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Kenney Patrick A - - 2012
Proper integration of surgery and systemic therapy is essential for improving outcomes in renal cell carcinoma (RCC). There is no current role for adjuvant therapy after nephrectomy for clinically localized disease. The potential benefits of neoadjuvant therapy for locally advanced nonmetastatic disease are in need of further study. In metastatic ...
Garcia Guillermo G - - 2012
World Kidney Day on 8 March 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end-stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost-effectiveness. Anything that is both cheaper and ...
Turner Joel P - - 2012
Dyspnea and hypotension often present a diagnostic challenge to the emergency physician. With limitations on traditional methods of evaluating these patients, lung ultrasound has become an essential assessment tool. With the sensitivity of lung ultrasound approaching that of CT scan for many indications, it is quickly becoming a fundamental technique ...
Ibler Kristina S - - 2012
Background. Hand eczema is common in healthcare workers, owing to intensive exposure to wet work and skin irritants. Targeted interventions and vocational guidance based on documented exposures and risk factors are needed. Objectives. The aims of the study were to investigate the relationship between exposures (domestic and at work) and ...
Rismo Renathe - - 2012
Abstract Objective. Mucosal cytokine profile determines T cell differentiation and may play an important role in the clinical course of inflammatory bowel disease (IBD). Cytokines from different T helper (Th) cell subsets are elevated in inflamed mucosa of patients with ulcerative colitis (UC), contributing to the inflammation. The aim of ...
Watkins Lynn - - 2012
PURPOSE OF STUDY:: This study describes a social-worker navigator transitional care model for at-risk seniors being discharged from hospital to home. The model is designed to prevent rehospitalizations so as to improve quality of life and patient outcomes. This model is different from others with its focus on the psychosocial ...
García-Cabrero Ana M - - 2012
Lafora disease is a progressive myoclonus epilepsy caused by mutations in the EPM2A gene encoding laforin or in the EPM2B gene encoding malin. It is characterized by the presence of polyglucosan intracellular inclusion bodies (Lafora bodies) in brain and other tissues. Targeted disruption of Epm2a or Epm2b genes in mice ...
Thyssen Jacob P - - 2012
Background. Chromium-tanned leather footwear, which releases >3 ppm hexavalent Cr(VI), may pose a risk of sensitizing and eliciting allergic dermatitis. Objectives. To determine the content and potential release of chromium in leather footwear and to discuss the prevention of chromium contact allergy and dermatitis. Methods. Sixty pairs of leather shoes, ...
Moder Daniel - - 2012
To investigate the influence of autogenous platelet concentrate (APC) on the long-term regeneration outcome 7 years after guided tissue regeneration (GTR) in deep intrabony periodontal defects. In 25 patients, two deep contra-lateral intrabony defects were treated according to GTR (randomized split-mouth-design). In the test defects, APC was additionally applied. After 7 years, ...
Kheterpal Emil - - 2012
Localized kidney cancer is ideally managed with surgical extirpation. Historically renal cell carcinoma has been treated with radical nephrectomy, but partial nephrectomy has become increasingly used because of a growing body of evidence demonstrating equivalent oncologic control and a potential benefit in overall survival. In this article, the authors demonstrate ...
McWilliam H E G - - 2012
Schistosomiasis remains one of the most common human helminthiases, despite the availability of an effective drug against the causative parasites. Drug treatment programmes have several limitations, and it is likely that a vaccine is required for effective control. While decades of vaccine development have seen the discovery and testing of ...
Skuk Daniel - - 2012
The aim of this study was to define the histologic features of acute rejection of myofibers, particularly in the context of therapeutic myogenic cell transplantation. Myoblasts expressing or not expressing β-galactosidase were transplanted into 13 macaques that were divided into 3 protocols: withdrawal of immunosuppression, low immunosuppression, and progressive reduction ...
Landeck Lilla - - 2012
Background. The warm und humid environment, friction and occlusion within shoes make the feet to a favorable body site to acquire allergic contact dermatitis. Objectives. To evaluate and compare patch test results in patients with suspected contact allergy of the feet with the results in those with concomitant involvement of ...
Terra Sandra M - - 2012
Medical futility is a timely topic and one fraught with ethical implications. Medical futility is a term used to describe medical interventions that are expected to result in little or no benefit to a patient. This Editorial examines some considerations and applications of medical futility to a specific patient or ...
Beijk Marcel A - - 2012
BACKGROUND: The e-Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth (e-HEALING) registry was designed to capture clinical data on the use of the endothelial progenitor cell capture stent (ECS) in routine clinical practice. In this analysis, we investigated the 12-month clinical outcomes in patients treated with an ECS for a bifurcation ...
Emi-Reynolds Geoffrey - - 2012
ABSTRACT: The status of radiation protection and safety of diagnostic medical x-ray facilities in the Greater Accra region in Ghana have been evaluated. In all, 62 medical facilities with 86 diagnostic x-ray units were considered for the survey. Out of the 86 diagnostic units, there were 56 general radiograph, 13 ...
Mir-Mari Javier - - 2012
To determine the prevalence of peri-implant diseases in private practice patients enrolled in a periodontal maintenance programme. A cross-sectional study was carried out in patients with dental implants attending the dental clinic to comply with a periodontal maintenance programme between January and June 2010. Implants with at least 1 year of ...
Lorah Brian - - 2012
ABSTRACT: A routinely used thyroid uptake counter in Nuclear Medicine is evaluated to determine if its sensitivity is sufficient to perform routine thyroid bioassays on Nuclear Medicine personnel involved in handling and administering radioactive iodine. The BiodexAtomlab 950 (PC) Medical Spectrometer thyroid uptake counter system is found to be sensitive ...
Jacob Mathias - - 2012
Background. Two preparations are currently in use for the diagnosis of allergic contact dermatitis caused by Asteraceae: (i) Sesquiterpene lactone (SL) mix [three pure sesquiterpene lactones (STLs)], whose use has been questioned, owing to an insufficient rate of true-positive results; and (ii) Compositae mix, consisting of five Asteraceae extracts, which ...
Schmeida Mary - - 2012
PURPOSE OF THE STUDY:: Pneumonia hospitalization and subsequent readmission among the elderly are frequent and costly both to patient and to the Medicare trust fund. In this study, we explored the factors that are associated with states having pneumonia readmission rates that are higher than the U.S. national rate. PRIMARY ...
Carbaugh Eugene H - - 2012
ABSTRACT: The production reactors at the U.S. Department of Energy Hanford Site used large graphite piles as the moderator. As part of long-term decommissioning plans, the potential need for C radiobioassay of workers was identified. Technical issues associated with C bioassay and worker monitoring were investigated, including anticipated graphite characterization, ...
Clegg P D - - 2012
Tendon and ligament injuries continue to be one of the most frequent causes of orthopaedic injury and early retirement in the Thoroughbred racehorse. In the UK, the Horserace Betting Levy Board has invested considerable research funding in the last decade in order to investigate aspects of tendon epidemiology, biology and ...
Etienne-Grimaldi Marie-Christine - - 2012
To examine the predictive value of gene polymorphisms potentially linked to toxicity, clinical response, time to progression and overall survival, following cetuximab-tegafur-uracil (UFT)-irinotecan therapy. Fifty-two patients with advanced colorectal cancer were enrolled in an ancillary pharmacogenetic study of the phase II CETUFTIRI trial. Treatment consisted of 21 day cycles of ...
Isakova Tamara - - 2012
The aim is to review data on the epidemiology of fibroblast growth factor 23 (FGF23) and adverse clinical outcomes in chronic kidney disease (CKD) and introduce recent insights into the pathophysiology behind the observed relationships. End-stage renal disease and cardiovascular disease are frequent events in patients with CKD, in whom ...
Eltawil Karim M - - 2012
Transarterial chemoembolization (TACE) is indicated for primary hepatic tumours when resection or local ablation are not feasible. Patients undergoing TACE have a better survival than best supportive therapy. However, there is paucity of prospective studies on the quality of life (QOL) after TACE for primary hepatic malignancies, especially in the ...
Lord Catherine - - 2012
The nosology of autism spectrum disorders (ASD) is at a critical point in history as the field seeks to better define dimensions of social-communication deficits and restricted/repetitive behaviors on an individual level for both clinical and neurobiological purposes. These different dimensions also suggest an increasing need for quantitative measures that ...
Malinin Nikolay L - - 2012
In the current review, we summarize recent progress on vasculature-specific function and regulation of integrins and integrin-associated proteins, including advances in our understanding of inside-out integrin activation. The studies on regulation of integrin activation received new impulse in 2009 with the identification of kindlin protein family members as crucial mediators ...
Sterke Carolyn S - - 2012
The contribution of selective serotonin re-uptake inhibitors (SSRIs) to injurious fall risk in patients with dementia has not been quantified precisely until now. Our objective was to determine whether a dose-response relationship exists for the use of SSRIs and injurious falls in a population of nursing home residents with dementia. ...
Toshima Takeo - - 2012
There are few reports on the efficacy of hepatectomy for hepatocellular carcinoma (HCC) in patients with renal dysfunction (RD). This study aimed to clarify the validity of hepatectomy for treating HCC in RD patients, and to compare postoperative courses in RD and non-RD patients. The clinical features of 722 HCC ...
Wegiel Jerzy - - 2012
The purposes of this study were to identify differences in patterns of developmental abnormalities between the brains of individuals with autism of unknown etiology and those of individuals with duplications of chromosome 15q11.2-q13 (dup[15]) and autism and to identify alterations that may contribute to seizures and sudden death in the ...
Weinger Jason G - - 2012
The abundant axonal microtubule-associated protein tau regulates microtubule and actin dynamics, thereby contributing to normal neuronal function. We examined whether mice deficient in tau (Tau(-/-)) or with high levels of human tau differ from wild-type (WT) mice in their susceptibility to neuroaxonal injury in experimental autoimmune encephalomyelitis, an animal model ...
Lin Fu-Yang - - 2012
We report X-ray crystallographic structures of three inhibitors bound to dehydrosqualene synthase from Staphylococcus aureus: 1 (BPH-651), 2 (WC-9), and 3 (SQ-109). Compound 2 binds to the S2 site with its -SCN group surrounded by four hydrogen bond donors. With 1, we report two structures: in both, the quinuclidine headgroup ...
Regatieri Caio V - - 2012
A structurally and functionally normal choroidal vasculature is essential for retinal function. Therefore, a precise clinical understanding of choroidal morphology should be important for understanding many retinal and choroidal diseases. PUBMED (http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed) was used for most of the literature search for this article. The criterion for inclusion of an article ...
Rosenberg Jonathan B - - 2012
Cocaine addiction is a major problem affecting all societal and economic classes for which there is no effective therapy. We hypothesized an effective anti-cocaine vaccine could be developed by using an adeno-associated virus (AAV) gene transfer vector as the delivery vehicle to persistently express an anti-cocaine monoclonal antibody in vivo, ...
Vrijens Bernard B AARDEX Group Ltd, Sion, Switzerland. - - 2012
Interest in patient adherence has increased in recent years, with a growing literature that shows the pervasiveness of poor adherence to appropriately prescribed medications. However, four decades of adherence research has not resulted in uniformity in the terminology used to describe deviations from prescribed therapies. The aim of this review ...
Lagadec Chann C Department of Radiation Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1714, - - 2012
Breast cancers are thought to be organized hierarchically with a small number of breast cancer stem cells (BCSCs) able to regrow a tumor while their progeny lack this ability. Recently, several groups reported enrichment for BCSCs when breast cancers were subjected to classic anticancer treatment. However, the underlying mechanisms leading ...
Nelson Peter T PT Sanders-Brown Center on Aging, Department of Pathology, University of Kentucky, Lexington 40536-0230, USA. - - 2012
Clinicopathologic correlation studies are critically important for the field of Alzheimer disease (AD) research. Studies on human subjects with autopsy confirmation entail numerous potential biases that affect both their general applicability and the validity of the correlations. Many sources of data variability can weaken the apparent correlation between cognitive status ...
Folio Lindsey S LS Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, - - 2012
Optical coherence tomography captures a major role in clinical assessment in eye care. Innovative hardware and software improvements in the technology would further enhance its usefulness. In this review, we present several promising initiatives currently in development or early phase of assessment that we expect to have a future impact ...
Stein Veronika M VM School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, - - 2012
Niemann-Pick disease type C (NPC disease) is an incurable cellular lipid-trafficking disorder characterized by neurodegeneration and intralysosomal accumulation of cholesterol and glycosphingolipids. Treatment with miglustat, a small imino sugar that reversibly inhibits glucosylceramide synthase, which is necessary for glycosphingolipid synthesis, has been shown to benefit patients with NPC disease. The ...
Nadler Zach Z Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, - - 2012
The broadening frontier of technology used in ocular imaging is continuously affecting the landscape of clinical eye care. With each wave of enhanced imaging modalities, the field faces the difficulties of optimally incorporating these devices into the clinic. Ocular imaging devices have been widely incorporated into clinical management after their ...
Huang Gang G Indiana University, School of Optometry, Bloomington, Indiana 47405, - - 2012
To develop a clinical planning module (CPM) to improve the efficiency of imaging subjects with a steerable wide-field adaptive optics scanning laser ophthalmoscope (AOSLO) and to evaluate the performance of this module by imaging the retina in healthy and diseased eyes. We developed a software-based CPM with two submodules: a ...
Howell Elizabeth A EA Department of Health Evidence & Policy, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. - - 2012
To estimate the effectiveness of a behavioral educational intervention to reduce postpartum depressive symptoms among minority mothers. We recruited 540 self-identified black and Latina mothers during their postpartum hospital stay and randomized them to receive a behavioral educational intervention or enhanced usual care. Those in the intervention arm received a ...
Hu Yun Y Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, - - 2012
Serum alanine aminotransferase (ALT) activity is a widely-used surrogate marker for liver injury. However, mild elevation of serum ALT is frequently observed in apparently healthy individuals, making it sometimes challenging to interpret whether this laboratory abnormality is medically benign or serious. To obtain a better understanding of the factors influencing ...
Tosh Dilip K - - 2012
Structures of G protein-coupled receptors (GPCRs) have a proven utility in the discovery of new antagonists and inverse agonists modulating signaling of this important family of clinical targets. Applicability of active-state GPCR structures to virtual screening and rational optimization of agonists, however, remains to be assessed. In this study of ...
Wentzensen Nicolas N Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852-7234, USA. - - 2013
Factors associated with progression from cervical intraepithelial neoplasia (CIN) grades 2 and 3 to invasive cancer are not well understood; most CIN2 and CIN3 do not progress to cancer. Among carcinogenic human papillomavirus (HPV) types, infections with HPV16 have the highest risk of progressing to cancer. We evaluated the heterogeneity ...
Wang L L Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing, - - 2012
Daptomycin, one of the A21978C factors produced by Streptomyces roseosporus, is an acidic cyclic lipopeptide antibiotic with potent activity against a variety of Gram-positive pathogens. To increase the titre of this extensively used and clinically important antibiotic, we applied a reported-guided rpsL mutation selection system to generate strains producing high ...
Flint Daniel D Department of Neurobiology and the Civitan International Research Center, Center for Glial Biology in Medicine, Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, AL 35294, - - 2012
Alexander disease (AxD) is a usually fatal astrogliopathy primarily caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament protein expressed in astrocytes. We describe three patients with unique characteristics, and whose mutations have implications for AxD diagnosis and studies of intermediate filaments. Patient 1 ...
Smillie Karen J - - 2012
Activity-dependent bulk endocytosis (ADBE) is the dominant SV endocytosis mode during intense neuronal activity. The dephosphorylation of Ser774 on dynamin I is essential for triggering of ADBE, as is its subsequent rephosphorylation by glycogen synthase kinase 3 (GSK3). We show that in primary cultures of cerebellar granule neurons the protein ...
Brikci-Nigassa Leila - - 2012
BACKGROUND.: We previously reported that transduction of the human interleukin (IL)-10 gene into the total fetal liver stem cells (hIL-10-TFLs) of mice protects against their rejection in an allogeneic host. In this study, we explored the effects of these cells in two different models of organ transplantation. METHODS.: Balb/c mice ...
West Diana C - - 2012
The evasion of apoptosis is a key characteristic of cancer, and thus strategies to selectively induce apoptosis in cancer cells hold considerable promise in personalized anticancer therapy. Structurally similar procaspase activating compounds PAC-1 and S-PAC-1 restore procaspase-3 activity through the chelation of inhibitory zinc ions in vitro, induce apoptotic death ...
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