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Leng Ping - - 2012
OBJECTIVE: To investigate a compound technique including gene therapy, injectable tissue engineering and Mosaicplasty to reconstruct large osteochondral defect. METHODS: Plasmid vector containing hIGF-1 cDNA was created and transfected into BMSCs in vitro with FuGene6. After gene expression determination, cells were mixed with calcium alginate gel. Osteochondral defects were created ...
Zhou Qiao - - 2012
In this issue of Cell Stem Cell and in a recent issue of PNAS, Thier et al. (2012), Han et al. (2012), and Lujan et al. (2012) report the derivation of multipotent neural stem/progenitor cells from cultured mouse fibroblasts using distinct reprograming approaches.
Olguín Juan - - 2012
Four bis-tetradentate N(4)-substituted-3,5-{bis[bis-N-(2-pyridinemethyl)]aminomethyl}-4H-1,2,4-triazole ligands, L(Tz1)-L(Tz4), differing only in the triazole N(4) substituent R (where R is amino, pyrrolyl, phenyl, or 4-tertbutylphenyl, respectively) have been synthesized, characterized, and reacted with M(II)(BF(4))(2)·6H(2)O (M(II) = Cu, Ni or Co) and Co(SCN)(2). Experiments using all 16 possible combinations of metal salt and L(TzR) were ...
Chowdhury Forhad H - - 2012
Aims. Tuberculum sellae meningiomas (TSMs) are usually removed through a transcranial approach. Recently, the sublabial transsphenoidal microscopic approach has been used to remove such tumours. More recently, endonasal extended transsphenoidal approach is getting popular for removal of tuberculum sellae meningioma. Here, we describe our initial experience of endonasal extended transsphenoidal ...
Sharma Neeraj - - 2012
Lithium-ion batteries power many portable devices and in the future are likely to play a significant role in sustainable-energy systems for transportation and the electrical grid. LiFePO4 is a candidate cathode material for second-generation lithium-ion batteries, bringing a high rate capability to this technology. LiFePO4 functions as a cathode where ...
Kim Eunsook - - 2012
Background: We previously reported the partial effectiveness of imatinib (also known as STI571, Glivec, or Gleevec) on anaplastic thyroid cancer (ATC) cells. Imatinib is a selective tyrosine kinase inhibitor which has been used for various types of cancer treatments. Recently, several reports have demonstrated that imatinib enhanced the sensitivity of ...
Choudhary Umesh - - 2012
Base-catalyzed thiol-maleimide click chemistry has been applied to the synthesis of neutral donor-acceptor [2]rotaxanes in good yield. This method is extended further to the synthesis of a glutathione-functionalized [2]pseudorotaxane, a precursor to integrated conjugates of interlocked molecules with proteins and enzymes.
Yajima Yoshifumi - - 2012
DAX1 is an orphan nuclear receptor and involved in development of steroidogenic organs, which activates transcription of genes involved in steroidogenesis. In this study, we analyzed the function of the zebrafish dax1 during early development of central nervous systems to appear unidentified aspects of DAX1 and decrease confusions concerned with ...
Duan Ye - - 2012
Rabies is a fatal infectious disease requiring efficient protection provided by post-exposure prophylaxis (PEP) with rabies immunoglobulin (RIG). The single-chain Fv fragment (scFv) is a small engineered antigen binding protein derived from antibody variable heavy (V(H)) and light (V(L)) chains. This novel antibody format may potentially replace the current application ...
Kirillova Marina V - - 2012
The facile aqueous medium reactions of copper(II) nitrate with BES biobuffer [(HOCH(2)CH(2))(2)N(CH(2)CH(2)SO(3)H), hereinafter referred as H(3)bes] in the presence of various benzenecarboxylic acids [benzoic (Hba), 3-hydroxybenzoic (Hhba), and 3,5-dihydroxybenzoic (Hdhba) acid] and lithium hydroxide gave rise to the self-assembly generation of three new heterometallic Cu(II)/Li materials, [Li(H(2)O)(4)][Cu(4)(μ(2)-Hbes)(4)(μ(2)-ba)]·H(2)O (1) and [Cu(4)(μ(3)-Hbes)(4)(L){Li(H(2)O)(2)}](n)·3nH(2)O ...
van Elmpt Wouter - - 2012
PURPOSE: The local site of relapse in non-small cell lung cancer (NSCLC) is primarily located in the high FDG uptake region of the primary tumour prior to treatment. A phase II PET-boost trial (NCT01024829) randomises patients between dose-escalation of the entire primary tumour (arm A) or to the high FDG ...
Jalalirad Mohammad - - 2012
Abstract The 5' untranslated region of HIV-1 genomic RNA (gRNA) contains 2 stem-loops that appear equally important for gRNA dimerization: the 57-nt long 5' TAR, at the very 5' end, and the 35-nt long SL1 (nt 243-277). SL1 is well known for containing the dimerization initiation site (DIS) in its ...
Mühlhausen J - - 2012
Sarcoidosis is a multi-systemic disease. A 21-year-old female patient was admitted to our department with lymphadenopathy, B symptoms, erythema nodosum and joint pain. Sarcoidosis showed a very atypical course, lacking any pulmonary symptoms or typical laboratory values. The diagnosis was finally confirmed histologically and thus various differential diagnoses such as microbiological ...
Zhang Ping - - 2012
The human WWOX gene, known as WW domain-containing oxidoreductase, is located on 16q23.3-24.1, a chromosome region that spans the common fragile site, FRA16D. Abnormal transcripts or even loss of expression are frequently found in a number of cancer cell types, including breast, ovarian, prostate and lung cancer cells. It has ...
Kara Ibrahim - - 2012
OBJECTIVE: The aim of this study is to evaluate our early and mid- term results and the qualities of life of the patients aged eighty years or older who underwent heart surgery. METHODS: Eighty- eight patients aged 80 years and older who underwent open-heart surgery at Göztepe ┼×afak Hospital between ...
Mochizuki Kazuki - - 2012
OBJECTIVE: In this study, we examined the relations between the rate of eating and circulating interleukin (IL)-1β and IL-6 levels in Japanese men not being treated for metabolic diseases. METHODS: We conducted a cross-sectional study of 170 men 40 to 59 y old (mean ± standard deviation, 51.4 ± 5.7 ...
Blanco-Lomas Marina - - 2012
The reversible photo-control of biomolecules requires chromophores that can efficiently undergo large conformational changes upon exposure to wavelengths of light that are compatible with living systems. We designed a benzylidene pyrroline chromophore that mimics the Schiff base of rhodopsin and can be used to introduce light-switchable intramolecular cross-links in peptides ...
Unsal Cuneyt - - 2012
BACKGROUND: The present study was performed to evaluate plasma adiponectin levels in the patients with PD. METHOD: The study group included a total of 28 patients (17 females, 11 males) and 23 age- and sex-matched healthy comparison subjects (10 females and 13 males). The plasma fasting glucose, total cholesterol, triglyceride, ...
Kim Youn Jeong - - 2012
This study examined the incidence of and risk factors for development of vancomycin-resistant enterococci (VRE) infection and death in VRE-colonized patients in a medical intensive care unit. VRE colonization was identified in 184 patients (17.6%) in whom VRE perianal swab cultures were obtained. Of these, 28 (11.9%) developed VRE infection. ...
Anastay M - - 2012
PURPOSE OF THE STUDY: The global epidemiology of extended spectrum betalactamases (ESBL) producing Enterobacteriaceae has evolved in recent years with the emergence of a new type of ESBL: CTX-M, mainly in Escherichia coli. These CTX-M type producing Enterobacteriaceae are responsible for both nosocomial and, more recently, community infections, including urinary ...
Deublein Stephan - - 2012
New Lennard-Jones plus point charge models are developed for earth-alkali cations. The cation parameters are adjusted to the reduced liquid solution density of aqueous earth-alkali halide salt solutions at a temperature of 293.15 K and a pressure of 1 bar. This strategy is analogous to the one that was recently ...
Wu Osmond C - - 2012
Among the families that have influenced the development of modern medicine into what it is today, the Monro lineage stands as one of the most notable. Alexander Monro primus (1697-1767) was the first of 3 generations with the same name, a dynasty that spanned 126 years occupying the Chair of ...
Espinal Laura - - 2012
The development of sorbents for next-generation CO2 mitigation technologies will require better understanding of CO2/sorbent interactions. Among the sorbents under consideration are shape selective microporous molecular sieves with hierarchical pore morphologies of reduced dimensionality. We have characterized the non-equilibrium CO2 sorption of OMS-2, a well known one-dimensional (1D) microporous octahedral ...
Luo Cheng-Ming - - 2012
To evaluate the long-term voice characteristics and quality of life of early glottic cancer patients after definitive treatment. Case series with chart review in a tertiary care medical center in Taiwan. Forty-two consecutive patients who received radiation therapy (RT) or transoral laser microsurgery (TLM) for early glottic cancer over 12 ...
Celik Mehmet - - 2012
OBJECTIVE: Advanced age, dilated right atrium, increased preoperative pulmonary artery pressure, increased right atrial pressure, technique of operation, and poor ventricular function were reported to be risk factors for postoperative arrhythmia. Aim of this study is to determine the risk factor for postoperative arrhythmia after Fontan operation with regard to ...
Zhang Weiwei - - 2012
The electron mobilities of two n-type pentacenequinone derivative organic semiconductors, 5,7,12,14-tetraaza-6,13-pentacenequinone (TAPQ5) and 1,4,8,11-tetraaza-6,13-pentacenequinone(TAPQ7), are investigated with use of the methods of electronic structure and quantum dynamics. The electronic structure calculations reveal that the two key parameters for the control of electron transfer, reorganization energy and electronic coupling, are similar ...
Tanpowpong Pornthep - - 2012
OBJECTIVES: To determine independent predictors of gluten avoidance and of a physician's decision to initiate a gluten-free diet (GFD) in children and adolescents without confirmed celiac disease. STUDY DESIGN: We performed a structured medical record review of 579 patients aged 1-19 years presenting for evaluation of celiac disease between January ...
Yang Hao - - 2012
In an effort to biochemically characterize metallo-β-lactamase NDM-1, several maltose binding protein (MBP)/NDM-1 fusion proteins with different N-termini (full-length, Δ6, Δ21, and Δ36) were cloned, over-expressed, purified, and characterized. All MBP/NDM-1 fusion proteins were soluble; however, only one, MBP-NDM-1Δ36 exhibited high activity and bound 2 equivalents of Zn(II). Thrombin cleavage ...
Sun Fang - - 2012
Myricetin, a naturally occurring phytochemical, has potent anticancer-promoting activity and contributes to the chemopreventive potential of several foods. In this preliminary study, we evaluate the chemopreventive potential of myricetin against bladder cancer and its mechanism of action. The results of a MTT assay showed that myricetin was able to inhibit ...
Teramura-Grönblad Mariko - - 2012
OBJECTIVES: To (1) explore clinical and demographic characteristics of users and nonusers of PPIs in 3 cohorts of institutionalized older people in Finland, and (2) compare the risk of death associated with use of PPIs in each setting. DESIGN: Cross-sectional assessment of 3 institutionalized cohorts with 1-year follow-up of all-cause ...
Caretta-Weyer Holly - - 2012
BACKGROUND: Our objective was to evaluate the impact of preoperative axillary ultrasound and core needle biopsy (CNB) on breast cancer treatment decision making. A secondary aim was to evaluate the impact on the utility of intraoperative sentinel lymph node (SLN) frozen section. METHODS: A review of 84 patients with clinically ...
Fuller Mark E - - 2012
The dissolution of the 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) from microscale particles (<250μm) of the explosive formulation Composition B was examined and compared to dissolution from macroscopic particles (>0.5mm). The dissolution of explosives from detonation soot was also examined. The measured mass transfer coefficients for the microscale particles ...
Choi Jin Hwan - - 2012
Flexible and transparent gas-diffusion barriers have played an important role in recent years. The present study describes a flexible barrier film with a tailored architecture of cationic polyelectrolytes and clay/polymer nanoassemblies. Highly oriented and well aligned barrier films were achieved by the consecutive absorption of flexible cationic polymer and anionic ...
Kobayashi Hirokazu - - 2012
We report nanosize-induced hydrogen storage in Ir, which does not absorb hydrogen in its bulk form. The mean diameter of the obtained Ir nanoparticles was estimated to be 1.5 ± 0.5 nm by transmission electron microscopy. Hydrogen storage has been confirmed from solid-state <sup>2</sup>H NMR and hydrogen pressure-composition isotherm measurements.
Erdal Nurten - - 2012
AIMS: To investigate the effect of insulin therapy on biomechanical properties of bone in streptozotocin (STZ)-induced type 1 diabetes mellitus (T1DM) in rats. METHODS: A total of 28 male Wistar-Albino rats (12-week-old; 210-300g) were divided into 4 groups (n=7 for each) including control [C; no treatment], sham [Sh; distilled water ...
Natelson Douglas - - 2012
Mechanical break junctions, particularly those in which a metal tip is repeatedly moved in and out of contact with a metal film, have provided many insights into electronic conduction at the atomic and molecular scale, most often by averaging over many possible junction configurations. This averaging throws away a great ...
Salciccioli Michael - - 2012
Fundamental knowledge of the elementary reaction mechanisms involved in oxygenate decomposition on transition metal catalysts can facilitate the optimization of future catalyst and reactor systems for biomass upgrade to fuels and chemicals. Pt catalyzed decomposition of glycolaldehyde, as the smallest oxygenate with alcohol and aldehyde functionality, was studied via a ...
Phethean Jill - - 2012
The purpose of this study was to determine if plantar pressure data in 4-7 year old children with normal development: (1) required normalising by body mass and/or body mass index and (2) should be separated or pooled for boys and girls. The outcome will guide the management of plantar pressure ...
Qian Erin Wei - - 2012
Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl β-d-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protective role of 1 in human erythrocytes remains unclear. This study ...
Steinsträter Olaf - - 2012
PURPOSE: A method was developed to convert clinically prescribed RBE (Relative Biological Effectiveness)-weighted doses from the approach used at the Heavy-Ion Medical Accelerator (HIMAC) at the National Institute of Radiological Science, Chiba, Japan, to the LEM (Local Effect Model)-based TReatment planning for Particles (TRiP98) approach used in the pilot project ...
Taïb Nada - - 2012
Nucleolipids are currently under investigation as vectors for oligonucleotides (ON) delivery thanks to their supramolecular organisation properties and their ability to develop specific interactions (i.e. stacking and potential Watson and Crick hydrogen bonds) for lipoplexes formation. To investigate the factors that govern the interaction events at a molecular level and ...
Scholtysek Peggy - - 2012
The T-shaped amphiphilic molecule A6/6 forms a columnar hexagonal liquid-crystalline phase between the crystalline and the isotropic liquid when studied in bulk (Chen et al., 2005). Due to the hydrophilic and flexible oligo(oxyethylene) side chain terminated by an 1-acylamino-1-deoxy-D-sorbitol moiety attached to a rigid terphenyl core with terminal hexyloxy alkyl ...
Matsushita Akihito - - 2012
BACKGROUND: Selection of a cannulation site for the repair of acute type A aortic dissection remains controversial. Several cannulation sites have been introduced, but each is associated with a risk of adverse complications. Transapical cannulation is a simple procedure to restore antegrade blood flow during ECC. However the efficacy of ...
Pandey Paritosh - - 2012
Object Grade III arteriovenous malformations (AVMs) are diverse because of their variations in size (S), location in eloquent cortex (E), and presence of central venous drainage (V). Because they may have implications for management and outcome, the authors evaluated these variations in the present study. Methods Between 1984 and 2010, ...
Shen Chun - - 2012
This paper presents a novel in-situ method to prepare mono-dispersed palladium nanoparticles supported on porous glass beads with an egg-shell structure at room temperature. This method integrates two processes of ion exchange and reduction in one step just by changing the solvent from water to alcohol. The mono-dispersed Pd nanoparticles ...
Tsipouras Markos G - - 2012
OBJECTIVE: In this study, a methodology is presented for an automated levodopa-induced dyskinesia (LID) assessment in patients suffering from Parkinson's disease (PD) under real-life conditions. METHODS AND MATERIAL: The methodology is based on the analysis of signals recorded from several accelerometers and gyroscopes, which are placed on the subjects' body ...
Maneerat Wisanu - - 2012
Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, ...
Wang Shouliang - - 2012
A series of novel chiral-bridged atropisomeric monophosphine ligands were synthesized via convenient and simple pathways. The prepared ligands, especially for ligand 7d, were found to be highly effective in the Pd-catalyzed Suzuki-Miyaura coupling reaction. The steric hindrance and electronic effect of substrates on the reactivity and enantioselectivity were explored preliminarily.
Choi Suk Hyun - - 2012
Partial acid hydrolysis of the tetrasaccharide (lycotetraose) side chain of the tomato glycoalkaloid α-tomatine resulted in the formation of four products with three, two, one, and zero carbohydrate side chains, which were separated by high-performance liquid chromatography (HPLC) and identified by thin-layer chromatography (TLC) and liquid chromatography ion-trap time-of-flight mass ...
Ando Takashi - - 2012
OBJECTIVE: Helicobacter pylori is known to affect the host's nutritional status. This study was performed to elucidate the relationship between H. pylori status and the dynamics of the ghrelin system, in the context of ghrelin O-acyltransferase (GOAT) expression. METHODS: We conducted a clinical study of 30 subjects focusing on the ...
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