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Results 401 - 450 of 4190
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Kaikkonen Jari E - - 2012
There is a paucity of detailed information about the role of childhood food patterns or on the impact of individual nutrients on adulthood cardiovascular disease (CVD). We review here the reports that have investigated these questions in the Young Finns Study with its 3596 subjects at baseline, aged 3 to ...
Sarlo Michela - - 2012
The present study aimed at investigating whether the way offers are framed in the Ultimatum Game (UG) affects behavioral and autonomic responses in men and women. The "I give you" and "I take" expressions were used as gain and loss frames, respectively. Skin conductance and heart rate were recorded as ...
Bückmann Tiemo - - 2012
Dip-in direct-laser-writing (DLW) optical lithography allows fabricating complex three-dimensional microstructures without the height restrictions of regular DLW. Bow-tie elements assembled into mechanical metamaterials with positive/zero/negative Poisson's ratio and with sufficient overall size for direct mechanical characterization aim at demonstrating the new possibilities with respect to rationally designed effective materials.
Bussu Francesco - - 2012
BACKGROUND: Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ-preserving strategies. METHODS: The medical records of 166 patients with advanced (stages III and IV) laryngeal squamous cell carcinoma (SCC) who were treated with a total laryngectomy, ...
Rodrigues Amanda - - 2012
The aim of this study was to compare the percentage of gutta-percha (PGP) in mesial root canals of mandibular molars obturated with LC (Lateral Compaction) or SC (Single Cone) ProTaper Universal System techniques at different levels of the root. Mesial root canals of 20 human permanent molars with similar anatomical ...
- - 2012
Eculizumab in a Patient with Dense-Deposit Disease Correspondence, N Engl J Med 2012;366:1161-1163. In the second paragraph (page 1161), the final sentence should have read, "She continued to have nephrotic-range proteinuria," rather than ". . . nephritic-range proteinuria." We regret the error. The article is correct at NEJM.org.
Ning Yan - - 2012
Introduction: Colorectal cancer is the leading cause of death from gastrointestinal malignancy in the US. Chemokines and their receptors are being recognized as key regulators of cancers and increasingly as therapeutic targets for metastatic cancers, including colorectal cancer. Several studies have demonstrated that IL-8 and its receptor CXCR2 are two ...
Ishikura-Kinoshita Seiko - - 2012
Collagen fibers, structural elements responsible for mechanical strength in skin, are synthesized constitutively in response to cytokines such as IGF-I. However, little is known about their intracellular trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus during synthesis. We demonstrate herein that the BBF2 human homolog on chromosome 7 ...
Zhao Jintong - - 2012
In this study, novel endophytic fungi producing cajaninstilbene acid (CSA) from pigeon pea [Cajanus cajan (L.) Millsp.] were investigated and screened. CSA has prominent pharmacological activities. A total of 110 endophytic fungi isolates were grouped into 8 genera based on the morphological characteristics, and CSA-producing fungi were screened by liquid ...
Iannitti T - - 2012
J Oral Pathol Med (2012) Free radicals play a key role in the development of several pathological conditions. Therefore, several methods have been developed to measure oxidative stress from bodily fluids including blood, urine and, more recently, saliva. Free radical and antioxidant defences within the oral cavity may play a ...
Chen Kehung - - 2012
Fast and accurate detection of aqueous contaminants is of significant importance as these contaminants raise serious risks for human health and the environment. Mercury and its compounds are highly toxic and can cause various illnesses; however, current mercury detectors suffer from several disadvantages, such as slow response, high cost, and ...
Sharma Kuldeep - - 2012
A highly sensitive, rapid assay method has been developed and validated for the estimation of bicalutamide in mouse plasma using liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the negative-ion mode. The assay procedure involves extraction of bicalutamide and tolbutamide (internal standard, IS) from mouse plasma with ...
Jin Weina - - 2012
We studied the effect of hypoxia on the differentiation of chronic myeloid leukemic K562 cells, and characterized the role of Na+/H+ exchanger 1 (NHE1) in this process. The K562 cells were tested for differentiation-related morphological characterization using light microscopy. The fluorescent probe BCECF was used for intracellular pH (pHi) measurements. ...
Só Marcus Vinícius Reis - - 2012
To evaluate the efficacy of ProTaper Universal rotary retreatment system and the influence of sealer type on the presence of filling debris in the reinstrumented canals viewed in an operative clinical microscope. Forty-five palatal root canals of first molars were filled with gutta-percha and one of the following sealers: G1, ...
Keehn Brandon - - 2012
Although autism is usually characterized with respect to sociocommunicative impairments, visual search is known as a domain of relative performance strength in this disorder. This study used functional MRI during visual search in children with autism spectrum disorder (n = 19; mean age = 13;10) and matched typically developing children ...
Ackermann Elizabeth J - - 2012
Transthyretin (TTR)-associated amyloidosis is a late-onset autosomal-dominant genetic disease. Over 100 amyloidogenic mutations have been identified in TTR which destabilize the TTR tetramer thereby inducing the formation of amyloid fibrils in tissues such as the heart and peripheral nerves. This disease mainly affects peripheral nerves, causing familial amyloid polyneuropathy (FAP) ...
Jarosz M - - 2012
Therapy targeting tumor blood vessels ought to inhibit tumor growth. However, tumors become refractory to antiangiogenic drugs. Therefore, therapeutic solutions should be sought to address cellular resistance to antiangiogenic therapy. In this regard, reversal of the proangiogenic and immunosuppressive phenotype of cancer cells, and the shift of the tumor microenvironment ...
Han Steven - - 2012
Abstract Objectives: To compare effects of fixed-dosed combinations (FDCs) and coadministered dual therapy (CDT) of antihyperglycemic agents on glycemic control (i.e., HbA(1c)) and medication adherence. Methods: A systematic literature review and meta-analysis were performed to compare the HbA(1c) response and medication adherence between the two drug regimens. Selected articles were ...
Erdoǧan Serkan - - 2012
This research aimed to examine the morphological features of the tongue and laryngeal entrance of long-legged buzzard by macroscopic and scanning electron microscopic methods. Two adult buzzards were used as material. The tongue was fairly elongated and terminated in oval shovel-like apex. Scale-like projections were localized on the apex and ...
Dalal Vijay K - - 2012
To understand the impact of water stress on the greening process, water stress was applied to six-day old etiolated seedlings of a drought-sensitive cultivar of rice (Oryza sativa), Pusa Basmati-1 by immersing their roots in 40 mM PEG 6000 (-0.69 MPa) or 50 mM PEG 6000 (-1.03 MPa) dissolved in ...
D'Cruz A K - - 2012
Concurrent chemoradiation is currently the accepted 'standard of care' for locally advanced laryngeal and hypopharyngeal cancers. However, there is a subset of patients not suitable for chemoradiation, in whom primary surgery is the best option. Speech preservation is of prime importance in these patients. Near-total laryngectomy is a voice-preserving procedure ...
Hwynn Nelson - - 2012
Abstract Deep brain stimulation has been utilized in both dystonia and in medication refractory Tourette syndrome. We present an interesting case of a patient with a mixture of disabling dystonia and Tourette syndrome whose co-existent dystonia and tics were successfully treated with 60 Hz-stimulation of the globus pallidus region.
Sahin Alparslan - - 2012
Objectives:  The aim of this study was to investigate the effect of I-gel(TM) laryngeal mask airway on intraocular pressure (IOP) in children with strabismus undergoing balanced anesthesia with sevoflurane or desflurane. Methods:  Forty-seven children, ASA physical status I, were scheduled for elective strabismus surgery. Patients were randomly assigned to one ...
Cummins Scott F - - 2012
Covering: up to 2011This review covers the subject of pheromones, attractants and other chemical cues of aquatic invertebrates, fishes and amphibians (including salamanders and anurans). Major topics include the sex pheromones of gastropods, salamanders and a giant tree frog, and the conspecific attraction of sperm to ova of some of ...
Huang Peng - - 2012
A new organic-inorganic hybrid, [Cu(en)(2)](3){[Cu(en)(2)][H(6)SiNb(18)O(54)]}·22H(2)O (1, en = ethylenediamine) containing the crescent-shaped polyoxoanion [H(6)SiNb(18)O(54)](8-) and copper-organic cations has been successfully synthesized, and elemental analyses, IR spectra, thermogravimetric analyses and single-crystal X-ray diffraction were investigated.
Ignagni Karen - - 2012
To the Editor: Cooper and Trivedi (Jan. 12 issue)(1) present intriguing results suggesting that insurance plans may attract and retain a healthier subgroup of the Medicare population by offering fitness plans. These results are, however, derived from a difference-in-differences approach. A critical assumption that cannot be tested is that, had ...
Largent Emily - - 2012
Payment to recruit research subjects is a common practice but raises ethical concerns relating to the potential for coercion or undue influence. We conducted the first national study of IRB members and human subjects protection professionals to explore attitudes as to whether and why payment of research participants constitutes coercion ...
Prabakar I - - 2012
I. Prabakar, E. L. Moss, G. Douce, J. Parkes and C. W. E. Redman Review of invasive cervical cancers and uptake of disclosure of results: an audit of procedures and response Objective:  To audit the process and outcome of case reviews performed for invasive cervical cancers diagnosed between 2003 and ...
Aristilde Ludmilla - - 2012
A recent study of the effect of pH on Zn and Cd bioavailability shows that binding to weak organic ligands can increase the pool of metals available to phytoplankton in the presence of strong chelating agents. We explore the underlying mechanism in laboratory experiments with the model species Emiliania huxleyi ...
Llusá Marcos - - 2012
Context: Excipient selection is key to product development because it affects their processability and physical properties, which ultimately affect the quality attributes of the pharmaceutical product. Objective: To study how the flowability of lubricated formulations affects acetaminophen (APAP) homogeneity. Materials and methods: The formulations studied here contain one of two ...
Saito Makoto - - 2012
Recently, the development of two-dimensional speckle-tracking (2DST) technology has allowed the direct measurement of the elastic parameters of the carotid arterial wall. The aims of this study were to determine the feasibility of measuring peak circumferential strain (CS) of the carotid arterial wall using 2DST and to compare this value ...
Levy Tal Bergman - - 2012
Euthanasia and physician assisted-suicide are terms used to describe the process in which a doctor of a sick or disabled individual engages in an activity which directly or indirectly leads to their death. This behavior is engaged by the healthcare provider based on their humanistic desire to end suffering and ...
Kondo T - - 2012
OBJECTIVES: The purpose of this study was to test the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the non-lesional hemisphere on motor neuron excitability of the paretic upper limb in post-stroke patients by electrophysiological examination. MATERIALS AND METHODS: Thirteen post-stroke patients with spastic upper limb hemiparesis were studied ...
Fang X-H - - 2012
Background and purpose:  The incidence of ischaemic stroke has increased or remained high in China; however, little population-based evidence is available on the incidence and survival of lacunar infarction (LAC). We examined the incidence of LAC in a northern Chinese (Beijing) population and monitored survival. Methods:  A prospective registry population-based ...
Johansson E P - - 2012
BACKGROUND: Carotid endarterectomy yields greater risk reduction for ipsilateral ischemic stroke when performed within two-weeks of the last cerebrovascular symptom than when performed two-weeks or more after the last symptom. However, additional benefit might be gained if carotid endarterectomy is performed earlier than within two-weeks. AIMS: To investigate the 90-day ...
Jafferbhoy Sadaf - - 2012
A 43-year-old woman presented to the surgical clinic with an 8-month history of weight loss and progressive dysphagia to solids and liquids. She also had dyspepsia and depression.
Lee De-Hyung - - 2012
Introduction: Myelin oligodendrocyte glycoprotein (MOG) is a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. In ...
McDonald Heather - - 2012
ABSTRACT Objectives: A cost-effectiveness model for rivaroxaban evaluated the cost-effectiveness of prophylaxis with rivaroxaban (a once-daily, orally administered Factor Xa inhibitor) versus enoxaparin in the prevention of venous thromboembolism (VTE) after total hip replacement (THR) and total knee replacement (TKR). This Canadian analysis was conducted using the Ontario Ministry of ...
Harford Philip J - - 2012
Reaction of in situ generated lithium phosphides with 0.5 eq. Cu(i) is employed as a means of targeting lithium phosphidocuprates of either Gilman- or Lipshutz-type formulation - e.g., (R(2)P)(2)CuLi·n(LiX) (n = 0, 1). For R = Ph, X = CN in toluene followed by thf or R = Ph, X ...
Iseki Hiroyoshi - - 2012
Arm protein lost in epithelial cancers, on chromosome X (ALEX; also known as armadillo repeat containing, X-linked (ARMCX)) is a novel subgroup within the armadillo (ARM) family which has several ARM repeat domain. The biological function of classical ARM family members such as β-catenin is well understood, but that of ...
Zhu Jian-Hua - - 2012
Targeting αvβ3 is a promising therapeutic strategy for suppressing tumor metastasis. However, it is unclear whether the therapeutic efficacy could be influenced by metastasis-promoting factor(s) in vivo. Here we report that TLR4 ligand released from the damaged tumor cells or bacteria had a negative effect on the therapeutic effect of ...
Ji Chang G - - 2012
Molecular dynamics simulation in explicit water for the binding of the benchmark barnase-barstar complex was carried out to investigate the effect polarization of interprotein hydrogen bonds on its binding free energy. Our study is based on the AMBER force field but with polarized atomic charges derived from fragment quantum mechanical ...
Kobmoo N - - 2012
Ophiocordyceps unilateralis (Hypocreales, Ascomycetes) is an entomopathogenic fungus specific to formicine ants (Formicinae, Hymenoptera). Previous works have shown that the carpenter ant Camponotus leonardi acts as the principal host with occasional infections of ants from the genus Polyrhachis (sister genus of Camponotus). Observations were made on the permanent plots of ...
Nakamura Koshi - - 2012
BackgroundEpidemiological studies have observed conflicting patterns as to whether overtime work increases blood pressure (BP), probably as a consequence of methodological issues.MethodsWe conducted a prospective cohort study to investigate the relationship between overtime work hours and 1-year changes in BP in 1,235 normotensive Japanese male workers who carried out a ...
Choi Wonseon - - 2012
Interactions between melanocytes and neighboring cells in the skin (keratinocytes and fibroblasts) play important roles in regulating human skin color. We recently reported that neuregulin-1 (NRG1) is highly expressed in fibroblasts from Fitzpatrick type VI skin (the darkest), and at least in part determines the constitutive color of human skin. ...
Mori Kenichi - - 2012
GM1 gangliosides form microdomain with sphingomyeline (SM) and cholesterol (Chol) and are deeply involved in the aggregation of amyloid beta (Aβ) peptides on neural membrane. We performed molecular dynamics simulations on two kinds of lipid bilayers containing GM1 ganglioside; GM1/SM/Chol and GM1/POPC. Both of 10 ns and 100 ns simulations ...
Jones Christine L - - 2012
T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent in cells of hematopoietic origin. Aberrant PLS3 expression has been demonstrated in lymphocytes from Sézary syndrome (SS) patients and has been proposed as a biomarker for SS; however, the mechanism underlying dysregulation of PLS3 has not been ...
Wee D T H - - 2012
Salivary duct carcinoma is an aggressive malignancy with a high mortality rate, which phenotypically resembles high-grade breast ductal carcinoma. The parotid gland is the most common location. Standard treatment is surgery to the primary tumour together with post-operative radiotherapy. Despite this, there is a high rate of local recurrence, cervical ...
Pullar Christine E - - 2012
Skin wound healing is a complex process requiring the coordinated, temporal orchestration of numerous cell types and biological processes to regenerate damaged tissue. Previous work has demonstrated that a functional β-adrenergic receptor autocrine/paracrine network exists in skin, but the role of β2-adrenergic receptor (β2AR) in wound healing is unknown. A ...
Debes Marun Carina S - - 2012
Chromosomal abnormalities in plasma cells (PCs) from multiple myeloma (MM) provide a clonal signature to identify malignant cells. BM-lymphocytes from MM aspirates, defined by stringent criteria, were screened for the same chromosomal abnormalities as autologous PCs, including translocations, deletions, and amplifications. For 200 MM patients, we evaluated BM mononuclear cells ...
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