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Results 401 - 450 of 4191
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Cruz Márcia Waddington - - 2012
Abstract Familial amyloidotic polyneuropathy (FAP) is a worldwide disease with various clinical presentations according to geographical origin of the cases. Brazil is a country of Portuguese colonization and Portuguese descendants are estimated to be more than 25 millions. The Brazilian FAP population was characterized in this text as having basically ...
Kim Chan-Won - - 2012
Previous studies have reported a relationship between short sleep duration and childhood overweight. Although school-aged children tend to compensate for weekday sleep deficit by increasing weekend sleep duration, the association between weekend catch-up sleep and childhood overweight remains unclear. This study aimed to examine the relationship between weekend catch-up sleep ...
Jones Mathew Wynne - - 2012
Direct polymer conjugation at peptide tyrosine residues is described. In this study Tyr residues of both Leucine enkephalin and salmon calcitonin (sCT) were targeted using appropriate diazonium salt terminated linear mPEGs and poly(mPEG) methacrylate prepared by ATRP. Judicious choice of the reaction conditions - pH, stoichiometry and chemical structure of ...
Kungwan Nawee - - 2012
The dynamics of the excited-state proton transfer (ESPT) in a cluster of 2-(2'-hydroxyphenyl)benzothiazole (HBT) and hydrogen-bonded water molecules was investigated by means of quantum chemical simulations. Two different enol ground-state structures of HBT interacting with the water cluster were chosen as initial structures for the excited-state dynamics: (i) an intramolecular ...
Plieskatt Jordan L JL Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, USA. - - 2012
A bivalent recombinant vaccine for human hookworm disease is under development. One of the lead candidate antigens in the vaccine is a glutathione S-transferase cloned from the hookworm Necator americanus (Na-GST-1) which is expressed in the yeast Pichia pastoris. Based on preliminary studies demonstrating that the recombinant protein was not ...
McPherson Kathryn M - - 2012
For some people, the word "technology" in rehabilitation brings to mind equipment and assistive devices. For others - it is a brave new frontier where robotic advance means many of the functional consequences of impairment are/will be alleviated, and many roles health professionals and carers currently perform will disappear. Like ...
Nakabayashi Keita - - 2012
A diagram of energies between the HOMO of donor (D) and LUMO of acceptor (A) vs. ΔE(1/2)(DA) (= E(1/2)(D) - E(1/2)(A): E(1/2) = first-redox potential) clearly demonstrates the ionicity in the series of D/A assemblies, [{Ru(2)(CF(3)CO(2))(4)}(2)(TCNQR(x))]·n(solv) (TCNQR(x) = 2,5- or 2,3,5,6-R-substituted 7,7,8,8-tetracyano-p-quinodimethane; R(x) = H(4), F(2), Cl(2), Br(2), F(4), Me(2), ...
Kennally William C - - 2012
To the Editor: In their Perspective article on generic atorvastatin and health care costs, Jackevicius et al. (Jan. 19 issue)(1) refer to agreements that we at Pfizer have reached with health plans and pharmacy benefit managers to ensure that patients can continue to have access to Lipitor in the 180-day ...
Enter Dorien - - 2012
There is increasing interest in the role of striatal dopaminergic activity in social approach-avoidance motivation. The 9-repeat allele of the dopamine transporter gene, associated with increased striatal dopamine levels, has been found to be related to increased sensitivity to reward. However, it remains unexplored whether this polymorphism influences automatic action ...
Dolasık Ilhan - - 2012
Diabetes mellitus (DM) is an independent risk factor for cardiovascular diseases. Metformin, the most commonly used antidiabetic, also has an antiatherogenic effect. Mean platelet volume (MPV) is increased in patients with high thrombogenic activation and also at risk for atherosclerosis. The purpose of this study was to examine the effects ...
Vidale Simone - - 2012
Stroke is the leading cause of disability in adulthood, and the principal aim of care in cerebrovascular disease is the reduction of this negative outcome and mortality. Several studies demonstrated the efficacy of thrombolytic therapy in ischemic stroke, but up to 80% of cases could not be treated because the ...
Rapezzi Claudio - - 2012
Hereditary transthyretin-related amyloidosis remains a widely underdiagnosed condition, owing to its extreme phenotypic variability: the clinical spectrum of the disease ranges from an almost exclusive neurologic involvement to strictly cardiac manifestations. This heterogeneity is linked to several factors including specific transthyretin mutations, geographic distribution and endemic vs. non-endemic aggregation type. ...
Johri Mira - - 2012
Objectives: The aim of this study was to promote approaches to health technology assessment (HTA) that are both evidence-based and values-based. We conducted a systematic review of published studies describing formal methods to consider equity in the context of cost-effectiveness analysis (CEA).Methods: Candidate studies were identified through an unrestricted search ...
Raghavan Rajeev - - 2012
Emergent hemodialysis is the practice of dialyzing a patient only when there is a life-threatening need for this treatment. Undocumented immigrants in many cities depend on this practice, as they are not entitled to the regularly scheduled hemodialysis treatments available to US citizens. There are several medical and ethical challenges ...
Morita Naruhiko - - 2012
BACKGROUND: Papillary thyroid carcinoma (PTC) occasionally metastasizes to lung and bone, but rarely to skeletal muscles. In this study, we present an unusual case of metastasis of PTC to the infratemporal fossa of a previously treated patient with PTC. METHODS AND RESULTS: A 74-year-old man with a diagnosis of PTC ...
Morgan Gareth J - - 2012
Based on the clinical features of myeloma and related malignancies of plasma cells, it has been possible to generate a model system of myeloma progression from a normal plasma cell through smouldering myeloma to myeloma and then plasma cell leukaemia. Using this model system we can study at which points ...
van Mullem Alies - - 2012
A father and daughter with a mutation in the nuclear receptor gene for thyroid hormone (THRA) have abnormal levels of thyroid hormone, normal thyrotropin levels, growth retardation, and mildly delayed motor and cognitive development.
Carota Antonio - - 2012
We describe the case of a 69-year-old professor of mathematics (GV) who was examined 2 years after left-hemispheric capsular-thalamic haemorrhage. GV showed disproportionate impairment in subtractions requiring borrowing (22 - 7). For large subtraction problems without borrowing (99 - 12) performance was almost flawless. Subtractions with borrowing mostly relied on inadequate attempts to invert ...
Pincebourde Sylvain - - 2012
Ecology Letters (2012) ABSTRACT: Climate warming experiments generally test the ecological effects of constant treatments while neglecting the influence of more realistic patterns of environmental fluctuations. Thus, little is known regarding how the temporal interaction between multiple episodes of thermal stress influences biotic interactions. We measured the sensitivity of predation ...
Kataoka Keisuke - - 2012
It has become evident that acute myeloid leukemia (AML) is organized as a cellular hierarchy initiated and maintained by a subset of self-renewing leukemia stem cells (LSCs). Recent gene expression profile analysis of human LSC and hematopoietic stem cell (HSC) populations identified a key transcriptional program shared by LSCs and ...
Cho Hyun-Min - - 2012
The Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is upregulated in diverse models of hypertension. We hypothesized that NKCC1 is upregulated via histone modification in the aortas of angiotensin II (Ang II)-induced hypertensive rats. An osmotic mini-pump containing Ang II was implanted in the subcutaneous tissues of the backs of Sprague-Dawley (SD) rats ...
Robotta Marta - - 2012
α-synuclein is abundantly present in Lewy Bodies, characteristic of Parkinson's disease. Its exact physiological role has yet to be determined, but mitochondrial membrane binding is suspected to be a key aspect of its function. Electron paramagnetic resonance spectroscopy in combination with site-directed spin-labeling allowed for a locally resolved analysis of ...
Auguet Jean-Christophe - - 2012
Freshwater habitats have been identified as one of the largest reservoirs of archaeal genetic diversity, with specific lineages of ammonia-oxidizing archaea (AOA) populations different from soils and seas. The ecology and biology of lacustrine AOA is, however, poorly known. In the present study, vertical changes in archaeal abundance by CARD-FISH, ...
Ruan Xiangyan - - 2012
Objectives: Recently the first monophasic contraceptive pill containing estradiol has been developed which is thought to be a milestone in contraception. Nomegestrol acetate (NOM) is the progestogenic component. Progesterone receptor membrane component 1 (PGRMC1) is highly expressed in the tissue of breast cancer patients, and can predict a progestogen dependent ...
Salgado Claudio Guedes - - 2012
A 57-year-old man presented with a 7-year history of diffuse skin infiltration associated with sensory loss in his left hand. His face had multiple nodular lesions that coalesced into plaques, especially on the forehead, ears, nose, and lips.
Perbal Laurence - - 2012
The 'gene of' is a teleosemantic expression that conveys a simplistic and linear relationship between a gene and a phenotype. Throughout the 20th century, geneticists studied these genes of traits. The studies were often polemical when they concerned human traits: the 'crime gene', 'poverty gene', 'IQ gene', 'gay gene' or ...
Thomopoulos C - - 2012
Hypertensive complications in pregnancy are the leading cause of maternal morbidity, at least in the developed countries. In recent years, infertility issues are managed with ever growing therapeutic options namely assisted reproductive technologies (ART), which improve the ratio of successful induction of pregnancy. It is still debated whether various ART ...
Palmer Shannon J - - 2012
Abstract There has been raising interest in evaluating spinal reflex activity within the clinical population, however no study has yet investigated the reliability of presynaptic inhibition (PI) on patients with diabetic peripheral neuropathy (DPN). Because neuropathy is closely related to central nervous system modification, it is important to understand the ...
Lee Yoo-Kyung - - 2012
High dysadherin expression has been recognized as a biological predictor of metastasis and poor prognosis for many different cancer types; however, the molecular mechanisms of how dysadherin affects cancer progression are still poorly understood. In this study, we examined whether AKT signaling could link dysadherin expression with downstream events that ...
Agata Hideki - - 2012
Background aims. Although bone marrow (BM) stromal cells (SC; BMSC) isolated from adherent cultures of untreated BM are known to contain both committed and uncommitted osteogenic cells, it remains unknown whether BMSC isolated either by hemolysis or Ficoll centrifugation also contain both of these populations. Methods. Differences in the osteogenic ...
Au K - - 2012
Application of LaAlO(3) /SrTiO(3) interfacial two-dimensional electron gas (2DEG) as a polar molecule sensor is demonstrated. The sensing mechanism is due to the formation of a metal-semiconductor Schottky junction when the center of LaAlO(3) surface is covered with polar molecules such as water. These results also evidence the existence of ...
Beissel Daniel J - - 2012
Introduction.  Pulse oximetry can be used as a screening tool to detect critical congenital heart disease (CCHD) in neonates prior to hospital discharge and the development of symptoms. Newborns suspected of having CCHD based on pulse oximetry screening should have the diagnosis excluded or confirmed with echocardiography. However, echocardiography is ...
Zayed Amira - - 2012
Abstract Background: Background: Despite several therapeutic modalities, acanthosis nigricans (AN) remains a difficult dermatosis to treat. Objective: This study aims to test the safety and efficacy of trichloroacetic acid as a chemical peel in the treatment of acanthosis nigricans in a random sample of Egyptian female patients. Method: Six females ...
Ji Xiaofan - - 2012
All the previously reported supramolecular polymers based on crown ether-based molecular recognition have been prepared in anhydrous organic solvents. This is mainly due to the weakness of crown ether-based molecular recognition in the presence of water. Here we report a linear supramolecular polymer constructed from a heteroditopic monomer in an ...
Kaikkonen Jari E - - 2012
There is a paucity of detailed information about the role of childhood food patterns or on the impact of individual nutrients on adulthood cardiovascular disease (CVD). We review here the reports that have investigated these questions in the Young Finns Study with its 3596 subjects at baseline, aged 3 to ...
Sarlo Michela - - 2012
The present study aimed at investigating whether the way offers are framed in the Ultimatum Game (UG) affects behavioral and autonomic responses in men and women. The "I give you" and "I take" expressions were used as gain and loss frames, respectively. Skin conductance and heart rate were recorded as ...
Chen Di - - 2012
With the features of high mobility, a high electric on/off ratio and excellent transparency, metal oxide nanowires are excellent candidates for transparent thin-film transistors, which is one of the key technologies to realize transparent electronics. This article provides a comprehensive review of the state-of-the-art research activities that focus on transparent ...
Buchheiser Anja - - 2012
Background aims. Amongst different stem cell populations derived from human cord blood (CB), unrestricted somatic stem cells (USSC) are distinguished from CB mesenchymal stromal cells (CB MSC) by expression patterns of homeobox (HOX) genes, delta-like1 homolog (DLK1) expression and adipogenic differentiation potential. In this study we investigated the effects of ...
Lubbe D E - - 2012
Objective:We report the use and benefits of the ultrasonic dissector in the resection of difficult skull base lesions.Method:Five case reports are presented, and the utilisation of ultrasonic dissectors in otorhinolaryngology is reviewed.Results:The ultrasonic dissector was found to be a useful tool during the endoscopic resection of poorly accessible skull base ...
Fischer Thomas - - 2012
Abstract Purpose: We studied the response of human embryonic stem cells (hESC) to the β-emitter (131)I, which affects the entire cell and to the Auger electron emitter (125)I -deoxyuridine ((125)I-dU), primarily affecting the deoxyribonuleic acid (DNA). The effects were also studied in keratinocytes as a prototype for somatic cells. Methods: ...
Dyson S - - 2012
Reasons for performing study: There is limited knowledge about both histological features in early navicular disease and what histological features are represented by increased signal intensity in fat-suppressed magnetic resonance (MR) images of the navicular bone. Objective: To characterise increased signal intensity in the spongiosa of the navicular bone in ...
Martins Jose Diogo Ferreira - - 2012
This article, which shows a technically very challenging angioplasty of a near-atretic coarctation of the aorta, underlines the importance of an anticipated procedure planning and of the right selection of available technology. Additionally, the performance and clinical setting of utilization of a new small premounted stent-the Advanta Atrium stent-is highlighted.
- - 2012
To the Editor: In their Perspective article on generic atorvastatin and health care costs, Jackevicius et al. (Jan. 19 issue)(1) refer to agreements that we at Pfizer have reached with health plans and pharmacy benefit managers to ensure that patients can continue to have access to Lipitor in the 180-day ...
Ratnayake Nilantha - - 2012
OBJECTIVE: To determine the factors associated with sugar-sweetened soft drink consumption in adolescents from Sri Lanka. DESIGN: A cross-sectional study where the data were collected by means of a self-administered questionnaire. SETTING: Government, private and international schools in the Colombo district of Sri Lanka. SUBJECTS: Adolescents aged 17 years attending ...
Hwynn Nelson - - 2012
Abstract Deep brain stimulation has been utilized in both dystonia and in medication refractory Tourette syndrome. We present an interesting case of a patient with a mixture of disabling dystonia and Tourette syndrome whose co-existent dystonia and tics were successfully treated with 60 Hz-stimulation of the globus pallidus region.
Sahin Alparslan - - 2012
Objectives:  The aim of this study was to investigate the effect of I-gel(TM) laryngeal mask airway on intraocular pressure (IOP) in children with strabismus undergoing balanced anesthesia with sevoflurane or desflurane. Methods:  Forty-seven children, ASA physical status I, were scheduled for elective strabismus surgery. Patients were randomly assigned to one ...
Cummins Scott F - - 2012
Covering: up to 2011This review covers the subject of pheromones, attractants and other chemical cues of aquatic invertebrates, fishes and amphibians (including salamanders and anurans). Major topics include the sex pheromones of gastropods, salamanders and a giant tree frog, and the conspecific attraction of sperm to ova of some of ...
Treviño-Rangel Rogelio De J Rde J Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León , Monterrey, Nuevo León, - - 2012
Recently, it was proposed that the opportunistic yeast pathogen Candida parapsilosis was a complex composed of the following three species: Candida parapsilosis sensu stricto, Candida orthopsilosis, and Candida metapsilosis. A set of 344 clinical isolates of Candida parapsilosis from Monterrey, Mexico was re-identified by RFLP. Their antifungal susceptibility to fluconazole, ...
Huang Peng - - 2012
A new organic-inorganic hybrid, [Cu(en)(2)](3){[Cu(en)(2)][H(6)SiNb(18)O(54)]}·22H(2)O (1, en = ethylenediamine) containing the crescent-shaped polyoxoanion [H(6)SiNb(18)O(54)](8-) and copper-organic cations has been successfully synthesized, and elemental analyses, IR spectra, thermogravimetric analyses and single-crystal X-ray diffraction were investigated.
Verma Ramesh R Department of Community Medicine, Rohtak, India. - - 2012
Rubella is a contagious viral disease, which mainly affects the fetus, if the mother is infected in the 1st trimester of her pregnancy. All adolescent girls (aged 11 to 19 y) and women of childbearing age are at risk of developing rubella. This disease is mild and self-limiting, and incubation ...
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