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Chan Tyani D - - 2012
Summary:  Interactions between B-cell antigen receptors (BCRs) and their ligands have a complexity and variability that is unparalleled within known biology. Each developing B cell undergoes gene rearrangements to generate a BCR encoded by a unique pair of immunoglobulin (Ig) variable region genes, which serves to make the antigen-binding capabilities ...
Galligan James J - - 2012
Hepatic oxidative stress and subsequent lipid peroxidation are well-recognized consequences of sustained ethanol consumption. The covalent adduction of nucleophilic amino acid side-chains by lipid electrophiles is significantly increased in patients with alcoholic liver disease (ALD); a global assessment of in vivo protein targets and the consequences of these modifications, however, ...
Green Jesse A - - 2012
Germinal centers (GCs) are sites of rapid B-cell proliferation and somatic mutation. These ovoid structures develop within the center of follicles and grow to a stereotypic size. The cell migration and interaction dynamics underlying GC B-cell selection events are currently under intense scrutiny. In recent study, we identified a role ...
DeFranco Anthony L - - 2012
Toll-like receptors (TLRs) have emerged as one of the most important families of innate immune receptors for initiating inflammation and also for promoting adaptive immune responses. Recent studies have examined the ability of TLRs to promote antibody responses, including T-cell-dependent antibody responses. Initial study suggested that TLR stimulation promotes primarily ...
Marcum Zachary A - - 2012
Despite the fact that medication adherence has been extensively described in the literature over the last several decades, a quote by Becker and Maiman from over 35 years ago best captures the current state of our understanding: “Patient compliance[sic adherence] has become the best documented, but least understood, health behavior.” ...
Lee Sung-Uk - - 2012
The germinal center (GC) is a unique histological structure found in peripheral lymphoid organs. GCs provide an important source of humoral immunity by generating high affinity antibodies against a pathogen. The GC response is tightly regulated during clonal expansion, immunoglobulin modification, and affinity maturation, whereas its deregulation has a detrimental ...
Balkus Jennifer E - - 2012
We previously demonstrated a decrease in bacterial vaginosis (BV) and an increase in Lactobacillus colonization among randomized controlled trial (RCT) participants who received monthly oral periodic presumptive treatment (PPT; 2 g metronidazole + 150 mg fluconazole). Posttrial data were analyzed to test the hypothesis that the treatment effect would persist ...
McRee Annie-Laurie - - 2012
Mother-daughter communication about sex is associated with healthier behavior during adolescence. We sought to characterize mothers' communication with their daughters about human papillomavirus (HPV) vaccine and the potential for these discussions to provide an opportunity for talking about sexual health. During December 2009, we conducted an online survey with a ...
Mitchell Jason W - - 2012
Less data exist on HIV testing rates among male couples. By using dyadic data from 142 male couples, we found that less than a quarter of the men had been tested for HIV in the previous 3 months. Few factors also were associated with their most recent HIV test.
Stanaway Jeffrey D - - 2012
Although growing evidence suggests that condoms offer moderate protection against herpes simplex virus type 2 (HSV-2), inability to control for unknown or unmeasured confounders associated with sexual activity may reduce the accuracy of the estimates. The case-crossover design offers increased control of individual-level confounders, and was thus used with the ...
In Haejin - - 2012
We sought to evaluate differences in guideline concordance between National Cancer Institute (NCI)-designated and other centers and determine whether the level of available evidence influences the degree of variation in concordance. The National Cancer Institute recognizes centers of excellence in the advancement of cancer care. These NCI-designated cancer centers have ...
Lossing Laura Ashley - - 2012
To develop a measurement protocol for changes in the shape and size of the ciliary muscle with accommodation using the Zeiss Visante™ anterior segment optical coherence tomography (AS-OCT) and to determine the test-retest repeatability of these measurements. Subjects were 25 adults aged 23 to 28 years. The ciliary muscle was ...
Lewis Helen Annie - - 2012
To investigate the morphology of the ciliary muscle during the act of accommodation in a population of children. Thirty children aged 6 to 12 years were enrolled. Accommodative response was measured through habitual correction. Height was measured as a control variable. Central axial length was measured with the IOLMaster. Four ...
Weinstein Jason S - - 2012
Follicular helper T (Tfh) cells play an essential role in helping B cells generate antibodies upon pathogen encounters. Such T-cell help classically occurs in germinal centers (GCs) located in B-cell follicles of secondary lymphoid organs, a site of immunoglobulin affinity maturation and isotype switching. B-cell maturation also occurs extrafollicularly, in ...
Hartono Juanda Leo - - 2012
To examine the differences in the prevalence and severity of anxiety and depression in patients with functional dyspepsia (FD), nonerosive reflux disease (NERD), irritable bowel syndrome (IBS) and healthy controls. Consecutive patients undergoing an index endoscopic examination for various symptoms were interviewed. All the three functional gastrointestinal disorders (FGIDs) were ...
Moore Jane - - 2012
The number of individuals with chronic illness is growing at an astonishing rate because of the rapid aging of the population and the increased longevity of persons with chronic conditions. Nurses in clinical nurse specialist (CNS) roles are well positioned and ideally suited to meet the needs of a growing ...
Richardson Barbara - - 2012
The goal of this article was to outline a process change in medication administration using technology and led by clinical nurse specialists (CNSs) that has been successful and sustainable over time. The Institute of Medicine published a landmark report in September 1999 estimating that between 44 000 and 98 000 ...
Garrioch Robert R Medical College of Wisconsin, Milwaukee, Wisconsin 53226, - - 2012
To assess the repeatability and measurement error associated with cone density and nearest neighbor distance (NND) estimates in images of the parafoveal cone mosaic obtained with an adaptive optics scanning light ophthalmoscope (AOSLO). Twenty-one participants with no known ocular pathology were recruited. Four retinal locations, approximately 0.65° eccentricity from the ...
Gokula Murthy M Geriatric Medicine Fellowship Program, St. Luke's Hospital/University of Toledo, OH 43537, USA. - - 2012
The reduction in polypharmacy and avoidance of inappropriate medications is a common goal in the care of older persons, regardless of setting. While multidisciplinary teams and regular medication reconciliation and review can identify and reduce medication-related problems, tools to decrease the use of high-risk/low benefit medications can help the individual ...
Hess Kristen L KL Department of Epidemiology, University of California, Los Angeles, CA 90095-1772, USA. - - 2012
Intimate partner violence (IPV) is common among young adult relationships, and is associated with significant morbidity, including sexually transmitted infections (STI). This study measured the association between IPV victimization and perpetration and prevalent STIs and STI-risk behaviors among a sample of young women. This analysis uses wave 3 of the ...
Miklowitz David J DJ Department of Psychiatry and Behavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90024-1759, USA. - - 2012
The initial onset of bipolar disorder occurs in childhood or adolescence in about 50% of patients. Early-onset forms of the disorder have a poorer prognosis than adult-onset forms and are frequently characterized by comorbid substance abuse. Clinical trials research suggests that family psychoeducational approaches are effective adjuncts to medication in ...
Sanders Robert D RD Magill Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK. - - 2012
To identify independent preoperative predictors of outcome for total hip or knee replacement (THKR) and abdominal aortic aneurysm (AAA) repair, including the importance of the time interval between an acute coronary syndrome (ACS) or stroke and surgery. Present guidelines do not advocate a prolonged delay after ACS though recent data ...
Lagace-Wiens Philippe R S PR University of Manitoba, Faculty of Medicine, Department of Medical Microbiology and Infectious Diseases, Winnipeg, MB, Canada. - - 2012
We have recently reported high levels of fluoroquinolone resistance in a single region of Kenya. In this article, we report high prevalence of fluoroquinolone resistance (53.2%) in Neisseria gonorrhoeae isolates from 4 clinics in 3 additional regions of Kenya. These findings highlight the need to change first-line treatment in these ...
Althaus Christian L CL Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. - - 2012
There is a lack of a common concept on how to estimate transmissibility of Chlamydia trachomatis from cross-sectional sexual partnership studies. Using a mathematical model that takes into account the dynamics of chlamydia transmission and sexual partnership formation, we report refined estimates of chlamydia transmissibility in heterosexual partnerships.
Homma Ryousuke - - 2012
Bitterness-masking compounds were identified in a natural white mold cheese. The oily fraction of the cheese was extracted and further fractionated by using silica gel column chromatography. The four fractions obtained were characterized by thin-layer chromatography and nuclear magnetic resonance spectroscopy. The fatty acid-containing fraction was found to have the ...
Jin Xiaoxia - - 2012
Cell motion in a magnetic field reveals the presence of intracellular paramagnetic elements, such as iron or manganese. Under controlled field and liquid media composition, such motion previously allowed us to compare the paramagnetic contribution to cell magnetic susceptibility in erythrocytes differing in the spin state of heme associated with ...
Herbert Myles B - - 2012
The decomposition of a Z-selective ruthenium metathesis catalyst and structurally similar analogues has been investigated utilizing X-ray crystallography and density functional theory. Isolated X-ray crystal structures suggest that recently reported C-H activated catalysts undergo decomposition via insertion of the alkylidene moiety into the chelating ruthenium-carbon bond followed by hydride elimination, ...
Sjoelund Virginie - - 2012
A new affinity chromatography method was developed by modifying a zonal elution method. The new method targets transient protein-protein interactions, such as those encountered during direct ligand transfer between the ligand transporter and its cognate receptor. A ligand-loaded transport protein is immobilized on the solid support, and a plug containing ...
Mak Puiying A - - 2012
Growing evidence suggests that the presence of a subpopulation of hypoxic non-replicating, phenotypically drug-tolerant mycobacteria is responsible for the prolonged duration of tuberculosis treatment. The discovery of new antitubercular agents active against this subpopulation may help in developing new strategies to shorten the time of tuberculosis therapy. Recently, the maintenance ...
Wang Miao - - 2012
4-Hydroxyalkenal species are a class of peroxidative products of polyunsaturated fatty acids, which serve as "toxic second messengers" in cellular systems. Investigation of their cellular role is hindered due to the lack of sensitive, reliable, robust method for identification and quantification of these metastable metabolites. Herein, we explored the facile ...
Stewart Alan - - 2012
Modifying the surfaces of metal nanoparticles with self-assembled monolayers of functionalized thiols provides a simple and direct method to alter their surface properties. Mixed self-assembled monolayers can extend this approach since, in principle, the surfaces can be tuned by altering the proportion of each modifier that is adsorbed. However, this ...
Light Samuel H - - 2012
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAHPS) catalyzes the first step in the biosynthesis of a number of aromatic metabolites. Likely because this reaction is situated at a pivotal biosynthetic gateway, several DAHPS classes distinguished by distinct mechanisms of allosteric regulation have independently evolved. One class of DAHPSs contains a regulatory domain with ...
Leung Cheryl S - - 2012
The effects of addition of a methyl group to a lead compound on biological activity are examined. A literature analysis of >2000 cases reveals that an activity boost of a factor of 10 or more is found with an 8% frequency, and a 100-fold boost is a 1 in 200 ...
Torres Diego Amado - - 2012
We report a new approach for the rapid screening of analyte binding affinities for a target protein. We demonstrate that a molecular probe, with a pro-fluorophore substrate and ligand moieties, can be hindered from enzymatic access when bound to the target protein. When analytes displace the probe from the protein's ...
Bellows-Peterson Meghan L ML Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey 08544, - - 2012
Targeting the complement component 3a receptor (C3aR) with selective agonists or antagonists is believed to be a viable therapeutic option for several diseases such as stroke, heart attack, reperfusion injuries, and rheumatoid arthritis. We designed a number of agonists, partial agonists, and antagonists of C3aR using our two-stage de novo ...
Cuezva S - - 2012
The walls and ceiling of Altamira Cave in Spain are coated with different coloured spots (yellow, white and grey). An electron microscopy study revealed that the grey spots are composed of bacteria and bioinduced CaCO(3) crystals. The morphology of the spots shows a dense network of microorganisms organised in well-defined ...
Jiang Zan - - 2012
A new series of pH responsive Gemini surfactants with 2-pyrrolidone head groups, N, N'-dialkyl-N, N'-di(ethyl-2-pyrrolidone) ethylenediamine (Di-CnP, where n = 6, 8 10, 12), were synthesized and characterized by 1HNMR, 13CNMR, ESI-MS and Elemental analysis. The surface activity and micellization behavior at pH acidic, neutral and basic conditions were characterized ...
Gong Li - - 2012
We investigated the role of neutrophil gelatinase-associated lipocalin (NGAL) on renal tubular epithelial cell in the renal ischemia/reperfusion injury (IRI) rats. Male Sprague-Dawley rats were randomly assigned to three groups. The control group (n = 5) underwent left nephrectomy. The ischemia/reperfusion (I/R) + normal saline (NS) (n = 5) and ...
Monteiro Alexandre - - 2012
Nanoparticles of BCS Class II drugs are produced in wet stirred media mills operating in batch or recirculation mode with the goal of resolving the poor water-solubility issue. Scant information is available regarding the continuous production of drug nanoparticles via wet media milling. Griseofulvin and Naproxen were milled in both ...
Goel R - - 2012
Summary.  To describe the in-hospital epidemiology of haemophilia A and B in the US we analysed the National Inpatient Sample (NIS), a stratified probability sample of 20% of all hospital discharges in the US for the year 2007. We applied sampling weights to represent all hospital discharges for haemophilia A ...
Doucet Gaëlle - - 2012
Mesial temporal lobe epilepsy (MTLE) is the most frequent form of focal epilepsy. At rest, there is evidence that brain abnormalities in MTLE are not limited to the epileptogenic region, but extend throughout the whole brain. It is also well established that MTLE patients suffer from episodic memory deficits. Thus, ...
Stephan Douglas W - - 2012
This perspective article discusses developments of metal-free hydrogenation catalysts derived from "frustrated Lewis pair" (FLP) systems. The range of catalysts uncovered and the applications to reductions of imines, aziridines, enamines, silyl enol ethers, diimines, metallocene derivatives and nitrogen-based heterocycles are described. In addition, FLP aromatic reduction of aniline derivatives to ...
Blume-Peytavi Ulrike - - 2012
Menopause is defined by 12 months of amenorrhea after the final menstrual period. The reduction in ovarian hormones and increased androgen levels can manifest as hair and skin disorders. Although hirsutism, unwanted facial hair, alopecia, skin atrophy and slackness of facial skin are common issues encountered by post-menopausal women, these problems ...
Tanaka Midori - - 2012
Aim: FTO is the most important polygene for obesity and type 2 diabetes. Our aims were to investigate whether a variant in FTO affects glucose dysregulation through its effect on fat accumulation or distribution, and when and how FTO influences fat accumulation and distribution and glucose dysregulation from birth until ...
Reed Karl M - - 2012
A series of five near-monodisperse sterically stabilized polystyrene (PS) latexes were synthesized using three well-defined poly(glycerol monomethacrylate) (PGMA) macromonomers with mean degrees of polymerization (DP) of 30, 50 or 70. The surface coverage and grafting density of the PGMA chains on the particle surface were determined using XPS and 1H ...
Cross N C P - - 2012
The International Randomized Study of Interferon and STI571 (IRIS) demonstrated long-term cytogenetic responses in patients with chronic-phase chronic myeloid leukemia (CML-CP) treated with the tyrosine kinase inhibitor (TKI) imatinib. However, deep molecular responses (MRs), as measured by reductions in BCR-ABL transcript levels below the threshold of major MR, were achieved ...
Kobayashi Motoyasu - - 2012
The surface wettabilities of polymer brushes with hydrophobic and hydrophilic functional groups were discussed based on conventional static and dynamic contact angles measurements of water and hexadecane in air, and captive bubble measurement in water. Various types of high-density polymer brushes with nonionic and ionic functional groups were prepared on ...
Leiterer Christian - - 2012
Reliable and efficient identification of DNA is a major goal in on-site diagnostics. One dimensional nanostructures like nanowires (NW) represent potential sensor structures due to their extreme surface-to-bulk ratio, enabling enhanced biomolecule binding which results in optimal signals. While silicon NW are already well studied, NW made from other materials ...
Krishnamoorthy Paramasivam - - 2012
Three new bivalent nickel hydrazone complexes have been synthesised from the reactions of [NiCl(2)(PPh(3))(2)] with H(2)L {L = dianion of the hydrazones derived from the condensation of o-hydroxynaphthaldehyde with furoic acid hydrazide (H(2)L(1)) ()/thiophene-2-acid hydrazide (H(2)L(2)) ()/isonicotinic acid hydrazide (H(2)L(3)) ()} and formulated as [Ni(L(1))(PPh(3))] (), [Ni(L(2))(PPh(3))] () and [Ni(L(3))(PPh(3))] ...
Jungsuttiwong Siriporn - - 2012
The ground-state structure and frontier molecular orbital of D-π-A organic dyes, CFT1A, CFT2A, and CFT1PA were theoretically investigated using density functional theory (DFT) on B3LYP functional with 6-31G(d,p) basis set. The vertical excitation energies and absorption spectra were obtained using time-dependent DFT (TD-DFT). The adsorptions of these dyes on TiO(2) ...
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