Search Results
Results 301 - 350 of 2952
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Mouzakiti E - - 2012
Mouzakiti E, Pepelassi E, Fanourakis G, Markopoulou C, Tseleni-Balafouta S, Vrotsos I. Expression of MMPs and TIMP-1 in smoker and nonsmoker chronic periodontitis patients before and after periodontal treatment. J Periodont Res 2012; doi: 10.1111/j.1600-0765.2011.01465.x.© 2012 John Wiley & Sons A/S Background and Objective:  Nonsurgical periodontal treatment controls periodontal inflammation. ...
Bonevski Billie - - 2012
Introduction and Aims. Despite substantial health disadvantage, few intervention studies have examined ways to deliver smoking cessation support to homeless people. This proof-of-concept study explored the feasibility and acceptability of a novel, low-cost, telephone-delivered program. Design and Methods. Clients aged over 18 years, English-speaking and currently receiving accommodation support from a ...
Buddhe Sujatha - - 2012
Buddhe S, Du W, L'Ecuyer T. Impact of pulmonary hypertension on transplant outcomes in pediatric cardiomyopathy patients. Pediatr Transplantation 2012. © 2012 John Wiley & Sons A/S. Abstract:  Controversy exists over whether PHTN in heart transplant candidates increases post-transplant mortality. We performed analysis of data reported to UNOS for children ...
Tedaldi Lauren M - - 2012
Thiomaleimides, generated by the addition of bromomaleimides to thiols including cysteine, undergo highly efficient [2 + 2] photocycloadditions.
Sangeetha Selvam - - 2012
We report two fluorophores with open coordination sites for specific sensing of Ni(2+) and Cu(2+) ions via a simple synthetic route. The fluorescence activity was completely quenched on coordination of the metal ions with the phenanthroline ring present in the fluorophore as is clearly evident from the photophysical studies.
Kim-Kaneyama Joo-Ri - - 2012
Hydrogen peroxide-inducible clone-5 (Hic-5) is a focal adhesion scaffold protein primarily expressed in vascular and visceral smooth muscle cells. We recently generated mice lacking Hic-5, which grew with no apparent abnormality (Kim-Kaneyama J, et al. J Mol Cell Cardiol. 2011;50(1):77-86). However, we discovered that recovery of arterial media following vascular ...
Greenbaum L - - 2012
BACKGROUND: Pain is a one of the most disturbing non-motor symptoms of Parkinson disease (PD). The susceptibility to pain varies substantially among patients with PD. The aim of this study was to assess a potential association of genetic variants to PD-related pain. METHODS: We analysed 20 candidate SNPs from 12 ...
Phelps Ceri - - 2013
The objective of this study is to evaluate the effectiveness of a self-help coping intervention in reducing intrusive negative thoughts while waiting for cancer genetic risk information. Between August 2007 and November 2008, 1958 new referrals for cancer genetic risk assessment were invited to participate in a randomised trial. The ...
Pacha Omar O Department of Dermatology, University of Texas Health Science Center, Houston, - - 2013
Ecthyma gangrenosum is the cutaneous manifestation of pseudomonas infection in patients with sepsis. A previously healthy 7-month-old girl who developed ecthyma gangrenosum without apparent inciting factors became neutropenic secondary to autoimmune neutropenia 2 months after initial presentation. She was treated with appropriate surgical and medical intervention and was discharged in ...
Wegner Ingmar - - 2012
BACKGROUND: While electromagnetic tracking (EMT) holds great promise, there are substantiated concerns about interference within the clinical environment. The purpose of this study was to address accuracy and isolate pitfalls for using multiple or adjacent EMT sensors in clinical routine. METHODS: A phantom simulating an EMT-guided puncture of the kidney ...
Jones Hendrée E HE RTI International, Research Triangle Park, NC 27709, USA. - - 2013
The present paper considers naltrexone to treat opioid dependence during pregnancy. The public health problem of opioid dependence and its treatment during pregnancy is reviewed first. Next, the naltrexone and opioid dependence treatment literature is summarized, with overviews of the pre-clinical and clinical research on prenatal naltrexone exposure. Finally, considerations ...
Hirsch Sven - - 2012
The cerebrovascular system continuously delivers oxygen and energy substrates to the brain, which is one of the organs with the highest basal energy requirement in mammals. Discontinuities in the delivery lead to fatal consequences for the brain tissue. A detailed understanding of the structure of the cerebrovascular system is important ...
El Magraoui Fouzi - - 2012
The RING-finger peroxins Pex2p, Pex10p and Pex12p are central components of the peroxisomal matrix protein import machinery. The RING-domain enables each of these proteins to exhibit ubiquitin-protein-ligase (E3) activity, which has been linked to ubiquitin-dependent regulation of the peroxisomal import receptor Pex5p. The RING-peroxins are thought to form a heteromeric ...
Khanna R - - 2012
Background  There has been a significant increase in the prevalence of autism in the USA in the past few decades. The purpose of this study was to provide recent estimates of psychotropic drug use and costs among individuals with autism enrolled in Medicaid programme. Method  A cross-sectional analysis of 2007 ...
Liu J J Faculty Member of MPH at School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2013
Aggressive behaviour is the observable manifestation of aggression and is often associated with developmental transitions and a range of medical and psychiatric diagnoses across the lifespan. As healthcare professionals involved in the medical and psychosocial care of patients from birth through death, nurses frequently encounter - and may serve as ...
Kawai Hiroyuki - - 2012
Ether way: The cinchona-alkaloid-catalyzed title reaction was achieved in high yields with high to excellent ee values for the first time, and affords key intermediates for the biologically important 2 having a trifluoromethylated all-carbon quaternary chiral center. Ether-type catalysts (1) are more efficient in this transformation than the conventional hydroxy ...
Moehrle Matthias - - 2012
  Propranolol has become the treatment of choice of large and complicated infantile hemangiomas. There is a controversy concerning the safety of systemic propranolol. Here we show that topical use of the beta-blocker timolol can also inhibit the growth and promote regression of infantile hemangiomas. In this case series we ...
Ishimoto Ryo - - 2012
Acid assists: The reaction of [{WO(O(2) )(2) }(2) (μ-O)](2-) with 0.5 equivalents of HNO(3) gave a tetranuclear peroxotungstate (1; see picture) that has a dramatically enhanced activity for the epoxidation of cyclooctene with H(2) O(2) compared to various peroxotungstates. The 1-catalyzed system was applicable to the selective oxidation of various ...
Yamamoto Kohta - - 2012
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered as a possible therapeutic agent for cancer treatment. This is because of its selective cytotoxicity against various cancer cells without a detrimental effect on normal cells. However, recent studies have reported that the potential application of TRAIL in cancer therapy is ...
Hassan Abbas A Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, - - 2012
Commercially available (2-fluoro)allyl chloride serves as an efficient allyl donor in highly enantioselective iridium catalyzed carbonyl (2-fluoro)allylations from the alcohol or aldehyde oxidation level via transfer hydrogenation. Diastereoselective Crabtree hydrogenation of the resulting homoallylic alcohols provides syn-3-fluoro-1-alcohols.
Morris J - - 2012
Significant efforts are under way to develop analytic surveillance systems that can leverage observational health-care data to monitor biopharmaceutical products. The systems are being designed to identify safety-related events in a postapproval setting, when the products are already on the market. An additional application of such a system would be ...
Dobrovetsky Roman - - 2012
SiH bonds can be activated by organozinc and silylzinc compounds in the presence of minute amounts of radical initiators such as tBu(2) Hg or AIBN, yielding zinciosilanes in good yields. Activation of dihydridosilanes leads to geminal dizinciosilanes. Zincio-bridged disilyllithium compounds, which have three (1) and four metal-silicon bonds, were also ...
Giannini Edoardo G - - 2012
BACKGROUND: In patients with chronic hepatitis C virus (HCV) infection, the presence of peripheral blood cytopaenia may represent an obstacle to pegylated interferon and ribavirin treatment. AIMS: To evaluate the prevalence of anaemia, neutropaenia and thrombocytopaenia potentially limiting initiation of pegylated interferon and ribavirin treatment in patients with chronic HCV ...
Weitz Nicole N School of Medicine, College of Physicians and Surgeons, Columbia University, New YorkDepartment of Dermatology, Columbia University, New YorkDepartment of Pediatrics, Columbia University, New YorkDepartment of Surgery, Columbia University, New York, New - - 2013
Hermansky-Pudlak syndrome (HPS) is a rare autosomal-recessive disorder characterized by oculocutaneous albinism, a hemorrhagic diathesis due to platelet dysfunction, and lysosomal ceroid accumulation that can cause a Crohn's-like granulomatous colitis and pulmonary fibrosis. We report peristomal and vulvar cutaneous involvement of the granulomatous colitis in HPS.
Ding Zhenhua - - 2012
Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine-pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful ...
Armand Philippe P Departments of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA. - - 2012
A growing body of evidence suggests that iron overload is associated with inferior outcomes after myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). However, all of those studies used surrogate markers of iron overload, especially serum ferritin, and most had a retrospective design. We conducted a prospective observational study in patients ...
Song Min Sup - - 2012
The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular ...
Hirakawa Kazutaka - - 2012
An electron donor-connecting water-soluble porphyrin, meso-(1-pyrenyl)-tris(N-methyl-p-pyridinio)porphyrin, did not demonstrate singlet oxygen generating activity under photo-irradiation. The interaction with DNA successfully recovered the photosensitized singlet oxygen generation by this porphyrin.
Glimvall P - - 2012
Glimvall P, Wickström C, Jansson H. Elevated levels of salivary lactoferrin, a marker for chronic periodontitis? J Periodont Res 2012: doi: 10.1111/j.1600-0765.2012.01479.x. © 2012 John Wiley & Sons A/S Background and Objective:  Whole saliva is a complex mixture of fluids essential for the well-being of the oral hard and soft ...
Riis Ase - - 2012
Patients with Crohn's disease (CD) may need anti-inflammatory drugs for decades. Anti-TNF-α agents have good efficacy and adverse events similar to placebo in randomized controlled trials (RCTs), but there are still questions about long-term safety and efficacy. In this respect, reports from clinical practice may be useful. We currently report ...
Morrow Daniel D Division of NeonatologyDepartment of PediatricsDepartment of Pediatric Dermatology, Doernbecher Neonatal Care Center, Oregon Health and Science University, Portland, OregonCasey Eye Institute, Oregon Health and Science University, Portland, OregonDepartment of Pediatric Plastic and Reconstructive Surgery, Oregon Health and Science University, Portland, - - 2013
Aplasia cutis congenita (ACC) is the congenital absence of skin. There are a number of different classifications based on distribution and associated findings. Type V ACC is unique in that the lesions are typically symmetric and found primarily on the trunk but can also include the upper and lower extremities. ...
Ahn Woojin - - 2012
BACKGROUND: Dynamic lattice-based free-form deformation (FFD) allows efficient simulation of global deformation of complex geometric objects. However, directly imposing a number of position constraints due to contact with a tool is non-trivial since it is an over-determined problem. METHOD: This paper extends the FFD to directly impose a number of ...
Michelin McAn - - 2012
Oral Diseases (2012) doi: 10.1111/j.1601-0825.2012.01917.x Aim:  Infective agents may affect pregnancy outcomes by deregulating homeostasis. Objectives:  The effects of Porphyromonas gingivalis infection before and at different gestation periods were evaluated. Materials and Methods:  Wistar rats infected via subcutaneous with P. gingivalis W83, one week before mating (BM), days 1 (PR1) and ...
Nagy A - - 2012
Reasons for performing study: There is limited information on potential diffusion of local anaesthetic solution after various diagnostic analgesic techniques of the proximal metacarpal region. Objective: To document potential distribution of local anaesthetic solution following 4 techniques used for diagnostic analgesia of the proximal metacarpal region. Methods: Radiodense contrast medium ...
Tessier P - - 2012
TESSIER P., LELORAIN S. & BONNAUD-ANTIGNAC A. (2012) European Journal of Cancer Care A comparison of the clinical determinants of health-related quality of life and subjective well-being in long-term breast cancer survivors Research concerning long-term breast cancer survivors (BCS) has primarily analysed their health-related quality of life (HRQoL). However, other ...
Macdonald Christy - - 2012
Introduction:  Numerous factors influence career decisions for Internal Medicine Trainees and Fellows. There is a perception that a greater emphasis is placed on work-family balance by younger physicians(1) . Aims:  To determine the characteristics of the modern Internal Medicine Workforce, and ascertain whether job flexibility is important to career decision ...
Humblot Vincent - - 2012
Adsorption of biomolecules at metal surfaces often creates 2D ordering of the adlayers. However metal substrate reconstruction is less commonly observed, unless upon annealing of the molecule/surface system. Here, we report on the drastic room temperature reconstruction of the Au(111) surface driven by the adsorption of tripeptides IGF molecules. STM ...
Megiatto Jackson D - - 2012
A straightforward procedure based on the formation of intramolecular hydrogen bonds to impart selectivity in the preparation of multi-functionalized porphyrins has been developed. To illustrate the concept, the synthesis of a biomimetic artificial photosynthetic model able to undergo electron and proton transfer reactions upon irradiation is reported.
Jenaro C - - 2012
Background  Concepts such as support, quality of life and quality of services are customary in services for people with intellectual disabilities. The identification of the different ways of conceiving, prioritising and implementing these concepts by service providers can help to drive changes to achieve better personal outcomes for this population. ...
Qin Jian - - 2012
The RAFT agents RAFT-1 and RAFT-2 were used for RAFT polymerization to synthesize well-defined bimodal molecular-weight-distribution (MWD) polymers. The system showed excellent controllability and "living" characteristics toward both the higher- and lower-molecular-weight fractions. It is important that bimodal higher-molecular-weight (HMW) polymers and block copolymers with both well-controlled molecular weight (MW) ...
Wagener Theodore L - - 2012
Concerns have been raised that the advent of electronic cigarettes (e-cigarettes) may be harmful to public health, and smokers have been advised by important agencies such as the US Food and Drug Administration not to use them. This paper argues that, while more research is needed on the cost-benefit equation ...
Khajehpour Kamran J - - 2012
We synthesised a novel gold-on-porous silicon hybrid material that exhibits a highly sensitive and reproducible surface-enhanced Raman spectroscopy (SERS) response. The material was fabricated simply by reducing gold chloride with hydrofluoric acid on the surface of macro-porous silicon (macro-PSi). The material consists of thorn-shaped gold nanocrystals with characteristic shapes and ...
Hart John S - - 2012
Tripodal pyrrole imine and amide ligands provide platforms for combined primary and secondary coordination sphere interactions in square planar Pd and Cu, and octahedral Ti complexes.
Weissmann-Brenner Alina - - 2012
Objective. To compare maternal and neonatal outcomes of term large-for-gestational age (LGA) pregnancies and adequate-for-gestational age (AGA) pregnancies. Design. Retrospective analysis. Setting. Large university research medical center. Population. All term singleton LGA (birthweight ≥90(th) percentile) and AGA pregnancies (birthweight 10.1-89.9(th) percentile) delivering between 2004 and 2008. Methods. Data collected included ...
Robinson Pc - - 2012
Objectives:  Gout is a growing worldwide health problem especially in affluent countries such as Australia. Gout and hyperuricemia are associated with the metabolic syndrome, diabetes mellitus, obesity and hypertension. Importantly Australia has a growing prevalence of these important health problems. The aim of the study was to systematically review published ...
Bendorf Aric - - 2012
During the past 20 years Australian federal and state governments have funded many initiatives to bolster organ donation. Despite large investments of time, effort and money, Australia's deceased donation rate is amongst the world's lowest and has only slightly increased from 11.9 donors per million people (pmp) in 1990 to ...
Liang Chung-Yu - - 2012
  Psoriasis of the nail greatly affects quality of life because of the difficulty in achieving long-lasting remission. Pustular psoriasis of the nail apparatus is characterized by the formation of sterile pustules, starting on one or two fingers or less often on the toes, and spontaneous improvement has rarely been ...
Yao Bo - - 2012
Two is better than one: In the presence of Pd(OAc)(2) and Cu(OAc)(2) , o-(1-alkynyl)benzamides 1 were converted into bis-iminobenzoisofurans with an axially chiral 1,3-diene 2 unit. The coexistence of both Pd and Cu catalysts was found to be essential for both the cyclizative dimerization process and for the observed unusual cyclization ...
Dominguez C A - - 2012
BACKGROUND: Chronic pain of neuropathic nature after spinal cord injury (SCI) is common and its underlying mechanisms are poorly understood. Genes, as well as sex, have been implicated, but not thoroughly investigated in experimental genetic models for complex traits. We have previously found that inbred Dark-Agouti (DA) rats develop more ...
Knight Rod - - 2012
Sexually transmitted infection testing rates among young men remain low, and their disengagement from sexual health services has been linked to enactments of masculinity that prohibit or truncate discussions of sexual health. Understanding how men align with multiple masculinities is therefore important for tailoring interventions that appropriately respond to their ...
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