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Teo Bryon J X BJ Yong Loo Lin School of Medicine, National University of Singapore, Singapore, - - 2013
Recent advances have been made in using chondrocytes and other cell-based therapy to treat cartilage defects in adults. However, it is unclear whether these advances should be extended to the adolescent and young adult-aged patients. We assessed cell-based surgical therapy for patellar osteochondritis dissecans (OCD) in adolescents and young adults ...
Maturen Katherine E KE Department of Radiology, University of Michigan Hospitals, 1500 E Medical Center Drive, UH B1D530H, Ann Arbor, MI 48109-5030, USA. - - 2013
Renal vein leiomyosarcoma is a rare tumor whose clinical and imaging features can significantly overlap with those of advanced primary renal neoplasms, particularly renal cell carcinoma. IRB approval was obtained for a retrospective review of clinical and imaging information for five patients with the pathologically proven diagnosis of renal vein ...
O'Donnell Marie Anne - - 2012
The mechanisms regulating cell survival and thus its corollary, cell death, have been intensively studied over the last two decades. Recent studies have shed new light into how non-degradative ubiquitination of the kinase RIPK1 is critical in determining this cell fate. In this review, we summarize recent findings on how ...
Cunningham-Rundles Charlotte - - 2012
While primary immune defects are generally considered to lead to severe and easily recognized disease in infants and children, a number of genetic defects impairing B cell function may not be clinically apparent or diagnosed until adult life. The commonest of these is common variable immune deficiency, the genetic origins ...
van Assema Daniëlle M E - - 2012
P-glycoprotein (Pgp) is an efflux transporter involved in transport of several compounds across the blood-brain barrier (BBB). Loss of Pgp function with increasing age may be involved in the development of age-related disorders, but this may differ between males and females. Pgp function can be quantified in vivo using (R)-[(11)C]verapamil ...
Chorny Alejo - - 2012
Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T-cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a ...
Hoefsmit Nicole - - 2012
In many Western countries, a vast amount of interventions exist that aim to facilitate return to work (RTW) after sickness absence. These interventions are usually focused on specific target populations such as employees with low back pain, stress-related complaints or adjustment disorders. The aim of the present study is to ...
Petralia Ronald S RS Advanced Imaging Core, NIDCD/NIH, Bethesda, MD, 20892, - - 2012
The Sonic hedgehog (Shh) signaling pathway carries out a wide range of biological functions such as patterning of the embryonic neural tube and expansion of cerebellar granule cell precursors. We previously have found that the Shh signaling receptors, Patched1 (Ptch1) and Smoothened (Smo), are expressed in hippocampal neurons of developing ...
Kidd Sharon A SA School of Public Health, University of California, 101 Haviland Hall, Berkeley, CA 94720, USA. - - 2012
We examined daytime salivary cortisol and salivary alpha-amylase (sAA) secretion levels and variability in preschool-aged children with autism (AUT) and typically developing children (TYP). Fifty-two subjects (26 AUT and 26 TYP) were enrolled. Salivary samples were obtained at waking, midday, and bedtime on two consecutive days at three phases (baseline, ...
Geana Mugur V MV William Allen White School of Journalism and Mass Communications, University of Kansas, Lawrence, KS 66045, USA. - - 2012
American Indians and Alaska Natives suffer significant health disparities for many infectious and chronic diseases as compared to the general population. Providing accurate and culturally tailored health information to underserved groups has been shown to influence health behaviors and health outcomes. Little prior research has explored American Indians health information ...
Kwan Wing-hong WH Department of Medicine, Recanati Miller Transplant Institute and Immunology Institute, Mount Sinai School of Medicine, Box 1243, One Gustave L. Levy Plaza, New York, NY 10029, - - 2012
Results of studies published since 2002 reveal that T cells and antigen-presenting cells (APCs) produce complement proteins. The immune cell-derived, alternative pathway complement components activate spontaneously, yielding local, but not systemic, production of C3a and C5a. These anaphylatoxins bind to their respective G-protein-coupled receptors, C3aR and C5aR, expressed on both ...
Noumeir Rita - - 2012
The Digital Imaging and Communications in Medicine (DICOM) is the standard for encoding and communicating medical imaging information. It is used in radiology as well as in many other imaging domains such as ophthalmology, dentistry, and pathology. DICOM information objects are used to encode medical images or information about the ...
Strand Michael T - - 2012
Working memory (WM) is considered a core deficit in Attention-Deficit/ Hyperactivity Disorder (ADHD), with numerous studies demonstrating impaired WM among children with ADHD. We tested the degree to which WM in children with ADHD was improved by performance-based incentives, an analog of behavioral intervention. In two studies, WM performance was ...
Rademakers L M - - 2012
We describe a case of critical hand ischaemia after transradial cardiac catheterisation. The patient presented with hand ischaemia 5 days after transradial coronary angiography. Urgent angiography demonstrated radial artery occlusion with embolisation to the palmar arch and digital arteries. The ischaemia was refractory to an extensive thrombolytic regimen, and subsequently, the ...
Lu Wenping - - 2012
Deleterious mutations in the RAD51C gene, which encodes a DNA double-strand break repair protein, have been reported to confer high-penetrance susceptibility to both breast and ovarian cancer. To confirm this we conducted a mutation screen of the RAD51C gene in 192 probands from high-risk breast and/or ovarian cancer families that ...
Coffman Donna L DL The Methodology Center, The Pennsylvania State University, 204 E. Calder Way, Ste. 400, State College, PA 16801, USA. - - 2012
Researchers often hypothesize that a causal variable, whether randomly assigned or not, has an effect on an outcome behavior and that this effect may vary across levels of initial risk of engaging in the outcome behavior. In this paper, we propose a method for quantifying initial risk status. We then ...
Aries Marcel J H MJ Academic Neurosurgery Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. - - 2012
Guidelines for the management of traumatic brain injury (TBI) call for the development of accurate methods for assessment of the relationship between cerebral perfusion pressure (CPP) and cerebral autoregulation and to determine the influence of quantitative indices of pressure autoregulation on outcome. We investigated the relationship between slow fluctuations of ...
Feldman Laurie Beth LB University at Albany, State University of New York, Albany, NY SS 369, USA. - - 2012
Semantically similar (e.g., coolant-COOL) primes have produced greater facilitation than have form-similar but semantically dissimilar (e.g., rampant-RAMP) primes when English words have appeared in the forward-masked primed lexical decision task (Feldman, O'Connor, & Moscoso del Prado Martín, Psychonomic Bulletin & Review 16: 684-691, 2009). These results challenge claims that form-based, ...
Youssef Nagy A - - 2012
Emerging data suggest that second-generation antipsychotics such as aripiprazole may be effective in the treatment of post-traumatic stress disorder (PTSD). However, few clinical trials have used aripiprazole in PTSD, and data are limited on its use in Veterans with PTSD. The objective of this pilot trial was to investigate the ...
Vaina Lucia M - - 2012
Previous studies investigating transfer of perceptual learning between luminance-defined (LD) motion and texture-contrast-defined (CD) motion tasks have found little or no transfer from LD to CD motion tasks but nearly perfect transfer from CD to LD motion tasks. Here, we introduce a paradigm that yields a clean double dissociation: LD ...
Carlson Dustin A - - 2012
The Chicago Classification for esophageal motility disorders was developed to complement the enhanced characterization of esophageal motility provided by high-resolution esophageal pressure topography (HREPT) as this new technology has emerged within clinical practice. This review aims to summarize the evidence supporting the evolution of the classification scheme since its inception. ...
Baldwin David S - - 2012
The purpose of this study was to investigate the long-term maintenance of the efficacy of Lu AA21004 5 or 10 mg/day in the prevention of relapse in patients with generalized anxiety disorder (GAD). Patients (n = 687) with a primary diagnosis of GAD (DSM-IV criteria) and a baseline Hamilton Anxiety ...
Byrd John C - - 2012
Lucatumumab is a fully humanized anti-CD40 antibody that blocks interaction of CD40L with CD40 and also mediates antibody-dependent cell-mediated cytotoxicity (ADCC). We evaluated lucatumumab in a phase I clinical trial in chronic lymphocytic leukemia (CLL). Twenty-six patients with relapsed CLL were enrolled on five different dose cohorts administered weekly for ...
Fletcher Nicholas D - - 2012
Early Onset Scoliosis (EOS) may be associated with long-term pulmonary morbidity, which is not commonly seen in Adolescent Idiopathic Scoliosis. Initial evaluation is based on determining any underlying etiology related to congenital or syndromic conditions. Assessing the impact of scoliosis on thoracic development may help guide treatment, which is often ...
Lieberman Jay A - - 2012
This review summarizes recent reports on nonallergen-specific therapies for food allergy. These therapies are especially appealing for food allergy because unlike allergen-specific immunotherapy, they would allow the treatment of multiple food allergies in a single patient with one therapy. Chinese herbal therapy, anti-IgE, probiotics, engineered lactic acid bacteria, and helminth ...
Wertheim Jason A - - 2012
The success of liver transplantation has increased over the past 20 years due to improved immunosuppressive medications, surgical technique and donor-recipient selection. To date, the number of patients waiting for a liver transplant exceeds the number of transplants performed yearly by over a 2 : 1 ratio. Despite efforts to expand the ...
Bultink Irene E M - - 2012
Inflammatory joint diseases such as rheumatoid arthritis, as well as other rheumatic conditions, such as systemic lupus erythematosus (SLE) and ankylosing spondylitis, comprise a heterogeneous group of joint disorders that are all associated with extra-articular side effects, including bone loss and fractures. The concept of osteoimmunology is based on growing ...
Yang Yongping - - 2012
We assessed the safety and efficacy of sorafenib with cryotherapy (cryoRx) in advanced hepatocellular carcinoma (HCC). One hundred four HCC patients were enrolled, who met the following criteria: (i) Barcelona Clinic Liver Cancer stage C; (ii) HCC without distant metastasis; (iii) the presence of portal vein thrombosis (PVT); (iv) Child-Pugh ...
Goldschmidt-Clermont Pascal J - - 2012
Atherosclerosis is a peculiar form of inflammation triggered by cholesterol-rich lipoproteins and other noxious factors such as cigarette smoke, diabetes mellitus, and hypertension. Genetics also play an important role in the disease, accounting for about 40% of the risk. Of surprise in recent years of post-human genome sequencing, atherosclerosis-relevant genes ...
Pohl Daniela - - 2012
Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease, characterized by an acute onset of polyfocal central nervous system (CNS) deficits, including encephalopathy, demonstrating multifocal lesions on MRI. ADEM is typically a monophasic disorder, but recurrent and multiphasic courses have been described. Furthermore, an ADEM presentation has been reported in ...
Butt Zeeshan - - 2012
In this review, we briefly summarize three fruitful, emerging areas in liver transplantation research, quality of life; risk assessment; and patient safety. Our goal is to highlight recent findings in these areas, with a call for increased integration of social scientists and transplant clinicians to address how best to shape ...
Morris Huw R HR MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK. - - 2012
There is a clinical and pathological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). A number of autosomal-dominant genes have been described that primarily cause ALS or FTLD such as progranulin (GRN), valosin-containing protein (VCP), and TAR DNA-Binding Protein (TARDBP), and for each of these conditions there ...
Bar-Lev Adi A Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, - - 2012
Disease states characterized by abnormal cellular function or proliferation frequently reflect aberrant genetic information. By revealing disease-specific DNA mutations, we gain insight into normal physiology, pathophysiology, potential therapeutic targets and are better equipped to evaluate an individual's disease risks. This review examines recent advances in our understanding of the genetic ...
Chen Neal X NX Division of Nephrology, Department of Medicine, Indiana University School of Medicine, 950 West Walnut Street, R2-Room 219, Indianapolis, IN 46202, USA. - - 2012
Vascular calcification can occur in nearly all arterial beds and in both the medial and intimal layers. The initiating factors and clinical consequences depend on the underlying disease state and location of the calcification. The best studied manifestation is coronary artery calcification, in part because of the obvious clinical consequences, ...
Gray Simon M SM Child Study Center, Yale University School of Medicine, New Haven, CT 06520, - - 2012
Several studies have examined levels of proinflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. This meta-analysis was conducted to examine the association between obsessive-compulsive disorder (OCD) and plasma serum levels of proinflammatory cytokines. Twelve studies met inclusion criteria. The meta-analysis demonstrated a significant reduction in IL-1β ...
Kitchens William H WH Emory Transplant Center, Emory University, Atlanta, GA, - - 2012
Recent evidence suggests that alloreactive memory T cells are generated by the process of heterologous immunity, whereby memory T cells arising in response to pathogen infection crossreact with donor antigens. Because of their diminished requirements for costimulation during recall, these pathogen-elicited allocrossreactive memory T cells are of particular clinical importance, ...
Yri Olav E OE Division for Surgery and Cancer Medicine, Institute for Cancer Research, The Norwegian Radium Hospital and Oslo University Hospital, Oslo, Norway. - - 2012
We genotyped 224 patients with Hodgkin lymphoma (HL) and 1056 healthy controls and related the risk for HL and outcome of chemotherapy treatment to polymorphisms in genes encoding interleukins and metabolizing enzymes by capillary electrophoresis. Patients with the UGT1A1 TA tandem repeat TA6/6 genotype had a poorer overall survival (OS) ...
Lieleg Oliver - - 2012
Mucus is a porous biopolymer matrix that coats all wet epithelia in the human body and serves as the first line of defense against many pathogenic bacteria and viruses. However, under certain conditions viruses are able to penetrate this infection barrier, which compromises the protective function of native mucus. Here, ...
Thiemens Mark H - - 2012
Historically, the physical chemistry of isotope effects and precise measurements in samples from nature have provided information on processes that could not have been obtained otherwise. With the discovery of a mass-independent isotopic fractionation during the formation of ozone, a new physical chemical basis for isotope effects required development. Combined ...
Domcke Wolfgang - - 2012
This review describes how conical intersections affect measured molecular spectra and simple photofragmentation processes. We consider excitations that result in electron ejection, that is, photoionization or photodetachment, as well as photoinduced H-atom elimination. Section 1 presents a brief overview of the history of conical intersections and their rise from an ...
Fryd Michael M - - 2012
Recent advances in the growing field of nanoemulsions are opening up new applications in many areas such as pharmaceuticals, foods, and cosmetics. Moreover, highly controlled nanoemulsions can also serve as excellent model systems for investigating basic scientific questions about soft matter. Here, we highlight some of the most recent developments ...
Giovambattista N - - 2012
The behavior of water confined on nanometer length scales is important in a diverse set of technical and scientific contexts, ranging from the performance of fuel cells and biological molecular machines to the design of self-assembling nanoscale materials. Here, we review recent insights into the structure and thermodynamics of confined ...
Sisson James C - - 2012
Since 1981, meta-iodobenzylguanidine (MIBG), labeled with (131)I and later (123)I, has become a valuable agent in the diagnosis and therapy of a number of endocrine tumors. Initially, the agent located pheochromocytomas and paragangliomas (PGLs), both sporadic and familial, in multiple anatomic sites; surgeons were thereby guided to excisional therapies, which ...
Nyquist Sharon K - - 2012
This article describes the unique practice of nurse-driven titration of continuous insulin infusion in post-cardiac surgery patients in the intensive care unit at a tertiary care teaching hospital. A prospective quality assurance study was conducted to support our innovative practice.
Nakajo Masatoyo - - 2012
PURPOSE:: To compare primary tumor F-fluorodeoxyglucose (FDG) maximum standardized uptake value (SUVmax) and diffusion-weighted imaging (DWI) apparent diffusion coefficient (ADC) obtained in the same patients with head and neck squamous cell carcinoma (HNSCC) to clarify the prognostic significance of both indexes. MATERIALS AND METHODS:: The study population comprised 26 patients ...
Karantanis Dimitrios - - 2012
Squamous papilloma is one of the most common benign neoplasms of the oral cavity and oropharynx. The F-FDG PET/CT metabolic phenotype of this entity has not been described. We document the incidental finding of a hypermetabolic lesion at the right base of the tongue on an FDG PET/CT that proved ...
Hesse Afua A J - - 2012
Parasitic infestation is common in developing countries especially in Africa. Children are often more vulnerable to these infections. Many health problems result from these infestations, including malnutrition, iron-deficiency anemia, surgical morbidities, and even impaired cognitive function and educational achievement. Surgical intervention may be needed to treat serious complications caused by ...
Hsieh Te-Chun - - 2012
A 38-year-old pregnant woman at 26-week gestation with left breast cancer requested an FDG PET/CT scan for more detailed staging of her breast cancer before treatment. After discussing the potential radiation-related risk and estimating possible absorbed dose to fetus, she consented for examination. By using a low-radiation-dose CT protocol and ...
York Nancy L - - 2012
Acute respiratory distress syndrome is considered the most severe form of acute lung injury resulting in high morbidity and mortality. This syndrome is characterized by noncardiogenic pulmonary edema, diffuse pulmonary infiltrates, and hypoxemia refractory to oxygen delivery. Critical care nurses should be aware of newer treatment modalities available for patients ...
Sadeghi Ramin - - 2012
: Metastatic involvement of the inguinal lymph nodes is associated with decreased survival and is a strong prognostic factor in penile squamous cell carcinoma. The aim of the current systematic review was to evaluate the accuracy of F-FDG PET/CT for inguinal lymph node staging in penile squamous cell carcinoma and ...
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