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Results 601 - 650 of 2634
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Ersdal Hege Langli - - 2012
OBJECTIVE:Early neonatal mortality within the first 24 hours contributes substantially to overall neonatal mortality rates. The definition of birth asphyxia (BA) is imprecise, and reliable cause-specific mortality data are limited; thus the estimated proportion of BA-related deaths globally remains questionable. The objective was to determine the presumed causes of neonatal ...
Komatsu Toshinori - - 2012
Porphyromonas gingivalis, a major periodontal pathogen, may contribute to atherogenesis and other inflammatory cardiovascular diseases. However, little is known about interactions between P. gingivalis and endothelial cells. E-selectin is a membrane protein on endothelial cells that initiates recruitment of leukocytes to inflamed tissue, and it may also play a role ...
Heald Robert Andrew - - 2012
Using structure-based design, two novel series of highly potent biaryl amine mitogen-activated protein kinase kinase (MEK) inhibitors have been discovered. These series contain an H-bond acceptor, in a shifted position compared with previously disclosed compounds, and an adjacent H-bond donor resulting in a bidentate interaction with the Ser212 residue of ...
Zhao Yanyan - - 2012
Binding of epigallocatechin gallate (EGCG) to highly purified short side-chain porcine gastric mucin similar to human MUC6 type has been studied by ultraviolet-visible absorption spectroscopy (UV-vis), ultrafiltration isothermal titration microcalorimetry (ITC) and transmission electro microscopy (TEM). The thermodynamic equilibrium of EGCG binding to mucin has been quantitatively determined using ultrafiltration ...
Mutoh Tatsuro - - 2012
Mutations in the presenilin 1 (PS1) gene are associated with early onset familial Alzheimer's disease (FAD). In this study, we found that the expression of mutant-PS1 in stable transfectants of SH-SY5Y neuroblastoma cells results in a reduction of the biosynthesis and steady-state levels of glucosylceramide. As an in vivo corroboration ...
Johnson Sheri L SL Department of Psychology, University of California, Berkeley, 94720, USA. - - 2012
The dominance behavioral system (DBS) can be conceptualized as a biologically based system that guides dominance motivation, dominant and subordinate behavior, and responsivity to perceptions of power and subordination. A growing body of research suggests that problems with the DBS are evident across a broad range of psychopathologies. We begin ...
Brophy Robert H - - 2012
An increasing emphasis has been placed across health care on evidence-based medicine with higher level studies, such as randomized trials and prospective cohort studies. Historically, clinical research in orthopedic surgery has been dominated by studies with low patient numbers from a limited number of surgeons. The purpose of this study ...
Ten Brummelhuis Lieke L - - 2012
The objective of this article is to provide a theoretical framework explaining positive and negative work-home processes integrally. Using insights from conservation of resources theory, we explain how personal resources (e.g., time, energy, and mood) link demanding and resourceful aspects of one domain to outcomes in the other domain. The ...
Tousson Ehab - - 2012
Schistosomiasis is one of the major human parasitic diseases in many developing countries and is one of the causes of morbidity and mortality in the human population. The present work has been planned to study the histopathological and immunohistochemical expression of P53 and CD68 in mouse liver tissues experimentally infected ...
Valkhoff Vera E - - 2012
BACKGROUND: Guidelines recommend co-prescription of gastroprotective agents (GPAs) in users of cyclooxygenase-2 inhibitors (coxibs) at high risk (i.e. those with a previously complicated ulcer, or with multiple risk factors) of upper gastrointestinal (UGI) complications. Suboptimal GPA adherence has been shown to diminish the gastroprotective effect during non-selective NSAID use, but ...
Vallebona Alessandro - - 2012
©2012 Wiley Periodicals, Inc. Heart failure (HF) is a leading cause of morbidity and mortality. The detection of patients at high risk for death is a major challenge in HF management. The authors compared the prognostic value of 23 clinical Doppler echocardiography and cardiopulmonary exercise indexes in a stable, moderately ...
Varma Amit - - 2012
©2012 Wiley Periodicals, Inc. A 42-year-old diabetic man was admitted with systolic heart failure and pulmonary hypertension being treated with sildenafil for the previous year. With an increase in creatinine, he experienced 3 episodes of ventricular tachycardia and ventricular fibrillation. Withdrawal of the phosphodiesterase (PDE) inhibitor resulted in no further ...
Foster Page Lyndie A - - 2012
Objective: To examine dental caries experience among New Zealand adolescents and determine the nature of caries-associated differences in oral-health-related quality of life (OHRQoL) among adolescents. Method: Follow-up was conducted of a random sample of 430 children first examined in 2003 at age 13, when they completed the Child Perceptions Questionnaire ...
Al Suwaidi Jassim - - 2012
©2012 Wiley Periodicals, Inc. The association between age, risk factors, and outcome of non-Caucasian patients hospitalized with heart failure (HF) is not clear. A total of 7066 consecutive patients hospitalized with HF at Hamad General Hospital, Doha, Qatar, from 1991 through 2010 were studied. Patients were divided into 3 groups ...
Yin Na N Center for Vascular and Inflammatory Diseases, University of Maryland, Baltimore, MD 21201, - - 2012
Dendritic cells (DC) play important roles in both tolerance and immunity to β cells in type 1 diabetes. How and why DC can have diverse and opposing functions in islets remains elusive. To answer these questions, islet DC subsets and their specialized functions were characterized. Under both homeostatic and inflammatory ...
Loan Le Thi Yen TY Department of Cardiology, Royal North Shore Hospital, Sydney, New South Wales, - - 2012
Low-dose mineralocorticoid receptor antagonists reduce morbidity and mortality in patients with heart failure and myocardial infarction, despite normal plasma aldosterone levels. Since apoptosis plays an important role in heart failure and postinfarction left ventricular remodeling, we examined whether low-dose mineralocorticoid receptor antagonists modulate cardiomyocyte death by regulating the apoptosis repressor ...
Perumalla Sathyanarayana Reddy - - 2012
Hydrogen chloride can exist in various forms. Indiscriminative uses of the abbreviation "HCl" for its different forms has led to considerable confusions in the literature. The discovery of hidden solid forms of widely studied molecules using different forms of hydrogen chloride highlights the need of clarifying terminology surrounding hydrogen chloride ...
- - 2012
Reports an error in "Treatment-Specific Changes in Decentering Following Mindfulness-Based Cognitive Therapy Versus Antidepressant Medication or Placebo for Prevention of Depressive Relapse" by Peter J. Bieling, Lance L. Hawley, Richard T. Bloch, Kathleen M. Corcoran, Robert D. Levitan, L. Trevor Young, Glenda M. MacQueen and Zindel V. Segal (Journal of ...
Witt Jessica K - - 2012
Stereotypes, expectations, and emotions influence an observer's ability to detect and categorize objects as guns. In light of recent work in action-perception interactions, however, there is another unexplored factor that may be critical: The action choices available to the perceiver. In five experiments, participants determined whether another person was holding ...
Shintani Ryo - - 2012
A palladium-catalyzed asymmetric synthesis of silicon-stereogenic dibenzosiloles has been developed through enantioselective C-H bond functionalization of prochiral 2-(arylsilyl)aryl triflates. High chemo- and enantioselectivities have been achieved by employing a Josiphos-type ligand under mild conditions.
Jung Yoon Suk - - 2012
BACKGROUND: Crohn's disease (CD) and intestinal Behcet's disease (BD) are transmural inflammatory diseases with fluctuating courses characterized by repeated episodes of relapse and remission that often require operation or reoperation. However, no study has directly compared the long-term prognoses of these two diseases. METHODS: We reviewed the medical records of ...
Han Qiaofeng - - 2012
The freestanding Sb2S3 films were easily synthesized at the interface of water and toluene at room temperature, where Na2S and (C2H5OCS2)3Sb (xanthate, O-ethyldithiocarbonate) acted as sulfur and antimony source, respectively. After 3 h of ageing, the Sb2S3 films with a flat surface towards organic side and rough surface towards aqueous ...
Galbiati Silvia - - 2012
In pregnancy, the discovery of fetal DNA in maternal blood outlined new scenarios for noninvasive prenatal diagnosis of numerous fetal pathological conditions based on a new source of fetal genetic material. Tests on fetal DNA circulating in maternal plasma are expected to replace or reduce invasive procedures, such as chorionic ...
Henningsson Louise - - 2012
BackgroundStaphylococcus aureus arthritis causes severe and rapid joint damage despite antibiotics. Thus, there is a need to identify new treatment targets in addition to antibiotics. Lately, interleukin (IL)-15 has been implicated both in osteoclastogenesis and in bacterial clearance - two important issues in S. aureus-induced joint destruction. This has prompted ...
Buchanan Ashley L - - 2012
Nonadherence to antiretroviral therapy among children/youth with HIV often is associated with disease progression. This study examined the agreement between child and caregiver perceptions of barriers to adherence and factors associated with these barriers. Children/youth with perinatally acquired HIV and their parents/caregivers (n = 120 dyads) completed a questionnaire about ...
Takashima Noriyuki - - 2012
Platypnea-orthodeoxia syndrome is a rare condition characterized by hypoxaemia in the upright position and arterial hypoxaemia induced by the upright position, and the syndrome is relieved by recumbency. We encountered a cerebral infarction patient who presented with low SpO(2) levels in the upright position. The patient was diagnosed with platypnea-orthodeoxia ...
Cho Daniel C DC Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. - - 2012
Lee and colleagues report that increase in serum cholesterol is associated with improved clinical outcomes in patients with renal cell carcinoma treated with temsirolimus. Although these findings must be validated prospectively, it should also be determined if this marker is a true mechanism-based toxicity or an epiphenomenon associated with therapy.
Fox Erin R - - 2012
ABSTRACT Acetaminophen injection is an antipyretic and analgesic agent recently marketed in the United States as Ofirmev. A recent review published in the Journal of Pain & Palliative Care Pharmacotherapy focused on the labeled uses of acetaminophen injection in the United States. A variety of studies were excluded that may ...
Ravaghi Vahid - - 2012
Objectives: This study investigated health inequality for self-reported oral health outcomes among adolescents. The role of oral health behaviors and psychological factors in explaining oral health inequality was investigated using the hypothesis of mediation. Methods: This was a cross-sectional study that used self-completed questionnaires. This study sampled 639 (315 male ...
Blankenburg M - - 2012
Aim  Sensory diabetic neuropathy, determined by nerve conduction studies, is common in children with Type 1 diabetes. Diabetic neuropathy diagnoses are rarely made in paediatric daily care because they are asymptomatic, vibration detection is mostly normal and nerve-conduction testing is impractical. The present study aims to: (1) describe somatosensory dysfunction in ...
Brumbaugh David E - - 2012
The intramyocellular deposition of lipid associates with metabolic dysregulation in adolescents and adults. Relatively little is known about the deposition of fat in muscle before the onset of puberty. Our objective was to describe the relationship between intramyocellular lipid (IMCL) accumulation and 1) visceral adiposity and 2) markers of insulin ...
Niebauer Josef - - 2012
Over the past decades undisputable evidence has accumulated identifying the panoply of beneficial effects of exercise training, smoking cessation, blood pressure lowering, glycaemic and lipid control, as well as psycho-social interventions on cardiovascular risk factors, the well-being, morbidity and mortality of patients with cardiac diseases with or without acute events. ...
Fu Hai Yan - - 2012
Ligand-free Pd(OAc)2 was found to catalyze very efficiently the direct arylation of imidazo[1,2-a]pyridines at C3 under very low catalyst concentration. The reaction can be performed employing as little as 0.1-0.01 mol% catalyst with electron-deficient and some electron-excessive aryl bromides.
Foulsham Tom - - 2012
Many modern theories propose that perceptual information is represented by the sensorimotor activity elicited by the original stimulus. Scanpath theory (Noton & Stark, 1971) predicts that reinstating a sequence of eye fixations will help an observer recognize a previously seen image. However, the only studies to investigate this are correlational ...
Yoccoz N G - - 2012
Ecosystems across the globe are threatened by climate change and human activities. New rapid survey approaches for monitoring biodiversity would greatly advance assessment and understanding of these threats. Taking advantage of next-generation DNA sequencing, we tested an approach we call metabarcoding: high-throughput and simultaneous taxa identification based on a very ...
Kurogi Toshiaki - - 2012
A functional methyl group donor is essential for the epigenetic regulation of all biological events due to the importance of DNA methylation and histone methylation as an epigenetic marker. However, the epigenetic alterations in the immune system due to methyl donor deficiency are not well known. In this study, we ...
Wood Raphael R - - 2012
Aims:  The effect of refrigeration on the seafood-borne pathogen Vibrio vulnificus was investigated in terms of genotype selection and persistence in refrigerated oysters Methods and Results:  Naturally occurring numbers of V. vulnificus in oysters from two different locations were compared during a two-week period under refrigeration conditions. At different time ...
Kanazawa Kazuki - - 2012
It is desirable to increase the flavonoid contents of postharvest vegetables since flavonoids play a beneficial role in human health promotion. In the present study, we show that postharvest vegetables increasingly produced flavonoids when irradiated with light near the absorption wavelength of flavonoids in the plant. Three-day exposure to UV-B ...
Okamura Takaaki - - 2012
We report an asymmetric oxy-Michael addition to a γ-hydroxy-α,β-unsaturated thioester via hemiacetal intermediates in the presence of Cinchona-alkaloid-thiourea-based bifunctional organocatalysts. This method provides a novel enantioselective route to β-hydroxy carboxyl compounds, which in turn can be used to synthesize valuable chiral building blocks.
Hoellein Alexander - - 2012
Cks1 is an activator of the SCF(Skp2) ubiquitin ligase complex that targets the cell cycle inhibitor p27(Kip1) for degradation. The loss of Cks1 results in p27(Kip1) accumulation and decreased proliferation and inhibits tumorigenesis. We identify here a function of Cks1 in mammalian cell cycle regulation that is independent of p27(Kip1). ...
Jo Kyu-Hong - - 2012
Abstract Perforation of the Schneiderian membrane constitutes a major intraoperative complication of maxillary sinus floor elevation with graft materials, but postoperative perforation of the sinus membrane is very rare. This case report demonstrates that conservative treatment involving drainage and the administration of systemic antibiotics can be used to successfully treat ...
Quaranta Alessandro - - 2012
Abstract Implant peri-apical lesion (IPL) is a periapical lesion, usually asyntomatic, in which the coronal portion of the implant achieves a normal bone to implant interface. A case of IPL following immediate implant placement and treated with GBR principles is described. Five year clinical and radiographic follow-up with cone-beam assessment ...
Nurputra Dian K - - 2012
Background:  Paramyotonia congenita (PMC) is an autosomal dominant disorder characterized by cold- or exercise-induced myotonia. PMC is caused by a mutation in SCN4A which encodes the α-subunit of the skeletal muscle sodium channel. Methods:  The patient was an 11-year-old Japanese girl who was diagnosed as having PMC. To confirm the ...
Kajfasz Jessica K - - 2012
The ability to cope with endogenous or host-generated reactive oxygen species is considered a key virulence attribute of the opportunistic pathogen Enterococcus faecalis, a leading cause of hospital-acquired infections. In this study, we used in silico and mutational analyses to identify and characterize the role of the Spx global regulator ...
Filippi L - - 2012
Abstract Objective: To report our experience in the selection of newborns candidate to therapeutic hypothermia. Methods: Retrospective study involving forty-seven newborns suffering from perinatal asphyxia from January 2008 to September 2011. Results: Thirty-five of forty-seven newborns admitted to our hospital fulfilled metabolic and neurological criteria for recruitment and were cooled. ...
Kirshner Jeffrey J JJ Hematology/Oncology Associates of Central New York, Community Clinical Oncology Program, East Syracuse, NY, USA. - - 2012
Pegfilgrastim-induced bone pain is a significant clinical problem that may result in discontinuation of pegfilgrastim and lead to less effective chemotherapy dosing. Interventions for pegfilgrastim-induced bone pain are needed. The University of Rochester Cancer Center Clinical Community Oncology Program Research Base randomly assigned 510 patients at 17 sites to receive ...
Mühleisen Beda - - 2012
OBJECTIVE: To evaluate chromosomal instability at 9p21-22 with p16 protein expression in organ transplant recipients (OTRs) compared with immunocompetent patients with squamous cell carcinoma (SCC). DESIGN: In a select population of intraepithelial and subsequent invasive SCC from the same anatomic region of the same patient at different times, we assessed ...
Balkir Nazli - - 2012
BACKGROUND: It is well known that the absence of both autonomy and social support (relatedness) are two important etiologic pathways to major depressive disorder (MDD). However, cross-cultural researchers state that the implications of autonomy and relatedness for mental health vary across cultures. AIM: To test these assumptions, the current study ...
Neary Nicola M - - 2012
ACTH-producing neuroendocrine tumor (NET) of the thymus is a rare cause of Cushing's syndrome (CS). The literature consists mainly of isolated case reports. We studied 12 cases (eight males and four females) diagnosed between 1986 and 2010 with CS and thymic NET who underwent surgical resection. We measured time from ...
Pritchett Cedric V - - 2012
OBJECTIVES: To evaluate the incidence of acute mastoiditis in children in the United States over the years 1997 through 2006 and to explore possible explanations for the conflicting conclusions of recent studies of this topic. DESIGN: Comparison of periodic incidence over a decade. SETTING: Academic and community, general, and pediatric ...
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