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Cheng Xin - - 2012
The use of human pluripotent stem cells for laboratory studies and cell-based therapies is hampered by their tumor-forming potential and limited ability to generate pure populations of differentiated cell types in vitro. To address these issues, we established endodermal progenitor (EP) cell lines from human embryonic and induced pluripotent stem ...
Kessler Sean H - - 2012
The oxidative evolution ("aging") of organic species in the atmosphere is thought to have a major influence on the composition and properties of organic particulate matter, but remains poorly understood, particularly for the most oxidized fraction of the aerosol. Here we measure the kinetics and products of the heterogeneous oxidation ...
Irwin Curt B - - 2012
Touch screens are becoming more prevalent in everyday environments. Therefore, it is important that this technology is accessible to those with varying disabilities. The objective of the current study was to evaluate performance and touch characteristics (forces, impulses, and dwell times) of individuals with and without a movement disorder during ...
Soeiro-de-Souza Márcio Gerhardt - - 2012
INTRODUCTION: Creativity is a complex human ability influenced by affective and cognitive components but little is known about its underlying neurobiology. Bipolar Disorder (BD) is highly prevalent among creative individuals. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophic factor, and has been implicated in the pathophysiology of BD. ...
Espinal Laura - - 2012
The development of sorbents for next-generation CO2 mitigation technologies will require better understanding of CO2/sorbent interactions. Among the sorbents under consideration are shape selective microporous molecular sieves with hierarchical pore morphologies of reduced dimensionality. We have characterized the non-equilibrium CO2 sorption of OMS-2, a well known one-dimensional (1D) microporous octahedral ...
Luo Cheng-Ming - - 2012
To evaluate the long-term voice characteristics and quality of life of early glottic cancer patients after definitive treatment. Case series with chart review in a tertiary care medical center in Taiwan. Forty-two consecutive patients who received radiation therapy (RT) or transoral laser microsurgery (TLM) for early glottic cancer over 12 ...
Lubs Herbert A - - 2012
X-Linked intellectual disability (XLID) accounts for 5%-10% of intellectual disability in males. Over 150 syndromes, the most common of which is the fragile X syndrome, have been described. A large number of families with nonsyndromal XLID, 95 of which have been regionally mapped, have been described as well. Mutations in ...
Asharani P V - - 2012
Bone morphogenetic protein 1 (BMP1) is an astacin metalloprotease with important cellular functions and diverse substrates, including extracellular-matrix proteins and antagonists of some TGFβ superfamily members. Combining whole-exome sequencing and filtering for homozygous stretches of identified variants, we found a homozygous causative BMP1 mutation, c.34G>C, in a consanguineous family affected ...
Gladding Sophia - - 2012
Globally competent pediatricians are in demand because of the increasing numbers of children from immigrant families living in the United States and the shortages of health care workers in low-income countries where the majority of the worlds' children live. This study sought to better understand the educational outcomes of international ...
Sathe Pragati Aditya - - 2012
Abstract Objective: Adrenal leiomyomas are rare, bilateral ones being rarer. Literature available on these rare tumors documents only four cases in children less than 12 years of age. All cases in literature have been associated with AIDS or some other immunodeficiency state. Here we present a rare case of large, ...
Velat Gregory J - - 2012
Object Intramedullary, or glomus, spinal arteriovenous malformations (AVMs) are rare vascular lesions amenable to resection with or without adjuvant embolization. The authors retrospectively reviewed the senior author's (R.F.S.'s) surgical series of intramedullary spinal AVMs to evaluate clinical and radiographic outcomes. Methods Detailed chart and radiographic reviews were performed for all ...
Yu Ming - - 2012
Thioethers have been proven to be reliable directing groups for palladium catalyzed alkenylation of arenes via C-H activation. Mechanistic investigation reveals that the C-H cleavage of arenes is the turnover-limiting step, and an acetate-bridged dinuclear cyclopalladation intermediate is involved. The alkenylated thioethers can be easily removed and transformed into a ...
Yang Chung-Yao - - 2012
Developing artificial scaffolding structures in vitro in order to mimic physiological-relevant situations in vivo is critical in many biological and medical arenas including bone and cartilage generation, biomaterials, small-scale biomedical devices, tissue engineering, as well as the development of nanofabrication methods. We focus on using simple physical principles (photolithography) and chemical techniques ...
Johnson Benjamin B - - 2012
Changes in cholesterol content of cell membranes affect many physiological and pathological events including the formation of arterial plaques, virus entry to cells, and receptor organization. Measuring trafficking and distribution of cholesterol is essential to understand how cells regulate sterol levels in membranes. Perfringolysin O (PFO) is a cytolysin secreted ...
Wan Rong - - 2012
Osteoarthritis (OA), with a high prevalence and economic impact, is a progressive diarthrodial joint disease that substantially reduces quality of life and is mainly characterized by degradation of the extracellular matrix (ECM) and the loss of a chondrogenic phenotype in articular cartilage. Strategic targeting of therapeutic genes to OA cartilage ...
Tremoulet Adriana H AH Department of Pediatrics, University of California at San Diego and Rady Children's Hospital, La Jolla, CA, - - 2012
To describe the clinical course and outcome of 10 patients with Kawasaki disease (KD) treated with a calcineurin inhibitor after failing to respond to multiple therapies. Demographic and clinical data were prospectively collected using standardized case report forms. T-cell phenotypes were determined by flow cytometry, and KD risk alleles in ...
Asari Reza - - 2012
BACKGROUND: The purpose of this study was to evaluate the frequency of malignancy, oncologic outcome and perioperative morbidity between small (≤60 mm) and large (>60 mm) adrenal tumors treated by endoscopic adrenalectomy (EA). METHODS: EA was performed in 289 consecutive patients with a mean follow-up of 87.7 ± 45.1 months. ...
Zuo Zhili - - 2012
Physical penetration and infectivity penetration of adenovirus and influenza virus aerosols through respirators were measured to better characterize the effectiveness of filtering facepiece respirators against airborne virus. A physical penetration of 2%-5% was found. However, large sample-to-sample variation made it difficult to quantify the difference in physical penetration caused by ...
Parmar Malin - - 2012
In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology ...
Namdari Surena - - 2012
BACKGROUND: The number of times an article has been cited has been used as a marker of its influence in a medical specialty. The purpose of this study was to determine the 50 most cited articles in shoulder surgery and their characteristics. METHODS: Science Citation Index Expanded was searched for ...
Kang Hahk-Soo - - 2012
Stigonemapeptin (1), a depsipeptide containing an Ahp (3-amino-6-hydroxy-2-piperidone) residue, was isolated from a bloom sample of the freshwater cyanobacterium Stigonema sp. collected from North Nokomis Lake in the Highland Lake District of northern Wisconsin. The planar structure was determined by 1D and 2D NMR experiments as well as HRESIMS analysis. ...
Cossa Daniel - - 2012
Methylmercury (MeHg) determinations in hake, its food-chain, and the surrounding waters and sediments, allowed us to show that the higher length or age normalized mercury concentrations of North-western Mediterranean (Gulf of Lions: GoL) muscle hakes compared to its North-eastern Atlantic (Bay of Biscay: BoB) counterpart are due to both biotic ...
Chokoe Mmaphuti Jackie - - 2012
Abstract Background: Necrotizing Enterocolitis (NEC) is the most common gastrointestinal emergency in neonates and is associated with significant morbidity and mortality. An association between HIV-positive maternal status and increased risk of NEC in preterm infants has been described and antiretroviral therapy has been proposed as an independent risk factor. Aim: ...
Koyama Alain A Northern California Institute For Research and Education, San Francisco, CA, USA. - - 2013
We investigated the association between serum level of oxidized low-density lipoprotein (oxLDL) and risk of cognitive impairment (dementia or mild cognitive impairment) among 572 nondemented community-dwelling women from a prospective cohort study of aging. After 5 years of follow-up, 228 (39.9%) developed cognitive impairment; and this did not differ by ...
Baño-Rodrigo Antonio - - 2012
In cystic fibrosis (CF) patients the right ventricle (RV) suffers a progressive deterioration, but it is not clear when these changes begin. The aim of this study was to analyze the RV function in CF patients with mild respiratory disease. Color-Doppler-Echocardiographic studies were prospectively performed in CF adolescent patients and ...
Ferrara Skylar J - - 2012
A synthesis of 1-(thioacetyl)triptycene (5), a convenient protected form of 1-(thiolato)triptycene [STrip](-), is described, a key transformation being the high yield conversion of tert-butyl 1-triptycenyl sulfide (8) to 5 by a protocol employing BBr(3)/AcCl. Syntheses of the two-coordinate copper(I) compounds [Bu(4)N][Cu(STrip)(2)], [Bu(4)N]10, and [(Cu(IMes)(STrip)] (13) proceed readily by chloride displacement ...
Gao Huile - - 2012
The treatment of a brain glioma is still one of the most difficult challenges in oncology. To effectively treat brain glioma and reduce the side effects, drugs must be transported across the blood brain barrier (BBB) and then targeted to the brain cancer cells because most anti-tumor drugs are highly ...
Kim Jang Il - - 2012
To overcome the unresolved issues of conventional therapeutic approaches such as radiation therapy, chemotherapy, combinational chemotherapy, and surgical treatment, we designed an injectable 'MRI-monitored long-term therapeutic hydrogel (MLTH)' system as an alternative/adjuvant approach for brain tumors. The MLTH system consists of a thermosensitive/magnetic poly(organophosphazene) hydrogel (the magnetic hydrogel) as a ...
Sulzer Philipp - - 2012
Fears of terrorist attacks have led to the development of various technologies for the real-time detection of explosives, but all suffer from potential ambiguities in the assignment of threat agents. Using proton transfer reaction mass spectrometry an unusual bias dependence in the detection sensitivity of 2,4,6 trinitrotoluene (TNT) on the ...
Vangeel I - - 2012
Bluetongue virus serotype 8 (BTV-8) emerged in Central Western Europe in 2006 causing a large scale epidemic in 2007 that involved several European Union (EU) countries including Belgium. As in several other EU member states, vaccination against BTV-8 with inactivated vaccines was initiated in Belgium in spring 2008 and appeared ...
Dumont Travis M - - 2012
Object Several randomized trials have emerged with conflicting data on the overall safety of carotid artery stenting (CAS) in comparison with carotid endarterectomy (CEA). The authors hypothesize that changes in national trends correspond to publication of randomized trials, including an increase in utilization of CAS after publication of trials favorable ...
Wang Zheng - - 2012
Nanog, Oct4, and Sox2 are the core regulators of mouse (m)ESC pluripotency. Although their basic importance in human (h)ESCs has been demonstrated, the mechanistic functions are not well defined. Here, we identify general and cell-line-specific requirements for NANOG, OCT4, and SOX2 in hESCs. We show that OCT4 regulates, and interacts ...
Lunsky Yona - - 2012
BACKGROUND: The objective of the current study is to arrive at a better understanding of individuals with intellectual disability (ID) who threaten or attempt suicide. METHODS: From a sample of 751 adults with ID who experienced a crisis, demographic and clinical profiles of 39 adults who threatened to commit suicide ...
Radcliff Kristen - - 2012
The load-sharing score (LSS) of vertebral body comminution is predictive of results after short-segment posterior instrumentation of thoracolumbar burst fractures. Some authors have posited that an LSS > 6 is predictive of neurological injury, ligamentous injury, and the need for surgical intervention. However, the authors of the present study hypothesized ...
Tai Patricia - - 2012
PURPOSE: It is commonly believed that prostate cancer patients with very high prostate-specific antigen (PSA) levels are unlikely to benefit from definitive local treatment, and patients with very high PSA are often underrepresented in, or excluded from, randomized clinical trials. Consequently, little is known about their optimal treatment or prognosis. ...
Niemeyer Helen - - 2012
OBJECTIVE: Meta-analyses are prone to publication bias, the problem of selective publication of studies with positive results. It is unclear whether the efficacy of psychotherapeutic interventions for schizophrenia is overestimated due to this problem. This study aims at enhancing the validity of the results of meta-analyses by investigating the degree ...
Yılmaz Osman - - 2012
OBJECTIVE: In juvenile idiopathic arthritis (JIA) cardiac involvement is usually silent without typical symptoms. The purpose of this study was to assess left ventricular functions with tissue Doppler echocardiography (TDE), strain and strain rate in children with JIA. METHODS: Our study was designed as a cross-sectional observational study. Thirty pediatric ...
Luo Zhipu - - 2012
Perfluorooctane sulfonate (PFOS) is a man-made fluorosurfactant and globally persistent organic pollutant. PFOS is mainly distributed in blood with a long half-life for elimination. PFOS was found mainly bound to human serum albumin (HSA) in plasma, the most abundant protein in human blood plasma, which transports variety of endogenous and ...
Perkins Z B - - 2012
BACKGROUND: Laryngoscopy and tracheal intubation provoke a marked sympathetic response, potentially harmful in patients with cerebral or cardiovascular pathology or haemorrhage. Standard pre-hospital rapid sequence induction of anaesthesia (RSI) does not incorporate agents that attenuate this response. It is not known if a clinically significant response occurs following pre-hospital RSI ...
Staff Michael M New South Wales Health Department, North Sydney 2060, Australia. - - 2012
A total of 265000 m(3) of dioxin contaminated soil and sediments from past industrial activity was treated on site in an urban setting in Sydney, Australia. To respond to local community concerns about potential dioxin exposure from fugitive emissions a human biomonitoring study was undertaken. To determine whether local residents ...
Uraguchi Daisuke - - 2012
A new strategy for developing stereoselective bond-forming reactions is introduced; it takes advantage of the ionic nucleophilic catalysis of chiral ammonium betaines to simultaneously utilize vinylic esters as an enolate precursor and an acylating agent for coupling with electrophiles. Its synthetic utility is clearly demonstrated by realizing a highly diastereo- ...
Kleppe Maria - - 2012
In this issue of Cell Stem Cell, Heidel et al. (2012) use genetic and pharmacological approaches to reveal that Wnt/β-catenin signaling is required for leukemic stem cell (LSC) maintenance in chronic myeloid leukemia. They demonstrate that β-catenin inactivation targets imanitib-resistant LSCs in vivo.
Ota Megumi - - 2012
The study investigated age-related changes in the thickness of the deep and superficial abdominal muscles of 103 healthy women who could walk independently The participants were classified into five age groups: young (n=26; 20-24 years), young adult (n=26; 25-44 years), middle-aged (n=16; 45-64 years), young-old (n=16; 65-74 years), and old-old ...
Mory Adi - - 2012
Kohlschutter-Tonz syndrome (KTS) is a rare autosomal-recessive disorder of childhood onset, and it is characterized by global developmental delay, spasticity, epilepsy, and amelogenesis imperfecta. In 12 KTS-affected individuals from a Druze village in northern Israel, homozygosity mapping localized the gene linked to the disease to a 586,513 bp region (with a ...
Langen Katja M KM Department of Radiation Oncology, MD Anderson Cancer Center Orlando, Orlando, Florida, USA. - - 2012
To determine the daily and cumulative dosimetric effects of intrafraction prostate motion on step-and-shoot (SNS) intensity-modulated radiation therapy (IMRT) plans, to evaluate the correlation of dosimetric effect with motion-based metrics, and to compare on a fraction-by-fraction basis the dosimetric effect induced in SNS and helical tomotherapy plans. Intrafraction prostate motion ...
Gao Yan-Ping - - 2012
Incarvilleatone (1), an unprecedented dimeric cyclohexylethanoid analog with a racemic nature, was isolated from the whole plant of Incarvillea younghusbandii. HPLC chiral separation of 1 gave two enantiomers (-)-incarvilleatone and (+)-incarvilleatone. The structure of 1 was established by spectroscopic methods and single crystal X-ray diffraction. The absolute configurations of enantiomers ...
Takada Shimon - - 2012
Cryoglobulins are immunoglobulins that precipitate at low temperatures and redissolve upon rewarming. Cryoglobulinemia refers to the presence of circulating cryoglobulins in serum, and generally leads to a systemic inflammatory syndrome characterized by fatigue, arthralgia, purpura, neuropathy and glomerulonephritis. The disease mainly involves small to medium-sized blood vessels and causes vasculitis ...
Hehlgans Stephanie - - 2012
PURPOSE: Focal adhesion kinase (FAK), a main regulator of integrin signaling and cell migration, is frequently overexpressed and hyperphosphorylated in human head-and-neck squamous cell carcinoma (HNSCC). We have previously shown that pharmacologic FAK inhibition leads to radiosensitization of 3-dimensionally grown HNSCC cell lines. To further evaluate the role of FAK ...
Fuchs Noga - - 2012
OBJECTIVE: To address the consequences of surgical curettage following failed medical abortion. METHODS: A retrospective case-control study was performed in a tertiary gynecologic department. The case group comprised 104 women who underwent surgical curettage following failed medical abortion; the control group included 104 women who underwent early surgically induced abortion. ...
Bailey Arnold D - - 2012
Cockayne syndrome is a segmental progeria most often caused by mutations in the CSB gene encoding a SWI/SNF-like ATPase required for transcription-coupled DNA repair (TCR). Over 43Mya before marmosets diverged from humans, a piggyBac3 (PGBD3) transposable element integrated into intron 5 of the CSB gene. As a result, primate CSB ...
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