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Results 201 - 250 of 3791
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Brueckner Lena M - - 2012
Common fragile sites (cFSs) are non-random chromosomal regions that are prone to breakage under conditions of replication stress. DNA damage and chromosomal alterations at cFSs appear to be critical events in the development of various human diseases, especially carcinogenesis. Despite the growing interest in understanding the nature of cFS instability, ...
Kariuki J G - - 2012
Worldwide, lack of access to safe drinking water together with inadequate sanitation and hygiene is an overwhelming contributor to approximately 4 billion cases of illness annually. This study was set out to understand the effects of hygiene and sanitation interventions on targeted health outcomes including diarrhoeal prevalence in children's of ...
Chouhan Manil - - 2012
Background: Hepatocyte transplantation is a promising alternative to orthotopic liver transplantation, however, the fate of transplanted hepatocytes is not well defined. 99mTc-galactosyl-serum albumin (99mTc-GSA) is a clinical scintigraphic agent which is specifically taken up by the hepatocyte asialoglycoprotein receptor (ASGPR). ?Aims: To investigate labeling of fresh and cryopreserved human hepatocytes ...
López-Cedrún José Luis - - 2012
BACKGROUND: Mandible subcondylar fractures may be treated via a traditional visible access incision; however, with the advances in surgical endoscopy surgeons are transitioning to a minimally invasive approach in an effort to reduce surgical morbidity and external facial scarring. We sought to design a clinically applicable teaching tool in a ...
Loukas Constantinos - - 2012
BACKGROUND: This study aimed to investigate whether basic laparoscopic skills acquired with a virtual reality simulator (LapVR™) are transferable to a standard video trainer (VT) and vice versa. METHODS: Three basic tasks were considered: peg transfer, cutting, and knot-tying. The physical models were custom-built as identical copies of the virtual ...
Kelly John J - - 2012
The cochlear spiral ligament is a connective tissue that plays diverse roles in normal hearing. Spiral ligament fibrocytes are classified into functional sub-types that are proposed to carry out specialized roles in fluid homeostasis, the mediation of inflammatory responses to trauma, and the fine tuning of cochlear mechanics. We derived ...
Chen Delai - - 2012
Discovery of potent new materials for in vivo delivery of nucleic acids depends upon successful formulation of the active molecules into a dosage form suitable for the physiological environment. Due to the inefficiencies of current formulation methods, materials are usually first evaluated for in vitro delivery efficacy as simple ionic ...
Gao Yuanzhe - - 2012
Two novel three-dimensional (3D) extended vanadogermanate-based frameworks, [Co(pdn)(2)](3)[Co(2)(pdn)(4)][V(16)Ge(4)O(44)(OH)(2)(H(2)O)]·5H(2)O (), [Co(2)(en)(3)][Co(en)(2)](2)[Co(en)(2)(H(2)O)][V(16)Ge(4)O(44)(OH)(2)(H(2)O)]·10.5H(2)O (), (pdn = 1,2-propanediamine, en = ethylenediamine) have been synthesized under hydrothermal conditions via changing the organic amine. X-ray crystal structure analyses reveal that both frameworks are built of [V(16)Ge(4)O(44)(OH)(2)(H(2)O)](10-) anions and different Co-amine cations. They represent the first example ...
Zotor Francis - - 2012
Limited data exist regarding nutrient intakes and overall dietary quality in Canadian Arctic populations. This cross-sectional study determined the frequency of consumption of traditional meats (e.g. caribou, polar bear, seal, char and whale) and non-traditional store-bought foods including non-traditional meats (e.g. beef, pork and chicken), grains, dairy, fruits, vegetables and ...
Mondal John - - 2012
A magnetic nanoparticle conjugated mesoporous nanocatalyst (Fe(3)O(4)@mesoporous SBA-15) with a high surface area has been synthesized by chemical conjugation of magnetite (Fe(3)O(4)) nanoparticles with functionalized mesoporous SBA-15. Functionalized mesoporous SBA-15 containing surface carboxyl and amino groups was synthesized via the thiol-ene click reaction of cysteine hydrochloride and vinyl functionalized SBA-15. ...
Kim Eung-Sam ES School of Interdisciplinary Bioscience and Bioengineering, National Core Research Center for Systems Bio-Dynamics, Pohang University of Science and Technology, San 31 Hyoja-dong, Pohang, 790-784, South - - 2012
The proper orientation and lateral spacing of antibody molecules are a crucial element for an on-chip immunoassay in which the antibody or its antigen-binding fragments are immobilized on a solid surface. We covalently immobilized a modified protein G (Cys-protein G: protein G with only an N-terminal cysteine) on a dendron-coated ...
Gil Germán A - - 2012
Some 20 years ago c-Fos was identified as a member of the AP-1 family of inducible transcription factors (Angel and Karin in Biochim Biophys Acta 1072:129-157, 1991). More recently, an additional activity was described for this protein: it associates to the endoplasmic reticulum and activates the biosynthesis of phospholipids (Bussolino et ...
Todorov N D - - 2012
The structural data and Raman spectra of distorted R(3+)B(3+)O(3) perovskites (R(3+)-rare earth, B(3+)=Al, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Ga) with BO(6) octahedral tilts were critically reviewed in order to obtain the frequency (ω) versus BO(6) tilt angle (α) dependence of the quasi-soft vibrational modes. It was found ...
Ryska Ondrej - - 2012
Objectives: Extracorporeal liver support (ELS) may play a role in bridging therapy in patients with acute liver failure (ALF). The aim of this study was to compare the influence of nonbiological and biological methods on intracranial pressure (ICP) in an animal model of ALF. Methods: A surgical devascularization model of ...
Allaix Marco Ettore - - 2012
BACKGROUND: The purpose of this study was to evaluate short-term and oncologic outcomes of laparoscopic resection (LR) for patients with symptomatic stage IV colorectal cancer compared with open resection (OR). METHODS: This study is a retrospective analysis of a prospective database. Patients with a minimum follow-up of 12 months after LR ...
McGinnis Jennifer L - - 2012
The biological functions of RNA are ultimately governed by the local environment at each nucleotide. Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) chemistry is a powerful approach for measuring nucleotide structure and dynamics in diverse biological environments. SHAPE reagents acylate the 2'-hydroxyl group at flexible nucleotides because unconstrained nucleotides ...
Omrani Hengameh - - 2012
Excitation emission matrix (EEM) and cavity ring-down (CRD) spectral signatures have been used to detect and quantitatively assess contamination of jet fuels with aero-turbine lubricating oil. The EEM spectrometer has been fiber-coupled to permit in situ measurements of jet turbine oil contamination of jet fuel. Parallel Factor (PARAFAC) analysis as ...
Iio Kohei - - 2012
A 29-year-old female patient presented with shock and dyspnea due to heart failure and pulmonary edema. Echocardiography indicated excessive contraction limited to the left ventricular apex and akinesis of the basal and middle ventricle, which were confirmed by emergency left ventriculography. The finding was diagnostic of inverted Takotsubo cardiomyopathy. An ...
Samadi Abbas K - - 2012
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. While effective therapy exists for the primary tumor, there is a lack of effective treatment for metastatic disease currently. Natural withanolide withaferin A (WA) has shown efficacy in cancers demonstrating upregulation of pro-survival pathways. The purpose of the ...
Rao Deepa - - 2012
PURPOSE: While exploring experiences of psychological distress among psychiatric outpatients in Southern India, we set out to further understand interpersonal and socio-cultural factors that are associated with depressive symptoms. METHODS: Using a grounded theory framework, we thematically coded narrative accounts of the women who sought treatment at the psychiatric clinic. ...
Carpenter D - - 2012
Copy number variation (CNV) is becoming increasingly important as a feature of human variation in disease susceptibility studies. However, the consequences of CNV are not so well understood. Here, we present data exploring the functional consequences of CNV of CCL3L1 in 55 independent UK samples with no known clinical phenotypes. ...
Koop Gerrit - - 2012
This article discusses the use of somatic cell count (SCC) and bacteriological culture (BC) as monitoring tools to assess the udder health situation of dairy goats. Both SCC and BC can be applied for milk samples from individual goats or at bulk milk samples. The causative agent of primary concern ...
Destounis Stamatia - - 2012
BACKGROUND: The purpose of this study was to evaluate papillary lesions of the breast diagnosed at needle core biopsy and the outcomes of follow-up imaging and surgical findings. METHODS: Retrospective review of 13,806 needle core biopsies performed from 2004 to 2010 revealed 352 patients with 368 papillary lesions; 137 of ...
McGlone Emma Rose - - 2012
BACKGROUND: Sexual and urinary dysfunction is an established risk after pelvic surgery. Studies examining sexual and urinary function following laparoscopic and open rectal surgery give conflicting evidence for outcomes. The purpose of this study was to analyse the impact of the surgical technique on functional outcomes following laparoscopic or open ...
Fujita Hisayo - - 2012
BACKGROUND: Prehypertension is defined as blood pressure (BP) ≥90th percentile, or ≥120/80 mmHg, but <95th percentile for age, sex, and height. Since the definition is made by conventional BP measurements and office BP can be quite variable, we studied whether prehypertension could be differentiated by ambulatory BP monitoring from normotension or ...
Andrews M - - 2012
Adipose tissue secretes numerous pro-inflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α that can lead to insulin resistance (IR). In the liver, both IL-6 and TNF-α induce IR by inhibiting phosphorylation or ubiquitination of IRS1. In IR development, Fe is a risk factor in type-2 diabetes development. ...
Vasilescu Catalin - - 2012
BACKGROUND: This study was designed to compare the laparoscopic subtotal splenectomy with the robotic approach in patients with hereditary spherocytosis. METHODS: Thirty-two consecutive subtotal splenectomies by minimal approach in patients with hereditary spherocytosis were analyzed (10 robotic vs. 22 laparoscopic subtotal splenectomies). RESULTS: A significant difference was found for the ...
von Strauss Und Torney M - - 2012
BACKGROUND: Duration of surgery is a main cost factor of surgical training. The purpose of this analysis of operative times for laparoscopic cholecystectomies (LC) was to quantify the extra time and related costs in regards to the surgeons' experience in the operating room (OR). METHODS: All LC performed between January ...
McCann Malachy - - 2012
[Ag(2)(9-aca)(2)] () (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)(2.3)(CH(3)CN)(0.7)](9-aca) (), [Ag(6)(imidH)(4)(9-aca)(6)(MeOH)(2)] (), {[Ag(1-Me-imid)(2)](2)[Ag(4)(9-aca)(6)]} (), {[Ag(1-Bu-imid)(2)](2)[Ag(4)(9-aca)(6)]} () and [Ag(apim)](9-aca)·H(2)O () (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex , hexanuclear , and polymeric , were all characterised using ...
Hasell Tom - - 2012
A crystalline porous organic cage molecule, CC3, is shown to adsorb up to 20.1 wt% water reversibly. This was confirmed by both gravimetric sorption and by crystallographic analysis. Crystals of CC3 are stable in boiling water for at least 4 h. The surprising chemical and supramolecular stability of these imine-based ...
Sakiroglu Muhammet - - 2012
Association mapping enables the detection of marker-trait associations in unstructured populations by taking advantage of historical linkage disequilibrium (LD) that exists between a marker and the true causative polymorphism of the trait phenotype. Our first objective was to understand the pattern of LD decay in the diploid alfalfa genome. We ...
Juritzen Truls I - - 2012
Empowerment and user participation represents an ideal of power with a strong position in the health sector. In this article we use text analysis to investigate notions of power in a program plan for health workers focusing on empowerment. Issues addressed include: How are relationships of power between users and ...
Polakof Sergio - - 2012
Teleost fishes represent a highly diverse group consisting of more than 20,000 species living across all aquatic environments. This group has significant economical, societal and environmental impacts, yet research efforts have concentrated primarily on salmonid and cyprinid species. This review examines carbohydrate/glucose metabolism and its regulation in these model species ...
Yang Fu-Ming - - 2012
Complexation of 2,7-dipyridin-2-ylnaphthyridine (bpnp) with a mixture of (PhCN)(2)PdCl(2) and Pd(2)(dba)(3) resulted in the formation of a water soluble and air-stable tripalladium cluster [Pd(3)(bpnp)(2)Cl(2)]Cl(2), which was characterized by NMR spectroscopic and X-ray crystallographic analyses.
Finocchietti Sara S Laboratory for Musculoskeletal Pain and Motor Control, Department of Health Science and Technology, Faculty of Medicine, Center for Sensory-Motor Interaction (SMI), Aalborg University, Fredrik Bajers Vej 7D-3, 9220 Aalborg E, - - 2012
Temporal summation due to repeated pain stimulation of deep somatic structures is facilitated in chronic musculoskeletal pain. In this study, the relation between repeated pressure-induced pain and stress/strain distribution within the deep tissue was evaluated to understand whether tissue characteristics may change during repeated stimulation. This information is important for ...
Habets Jesse - - 2012
Multislice CT evaluation of prosthetic heart valves (PHV) is limited by PHV-related artifacts. We assessed the influence of different kV settings, a metal artifact reduction filter (MARF) and an iterative reconstruction algorithm (IR) on PHV-induced artifacts in an in vitro model. A Medtronic-Hall tilting disc and St Jude bileafet PHV ...
Ratola Nuno - - 2012
A methodology for the extraction and quantification of 16 polycyclic aromatic hydrocarbons (PAHs) based on microwave-assisted extraction coupled with headspace solid-phase microextraction followed by gas chromatography/mass spectroscopy was validated for needles and bark of two pine species (Pinus pinaster Ait. and Pinus pinea L.). The limits of detection were below ...
Tsuji Wakako - - 2012
INTRODUCTION: Previous studies have shown that primary breast cancer patients with estrogen receptor (ER)-positive status have better outcomes in terms of both overall survival and disease-free intervals (DFI). However, 25.2 % of our ER-positive patients experienced recurrence. This study aimed to define factors potentially predicting survival after first recurrence in surgically ...
Chen Chun-Yen - - 2012
As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was to determine whether a low adiponectin level contributes to cardiovascular events, and to investigate the factors influencing adiponectin ...
Vargas G - - 2012
We followed lifetime trajectories of reproductive allocation in Coleomegilla maculata females of three different size classes produced by rearing beetles on three different daily larval feeding regimes (30 min, 6 h or ad libitum access to eggs of Ephestia kuehniella). We hypothesized that small females would produce fewer and smaller ...
Yamochi Takayuki - - 2012
SummaryInterspecies somatic cell nuclear transfer (ISCNT) has been proposed as a technique to produce cloned offspring of endangered species as well as to investigate nucleus-cytoplasm interactions in mammalian embryo. However, it is still not known which embryo culture medium is optimal for ISCNT embryos for the nuclear donor or the ...
Arenas Núñez Marco Antonio - - 2012
SummaryWe evaluated the effect of glycerol on the perinuclear theca (PT) of boar sperm. Samples from six ejaculates obtained from three different boars were incubated in the detergent Brij 36-T. Spermatozoa were treated with a glycerol concentration of either 2 or 4%, and incubated for 10 or 30 min; two ...
Gumus Hatice - - 2012
PURPOSE: The aim of this study was to determine the causes and rate of failure in removing calcification in microcalcification-only lesions using 11-gauge stereotactic vacuum-assisted biopsy (VAB). MATERIALS AND METHODS: In total, 1365 microcalcification-only lesions were included in this study. The breast biopsy database was reviewed retrospectively. The biopsies were ...
Yang Yi-Ling - - 2012
In 2009, ASCO/CAP expanded its human epidermal growth factor receptor type 2 (HER2) testing guideline to define HER2 genetic heterogeneity (GH). However, the clinical significance of GH is unclear. We investigated the impact of HER2 GH on HER2 testing and studied its clinicopathologic significance. Paraffin-embedded tumor tissues of surgical resections ...
Cai Xiaojun - - 2012
PURPOSE: Biodegradable polymers containing acid-labile segments and galactose grafts were formulated into nanoparticles in current study, and enhanced cellular uptake and subcellular distribution were clarified. METHODS: Quantum dots (QDs) was utilized as an imaging agent and a model of bioactive substances, and entrapped into nanoparticles of around 200 nm through a ...
Stökl Johannes - - 2012
Chemical defense mechanisms are widespread among insects but have rarely been demonstrated in parasitoid wasps. Here, we show that the Drosophila parasitoid Leptopilina heterotoma (Hymenoptera, Figitidae) produces (-)-iridomyrmecin and (+)-isoiridomyrmecin in a cephalic gland, and that these chemicals have a highly repellent effect on ants. Stereoselective synthesis of 4 stereoisomers ...
Flaherty Keith T - - 2012
The past decade has revealed that melanoma is comprised of multiple subclasses that can be categorized on the basis of key features, including the clinical stage of disease, the oncogenic molecular 'drivers', the anatomical location or the behaviour of the primary lesion and the expression of specific biomarkers. Although exercises ...
Li Yang-Chun - - 2012
Myxosporean genera Henneguya and Myxobolus (Bivalvulida: Myxobolidae) are closely related in morphology and molecular phylogeny, speciose with approximately 1,000 nominal species. The majority of them are recorded from freshwater fish worldwide, and few are known from marine fish. In this study, three myxobolid spp. are described from marine fish around ...
Lajevardipour A - - 2012
Using the valence force field model of Perebeinos and Tersoff (2009 Phys. Rev. B 79 241409(R)), different energy modes of suspended graphene subjected to tensile or compressive strain are studied. By carrying out Monte Carlo simulations it is found that: (i) only for small strains (|ε| ⪅ 0.02) is the total energy symmetrical ...
Tchirkov Vitaly - - 2012
Purpose: According to the last general census of 1996, the deficiency of lower limbs is the main cause of handicap in the Republic of Guinea. The objective of this study that took place in 2008 in Conakry is to analyze the main causes of this phenomenon, as well as to ...
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