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Cantón R - - 2012
Clin Microbiol Infect 2012; 18: 413-431 ABSTRACT: Plasmid-acquired carbapenemases in Enterobacteriaceae, which were first discovered in Europe in the 1990s, are now increasingly being identified at an alarming rate. Although their hydrolysis spectrum may vary, they hydrolyse most β-lactams, including carbapenems. They are mostly of the KPC, VIM, NDM and ...
- - 2012
Buffaloes (Bubalus bubalis) constitute an important animal in the dairy economy of India and South Asian countries. Implementation of embryo-related artifi cial reproductive technologies will facilitate planned improvement strategies for this species. Yet more needs to be understood about its embryonic development. Verma et al. (in this issue) contribute to ...
Pfingstler Lisa F - - 2012
Instructions: In answering each question, refer to the specific directions provided. Because it is often necessary to provide information occurring later in a series that gives away answers to earlier questions, please answer the questions in each series in sequence.
Kumar A - - 2012
The Revised National Tuberculosis Control Programme (RNTCP) in India uses a fully intermittent thrice-weekly rifampicin-containing regimen for all tuberculosis (TB) patients, including those who are human immunodeficiency virus (HIV) infected, whereas the World Health Organization (WHO) recommends daily anti-tuberculosis treatment at least during the intensive phase. The WHO recommendation was ...
Akova M - - 2012
Clin Microbiol Infect 2012; 18: 439-448 ABSTRACT: The wide dissemination of carbapenemase-producing Gram-negatives (CPGNs), including enterobacterial species and non-fermenters, has caused a public health crisis of global dimensions. These organisms cause serious infections in hospitalized patients, and are associated with increased mortality. Cross-transmission is common, and outbreaks may occur in ...
Draelos Zoe Diana - - 2012
Skin health depends on an intact barrier composed of protein-rich corneocytes surrounded by the lamellar intercellular lipids. This barrier provides waterproof protection for the body, preventing infection, regulating electrolyte balance, maintaining body temperature, and providing a mechanism for sensation. Damage to the skin barrier results in skin disease that can ...
Lo Celia C - - 2012
The study examined how marriage and religiosity can protect members of certain racial/ethnic groups against co-occurring substance use and serious psychological distress. Using the national dataset 2007 National Survey on Drug Use and Health, we analyzed data via multinomial logistic regression, observing several important results. Our findings generally support the ...
Wolf Ronni - - 2012
Despite the acknowledged contributions of a defective epidermal permeability barrier, dryness of the skin, and the propensity to develop secondary infections to the etiology and pathophysiology of atopic dermatitis (AD), these epidermal changes have, until recently, been assumed to reflect downstream consequences that are secondary phenomena of the primary immunologic ...
Lin Chih-Yun - - 2012
ABSTRACT: Severe inflammation leads to cardiac diastolic dysfunction, an independent prognostic marker for the mortality of critically ill patients. We investigated the possible molecular mechanism from inflammatory cytokines (tumor necrosis factor α [TNF-α] and interleukin 6 [IL-6]) causing left ventricular (LV) diastolic dysfunction in critically burned patients. We consecutively enrolled ...
- - 2012
Spoelstra, S., Given, B., & Given, C. (2011). Fall Prevention in Hospitals: An Integrative Review. Clinical Nursing Research. 21(1), 92-112. Original DOI: 10.1177/1054773811418106.
Xie Keliang - - 2012
Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H2) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H2 ameliorates lung ...
Sotoodian Bahman - - 2012
New bioengineering techniques provide noninvasive opportunities to evaluate clinically the application of various products on the skin. The skin barrier function and its integrity can be studied by transepidermal water loss, stratum corneum water content, transcutaneous flux of carbon dioxide and oxygen, and transepidermal movement of ions, particularly chloride, potassium, ...
Lozier Matthew J - - 2012
Twenty-nine commercial pesticide applicator households in eastern Iowa were enrolled to investigate in-home contamination of atrazine, the most commonly used corn herbicide in the Unites States. From each home, four vacuum dust samples were collected during atrazine application season (Visit 1) and again 6 months later during winter months (Visit ...
Feingold Kenneth R - - 2012
A major function of the skin is to provide a barrier to the movement of water and electrolytes, which is required for life in a terrestrial environment. This permeability barrier is localized to the stratum corneum and is mediated by extracellular lipid-enriched lamellar membranes, which are delivered to the extracellular ...
Kawakubo Kazumichi - - 2012
Self-expandable metal stents (SEMS) are widely used for the palliative treatment of unresectable malignant biliary obstruction. However, the long-term durability of SEMSs in biliary strictures is not clear. We describe a case of endoscopic removal of spontaneously fractured uncovered biliary SEMS. A 59-year-old woman presented to our institution with a ...
Rowley Nicola Jayne - - 2012
This study aimed to investigate localized and systemic effects of chronic exercise and inactivity on conduit artery remodeling in humans. We recruited elite athletes engaged in predominantly lower limb (LL runners/cyclists, n = 10) or upper limb (UL canoe paddlers, n = 12) exercise and matched able-bodied, recreationally active, controls ...
Kopecky Benjamin - - 2012
Three-dimensional development of a mouse inner ear from embryonic day 11.5 (top left) to postnatal day 15 (bottom right) using Thin-Sheet Laser Imaging Microscopy followed by segmentation provides an added dimension to inner ear analysis. From Kopecky et al., Developmental Dynamics 241:465-480, 2012.
Wolf Ronni - - 2012
The past decade has witnessed an explosion of new impartial information about the complex interaction of the skin with topically applied substances, including soaps and detergents. Despite of all these new data, our knowledge on the exact pathomechanism and molecular events leading to detergent-induced barrier dysfunction remains incomplete and the ...
Ebbers Hans C - - 2012
Background: The characteristics of biopharmaceuticals may require a tailored approach to their safety management. However, information on what tools and methods are employed to assess the safety of biopharmaceuticals post-authorization is lacking. Objective: This study investigates determinants that contribute to the post-authorization management of biopharmaceuticals. Methods: A cohort study was ...
Wolf Ronni - - 2012
Almost 2 decades ago, Williams and Elias suggested a unifying concept for the pathogenesis of disorders of cornification, according to which the integrity of the epidermal barrier and its effective function is an important factor in the regulation of epidermal DNA synthesis. Interference with the barrier integrity or function will ...
Reis Ben Y - - 2012
Background: Recent withdrawals of major drugs have highlighted the critical importance of drug safety surveillance in the postmarketing phase. Limitations of spontaneous report data have led drug safety professionals to pursue alternative postmarketing surveillance approaches based on healthcare administrative claims data. These data are typically analysed by comparing the adverse ...
Nordmann P - - 2012
Clin Microbiol Infect 2012; 18: 432-438 ABSTRACT: Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers ...
Ramos-E-Silva Marcia - - 2012
The skin is a vital organ for life and, among its many functions, the role as a protective barrier is one of the most important. It is the main boundary between the body and the external environment. As defensive barrier, the epidermis protects internal organs from physical and chemical trauma, ...
Ellwood P - - 2012
The International Study of Asthma and Allergies in Childhood (ISAAC) used standardised methods to examine symptom prevalence of asthma, rhinitis and eczema in adolescents and children between Phases I and III. Centres followed essential rules to ensure comparability of methodology, examined by a centralised data centre. Centre reports (CRs) were ...
Lam D C L - - 2012
Forced expiratory volume in 3 seconds (FEV(3)) and 6 seconds (FEV(6)) could complement FEV(1) and forced vital capacity (FVC) for detecting airflow obstruction. To compare FEV(1)/ FEV(6) and FEV(3)/FVC with FEV(1)/FVC in the detection of airflow obstruction. Previous lung function data were re-analysed to establish reference values for FEV(3) and ...
Proksch Ehrhardt - - 2012
A crucial role of the epidermal permeability barrier is obvious in contact dermatitis. An intact skin barrier prevents the penetration of harmful substances into the skin. Irritants and allergens that stay on the skin surface and come into contact with the stratum corneum only do not harm the skin. After ...
Ramos-E-Silva Marcia - - 2012
Skin, together with its appendages, forms an organ with several defensive roles; among them it acts as a barrier, which is one of its very important protective functions. There has been increased interest in studying the effects of age on these functions. There are different intensities and timing involved in ...
Sakuma Toshie - - 2012
More than two decades have passed since genetically modified HIV was used for gene delivery. Through continuous improvements these early marker gene-carrying HIVs have evolved into safer and more effective lentiviral vectors. Lentiviral vectors offer several attractive properties as gene-delivery vehicles, including: (i) sustained gene delivery through stable vector integration ...
Nici Anthony J - - 2012
Pancreatic pseudocysts are frequent complications of pancreatitis episodes. The current therapeutic modalities for drainage of pancreatic pseudocysts include surgical, percutaneous, and endoscopic drainage modalities. Endosonography-assisted endoscopic drainage of these pseudocysts with the placement of multiple plastic or fully covered self-expanding biliary metal stents is becoming more commonly carried out. The ...
Rakhshandehroo Maryam - - 2012
In mammals there are two types of adipocytes with opposing functions. Brown adipocytes are characterized by a high number of mitochondria and are specialized for heat production (thermogenesis), expressing thermogenic genes such as UCP1 (uncoupling protein 1). White adipocytes, on the other hand, store energy. Although many key regulators in ...
Duman Iltekin - - 2012
Childhood laminectomy can lead to spinal deformity. This is a report of a case of paraplegia caused by rotokyphoscoliosis, a late complication of laminectomy. A 55-year-old woman developed paraplegia due to post-laminectomy kyphoscoliosis. She had surgery for a spinal tumor at age 13 years. She developed kyphosis 2 years after ...
Elias Peter M - - 2012
Ichthyoses, including inherited disorders of lipid metabolism, display a permeability barrier abnormality in which the severity of the clinical phenotype parallels the prominence of the barrier defect. The pathogenesis of the cutaneous phenotype represents the consequences of the mutation for epidermal function, coupled with a "best attempt" by affected epidermis ...
Rose Jon - - 2012
Developmental phases affect how individuals cope with and challenge threats to self-concept, health and functioning. Understanding prominent models of adult psychological development can help spinal cord injury/disease (SCI/D) rehabilitation professionals facilitate positive change and growth. Author's theoretical model informed by literature review and personal experience. Veterans administration (VA) medical center ...
Brotherton Sandra S - - 2012
To identify and describe the frequency of reliance on assistive devices and/or people for ambulating distances and stair climbing. Survey. A total of 429 adults with traumatic spinal cord injury who were able to walk at least 10 m were identified through inpatient and outpatient hospital databases at a specialty ...
Attardo Geoffrey M - - 2012
Female tsetse flies undergo viviparous reproduction, generating one larva each gonotrophic cycle. Larval nourishment is provided by the mother in the form of milk secretions. The milk consists mostly of lipids during early larval development and shifts to a balanced combination of protein and lipids in the late larval instars. ...
McHenry Colleen L - - 2012
The distal femur is the primary fracture site in patients with osteoporosis after spinal cord injury (SCI). To mathematically compare the compression and shear forces at the distal femur during quadriceps stimulation in the standing, supine, and seated positions. A force analysis across these positions may be a consideration for ...
Raina Shashank - - 2012
Impact forces experienced by the upper limb at the beginning of each wheelchair propulsion (WCP) cycle are among the highest forces experienced by wheelchair users. To determine whether the magnitude of hand/forearm velocity prior to impact and effectiveness of rim impact force are dependent on the type of hand trajectory ...
Kanchiku Tsukasa - - 2012
Combination therapy is essential for functional repairs of the spinal cord. Rehabilitative therapy can be considered as the key for reorganizing the nervous system after spinal cord regeneration therapy. Functional electrical stimulation has been used as a neuroprosthesis in quadriplegia and can be used for providing rehabilitative therapy to tap ...
Han Jae-Young - - 2012
Simultaneous pulmonary thromboembolism (PTE) and hemopericardium is a rare but life-threatening condition. As hemopericardium is a contraindication to anticoagulation treatment, it is challenging to handle both conditions together. The objective of the study was to report a rare case of a man with thoracic spinal cord injury presenting with simultaneous ...
Dolbow David R - - 2012
Sedentarism is common among people with spinal cord injury (SCI). However, new technologies such as functional electrical stimulation cycles with internet connectivity may provide incentive by removing some of the limitations and external barriers. To determine the effectiveness of a long-term home-based functional electrical stimulation lower extremities cycling (FES-LEC) program ...
Haimovic Adele - - 2012
Sarcoidosis is a common systemic, noncaseating granulomatous disease of unknown etiology. The development of sarcoidosis has been associated with a number of environmental factors and genes. Cutaneous sarcoidosis, the "great imitator," can baffle clinicians because of its diverse manifestations and its ability to resemble both common and rare cutaneous diseases. ...
Gertz Morie A - - 2012
Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, and lymphadenopathy. Presence of IgM monoclonal protein associated with ≥10% clonal lymphoplasmacytic cells in bone marrow confirms the diagnosis. Age, hemoglobin level, platelet count, β(2) microglobulin, and monoclonal IgM concentrations are ...
Armitage James O - - 2012
T-cell lymphomas make up approximately 10-15% of lymphoid malignancies. The frequency of these lymphomas varies geographically, with the highest incidence in parts of Asia. The diagnosis of aggressive peripheral T-cell lymphoma (PTCL) is usually made using the WHO classification. The ability of hematopathologists to reproducibly diagnose aggressive PTCL is lower ...
Obenour Daniel R DR School of Natural Resources & Environment, University of Michigan, Ann Arbor, Michigan 48109-1041, United States. - - 2012
Stratification and nutrient loading are two primary factors leading to hypoxia in coastal systems. However, where these factors are temporally correlated, it can be difficult to isolate and quantify their individual impacts. This study provides a novel solution to this problem by determining the effect of stratification based on its ...
Yachnin Brahm J - - 2012
The Baeyer-Villiger monooxygenases (BVMOs) are a family of bacterial flavoproteins that catalyze the synthetically useful Baeyer-Villiger oxidation reaction. This involves the conversion of ketones into esters or cyclic ketones into lactones by introducing an oxygen atom adjacent to the carbonyl group. The BVMOs offer exquisite regio- and enantiospecificity while acting ...
Hamilton Niall M NM Cancer Research UK Drug Discovery Unit, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4 BX, UK. - - 2012
Novel derivatives of the steroid DHEA 1, a known uncompetitive inhibitor of G6PD, were designed, synthesized, and tested for their ability to inhibit this dehydrogenase enzyme. Several compounds with approximately 10-fold improved potency in an enzyme assay were identified, and this improved activity translated to efficacy in a cellular assay. ...
Frisz Jessica F JF Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United - - 2012
The ability to self-renew and differentiate into multiple types of blood and immune cells renders hematopoietic stem and progenitor cells (HSPCs) valuable for clinical treatment of hematopoietic pathologies and as models of stem cell differentiation for tissue engineering applications. To study directed hematopoietic stem cell (HSC) differentiation and identify the ...
Rieth Monica D - - 2012
Caveolin-1 is the most important protein found in caveolae, which are cell surface invaginations of the plasma membrane that act as signaling platforms. A single point mutation in the transmembrane domain of caveolin-1 (proline 132 to leucine) has deleterious effects on caveolae formation in vivo and has been implicated in ...
He Tao - - 2012
Three-dimensional charge transport anisotropy in organic semiconductor single crystals - both plates and rods (above and below, respectively, in the figure) - is measured in well-performing organic field-effect transistors for the first time. The results provide an excellent model for molecular design and device preparation that leads to good performance.
Etgar Lioz - - 2012
This is the first report of using anatase TiO(2) nanosheets with exposed (001) facets in a high-efficiency PbS quantum dot/TiO(2) heterojunction solar cell. The TiO(2) nanosheets have higher conduction band, and surface energy compared to normal anatase (101) TiO(2) nanoparticles. This PbS QD/TiO(2) heterojunction solar cell produces power conversion efficiency ...
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