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Dai Dao-Fu DF Department of Pathology, University of Washington, Seattle, - - 2012
Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in experimental animal models have indicated the central role of mitochondria both in lifespan determination and in cardiovascular aging. In this article we review the evidence supporting the role of mitochondrial oxidative stress, mitochondrial damage and ...
Bullmore Ed - - 2012
The brain is expensive, incurring high material and metabolic costs for its size - relative to the size of the body - and many aspects of brain network organization can be mostly explained by a parsimonious drive to minimize these costs. However, brain networks or connectomes also have high topological ...
Kadota Kyuichi K Division of Thoracic Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2012
The International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) has recently proposed a new lung adenocarcinoma classification. We investigated whether nuclear features can stratify prognostic subsets. Slides of 485 stage I lung adenocarcinoma patients were reviewed. We evaluated nuclear diameter, nuclear atypia, nuclear/cytoplasmic ...
Akey David L - - 2012
The world's oceans are a rich source of natural products with extremely interesting chemistry. Biosynthetic pathways have been worked out for a few, and the story is being enriched with crystal structures of interesting pathway enzymes. By far, the greatest number of structural insights from marine biosynthetic pathways has originated ...
Schievenbusch Stephanie - - 2012
We have previously identified Neighbor of Punc E 11 (Nope) as a specific cell surface marker of stem/progenitor cells in the murine fetal liver that is also expressed in hepatocellular carcinoma. Here, we focus on the differential expression pattern of Nope during fetal and postnatal liver development as well as ...
Xu-Monette Zijun Y - - 2012
The TP53 (p53) protein is a well-known tumor suppressor that plays a crucial role in maintaining genome stability under various cellular stresses. Loss of TP53 causes lymphomagenesis in mouse models and/or promotes tumor progression. However, the prognostic significance of TP53 has been inconsistent in human cancers including malignant lymphoma. In ...
Jensen Morten Ø - - 2012
The mechanism of ion channel voltage gating-how channels open and close in response to voltage changes-has been debated since Hodgkin and Huxley's seminal discovery that the crux of nerve conduction is ion flow across cellular membranes. Using all-atom molecular dynamics simulations, we show how a voltage-gated potassium channel (KV) switches ...
Riazi Afsane - - 2012
Purpose: Care home residents with multiple sclerosis (MS) are more physically dependent than the average residents. However, little is known about their quality of life (QoL). We investigated the experiences of residents with MS using qualitative research methods and developed a conceptual model of QoL. Methods: Twenty-one people with MS ...
Wang Lei - - 2012
A novel decanuclear Co(ii) cluster, [Co(10)(Q)(12)(μ(6)-CO(3))(4)]·2.5DMF () (Q = 8-hydroxyquinoline), has been synthesized under solvothermal conditions and characterized by powder XRD, TGA and IR spectroscopy. Single-crystal X-ray diffraction analysis shows that represents a new type of decanuclear cobalt cluster with an approximate supertruncated tetrahedral shape coordinated with coexisted Q ligands ...
Kimber Simon A J - - 2012
The candidate magnetoelectric Pb(3)Mn(7)O(15) has a structure consisting of one-third filled kagome layers linked by ribbons of edge sharing octahedra in the stacking direction. Previous reports have indicated a complex hexagonal-orthorhombic structural transition upon cooling through ∼335 K, although its origins are uncertain. Here both structures are revisited using a combination of ...
Poels J - - 2012
Understanding mechanisms controlling neuronal cell death and survival under conditions of altered energy supply (e.g., during stroke) is fundamentally important for the development of therapeutic strategies. The function of autophagy herein is unclear, as both its beneficial and detrimental roles have been described. We previously demonstrated that loss of AMP-activated ...
Kang N-H - - 2012
As human amniotic fluid-derived stem cells (hAFSCs) are capable of multiple lineage differentiation, extensive self-renewal and tumor targeting, they may be valuable for clinical anticancer therapies. In this study, we used hAFSCs as vehicles for targeted delivery of therapeutic suicide genes to breast cancer cells. hAFSCs were engineered to produce ...
Davidson Yvonne S - - 2012
Aims:  We aimed to investigate the role of the nuclear carrier and binding proteins, transportin-1 (TRN1) and transportin-2 (TRN2), TATA-binding protein-associated factor 15 (TAF15) and Ewing's Sarcoma protein (EWS) in inclusion body formation in cases of Frontotemporal Lobar Degeneration (FTLD) associated with Fused in Sarcoma protein (FTLD-FUS). Methods:  Eight cases ...
Hanson Buck T - - 2012
Polaromonas naphthalenivorans strain CJ2 is a Gram-negative betaproteobacterium that was identified, using stable isotope probing in 2003, as a dominant in situ degrader of naphthalene in coal tar-contaminated sediments. The sequenced genome of strain CJ2 revealed several genes conferring nitrogen fixation within a 65.6 kb region of strain CJ2's chromosome that ...
Choi Viann Wing Yan - - 2012
The microbeam irradiation system (Single-Particle Irradiation System to Cell, acronym as SPICE) at the National Institute of Radiological Sciences (NIRS), Japan, was employed to irradiate dechorionated zebrafish embryos at the 2-cell stage at 0.75 h post fertilization (hpf) by microbeam protons. Either one or both of the cells of the ...
Poulin Myles B - - 2012
Mycobacterial cell wall galactan, composed of alternating β-(1→5) and β-(1→6) galactofuranosyl residues, is assembled by the action of two bifunctional galactofuranosyltransferases, GlfT1 and GlfT2, which use UDP-galactofuranose (UDP-Galf) as the donor substrate. Kinetic analysis of synthetic UDP-Galf analogs identified critical interactions involved in donor substrate recognition by GlfT2, a processive ...
Himaki Takehiro - - 2012
The objective of this study was to examine the effect of postactivation treatment with latrunculin A (LatA), an actin polymerization inhibitor, on in vitro and in vivo development of somatic cell nuclear transfer (SCNT) embryos derived from kidney fibroblasts of an Clawn miniature boar (12 years old). After electric activation, ...
Feng Xuesong - - 2012
Epstein-Barr virus (EBV) was considered as a major factor that causes nasopharyngeal carcinoma (NPC), which is one of the sneakiest cancers frequently occurred in Southeast Asia and southern China Apoptosis and pro-apoptotic signals have been studies for decades. However, few researches have extended the prevailing view of EBV to its ...
Kirsten Lars - - 2012
The investigation of lung dynamics on alveolar scale is crucial for the understanding and treatment of lung diseases, such as acute lung injury and ventilator induced lung injury, and to promote the development of protective ventilation strategies. One approach to this is the establishment of numerical simulations of lung tissue ...
Li Wenbo - - 2012
A series of lanthanide amide complexes supported by bridged bis(amidinate) ligand L, LLnNHAr(1)(DME) (L = [Me(3)SiNC(Ph)N(CH(2))(3)NC(Ph)NSiMe(3)], Ar(1) = 2,6-(i)Pr(2)C(6)H(3), DME = dimethoxyethane, Ln = Y (), Pr (), Nd (), Gd (), Yb ()), [Yb(μ(2)-NHPh)](2)(μ(2)-L)(2) () and [LYb](2)(μ(2)-NHAr(2))(2) () (Ar(2) = (o-OMe)C(6)H(4)), were synthesized by reaction of LLnCl(THF)(2) with the ...
Sohn Won - - 2012
Background:  The widely accepted range of upper limits of normal ALT levels (ULN < 40 U/L) was recently challenged by several reports. And both ALT and AST are commonly used as surrogate marker of liver disease, almost all studies related aminotransferase activity limited to ALT activity. We investigated not only ...
Bostick Geoff P - - 2012
Purpose: To use quantitative data characterizing whiplash-associated disorder (WAD)-related pain beliefs over time to develop qualitative analysis exploring experiences informing these beliefs. Method: A mixed-method design was used. Quantitative and qualitative data were collected concurrently at baseline and 3 and 6 months postmotor vehicle collision. WAD-related pain beliefs were quantitatively ...
Ishikawa T - - 2012
The temperature and polarization dependence of the optical reflectivity  spectra of a quasi-one-dimensional 1/4-filled band system, (DMEDO-EBDT)(2)PF(6), have been investigated. We observed clear anisotropy in the electronic structures corresponding to the anisotropic transport properties. The appearance of a charge gap (E(g) > 0.1 eV) and transfer of the spectral weight accompanied by the ...
Karwa Amogh N - - 2012
This study demonstrates, for the first time, the manufacturing of novel nano-nonwovens that are comprised of three-dimensionally distributed carbon nanofibers within the matrices of traditional wet-laid nonwovens. The preparation of these nano-nonwovens involves dispersing and flocking carbon nanofibers, and optimizing colloidal chemistry during wet-lay formation. The distribution of nanofibers within ...
Han Hee - - 2012
A simple, cost-effective, and highly reliable method for constructing an air-bridged electrical contact on large arrays of vertically aligned nanowires was developed. The present method may open up new opportunities for developing advanced nanowire-based devices for energy harvest and storage, power generation, and sensing applications.
Xue Yan-Xue - - 2012
Drug use and relapse involve learned associations between drug-associated environmental cues and drug effects. Extinction procedures in the clinic can suppress conditioned responses to drug cues, but the extinguished responses typically reemerge after exposure to the drug itself (reinstatement), the drug-associated environment (renewal), or the passage of time (spontaneous recovery). ...
Lee Hyun Joon - - 2012
The inhibitory environment of the injured spinal cord is an obstacle for functional recovery and axonal regeneration in adult mammals. We had previously shown that injection of adeno-associated virus (AAV) encoding the L1 cell adhesion molecule (AAV-L1) at the time of acute thoracic compression injury of adult mice promotes locomotor ...
Chen Jia-Rong - - 2012
An unprecedented strategy to access highly enantioenriched dihydropyrazoles is described. It involves formal [4+1] cycloadditions of in situ-derived azoalkenes and sulfur ylides catalyzed by a chiral copper/Tol-BINAP complex. A variety of synthetically and biologically important dihydropyrazoles have been obtained with high enantioselectivities (up to 97:3 er) in good yields (83-97%).
Guillon Laurent - - 2012
Pyoverdine I (PVDI) is the major siderophore produced by Pseudomonas aeruginosa PAO1 to import iron. Its biosynthesis requires the coordinated action of cytoplasmic, periplasmic and membrane proteins. The individual enzymatic activities of these proteins are well known. However, their subcellular distribution in particular areas of the cytoplasm, periplasm, or within ...
Bader James D - - 2012
Objectives: The performance of a recently developed survey instrument that inquires about patients' experiences with the receipt of dental care was examined to evaluate its potential utility as a patient-reported outcome measure for dental care plans. Methods: Individuals with dental insurance (n = 1,216) were surveyed using the Consumer Assessment of Health ...
Shi Zhi-Cheng - - 2012
Random composites with nickel networks hosted randomly in porous alumina are proposed to realize double negative materials. The random composite for DNMs (RC-DNMs) can be prepared by typical processing of material, which makes it possible to explore new DNMs and potential applications, and to feasibly tune their electromagnetic parameters by ...
Black Brenna - - 2012
Beta-galactosidases (beta-Gal) of lactic acid bacteria produce oligosaccharides from lactose when suitable acceptor carbohydrates are present. This study aimed to elucidate the structure of oligosaccharides formed by galactosylation of N-acetylglucosamine (GlcNAc) and fucose. Crude cellular extract of Lactobacillus bulgaricus and LacLM of L. plantarum were used as source of beta-Gal ...
Makimura Yukitoshi - - 2012
Enteritis has been recognized as a major symptom in domestic animals and human patients suffering from feed and food poisonings. The aim of the present study was to clarify the excitatory mechanism of the pelvic nerve afferent which may influence the occurrence of enteritis in response to nociceptive chemical stimuli ...
Hanna N - - 2012
BC-819 is a DNA plasmid that was developed to target the expression of diphtheria-toxin gene under the control of H19 regulatory sequences. BC-819 has the potential to treat pancreatic cancer that overexpresses the H19 gene. The objectives were to assess the safety, tolerability, pharmacokinetics and preliminary efficacy of BC-819 administered ...
Iizuka Masahiro - - 2012
Background:  Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) of unknown etiology. We aimed to identify the etiological agent of CD using molecular cloning strategy that was particularly focused on identifying agents causing immune abnormalities and infectious agents. Methods:  We constructed a cDNA library derived from the inflamed ...
Kang Hoe-Jin - - 2012
Apoptosis or programmed cell death plays an essential role in chemotherapy-induced tumor cell killing, and inducers of apoptosis are commonly used in cancer therapy. Treatment with Zelkova serrata extracts was performed in human gingival fibroblast (HGF), mouth epidermoid carcinoma cell (KB), lower gingival squamous cancer cell (YD38) and tongue mucoepidermoid ...
Nakano Shogo - - 2012
Assimilatory nitrite reductase (aNiR) reduces nitrite to an ammonium ion, and has siroheme and a [Fe(4) S(4) ] cluster as prosthetic groups. A reaction mechanism for Nii3, an aNiR from tobacco, is proposed based on high resolution X-ray structures and UV-Vis microspectroscopy of Nii3-ligand complexes. Analysis of UV-Vis spectral changes ...
Miszalski-Jamka Tomasz - - 2012
Background: Two-dimensional speckle-tracking echocardiography (STE) is a novel technique providing accurate assessment of myocardial function. However, its value in granulomatosis with polyangiitis (Wegener's) (WG) has not been studied. Objective: To assess the presence and frequency of systolic left ventricular (LV) dysfunction using STE and to determine incremental value of STE ...
Das Tanmoy - - 2012
We present a phenomenological calculation of the quasiparticle interference (QPI) pattern and inelastic neutron scattering (INS) spectra in iron-pnictide and layered iron-selenide compounds by using material specific band structure and superconducting (SC) gap properties. As both the QPI and the INS spectra arise due to scattering of the Bogolyubov quasiparticles, ...
Di Ciaula Agostino - - 2012
Background:  Impaired gallbladder and gastric motility have been associated with obesity in adults. The timing of appearance of this dysfunction, however, is unclear. Methods:  Lean and obese subjects from 3 different age groups were studied noninvasively: 50 newborns (1-12 months old, 6 obese), 18 preadolescents (7-8 years old, 7 obese), ...
Usami Noritaka - - 2012
We propose a novel solar cell structure with photonic nanocrystals coupled to quantum dots (QDs) for advanced management of photons and carriers. The photonic nanocrystals at the surface create an extra interaction between the photons and the QDs, which promotes light trapping. Photo-generated carriers can be efficiently transported by preparing ...
Zhang Dan - - 2012
A novel composite of vinyl group functionalized multiwalled carbon nanotubes (MWCNTs) molecularly imprinted polymer (MIP) was synthesized and applied as a molecular recognition element to construct an electrochemical sensor for parathion-methyl in this paper. The special molecular recognition properties of parathion-methyl mainly dominated by π-π, p-π interaction and hydrogen bonding ...
Butterworth P A - - 2012
The primary aim of this systematic review was to investigate the relationship between body mass index (BMI) and foot disorders. The secondary aim was to investigate whether weight loss is effective for reducing foot pain. Five electronic databases (Ovid MEDLINE, Ovid EMBASE, Ovid AMED, CINAHL and The Cochrane Library) and ...
Girling P Ricardo - - 2012
Reaction of methoxyvinylmethylketone with different amines and aldehydes under Lewis-acid catalysed conditions results in a novel, formal, step-wise [1+2+1+2]-cycloaddition to give dihydropyridine products.
Dutta Debapriya D Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, - - 2012
The prevalence of cardiovascular disease increases with advancing age. Although long-term exposure to cardiovascular risk factors plays a major role in the etiopathogenesis of cardiovascular disease, intrinsic cardiac aging enhances the susceptibility to developing heart pathologies in late life. The progressive decline of cardiomyocyte mitochondrial function is considered a major ...
Mogilner Alex - - 2012
Among a number of innovative approaches that have modernized cell biology, modeling has a prominent yet unusual place. One popular view is that we progress linearly, from conceptual to ever more detailed models. We review recent discoveries of cell polarity mechanisms, in which modeling played an important role, to demonstrate ...
Marks J R - - 2012
Optometrists are becoming increasingly involved in the co-management of glaucoma patients as the burden on the Hospital Eye Service continues to escalate. The aim of this study was to assess the agreement between specially trained optometrists and glaucoma-specialist consultant ophthalmologists in their management of glaucoma patients. Four optometrists examined 23-25 ...
Lee Yun-Hsuan - - 2012
Background/Aim:  Renal insufficiency (RI) often coexists with hepatocellular carcinoma (HCC) and predicts a poor outcome in patients receiving transarterial chemoembolization (TACE). The modification of diet in renal disease (MDRD) and chronic kidney disease epidemiology collaboration (CKD-EPI) equations are used to provide estimated glomerular filtration rate (eGFR). This study aimed to ...
de Oteyza D G - - 2012
Pattern collapse of small or high aspect ratio lines during traditional wet development is a major challenge for miniaturization in nanolithography. Here we report on a new dry process which combines high resolution resist exposure with selective laser ablation to achieve high resolution with high aspect ratios. Using a low ...
Shulman M D - - 2012
Quantum computers have the potential to solve certain problems faster than classical computers. To exploit their power, it is necessary to perform interqubit operations and generate entangled states. Spin qubits are a promising candidate for implementing a quantum processor because of their potential for scalability and miniaturization. However, their weak ...
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