Search Results
Results 551 - 600 of 2634
< 7 8 9 10 11 12 13 14 15 16 17 >
Ghanim Husam - - 2012
Obesity and type 2 diabetes are associated with an increase in the incidence and prevalence of Alzheimer's disease (AD) and an impaired cognitive function. Because peripheral blood mononuclear cells (MNC) express amyloid precursor protein (APP), the precursor of β-amyloid, which forms the pathognomonic plaques in the brain, we hypothesized that ...
Li Shu-Hong - - 2012
AimsThe study was designed to evaluate the mechanisms of cardiac regeneration after injury and to determine how to restore that capacity in aged individuals. The adult heart retains a small population of nascent cells that have myeloid, mesenchymal, and mesodermal capabilities, which play an essential role in the recovery of ...
O'Connor Nicholas - - 2012
OBJECTIVES: To describe a new type of acute inpatient unit, the Acute Recovery Unit, at the Concord Centre for Mental Health, Sydney and to report patient characteristics and outcome data for the first 18 months of operation. METHODS: The mission, values, principles of care and operation of the Acute Recovery ...
Lolli Graziano - - 2012
CK2 is a Ser/Thr protein kinase essential for cell viability whose activity is anomalously high in several cancers. CK2 is a validated target for cancer therapy with one small molecule inhibitor in phase-I clinical trials. This enzyme is not regulated by mechanisms common to other protein kinases and how its ...
Sarahrudi Kambiz - - 2012
Sclerostin (SOST), an antagonist of Wnt signaling, is an important negative regulator of bone formation. However, no data on the role of SOST in the human fracture healing have been published so far. This study addressed this issue. Seventy-five patients with long bone fractures were included into the study and ...
Schütt M - - 2012
Aim  Elderly patients with Type 1 diabetes represent a growing population that requires thorough diabetes care. The increasing relevance of this subgroup, however, plays only a minor role in the literature. Here, we describe elderly patients with Type 1 diabetes on the basis of a large multi-centre database in order to point ...
von Ehrenstein Ondine S - - 2012
Although cytokines play a dual role in the developing neurologic system and in prenatal immune reactions, relations between fetal cytokine levels and child intellectual development remain unknown. The authors investigated associations between umbilical cord serum cytokine concentrations and intellectual outcomes in 369 children within a prospective cohort study, the Eunice ...
Skrok Jan - - 2012
To prospectively compare contrast material-enhanced (CE) magnetic resonance (MR) imaging-derived right-to-left ventricle pulmonary transit time (PTT), left ventricular (LV) full width at half maximum (FWHM), and LV time to peak (TTP) between patients with pulmonary arterial hypertension (PAH) and healthy volunteers and to correlate these measurements with survival markers in ...
Ahn Jeonghyun - - 2012
Antiviral therapeutics are currently unavailable for treatment of coxsackievirus B3, which can cause life-threatening myocarditis. A modified small interfering RNA (siRNA) containing 5'-triphosphate, 3p-siRNA, was shown to induce RNA interference and interferon activation. We aimed to develop a potent antiviral treatment using CVB3-specific 3p-siRNA and to understand its underlying mechanisms. ...
Gowdy Kymberly M KM Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. - - 2012
Graft-versus-host disease (GVHD) is a severe and frequent complication of allogeneic bone marrow transplantation (BMT) that involves the gastrointestinal (GI) tract and lungs. The pathobiology of GVHD is complex and involves immune cell recognition of host Ags as foreign. We hypothesize a central role for the collectin surfactant protein A ...
Scholtz Arne-Wulf - - 2012
Background: Vestibular neuritis (VN) is a strongly disabling disease of the peripheral vestibular system. Rapid and effective relief of symptoms is important to allow patients to promptly return to normal physical activity. Objective: The aim of this prospective, randomized, double-blind study was to evaluate the efficacy of a fixed low-dose ...
Briana Despina D - - 2012
Abstract Objective: To prospectively investigate cord blood concentrations of intestinal fatty acid-binding protein-[I-FABP, a useful marker in the early detection of necrotizing enterocolitis-(NEC)] in full-term intrauterine-growth-restricted-(IUGR, associated with NEC, regardless of gestational age) and appropriate-for-gestational-age-(AGA) pregnancies. We also aimed to determine cord blood I-FABP concentrations in IUGR cases with abnormal ...
Mohajeri Afshan - - 2012
The structural and thermodynamic characteristics of lowest-energy structures of mixed heptamers of group 13-15 in two distinct series [(HM)<sub>k</sub> (HM')<sub>l</sub> (NH)<sub>7</sub>] (M, M'=B, Al, Ga and k+l =7) and [(HGa)<sub>7</sub>(YH)<sub>m</sub>(Y'H)<sub>n</sub>] (Y,Y'= N, P, As and m+n =7) have been systematically investigated using the density functional approach. Our main goal is ...
Wendeln Christian - - 2012
Microcontact chemistry has been applied to patterned glass and silicon substrates by successive reaction of unprotected and monoprotected heterobifunctional linkers with alkene-terminated self-assembled monolayers (SAMs) to produce bi-, tri-, and tetrafunctional surfaces. Photochemical microcontact printing of an azide thiol linker followed by immobilization of an acid thiol linker on an ...
Wöllner Clemens - - 2012
Aesthetic theories have long suggested perceptual advantages for prototypical exemplars of a given class of objects or events. Empirical evidence confirmed that morphed (quantitatively averaged) human faces, musical interpretations, and human voices are preferred over most individual ones. In this study, biological human motion was morphed and tested for prototype ...
Kuraoka Koji - - 2012
The primate amygdala consists of several subnuclei. Neurons in this brain area have been known to respond to stimuli belonging to specific categories of objects, such as faces, animals, and artifacts. However, little is known about the functional differences among the nuclei of the primate amygdala. To clarify functional differences ...
Zisman Timothy L TL Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, - - 2012
The goal of this study was to assess the natural history of low-grade dysplasia (LGD) and its risk of progression in ulcerative colitis (UC) patients by prospective endoscopic surveillance. Forty-two UC patients with LGD were followed prospectively using a uniform approach to surveillance colonoscopy with an average of 43 biopsies ...
Sampson Joshua N - - 2012
Genome-wide association studies (GWAS) have been successful in their search for common genetic variants associated with complex traits and diseases. With new advances in array technologies together with available genetic reference sets, the next generation of GWAS will extend the search for associations with uncommon SNPs (1% ⩽ MAF ⩽ ...
Ji Jianhui - - 2012
COM1/SAE2 is a highly conserved gene from yeast to higher eukaryotes. Its orthologs, known to cooperate with the MRX complex (Mre11/Rad50/Xrs2), are required for meiotic DNA double-strand break (DSB) ends resection and specific mitotic DSB repair events. Here, the rice (Oryza sativa, 2n=2x=24) COM1/SAE2 homolog was identified through positional cloning, ...
Abate Débora Tavares de Resende E Silva - - 2012
Assess the effects of exercise-training on resting arterial pressure and heart rate, placental fetuses morphologic alterations in pregnant spontaneously hypertensive rats (SHRs).Twenty SHRs and their respective control normotensive rats (WKY) were submitted or not to a swimming protocol during 9 weeks, resulting in four pregnant experimental groups: sedentary hypertensive (PSH), ...
Roux Maria Victoria - - 2012
This paper reports an experimental and computational thermochemical study on 2-thiobarbituric acid (2-thioxodihydropyrimidine-4,6(1H,5H)-dione), [CAS 504-17-6]. The value of the standard (pPoP = 0.1 MPa) molar enthalpy of formation in the gas phase at T = 298.15 K has been determined. The energy of combustion was measured by bomb combustion calorimetry, ...
Zhang Jingwen - - 2012
ABSTRACT: A dodecagonal quasicrystalline (QC) mor-phology is identified in a poly(styrene-b-isoprene-b-styrene-b-ethylene oxide) (SISO) tetrablock terpolymer based on evidence provided by transmission electron microscopy (TEM), small-angle x-ray scattering and dy-namic mechanical spectroscopy measurements. The QC state occurs at temperatures between those associated with simple hexagonal order (HEX) and the -phase (P42/mnm), ...
Gonzalez-Stawinski Gonzalo V - - 2012
Abstract  In this report we provide another method of ventricular assist device separation by simply transecting the inflow graft of a Heart Mate II LVAD without the need of dissecting the left ventricular apex for cases of myocardial recovery. (J Card Surg 2012;**:1-3).
Wada Hidefumi - - 2012
A phase I study was conducted to evaluate the safety, tolerability, pharmacokinetics (PK) and efficacy of the oral histone deacetylase (HDAC) inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL). Six patients received vorinostat (400 mg p.o., once daily). Dose-limiting toxicities (DLT) were evaluated in all six ...
Christensen Robert D - - 2012
BACKGROUND AND OBJECTIVE:Both high and low lymphocyte counts at birth have been associated with adverse outcomes. However, the validity of defining a lymphocyte count as "abnormal" depends on having an accurate reference range. We established a reference range for neonatal lymphocyte counts by using multihospital data and used this to ...
Lahon Benoit - - 2012
Primary calcified tumours of major central veins are extremely rare. Epithelioid haemangioendotheliomas (EHs) are malignant tumours of vascular origin with very limited reports in the literature. The aetiology is unknown. Immunohistochemically, tumours are often positive for at least one endothelial marker. We present a unique presentation of an EA in ...
Marohn Mark E ME University of Maryland School of Medicine, Baltimore, Maryland, - - 2012
Francisella tularensis is the causative agent of tularemia. Due to its aerosolizable nature and low infectious dose, F. tularensis is classified as a category A select agent and, therefore, is a priority for vaccine development. Survival and replication in macrophages and other cell types are critical to F. tularensis pathogenesis, ...
Marley Peter M - - 2012
Charge fluctuations along the quasi-1D frameworks of M(x)V(2)O(5) bronzes have evinced much recent interest owing to the manifestation of colossal metal-insulator transitions and superconductivity. Depending upon the nature of the intercalating cation (M), distinctive geometries of the V(2)O(5) framework are accessible. Herein, we demonstrate an unprecedented reversible transformation between double-layered ...
Marshall David T - - 2012
We wanted to investigate vitamin D in low-risk prostate cancer. The objective of the study was to determine whether vitamin D(3) supplementation at 4000 IU/d for 1 yr is safe and would result in a decrease in serum levels of prostate-specific antigen (PSA) or in the rate of progression. In ...
Schnell Oliver - - 2012
Diabetes is associated with an increased cardiovascular risk. The role for aspirin in diabetes is of high clinical interest. Guidelines recommend that primary prevention of cardiovascular disease (CVD) in diabetes with aspirin should be based on the individual risk for CVD. New mechanistic studies suggest that enhanced platelet turnover may ...
Whitford Veronica - - 2012
Language and oculomotor disturbances are 2 of the best replicated findings in schizophrenia. However, few studies have examined skilled reading in schizophrenia (e.g., Arnott, Sali, Copland, 2011; Hayes & O'Grady, 2003; Revheim et al., 2006; E. O. Roberts et al., 2012), and none have examined the contribution of cognitive and ...
Aksoy Olcay - - 2012
OBJECTIVES: To determine the role of percutaneous coronary intervention (PCI) and its impact on mortality in coronary artery disease (CAD). BACKGROUND: It's unclear whether PCI provides benefit in patients with CAD outside of acute settings. We sought to determine the role of PCI and its effect on mortality in patients ...
Cowley N J - - 2012
We report laboratory and clinical evaluations of a blood propofol concentration analyser. Laboratory experiments used volunteer blood spiked with known propofol concentrations over the clinically relevant concentrations from 0.5 to 16 μg.ml(-1) to assess linearity and the influence of haematocrit and concurrent drug administration. Analyser concentrations demonstrated excellent linearity (R(2)  = 0.999). ...
Clayton David D Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge, Institute for Medical Research, Cambridge University, United Kingdom. - - 2012
"Complex" diseases are, by definition, influenced by multiple causes, both genetic and environmental, and statistical work on the joint action of multiple risk factors has, for more than 40 years, been dominated by the generalized linear model (GLM). In genetics, models for dichotomous traits have traditionally been approached via the ...
Paik Se-Bum - - 2012
Maps representing the preference of neurons for the location and orientation of a stimulus on the visual field are a hallmark of primary visual cortex. It is not yet known how these maps develop and what function they play in visual processing. One hypothesis postulates that orientation maps are initially ...
Brand Frank - - 2012
Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 5 (MK5) deficiency is associated with reduced extracellular signal-regulated kinase 3 (ERK3) (mitogen-activated protein kinase 6) levels, hence we utilized the MK5 knockout mouse model to analyze the physiological functions of the ERK3/MK5 signaling module. MK5-deficient mice displayed impaired dendritic spine formation in mouse ...
Haaland Richard E - - 2012
The potent nonnucleoside reverse transcriptase inhibitor UC781 has been safety tested as a vaginal microbicide gel formulation for prevention of HIV-1 sexual transmission. To investigate whether UC781 retained anti-infective activity following exposure to the female genital tract, we conducted an ex vivo analysis of the UC781 levels and antiviral activity ...
Jiang Feng - - 2012
The primary purpose of this study was to investigate whether the theory of planned behavior (TPB) mediated the relationship between dialectical thinking and health behaviors. A sample of 285 undergraduates was tested with a dialectical thinking styles scale, health promoting lifestyle profiles, and TPB questionnaires. Structural equation modeling was used ...
Thas Olivier - - 2012
We present an adaptive percentile modified Wilcoxon rank sum test for the two-sample problem. The test is basically a Wilcoxon rank sum test applied on a fraction of the sample observations, and the fraction is adaptively determined by the sample observations. Most of the theory is developed under a location-shift ...
Compain Jean-Daniel - - 2012
The reaction of the ε-Keggin polyoxometalate (POM) [PMo(12)O(36)(OH)(4){La(H(2)O)(4)}(4)](5+) with Fe(II)(CN)(6)(4-) under typical bench conditions at room temperature and ambient pressure has afforded the novel [ε-PMo(12)O(37)(OH)(3){La(H(2)O)(5)(Fe(CN)(6))(0.25)}(4)] network, which exhibits a three-dimensional multilayered structure. The compound has been fully characterized by synchrotron-radiation X-ray crystallography, IR spectroscopy, elemental analysis, and thermogravimetric analysis. This ...
Brugières Laurence - - 2012
PURPOSEGermline mutations of the SUFU gene have been shown to be associated with genetic predisposition to medulloblastoma, mainly in families with multiple cases of medulloblastoma and/or in patients with symptoms similar to those of Gorlin syndrome. To evaluate the contribution of these mutations to the genesis of sporadic medulloblastomas, we ...
Barzilai Aviv - - 2012
BACKGROUND: Unlike T-cell neoplasms, B-cell lymphoproliferative disorders have a limited clinical spectrum of skin involvement. Cutaneous B-cell neoplasms mimicking rosacea or rhinophyma are rare. OBSERVATIONS: We described 12 patients with B-cell lymphoproliferative neoplasms presenting with a facial eruption clinically mimicking rosacea or rhinophyma. Eleven patients were women; ages ranged from ...
Tsuji Masaharu - - 2012
Rapid sphere-to-prism (STP) transformation of silver was studied in aqueous AgNO3/NaBH4/polyvinylpyrrolidone (PVP)/trisodium citrate (Na3CA)/H2O2 solutions by monitoring time-dependent surface plasmon resonance (SPR) bands in the UV-Vis region, by examining transmission electron microscopic (TEM) images, and by analyzing emitted gases during fast reaction. Roles of PVP, Na3CA, and H2O2 were studied ...
Gu Shi-Hong - - 2012
In recessive trimolter (rt) mutants of the silkworm, Bombyx mori, that have four larval instars rather than five larval instars of normal B. mori, a decrease after a small increase in the hemolymph ecdysteroid titer during the early stages of the last (fourth) larval instar appeared to be a prerequisite ...
Anwar Kamran - - 2012
The endoplasmic reticulum (ER) forms a network of tubules and sheets that requires homotypic membrane fusion to be maintained. In metazoans, this process is mediated by dynamin-like guanosine triphosphatases (GTPases) called atlastins (ATLs), which are also required to maintain ER morphology. Previous work suggested that the dynamin-like GTPase Sey1p was ...
D'Astek Beatriz A - - 2012
Abstract Shiga toxin-producing Escherichia coli (STEC) cause nonbloody (NBD) and bloody diarrhea (BD), and hemolytic uremic syndrome (HUS). Cattle have been described as their main reservoir. STEC O157:H7 is recognized as the predominant serotype in clinical infections, but much less is known about the dominant subtypes in humans and animals ...
Barve Aditya - - 2012
The metabolic genotype of an organism can change through loss and acquisition of enzyme-coding genes, while preserving its ability to survive and synthesize biomass in specific environments. This evolutionary plasticity allows pathogens to evolve resistance to antimetabolic drugs by acquiring new metabolic pathways that bypass an enzyme blocked by a ...
Mascaro Olivier - - 2012
What are the origins of humans' capacity to represent social relations? We approached this question by studying human infants' understanding of social dominance as a stable relation. We presented infants with interactions between animated agents in conflict situations. Studies 1 and 2 targeted expectations of stability of social dominance. They ...
Davies T - - 2012
The optimal method to develop expertise in ultrasound-guided regional anaesthesia is unknown. Studies of laryngoscopic expertise in novices demonstrate that the choice of laryngoscope affects performance. In this study, we aimed to compare the effect of two different linear array transducers (38-mm standard vs 25-mm hockey stick) on novice performance ...
Leontyev Danila - - 2012
A recognized paradigm for the therapeutic action of IVIG in immune thrombocytopenia (ITP) involves up-regulation of the inhibitory Fcγ receptor (FcγRIIB) in splenic macrophages. However, published data has indicated opposing results are obtained when using FcγRIIB-deficient mice on different strain backgrounds. Herein we show BALB/c FcγRIIB(-/-) and wild-type, with or ...
< 7 8 9 10 11 12 13 14 15 16 17 >