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Results 401 - 450 of 2657
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Mitsunuma Harunobu - - 2012
Direct access: Sterically hindered vicinal quaternary carbon stereocenters were constructed by catalytic enantio- and diastereoselective double Michael reaction, providing straightforward access to dimeric hexahydropyrroloindole alkaloids. A Mn(4-fluorobenzoate)(2) /Schiff base complex and a Mg(OAc)(2) /benzoic acid system were used as catalysts.
Guan Hasigaowa - - 2012
Pure-phase CoO octahedral nanocages were successfully fabricated by a novel simple method. The coordination etching agents play key roles in the formation of these non-spherical hollow structures. When tested as anode materials in lithium ion batteries (LIBs), these nanocages showed excellent cycling performance, good rate capability and enhanced lithium storage ...
Yang Yang - - 2012
The asymmetric direct vinylogous Michael reaction of α,β-unsaturated γ-butyrolactams with alkylidene malonates has been developed. Various 5-substituted 3-pyrrolidin-2-ones were obtained in high yields (up to 93%) with excellent stereoselectivities (up to 94% ee, 95 : 5 dr), using a novel bifunctional C(1)-symmetric guanidine organocatalyst embodied a secondary amine subunit.
Kundu Dipti S - - 2012
No slow down: A microporous recyclable heterogeneous catalyst made from a 1,1'-binaphthalene-2,2'-diol (binol)-derived phosphoric acid chloride is as active as the corresponding homogeneous catalyst when using the same mass of both in different reactions. Reaction rates, yields, and enantioselectivities are comparable.
Tucher Johannes - - 2012
The photochemical properties of homo- and heterometallic molybdate-based Lindqvist polyoxometalate clusters are investigated in a comparative study and it is shown that vanadium substitution can be used as a facile synthetic tool to optimize the visible light absorption and photocatalytic activity of the cluster. The mono-vanadium substituted unit, [VMo(5)O(19)](3-) shows ...
Wu Shijia - - 2012
We highlight a novel fluorescence analysis for sensitive and selective detection of EV-71 and CV-A16 by combining labelling technology based on dual-colour upconversion fluorescence nanoparticles (UCNPs) with magnetic bioseparation and concentration technology based on magnetite nanoparticles (MNPs).
Pai Irumee - - 2012
Abstract Conclusion: The bone-anchored hearing aid (BAHA) system can offer significant benefits to patients with single-sided deafness (SSD), primarily by lifting the head shadow effect. Objective: To evaluate the efficacy of BAHA for SSD by comparing pre- and postoperative speech, spatial and qualities of hearing scale (SSQ) scores. Methods: This ...
Chun In Koo - - 2012
This study aimed to examine the effects of bile salts and formulations on the absorption through gastrointestinal tract of pravastatin, which has low bioavailability. Pravastatin sodium physical mixtures and solid dispersions were prepared using various bile salts. The physicochemical characteristics and permeation profiles were investigated using pravastatin sodium-bile salt physical ...
Lin Ming-Yu - - 2012
Single-stranded DNA (ssDNA) with repetitive sequence was demonstrated to be a versatile nanotemplate for introducing biological activity in a self-assembled manner. Re-functionalization and rejuvenation of the ssDNA nanotemplate were achieved under mild biological conditions without using high temperature and strong alkaline treatment to denature DNA.
Li Lei - - 2012
BACKGROUND: Although the migration of hepatic stellate cells (HSCs) is essential to the hepatic fibrotic response, the intracellular and extracellular signals that regulate their migration are poorly understood. AIMS: To investigate the role of Rho guanosine triphosphatase (Rho GTPase) signalling, specifically via RhoA, in transforming growth factor β1 (TGFβ1)-induced HSC ...
Krol Lana - - 2012
The jejunal and medial iliac lymph nodes of 53 clinically normal dogs between the age of 4 and 6 weeks were examined ultrasonographically. At least two jejunal and both left and right medial iliac lymph nodes were seen in all dogs. One hundred forty-five jejunal, 53 right medial iliac and ...
Werno Anja M - - 2012
Determination of pneumococcal load by quantitative PCR may be useful for diagnostic and prognostic purposes. We hypothesised that higher pneumococcal load would be associated with increased pneumonia severity. Therefore, we tested serum, sputum and urine specimens from 304 adults with community-acquired pneumonia by a quantitative lytA pneumococcal real-time PCR assay. ...
Hirayama Lacie C - - 2012
We report the first one-pot process for the asymmetric addition of allyl, methallyl, and propargyl groups to aldehydes and ketones using B-chlorodiisopinocampheylborane (dDIP-Cl) and indium metal. Under Barbier-type conditions, indium metal was used to generate allyl- and allenylindium intermediates, and subsequent reaction with dDIP-Cl successfully promoted the transfer of these ...
Lionello Marco - - 2012
Abstract Angiogenesis is a hallmark of cancer, fundamental to its growth. The 'angiogenic switch' occurs when pro-angiogenic factors are not balanced by anti-angiogenic factors. A correlation between angiogenic properties and oncological prognosis (for laryngeal squamous cell carcinoma (LSCC) too) was first hypothesized in the 1990s. An exhaustive literature review was ...
Saravanan S - - 2012
Recyclable chiral amide based organocatalyst 5 efficiently catalyzed asymmetric Strecker reaction of various aromatic and aliphatic N-benzhydrylimine with ethyl cyanoformate as cyanide source at -10 degrees C to give high yield (95%) of alpha-aminonitriles with excellent chiral induction (ee, up to 99%) with added advantage of recyclability. Based on experimental ...
Ulrich Gilles - - 2012
An efficient protocol for the direct synthesis of 3 and 3,5-substituted Bodipy derivatives via electrophilic attack with NBS was developed. Various subsistent like ethers, sugar, hydroxyl, thiophen, sulfur, azide, tertiary amines, alkyne, vinyl or phosphonate groups were obtained in moderate to excellent yields. The amine substituted derivatives display unusual spectroscopic ...
Fani Melpomeni - - 2012
The overexpression of the folate receptor (FR) in a variety of malignant tumors, along with its limited expression in healthy tissues, makes it an attractive tumor-specific molecular target. Noninvasive imaging of FR using radiolabeled folate derivatives is therefore highly desirable. Given the advantages of Positron Emission Tomography (PET) and the ...
Shah Neil P - - 2012
In this issue of Blood, Yan et al and Walz et al exploit mouse genetics to investigate the contribution of signal transducer and activator of transcription 5 (STAT5) to the abnormal in vivo growth of hematopoietic cells expressing JAK2(V617F) or BCR-ABL. Eliminating STAT5 expression had dramatic effects in both contexts, ...
Murphy Lisa - - 2012
By using a tridentate N^C^N-coordinating ligand, the luminescence of a cyclometallated Pt(ii) complex can be shifted into the blue region, without the problematic drop-off in quantum yield observed for bidentate analogues. The combination of blue-shifted monomer and excimer allows white-emitting OLEDs with high colour rendering index to be produced.
Rocktäschel Tim - - 2012
MOTIVATION: The accurate identification of chemicals in text is important for many applications, including computer-assisted reconstruction of metabolic networks or retrieval of information about substances in drug development. But due to the diversity of naming conventions and traditions for such molecules, this task is highly complex and should be supported ...
Li Yan-Dong - - 2012
Abstract Conclusion: The selected scFv antibody could specifically recognize and target nasopharyngeal carcinoma (NPC), and could be applied to clinical diagnosis and therapy. Objective: The aim was to construct and screen fully human anti-NPC single chain Fv fusion phage libraries, and to identify the specificity of the scFv antibody. Methods: ...
Hashemi Seyed Armin - - 2012
The urban green space and environment should be considered to be among the most fundamental elements of the sustainability of natural and human life in the new citizenship. To investigate the effect of irrigation on northern Mashad municipal effluent treatment plant effluent on the chemical properties of soil and accumulation ...
Weichsel Julian - - 2012
Migration of motile cells on flat substrates is usually driven by the polymerization of a flat actin filament network. Theoretical models have made different predictions regarding the distribution of the filament orientation in the lamellipodium with respect to the direction of motion. Here we show how one can automatically reconstruct ...
Gee William J - - 2012
Combining copper(ii) chloride, 4-(1H-pyrazol-3-yl)pyridine and triethylamine in dimethylformamide (DMF) results in the instantaneous formation of a metallogel with as little as 0.51 wt% of gelator. The metallogel was found to encapsulate a luminescent lanthanide cluster, yielding a luminescent metallogel.
Lopes Bruno - - 2012
Acinetobacter baumannii is a multi-resistant opportunistic nosocomial pathogen responsible for several outbreaks worldwide. It can cause several infections at various sites of body. One of the main infections caused by this bacterium is the ventilator-associated pneumonia in patients in Intensive Care Units. Treating these infections is becoming difficult because of ...
Kim Yongseon - - 2012
Li(Ni0.8Co0.1Mn0.1)O2 (NCM811) was synthesized using alkali chlorides as a flux and the performance as a cathode material for lithium ion batteries was examined. Primary particles of the powder were segregated and grown separately in the presence of liquid state fluxes, which induced each particle to be composed of one primary ...
Brandstätter H - - 2012
Background and Objectives  Complement factor H (CFH) acts as major regulator of the alternative pathway of complement and its mutations and polymorphisms predispose to various human diseases. We aimed to develop a scalable purification process of CFH from human plasma fractions to supply a pathogen-safe and functional CFH concentrate. Materials ...
Okanya Patrick W - - 2012
A bioassay-guided fractionation of the crude methanol extract of the myxobacterium Hyalangium minutum, strain NOCB-2(T) (DSM 14724(T)), led to the isolation of hyaladione (1), a novel S-methyl cyclohexadiene-dione. The structure of 1 was established by HRESIMS, NMR, and IR spectroscopy as well as X-ray crystallography. Compound 1 was active against ...
Mahadevan Surianarayanan - - 2012
Industrial waste-water such as tannery and textile processing effluents are often characterized by a high content of dissolved organic dyes, resulting in large values of chemical and biological oxygen demand (COD and BOD) in the aquatic systems into which they are discharged. Such waste-water streams are of rapidly growing concern ...
Wang Junwei - - 2012
The reaction of phenyliodine bis(trifluoroacetate) (PIFA) with a series of anilides 1 (E = CO(2)Et) in CF(3)CH(2)OH was found to give 3-hydroxy-2-oxindole derivatives 2, while that with various anilides 1' (E = CON(R(4))Ar) afforded the C(2)-symmetric or unsymmetric spirooxindoles 3. These processes feature a metal-free oxidative C(sp(2))-C(sp(3)) bond formation, followed ...
Xu Hao-Ran - - 2012
Proton transport along different axes in an organic-inorganic compound [(C(6)H(10)N(2))(2)(SO(4))(2)·3H(2)O](n) () was investigated, revealing that proton transport is not only influenced by the structure of the proton transport pathway, but also by the order-disorder extent of proton carriers.
Tsujie Masanori - - 2012
Background/Aims: Single incision laparoscopic cholecystectomy (SILC) has two serious problems; its feasibility and cost. We report our experience and benefits of our original SILC procedure using homemade trocars that can solve those problems. Methodology: SILC was attempted for thirty-four patients at our hospital. The SILSTM Port (Covidien, Inc) was used ...
Goeke Friederike - - 2012
Abstract BACKGROUND:We previously identified amplification of fibroblast growth factor receptor 1 (FGFR1) gene as a potential therapeutic target for small molecule inhibitor therapy in squamous cell lung cancer (L-SCC). Currently, clinical phase 1 trials are underway to examine whether patients with FGFR1-amplified L-SCC benefit from a targeted therapy approach using ...
Soussi M S - - 2012
BACKGROUND: To evaluate the correlation and agreement between central venous saturation (ScvO(2)) and mixed venous saturation (SvO(2)) during cardiopulmonary bypass. METHODS: Twenty-two consecutive patients scheduled for coronary artery surgery were prospectively included. Paired measurements of ScvO(2) and SvO(2) were performed 5 minutes after aortic cross-clamping, after each cardioplegia dose and ...
Marcus Aaron J - - 2012
In a highly interesting, intricate, and novel paper in this issue of Blood, Fung and colleagues have extended their previous pioneering studies and now reveal that molecules such as ATP can promote platelet activation through the P2X1 receptor.
Lessard Joseph D - - 2012
An anion-adsorption technique in which [Au(OH)(4)](-) is preferentially adsorbed onto La(2)O(3) and La(2)O(2)SO(4) surfaces is used to prepare two catalysts active for the low-temperature water-gas shift reaction.
Tsukamoto Hiroki - - 2012
Recognition of LPS by the toll-like receptor 4 (TLR4)/MD-2 complex is a trigger of innate immune defense against bacterial invasion. However, excessive immune activation by this receptor complex causes septic shock and autoimmunity. Manipulation of TLR4 signaling represents a potential therapy that would avoid the detrimental consequences of unnecessary immune ...
Karaci Ali Riza - - 2012
Abstract  Background: This retrospective study evaluated factors associated with mortality and morbidity in patients having functionally biventricular heart (FBH) and functionally univentricular heart (FUH) undergoing total anomalous pulmonary venous connection (TAPVC) repair. Methods: We reviewed medical records retrospectively and identified 72 patients undergoing TAPVC repair between July 2002 and December ...
Scepaniak Jeremiah J - - 2012
Arylation of tris(2-benzylnitrile)amine with PhLi, followed by aqueous work-up, results in the formation of a tripodal tris(ketimine) scaffold, N(ArCNHPh)(3). N(ArCNHPh)(3) readily coordinates a number of Cu(I) salts, generating complexes that exhibit trigonal pyramidal geometries in the solid-state.
Fernández-Oliva Miguel - - 2012
The Growth Hormone Releasing Hexapeptide, GHRP-6 was the first of a family of synthetic peptides that enhance the release of the Growth Hormone by the pituitary gland in a dose-dependent manner. Since its discovery, it has been used as a benchmark and starting point in numerous researches aiming to obtain ...
Hu J - - 2012
A number of genetic markers for virulence of avian influenza viruses (AIVs) in different hosts have been identified. However, we isolated two H5N1 AIVs, A/Chicken/Jiangsu/k0402/2010(CK/10) and A/Goose/Jiangsu/k0403/2010(GS/10) with similar genetic background, but most well-defined molecular markers for virulence in mammals and avian species were not found in both viral genomes. ...
Rose Emma Jane - - 2012
Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than at the level of behavior. However, to date the relative sensitivity of imaging vs cognitive measures of these variants has not been quantified. We considered effect ...
Hirai M - - 2012
OBJECTIVES: To investigate the acceptability of newly developed separated elastic stockings, which are divided into two portions at the ankle. METHODS: The difficulty in putting on and taking off stockings was compared between the original or modified separated stockings with various techniques in order to reduce the shift of the ...
Hutson Thomas H - - 2012
BACKGROUND: Knocking down neuronal LINGO-1 using short hairpin RNAs (shRNAs) might enhance axon regeneration in the CNS. Integration-deficient lentiviral vectors have great potential as a therapeutic delivery system for CNS injuries. However, recent studies have revealed that shRNAs can induce an interferon response resulting in off-target effects and cytotoxicity. METHODS: ...
Ongkasuwan Julina - - 2012
OBJECTIVES/HYPOTHESIS: Diagnostic transnasal flexible endoscopy (TNFE) is a commonly used office procedure in otolaryngology. Currently there is a paucity of data on the impact of TNFE on physiologic parameters. This is relevant with the advent of office-based endoscopic procedures. The goal of this study is to measure the impact of ...
Morioka Ichiro - - 2012
Background: Young infants with influenza virus infection are frequently hospitalized, and are at risk of serious complications including death. With the emergence of pandemic influenza A/H1N1 2009, oseltamivir was approved for use in Europe and the USA, including use in infants aged < 3 months. However, few data are available regarding ...
Seke Etet Paul F - - 2012
Human African trypanosomiasis (HAT), or sleeping sickness, is a severe disease caused by Trypanosoma brucei (T.b.). The disease hallmark is sleep alterations. Brain involvement in HAT is a crucial pathogenetic step for disease diagnosis and therapy. In this study, a rat model of African trypanosomiasis was used to assess changes ...
Ebrahimi Mehdi - - 2012
The biphasic calcium phosphate (BCP) concept was introduced to overcome disadvantages of single phase biomaterials. Different composition ratios of BCP bioceramics have been studied, yet controversies regarding the effects of ratio on biomaterial behavior still exist. In this study, BCP scaffolds were prepared from nano hydroxyapatite (HA) and β-tricalcium phosphate ...
Damico Rachel - - 2012
Reactive oxygen species (ROS) have profound influences on cellular homeostasis. In excess, they can potentiate the oxidation of numerous molecules including proteins, lipids, and nucleic acids affecting function. Further, ROS mediated oxidation of proteins can directly or indirectly modulate gene expression via effects on redox-sensitive transcription factors or via effects ...
Lin C J - - 2012
BACKGROUND AND PURPOSE:Intracranial hemodynamics are important for management of SOAD. This study aimed to monitor peri-stent placement intracranial CirT of patients with SOAD.MATERIALS AND METHODS:Twenty-five patients received stent placement for extracranial ICA stenosis, and 34 patients with normal CirT were recruited as controls. Their color-coded DSAs were used to define ...
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