes of CAUTI occur each year in the USA alone. The milieu in which the catheter is placed is highly conducive to bacterial colonization, biofilm ...
Jardin Isaac - - 2012
Homer is a family of cytoplasmic adaptor proteins that plays different roles in cell function, including the regulation of G protein-coupled receptors. These proteins contain an Ena/VASP homology 1 domain that binds to the PPXXF sequence motif, which is present in different Ca2+-handling proteins such as IP3 receptors and TRPC ...
Chung C C Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, - - 2012
The analgesic properties and mechanisms of loperamide hydrochloride, a peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation. We examined the effects of systemic or local administration of loperamide on heat and mechanical hyperalgesia in rats after an L5 spinal nerve ligation (SNL).  (1) Systemic loperamide (0.3-10 mg/kg, ...
Lee Chi Chung - - 2012
The P-cluster of nitrogenase is largely known for its function to mediate electron transfer to the active cofactor site during catalysis. Here, we show that a P-cluster variant (designated P*-cluster), which consists of paired [Fe(4)S(4)]-like clusters, can catalyze ATP-independent substrate reduction in the presence of a strong reductant, europium(II) diethylenetriaminepentaacetate ...
Zhou Bing - - 2012
Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with ...
Li Yirong - - 2012
The malignant transformation of human prostatic epithelium is associated with the loss of androgen receptor (AR) in the surrounding stroma. However, the function and mechanisms of AR signaling in prostate cancer (PCa) stroma remain elusive. Here we report, by using proteomics pathway array analysis (PPAA), that androgen and its receptor ...
Davis David A - - 2012
Inhibitors of HIV protease have proven to be important drugs in combination anti-HIV therapy. These inhibitors were designed to target mature protease and prevent viral particle maturation by blocking Gag and Gag-Pol processing by mature protease. Currently there are few data assessing the ability of these protease inhibitors to block ...
Lässer Cecilia - - 2012
Exosomes are nano-sized (40 - 100 nm), extracellular vesicles, of endosomal origin. They are released by cells and found in many body fluids, including plasma. Exosomes contain proteins, microRNAs (miRNAs), and messenger RNAs (mRNAs) that can be transferred between cells. The discovery that exosomes contain RNA, and that this encapsulated ...
Lu Van B - - 2012
Changes in central neural processing are thought to contribute to the development of chronic osteoarthritis pain. This may be reflected as the presence of inflammatory mediators in the cerebral spinal fluid (CSF). We therefore exposed organotypically cultured slices of rat spinal cord to CSF from human subjects with osteoarthritis (OACSF) ...
Hartmann Eduard - - 2012
The two-directional desymmetrization of prochiral precursors with α,β-unsaturated branches by catalyst-controlled 1,4-addition of silicon and likewise boron nucleophiles allows for a general enantioselective access to syn,anti-triols with 1,n + 1,2n + 1 (n = 2 and 3) substitution patterns. The utility is demonstrated in the synthesis of the C17-C25 fragment ...
Magno Filho Luiz Carlos - - 2012
Abstract The primary stability of a dental implant is fundamental for the osseointegration. Therefore, the aim of this study was to assess the correlation between insertion torque (IT) and resonance frequency analysis (RFA) of implants placed in the mandible and maxilla of different bone densities. Eighty dental implants were placed ...
Syed Mohammad Adnan - - 2012
Most prokaryotic chromosomes contain a number of toxin-antitoxin (TA) modules consisting of a pair of genes that encode 2 components, a stable toxin and its cognate labile antitoxin. TA systems are also known as addiction modules, since the cells become "addicted" to the short-lived antitoxin product (the unstable antitoxin is ...
Kim T K - - 2012
SID530 is a new parenteral formulation of docetaxel containing hydroxypropyl-beta-cyclodextrin (HP-β-CD). In this study, a comparative pharmacokinetic study of 2 docetaxel parenteral solutions, SID530 and Taxotere, was carried out. In a crossover experimental design, 6 male cynomolgus monkeys received each formulation by intravenous infusion of a single dose. The concentration ...
Elliot Andrew J - - 2012
The authors examined avoidance personal goals as concurrent (Study 1) and longitudinal (Study 2) predictors of multiple aspects of well-being in the United States and Japan. In both studies, participants adopted more avoidance personal goals in Japan relative to the United States. Both studies also demonstrated that avoidance personal goals ...
Salvadó Z - - 2012
Aims: To identify genes and proteins involved in adaptation to low temperature fermentations in a commercial wine yeast Methods and Results: Nine proteins were identified as representing the most significant changes in proteomic maps during the first 24 hours of fermentation at low (13 °C) and standard temperature (25 °C). ...
Cao Senyang - - 2012
After birth, oocytes stay at the diplotene stage in prophase of meiosis I. Meiosis resumes about one day before ovulation, and arrests in metaphase II (MII) after ovulation. The mature, MII oocytes are then ready for fertilization and to provide materials for early embryonic development. Proteomic characterization of oocytes can ...
Lang Qiaolin - - 2012
Nanoporous PdCu alloys (np-PdCu) with different Pd/Cu ratios were prepared by the selective dealloying of Al from PdCuAl ternary alloys with predetermined metallic ratios in 1.0 M NaOH solution. The Cu content had a significant effect on the coarsening rate of the PdCu ligaments. A larger Cu content induced faster coarsening ...
Levy-Shraga Y - - 2012
Aims  To identify clinical characteristics and co-morbidity rates of children diagnosed with Type 1 diabetes mellitus at younger than 6 years of age. Methods  Data were obtained from a retrospective chart review of 103 patients diagnosed with Type 1 diabetes at younger than 6 years (study group) and 220 patients at older ...
Cornil Charlotte A - - 2012
Estrogens affect a diversity of peripheral and central physiological endpoints. Traditionally, estrogens were thought to be peripherally derived transcription regulators (i.e. slow acting). More recently, we have learned that estrogens are also synthesized in neuronal cell bodies and synaptic terminals and have potent membrane effects, which modulate brain function. However, ...
Fakhrullin Rawil F - - 2012
Living cells interfaced with a range of polyelectrolyte coatings, magnetic and noble metal nanoparticles, hard mineral shells and other complex nanomaterials can perform functions often completely different from their original specialisation. Such "cyborg cells" are already finding a range of novel applications in areas like whole cell biosensors, bioelectronics, toxicity ...
Shen H-N - - 2012
Aims  We prospectively assessed the age- and sex-specific incidence rates and relative risks of overall and severe acute pancreatitis in Taiwanese with diabetes. Methods  The study cohort included age- and-sex-matched groups of patients with (n = 547 554) and without (n = 584 373) diabetes. Incidence rate was estimated under Poisson assumption and relative risks of ...
Koch Manuel - - 2012
Helicobacter pylori is a gastric pathogen responsible for a high disease burden worldwide. Deregulated inflammatory responses, possibly involving macrophages, are implicated in H. pylori-induced pathology, and microRNAs, such as miR-155, have recently emerged as crucial regulators of innate immunity and inflammatory responses. miR-155 is regulated by Toll-like receptor (TLR) ligands ...
King Michael E - - 2012
Context:  Rapid mental health surveillance during the acute phase of a disaster response can inform the allocation of limited clinical resources and provide essential household-level risk estimates for recovery planning. Objective:  To describe the use of the PsySTART Rapid Mental Health Triage and Incident Management System for individual-level clinical triage ...
Liang Guo Hua - - 2012
Hydrogen sulfide (H₂S) is a gaseous vasodilator produced by endothelial cells. Mechanisms by which H₂S induces vasodilatation are unclear. We tested the hypothesis that H₂S dilates cerebral arterioles by modulating local and global intracellular Ca²⁺ signals in smooth muscle cells. High-speed confocal imaging revealed that Na₂S, an H₂S donor, increased ...
< 3 4 5 6 7 8 9 10 11 12 13 >