Search Results
Results 401 - 450 of 2657
< 4 5 6 7 8 9 10 11 12 13 14 >
Murabito Joanne M JM Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA. - - 2012
Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet the identification of the underlying genes remains a challenge. Longevity is a complex phenotype with modest heritability. Age-related phenotypes with higher heritability may have greater success in gene discovery. Candidate gene and genome-wide association studies (GWAS) for ...
Ren Yuanyuan - - 2012
Abstract Conclusion: The psychometric characteristics of the Congenital Aural Atresia Questionnaire (CAAQ) are proposed to be reliable and sensitive to determine clinical changes in a patient's quality of life (QOL) and the questionnaire has potential for clinical application. Objective: The aim of this study was to develop a quantifiable, self-assessed, ...
Maquirriain J - - 2012
Overuse injuries of the Achilles tendon cause impairment in lower leg muscle-tendon function. The purpose of this study was to evaluate leg stiffness in patients suffering unilateral Achilles tendinopathy. 51 athletes with unilateral Achilles tendinopathy underwent leg stiffness testing by modeling the vertical ground reaction force in a contact mat, ...
Gershon Andrea S - - 2012
Abstract Background. Along with age and sex, socioeconomic status is one of the most powerful determinants of health. We conducted a systematic review to examine the consistency and magnitude of the association between socioeconomic status and COPD health outcomes to determine the potential impact of SES disparity on the COPD ...
Støvring Henrik - - 2012
Background: The European Heart SCORE model constitutes the basis for national guidelines for primary prevention and treatment of cardiovascular disease (CVD) in several European countries. The model estimates individuals' 10-year CVD mortality risks from age, sex, smoking status, systolic blood pressure, and total cholesterol level. The SCORE model, however, is ...
Zhang Pengcheng - - 2012
The effective chemotherapy for glioblastoma multiform (GBM) requires a nanomedicine that can both penetrate the blood-brain barrier (BBB) and target the glioma cells subsequently. In this study, Transferrin (Tf) modified cyclo[Arg-Gly-Asp-D-Phe-Lys] (c[RGDfK])-paclitaxel conjugate (RP) loaded micelle (TRPM) was prepared and evaluated for its targeting efficiency, anti-glioma activity and toxicity in ...
Ulker Kahraman - - 2012
Background The 1983 Turkish Population Planning Act aimed at improving reproductive health outcomes. We examined the effects of the Act and of modernisation in a small, underdeveloped city and province, Kars. Methods Between June 2009 and January 2010, 576 parous women at a hospital in Kars participated in a study ...
Yu Fabiao - - 2012
We presented the design, synthesis, spectroscopy, and biological applications of DA-Cy, an on-off-on fluorescent probe to monitor H(2)O(2) oxidative stress and thiols reducing repair in living cells and tissues simply and directly.
Xin-Wei Yang - - 2012
Background/Aims: To summarize the experience of diagnosis and surgical treatment of mucin-producing bile duct tumors (MPBTs). Methodology: A retrospective analysis was undertaken to determine the radiography characteristics and results of surgical treatment of MPBTs over the past 9 years. Only eight patients underwent such treatment. The detailed data of diagnosis, ...
Nottebohm M - - 2012
A procedure is developed for the simultaneous determination of 1-naphthalene sulfonate, 2-naphthalene sulfonate, 1,5-naphthalene disulfonate, 1,6-naphthalene disulfonate, 2,6-naphthalene disulfonate and 2,7-naphthalene disulfonate from highly saline geothermal brines using ion-pair high-performance liquid chromatography with fluorescence detection after solid-phase extraction. The substances are baseline separated within 33 min and recoveries in brines ...
Nanashima Atsushi - - 2012
In locally advanced pancreatic body cancers, cancer infiltrates major vessels such as the celiac axis, common hepatic artery and superior mesenteric artery or vein, which is the borderline of resectability. Patients also suffer severe abdominal pain. Kondo and Hirano et al. developed a radical operation called "distal pancreatectomy with en ...
Ren Jian-Song - - 2012
BACKGROUND: Ecological and experimental studies have suggested an increased risk of gastric cancer in relation to consumption of pickled vegetables in East Asia. METHODS: We conducted a meta-analysis of epidemiologic observational studies to evaluate the existing evidence. Searching PubMed, Vip Chinese Periodical and China National Knowledge Infrastructure databases, we found ...
Dryza Viktoras - - 2012
Electronic spectra of the gas-phase isoquinoline<sup>+</sup>-Ar and quinoline<sup>+</sup>-Ar complexes are recorded using photodissociation spectroscopy by monitoring the Ar loss channel. The D<sub>3</sub><--D<sub>0</sub> and D<sub>4</sub><--D<sub>0</sub> band origins for isoquinoline<sup>+</sup>-Ar are observed at 15245±15 cm<sup>-1</sup> and 21960±15 cm<sup>-1</sup>, respectively, whereas for quinoline<sup>+</sup>-Ar they appear at 16050±15 cm<sup>-1</sup> and 21955±15 cm<sup>-1</sup>, respectively. Strong ...
Colombo Carlo - - 2012
Background: A single clone of methicillin-resistant Staphylococcus aureus (MRSA) was observed in a drug-use network starting in 1994, and was found to persist throughout 2001, with up to 19% MRSA colonization of intravenous drug users (IDUs). Recent clinical observations have shown low prevalences of this endemic drug clone among MRSA ...
Wienhöfer Gerrit - - 2012
A novel iron-catalyzed transfer hydrogenation of alkynes to the corresponding alkenes applying formic acid as a hydrogen donor is reported. An in situ combination of Fe(BF(4))(2)·6H(2)O and tetraphos allows for highly selective hydrogenation of a broad range of aromatic and aliphatic alkynes tolerating different functional groups.
Mathews Smitha - - 2012
Extracellular matrix plays an important role in regulating cell growth and differentiation. The biomimetic approach of cell-based tissue engineering is based on mirroring this in vivo micro environment for developing a functional tissue engineered construct. In this study, we treated normal tissue culture plates with selected extracellular matrix components consisting ...
Rombi E - - 2012
SH-functionalized SBA-15 was synthesized and gold nanoclusters were grafted inside its channels. Different portions of such gold-containing material were subjected to a variety of thermal treatments, including calcination in the 300-560 °C temperature range and further treatments under a hydrogen atmosphere at diverse temperatures (up to 600 °C). The resulting ...
Kovacs F M - - 2012
Data on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects. Patients in this study serving as cases were 35-50 years of age with low back pain lasting >90 days, for whom a ...
Chambless Dianne L - - 2012
We introduce the Journal of Clinical Psychology: In Session issue on couple and family therapies for adult psychological problems and health-compromising behaviors. The 8 articles, each with an extensive case study, represent different theoretical orientations (cognitive-behavioral, psychoeducational, systemic-strategic, experiential) and address problems with depression, anxiety, severe mental illness, substance use ...
Rose R A - - 2012
Transient, broadband infra-red absorption spectroscopy with picosecond time resolution has been used to study the dynamics of reactions of CN radicals with tetrahydrofuran (THF) and d(8)-THF in liquid solutions ranging from neat THF to 0.5 M THF in chlorinated solvents (CDCl(3) and CD(2)Cl(2)). HCN and DCN products were monitored via ...
Karamarković Aleksandar - - 2012
Background/Aims: Liver resections are still one of the most challenging operations. The aim of this study was to analyze the efficiency and safety of the intrahepatic Glissonean pedicle approach vs. classical Hilar dissection in major hepatectomies. Methodology: Thirty-four patients were assigned to the Glissonean approach (GA, n=34), while the Hilar ...
Ishizuka Mitsuru - - 2012
Background/Aims: To demonstrate the usefulness of a fluorescence imager (photodynamic eye; PDE) for observation of lymph flow in lower rectal cancer (LRC). Methodology: Between October 2006 and January 2010, PDE observations were performed in 14 patients with LRC. After induction of general anesthesia, a total of 2mL of indocyanine green ...
Imawaka Haruo - - 2012
Human pharmacokinetic study after intravenous (i.v.) administration is inevitable in calculating basic pharmacokinetic parameters such as bioavailability, clearance, and distribution volume. However, i.v. data are not always included in the dossier, although the regulatory guidance recommends the inclusion of i.v. studies for Japanese new drug applications. We investigated the adherence ...
Ferrando Isabel Martinez - - 2012
The cellular proto-oncogene c-Src is a nonreceptor tyrosine kinase involved in cell growth and cytoskeletal regulation. Despite being dysregulated in a variety of human cancers, its precise functions are not fully understood. Identification of the substrates of c-Src remains a major challenge, because there is no simple way to directly ...
Sanglar Corinne - - 2012
The preparation of steroid-based molecularly imprinted polymers (MIPs) based upon non-covalent interaction is particularly suited for selective capture of steroid hormones in biological and environmental samples. The success of this method lies in the optimisation of the interaction between steroids (template) and methacrylic acid (functional monomer) in the prepolymerization mixture. ...
Melesse A - - 2012
This study was conducted to assess the in vitro nutrient digestibility and utilisation of leaves and green pods of two Moringa species in supplementing the feed of ruminant animals during the dry season. Samples were analysed for proximate nutrients using official methods. The metabolisable energy (ME), organic matter digestibility (OMD) ...
Sakai Akihiro - - 2012
Abstract Conclusions: We successfully reduced the incidence of pharyngocutaneous fistulas (PCFs) in high-risk patients undergoing surgery by using pectoralis major myocutaneous flaps (PMMCFs) and deltopectoral flaps (DPFs) to cover suture lines. Objectives: We used coverage of suture lines with PMMCFs and DPFs in patients with high risk of PCFs undergoing ...
Roy Kunal - - 2012
Over the last two decades, a great deal of research has been oriented towards determination of correlation between molecular structures and a variety of responses exhibited by such molecules. Extensive attempts have been made to quantitatively determine the influence of structural fragments on the property profile of molecules through the ...
Ozkizilcik Asya - - 2012
Tissue engineering using scaffolds and growth factors is a crucial approach in bone regeneration and repair. The combination of bioactive agents carrying microparticles with porous scaffolds can be an efficient solution when controlled release of bio-signalling molecules is required. The present study was based on a recent approach using a ...
Bui Soi H SH Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, University of Manchester, 131 Princess Street, Manchester M1 7DN, United - - 2012
The Rhodococcus rhodochrous strain 11Y XplA enzyme is an unusual cytochrome P450-flavodoxin fusion enzyme that catalyzes reductive denitration of the explosive hexahydro-1,3,5-trinitro-1,3,5-triazene (RDX). We show by light scattering that XplA is a monomeric enzyme. XplA has high affinity for imidazole (K(d) = 1.6 μM), explaining previous reports of a red-shifted ...
Baker-Henningham Helen - - 2012
There is an urgent need for effective, affordable interventions to prevent child mental health problems in low- and middle-income countries. To determine the effects of a universal pre-school-based intervention on child conduct problems and social skills at school and at home. In a cluster randomised design, 24 community pre-schools in ...
Bejerot Susanne - - 2012
BACKGROUND: The 'extreme male brain' theory suggests that autism spectrum disorder (ASD) is an extreme variant of male intelligence. However, somewhat paradoxically, many individuals with ASD display androgynous physical features regardless of gender. AIMS: To assess physical measures, supposedly related to androgen influence, in adults with and without ASD. METHOD: ...
Li Zhe - - 2012
• Vacuolar processing enzyme (VPE), a cysteine protease, has been intensively studied in plant hypersensitive cell death, but the role and molecular mechanism of VPEs in response to abiotic stresses remain unclear. This work investigated the involvement of VPEs in Arabidopsis response to heat stress. • Under heat shock (HS), ...
El Ghoul Jamel - - 2012
Zygophyllum album has been mentioned in Tunisian system of folk medicine to be of value in the treatment of diabetes mellitus. The present study was designed to investigate the possible antihyperglycemic effects of ethanolic extracts of the whole plant of Z. album on blood glucose, plasma insulin, serum lipids and ...
Lin Leko - - 2012
As a potential alternative to currently available skin substitutes and wound dressings, we explored the use of bioactive scaffolds made of plant-derived proteins. We hypothesized that 'green' materials, derived from renewable and biodegradable natural sources, may confer bioactive properties to enhance wound healing and tissue regeneration. We optimized and characterized ...
Garety Philippa A PA Department of Psychology, Institute of Psychiatry, King’s College London, PO77, Henry Wellcome Building, De Crespigny Park, London SE5 8AF, UK. - - 2013
Cognitive models propose that cognitive and emotional processes, in the context of anomalies of experience, lead to and maintain delusions. No large-scale studies have investigated whether persecutory and grandiose delusions reflect differing contributions of reasoning and affective processes. This is complicated by their frequent cooccurrence in schizophrenia. We hypothesized that ...
Burke Thomaz Nogueira - - 2012
Objective: To compare the efficacy of balance training associated with muscle strengthening or stretching, relative to no intervention, in the postural control of elderly women with osteoporosis.Design: A randomized, controlled trial.Subjects and interventions: Sample consisted of 50 women aged 65 years or older, with osteoporosis, randomized into one of three ...
Park H - - 2012
Leptin is a protein hormone produced by adipocytes. It is secreted into the blood stream and plays a key role in regulating body energy homeostasis by inhibiting feeding behavior followed by decreased body weight. Because protein aggregation is a major problem in therapeutic proteins, we previously demonstrated that a stabilizing ...
Malik Zulfiqar A - - 2012
Apolipophorin III (apoLp-III) has been known as a lipid transport protein of insects. Recent studies indicated the involvement of apoLp-III in immune reactions and in the control of cell destruction, but no enzymatic activity has so far been detected. In the present study, a protease from the hemolymph of Schistocerca ...
Thorstensen Anders - - 2012
BACKGROUND: The study aimed to evaluate the diagnostic accuracy of a new method for direct echocardiographic quantification of the myocardial infarct size, using late enhancement magnetic resonance imaging (LE-MRI) as a reference method. METHODS AND RESULTS: Echocardiography and LE-MRI were performed on average 31 days after first-time myocardial infarction in ...
Chiviacowsky Suzete - - 2012
One factor that has consistently been shown to enhance learning in typical participants is self-controlled practice. The purpose of the present study was to examine whether the learning benefits of self-controlled feedback found previously in non-disabled adults would also be found in adults with Down syndrome. Participants with Down syndrome ...
Taylor John-Paul - - 2012
Visual hallucinations and visuoperceptual deficits are common in dementia with Lewy bodies, suggesting that cortical visual function may be abnormal. To investigate: (1) cortical visual function using functional magnetic resonance imaging (fMRI); and (2) the nature and severity of perfusion deficits in visual areas using arterial spin labelling (ASL)-MRI. In ...
Lee Chung-Ta - - 2012
Background/Aims: Preoperative chemoradiation therapy (CRT) is standard procedure for locally advanced rectal cancer. The correlation of tumor response evaluated using CT according to response evaluation criteria in solid tumors (RECIST) with the histological tumor regression grade (TRG) is not well-documented. Methodology: Ninety-one patients with rectal cancer underwent CT examinations before ...
Hallerbäck Maria Unenge - - 2012
Objective: To examine ADHD prevalence, rating scales, and relationship to nicotine use in adults with schizophrenia or Asperger syndrome. Method: Ninety-five individuals, 41 with schizophrenia and 54 with Asperger syndrome, were included. Self-rating of adult ADHD symptoms with the Wender-Reimherr Adult Attention Deficit Diagnostic Rating Scale (WRAADDS), parent rating of ...
Li Qi - - 2012
Abstract Conclusion: Real-time quantitative polymerase chain reaction (qPCR) with a TaqMan minor groove binding (MGB) probe is useful for large-scale screening for the C1494T mutation. The mitochondrial DNA(mtDNA) C1494T mutation has a low carrier frequency in Chinese patients with nonsyndromic hearing loss. Objective: To develop a simple, rapid, and reliable ...
Fracasso Hélio A A - - 2012
Sterna hirundinacea (Lesson, 1831) is a migratory seabird that breeds in the Pacific Coast (from Peru to Chile) and along the Atlantic coast of South America from Espírito Santo (Brazil) to Terra del Fuego (Argentina). This paper describes the reproductive success of South American Terns on Cardos Island, Florianopolis, Brazil ...
Testa Domenico - - 2012
Abstract Conclusions: The high oxidant levels in chronic otitis media with effusion (OME) observed in our research and the improvement seen in children with chronic OME after antioxidant treatment suggest that oxygen-derived free radicals play an important role in chronic OME. Objectives: OME is a common pathologic condition characterized by ...
Curchin Claudia - - 2012
We present a case of an amelanotic nodular melanoma occurring in a 26-year-old woman who carried a heterozygous (melancortin-1-receptor) MC1R 160R/W and tyrosinase (TYR) 402R/Q genotype and had a dark hair phenotype. We present dermoscopic, reflectance confocal microscopy (RCM) and histopathological images of the melanoma. We discuss the relationship between ...
Zhou Jian - - 2012
Osteomyelitis remains a difficult infection to treat for orthopaedic surgeons regardless of the continuous advances in surgical techniques and antimicrobial agents. The controlled release of vancomycin from local delivery system is a promising method for eliminating infection. In this study, biodegradable gelatin sponge containing different contents of β-tricalcium phosphate ceramic ...
Xie Xing - - 2012
Zinc blende-structured CdTe nanoribbons (NRs) were synthesized for the first time via a two-step process. The electronic, transport, and photoconductive properties of the CdTe NRs were studied systematically. It was revealed that the CdTe NRs showed p-type conductivity, and presented significant photoresponses to visible-NIR (400-800 nm) irradiation with high responsivity ...
< 4 5 6 7 8 9 10 11 12 13 14 >