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Results 301 - 350 of 2634
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Heim C - - 2012
Fracture minerals within the 1.8-Ga-old Äspö Diorite (Sweden) were investigated for fossil traces of subterranean microbial activity. To track the potential organic and inorganic biosignatures, an approach combining complementary analytical techniques of high lateral resolution was applied to drill core material obtained at -450 m depth in the Äspö Hard Rock ...
Ochner C N - - 2012
Pre-bariatric surgery requirements vary between surgeons and surgical centers, with standards of practice not yet established. The goal of this systematic review was to summarize and evaluate the available literature on pre-bariatric surgery weight loss requirements and the relation between preoperative weight loss and postoperative outcome. Major databases, including Medline, ...
Chow Cheryl-Emiliane T - - 2012
Marine myoviruses (i.e. bacteriophages with a contractile tail sheath) are numerically abundant and genetically diverse. We developed a terminal restriction fragment length polymorphism assay (TRFLP) for g23, the conserved gene encoding the major capsid protein, to investigate T4-like myovirus communities at USC's Microbial Observatory at the San Pedro Ocean Time-series ...
Mohaupt Jennifer - - 2012
The importance and necessity of interprofessional collaboration (IPC) present challenges for educators as they determine how best to achieve IPC through interprofessional education (IPE). Simulation-based teaching has been shown to enhance students' understanding of professional roles and promote positive attitudes toward team members; yet, empirical evidence providing direction on the ...
Liu J Y - - 2012
This study was to validate a mandarin Chinese version of Oral Health Impact Profile (OHIP-49) in China and to develop a shortened version of OHIP appropriate for use in partially dentate patients with implant-supported prostheses. The original 49 items of OHIP were translated into mandarin Chinese using a forward-backward method ...
Venugopal C - - 2012
Reasons for performing study: To determine and compare the reactive oxygen and nitrogen species (ROS and RNS) in pulmonary tissues of horses affected with recurrent airway obstruction (RAO) and clinically healthy horses, and to evaluate the effectiveness of potential therapeutic agents in reducing ROS and RNS in the tissues of ...
Gziri Mina Mhallem - - 2012
The co-occurrence of cancer and pregnancy is more frequently diagnosed. The effects of cancer treatment on maternal and fetal outcomes are less well known. The cardiotoxic effects of chemotherapy are a specific concern for the mother and fetus. We wanted to review the existing literature, mainly consisting of case reports, ...
Xie Zongde - - 2012
Background/aim: Epidemiological studies have shown that low birth weight (LBW) is associated with a higher incidence of hypertension in adulthood. LBW may affect the kidney development, which in turn leads to impaired renal function and hypertension. Methods: Sprague-Dawley rats were fed isocaloric diets containing either 21% (w/w) (control group) or ...
Tongprasert Fuanglada - - 2012
OBJECTIVE: To compare the levels of maternal serum free β-hCG and PAPP-A between pregnancies with fetal homozygous α-thalassemia-1 disease and unaffected pregnancies. MATERIALS AND METHODS: One hundred and forty eight pregnancies at risk for fetal homozygous α-thalassemia-1 disease scheduled for cordocentesis at 18 to 22 weeks were recruited into the ...
Song Jae-Min - - 2012
In this study, we tested the hypothesis that DNA vaccination in the skin using microneedles improves protective immunity compared to conventional intramuscular (i.m.) injection of a plasmid DNA vaccine encoding the influenza hemagglutinin (HA). In vivo fluorescence imaging demonstrated the expression of a reporter gene delivered to the skin using ...
Xiang Zhonghua - - 2012
Three porous luminescent covalent--organic polymers (COPs) have been synthesized through self-polycondensation of the monomers of tris(4-bromophenyl)amine, 1,3,5-tris(4-bromophenyl)benzene, and 2,4,6-tris-(4-bromo-phenyl)-[1,3,5]triazine by using Ni-catalyzed Yamamoto reaction. All the COP materials possess not only high Brunauer-Emmett-Teller (BET) specific surface area of about 2000 m(2) g(-1) , high hydrothermal stability, but also graphene-like layer ...
Liao Chen-Yu - - 2012
Initial studies linking Sirtuins to longevity in yeast initiated what is now a rich vein of aging research that is full of promise and fraught with controversy. Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals. Now Kanfi et al. provide the evidence but with an interesting ...
Malwitz Mark M - - 2012
The remarkable, vapor-induced transformation of the yellow polymorphs of [(C6H11NC)2AuI](AsF6) and [(C6H11NC)2AuI](PF6) into the colorless forms are reported along with related studies of the crystallization of these polymorphs. Although the interconversion of these polymorphs is produced by vapor exposure, molecules of the vapor are not incorporated into the crystals. Thus, ...
Pan Qiuwei - - 2012
Liver transplantation is an effective treatment for end-stage liver disease that is attributable to chronic HCV infection. However, long-term outcomes are compromised by universal virological recurrence in the graft. Reinfection that occurs after transplantation has increased resistance to current interferon-based antiviral therapy and often leads to accelerated development of cirrhosis. ...
Oh Hokyung H National Center for Lot Release, National Institute of Food & Drug Safety Evaluation, Korea Food & Drug Administration, Chungcheongbuk, South - - 2012
Specific toxicity test is a major quality control test for acellular pertussis (aP) vaccines performed by manufacturers and regulatory authorities. The 'mouse body weight gain test (MWGT)', the 'leukocytosis-promoting test (LPT)' and the 'histamine sensitization test (HIST)' have been conducted to check the specific toxicity of all batches of aP ...
Almeida Rodrigo C - - 2012
BACKGROUND: Celiac disease is an autoimmune disorder that occurs in genetically susceptible individuals in whom the ingestion of dietary gluten induces intestinal mucosa inflammation. Previous studies suggest that celiac disease may either be very rare or underdiagnosed in African and/or African-derived population. AIM: Determine the prevalence of celiac disease in ...
Hassanian-Moghaddam Hossein - - 2012
Phosphine is absorbed rapidly across mucous membranes causing systemic poisoning including functional cellular hypoxia. Following ingestion of metal phosphides, continuous absorption of phosphine could contribute to the intractable systemic manifestations. A 16-year-old male was admitted to hospital 1-hour post-ingestion of two fresh 3 g tablets of aluminum phosphide 56%. He ...
Harp Eric - - 2012
Granular cell tumor rarely occurs in the thyroid. This case report describes the cytologic features of a granular cell tumor seen in a fine needle aspirate obtained from a 27-year-old woman with a gradually enlarging thyroid nodule. The aspirate showed single as well as syncytial clusters of cells with abundant ...
Kohout Michal - - 2012
The synthesis, ab initio calculations, and a comparative nuclear magnetic resonance study of a novel chiral mefloquine-based selector (SO) are presented. On a series of variously N-acyl protected leucine selectands (SAs), a feasibility study of mefloquine carbamate as a basic chiral solvating agent, and potential fluorophilic high-performance liquid chromatography selector ...
Campana L G - - 2012
BACKGROUND: The aim of the study was to determine predictive factors for effectiveness, toxicity and local disease control in patients with malignant melanoma treated with bleomycin-based electrochemotherapy (ECT). METHODS: Electrochemotherapy was offered to patients with superficially disseminated melanoma metastases unsuitable for resection and unresponsive to chemotherapy. RESULTS: Eighty-five patients were ...
Axente Marian - - 2012
The purpose of this study was to investigate the increase in cell kill that can be achieved by tumor irradiation with heterogeneous dose distributions targeting hypoxic regions that can be visualized with non-invasive imaging. Starting with a heterogeneous distribution of microvessels, a microscopic two-dimensional model of tumor oxygenation was developed ...
McGlynn Katherine A KA Division of Hormonal and Reproductive Epidemiology, National Cancer Institute, Suite 550 6120 Executive Boulevard, Rockville, MD 20852, USA. - - 2012
The incidence of testicular cancer has been increasing over the past several decades in many developed countries. The reasons for the increases are unknown because the risk factors for the disease are poorly understood. Some research suggests that in utero exposures, or those in early childhood, are likely to be ...
Feldman B M - - 2012
Summary.  Severe haemophilia results in increased mortality and poorer quality of life. Factor prophylaxis leads to a more normal life, but is very costly; most of the cost is due to the high cost of replacement factor. Despite its high cost, factor prophylaxis has been adopted throughout the developed world ...
Wallace Lindsay M - - 2012
No treatment exists for facioscapulohumeral muscular dystrophy (FSHD), one of the most common inherited muscle diseases. Although FSHD can be debilitating, little effort has been made to develop targeted therapies. This lack of focus on targeted FSHD therapy perpetuated because the genes and pathways involved in the disorder were not ...
Zhao Ying Y - - 2012
Fibric acid derivatives (fibrates) have been shown to increase serum creatinine level in randomized trials. To assess renal outcomes in elderly adults within 90 days of a new fibrate prescription. Population-based cohort study. Ontario, Canada. Patients aged 66 years or older with a new outpatient prescription for a fibrate or ...
Klumpp Dorothee - - 2012
Nanofiber scaffolds have proven their various advantages for tissue engineering and have been analyzed extensively. However, to date the three-dimensional pattern of vascularization inside nanofibrous scaffolds is unknown. This study introduces a novel method to visualize and quantify vascularization of electrospun nanofibrous PCL/collagen scaffolds in 3D in vivo. Randomly spun ...
Henmi Masahiro - - 2012
A membrane with ordered 3D ionic nanochannels constructed by in situ photopolymerization of a thermotropic liquid-crystalline monomer shows high filtration performance and ion selectivity. The nanostructured membrane exhibits water-treatment performance superior to that of an amorphous membrane prepared from the isotropic melt of the monomer. Self-organized nanostructured membranes have great ...
Jia Zhiwei - - 2012
Multipurpose active capsule endoscopes (ACE) have drawn considerable attention in recent years, but these devices continue to suffer from energy limitations. In order to deliver stable and sufficient energy safely, a wireless power transmission system based on inductive coupling is presented. The system consists of a double-layer solenoid pair primary ...
Liu Shengyan - - 2012
Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance mechanisms prevailing in the eye, conventional drug delivery systems, such as eye drop solutions, suffer from low bioavailability. More invasive methods, such as intravitreal injections and implants, cause ...
Yarema Maksym - - 2012
Indium tin oxide (ITO) nano-patterned electrodes are prepared from colloidal solutions as material saving alternative to the industrial vapor phase deposition and top down processing. For that purpose highly monodisperse In1-xSnx (x < 0.1) colloidal nanocrystals (NCs) are synthesized with accurate size and composition control. The outstanding monodispersity of the ...
Milgrom Lionel L Programme for Advanced Homeopathic Studies, London. - - 2012
In this short response we show that Kevin Smith's moral and ethical rejections of homeopathy(1) are fallacious and rest on questionable epistemology. Further, we suggest Smith's presumption of a utilitarian stance is an example of scientism encroaching into medicine.
Shafran Yuri - - 2012
Novel self-condensation of 3-(azol-5-yl)-1,1-dimethylenamines has been found to form new C-C bonds leading to 2,4-(1,2,3-triazole-1,2,3-thiadiazole-3-phenylisothiazole)-(1E,3Z)-5-yl-butadiene-1-amines. The discovered reaction represents a new example of C-H functionalization in unsaturated systems and can serve an efficient synthetic approach to rational design of new 2,4-(diazole-5-yl)-dieneamines.
Zhao Shuzhi - - 2012
ABSTRACT Aims: To assess the association between the NOS3 4b/a, T-786C and G894T polymorphisms and diabetic retinopathy (DR) susceptibility. Materials and Methods: Twenty-one studies covering 8,111 subjects were included. The fixed or random effect model used was based on heterogeneity. Results: A significant association of the intron 4a allele in ...
Bobek Vladimir - - 2012
Circulating tumor cells (CTC) may reach multiple organ sites. However, CTC seeding and growth in distant organs is not random. Each metastatic site may contain a specific subpopulation of the original metastatic tumor capable of growing at that site. The fluorescent orthotopic prostate cancer model (PC-3-GFP) model was used for ...
Maher Tiffany R - - 2012
Three synthetic routes to the unusual supramolecular complex ([Cp(2)Co](2)[{(OC)(5)V}(2)(μ-1,4-CNC(6)Me(4)NC)])(∞), which was crystallographically characterized, are presented. The dianion [{(OC)(5)V}(2)(μ-1,4-CNC(6)Me(4)NC)](2-) constitutes the first subvalent organometallics featuring a diisocyanoarene linker.
Vandevanter Nancy - - 2012
The need for oral health services among patients with HIV, especially those in advanced stages of disease and those who smoke, has been well documented. Patients receiving HIV-related home care services provide an opportunity for assessment of oral health and smoking cessation needs; however, the majority of home care providers ...
Lange M - - 2012
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, increased impulsivity and emotion dysregulation. Linkage analysis followed by fine-mapping identified variation in the gene coding for Latrophilin 3 (LPHN3), a putative adhesion-G protein-coupled receptor, as a risk factor for ADHD. In order to validate the link between LPHN3 ...
van Middendorp J J - - 2012
Objectives:Despi te many years of research, there is currently no treatment available that results in major neurological or functional recovery after traumatic spinal cord injury (tSCI). In particular, no conclusive data related to the role of the timing of decompressive surgery, and the impact of injury severity on its benefit, ...
Bhutani Tina - - 2012
Abstract Background: Alefacept (Amevive®) was the first biologic agent to be approved by the FDA for use in moderate to severe chronic plaque psoriasis and remains one of the safest systemic agents. However, alefacept is the least utilized of all the biologic agents due to the finding that it is ...
Imazu Hiroo - - 2012
Abstract Objective. Autoimmune pancreatitis (AIP) is often misdiagnosed as pancreatic carcinoma (PC) despite recent advances in imaging tests. The aim of the study was to evaluate whether the quantitative perfusion analysis using software "Time intensity curve" with contrast-enhanced harmonic EUS (CH-EUS) facilitate the differentiation of AIP from PC. Methods. Consecutive ...
de Luca Alba C - - 2012
Poly-ε-caprolactone (PCL) is a biodegradable and biocompatible polymer used in tissue engineering for various clinical applications. Schwann cells (SCs) play an important role in nerve regeneration and repair. SCs attach and proliferate on PCL films but cellular responses are weak due to the hydrophobicity and neutrality of PCL. In this ...
Iacovella C - - 2012
The aim of this study was to investigate if increased first-trimester uterine artery Doppler resistance indices (RI) are related to stillbirth. Uterine artery Doppler indices were assessed prospectively during a routine first-trimester ultrasound scan. Patients were categorised as having a high uterine artery mean Doppler RI if the index was ...
Smith Kevin - - 2012
In opposition to the premises of Against Homeopathy - a Utilitarian Perspective, all four respondents base their objections on the central claims that homeopathy is in fact scientifically plausible and is supported by empirical evidence. Despite ethical aspects forming the main thrust of Against Homeopathy, the respondents' focus on scientific ...
Xu Ruijuan - - 2012
The purpose of the current study was to determine whether glycyrrhizin (GL) maintains hepatic glutathione (GSH) levels by inhibiting GSH biliary secretion in normal rats. The effects of GL on hepatic glutathione content, bile flow and biliary secretion of glutathione were examined. Because glutathione is a substrate for multidrug resistance ...
Lu Yanbin - - 2012
The Kodak Image Station In-Vivo FX has an x-ray module with cone-beam configuration for radiographic imaging but lacks the functionality of tomography. To introduce x-ray tomography into the system, we choose the two-circles-plus-one-line trajectory by mounting one translation motor and one rotation motor. We establish a reconstruction algorithm by applying ...
Pichinuk Edward - - 2012
The cell surface glycoprotein MUC1 is a particularly appealing target for antibody targeting, being selectively overexpressed in many types of cancers and a high proportion of cancer stem-like cells. However the occurrence of MUC1 cleavage, which leads to the release of the extracellular alpha-subunit into the circulation where it can ...
Whelan Jane J Centre for Infectious Disease Control, National Institute for Public Health and Environment, Bilthoven, The Netherlands. - - 2012
The hexavalent vaccine Infanrix hexa was introduced into the national childhood vaccination schedule in the Netherlands in 2006. It is offered, concomitantly with pneumococcal vaccine (Prevenar), to children at increased risk of hepatitis B, administered in a 4-dose schedule at 2, 3, 4 and 11 months of age. We assessed ...
Gállego Pérez-Larraya Jaime - - 2012
BACKGROUND.: The assessment of carotid intima-media thickness (CIMT) may improve cardiovascular risk prediction. The optimal protocol for CIMT measurement is unclear. CIMT may be measured in the common carotid artery (CCA), carotid bifurcation (CB), and internal carotid artery (ICA), but measurements from CB and ICA are more difficult to obtain. ...
Gao D - - 2012
Background:Adipose tissue expansion during obesity is associated with a state of low-grade inflammation and an increase in macrophage infiltration, which predisposes to insulin resistance and vascular malfunction. Growing evidence suggests that vitamin D(3) has immunoregulatory effects and adipose tissue could be a target for vitamin D(3) action. Preadipocytes, one of ...
Martin Michel - - 2012
ABSTRACT A simple theoretical model for the size selectivity, Sd, in the lift mode of retention in field-flow fractionation (FFF) is developed on the basis of the near-wall lift force expression. Sd is made up of two contributions: the flow contribution, Sd,f, arising from the variation of the flow velocity ...
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