Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases and involves stabilization of transcription factors, hypoxia-inducible factor-1α (Hif-1α) and nuclear factor erythroid 2-related factor 2 (Nrf2) that mediate survival responses. On the contrary, release of cytochrome c into the cytosol during hypoxic stress triggers ...

SUMMARY AT A GLANCE: While this is a single centre study, the size of the study population is not insignificant. The hypothesis is novel and provides room for another alternative biomarker for measuring outcomes in peritoneal dialysis, where current markers are less than satisfactory. ABSTRACT: Background Tumor necrosis factor-related apoptosis-inducing ...

Antifouling surfaces are critical for the good performance of functional materials in various applications including water filtration, medical implants, and biosensors. In this study, we synthesized amphiphilic triblock terpolymers (tri-BCPs, coded as KB) and fabricated amphiphilic nanofibers by electrospinning of solutions prepared by mixing the KB with poly(lactic acid) (PLA) ...

Tolerance induction to alloantigens remains a major challenge in transplant immunology. Progress in the last decade of our understanding of T-cell activation has led to the development of new immunotherapeutic strategies to replace conventional immunosuppression which inhibits the immune system in a nonspecific way. In particular, positive and negative costimulatory ...

A polarization-independent optical sensor is created by fabricating a concentric gold ring grating with a period of 900 nm on the end facet of an optical fiber. The sensing function of this miniaturized device is realized by sending white light as a probe to the gold rings and collecting the ...

Hemoglobinopathies are highly prevalent in Indian population. DNA analysis to detect causative mutations is required for identifying rare hemoglobin variants or when hematological results are discordant with the clinical phenotype. In this report, we describe a novel hemoglobin variant caused by a mutation in beta-globin gene, Codon 7 GAG→CAG (Glu→Gln) ...

Biomimetic materials which display the complexity of biominerals like nacre are synthetically difficult to prepare. The formation of chitin/calcium carbonate composites, where CaCO(3) is present as aragonite, was achieved via reacetylation of preformed chitosan scaffolds followed by the combination of presoaking of chitin templates with mineral solutions in the presence ...

Background and Objectives  Multicomponent collection (MCC) enables production and processing of various blood components during one apheresis session. In this prospective crossover study, the effects of donating platelets (PLTs) and packed red blood cells (PRBCs) on donor's blood cell count, coagulation, PLT function and iron state were analysed. Materials and ...

This study is a baseline analysis of the demographic and behavioral characteristics of freshmen students recruited to enter a longitudinal multi-component intervention program based on the Brief Alcohol Screening, and Intervention for College Students (BASICS) program. The aim of the study was to determine the associations among the participants' gender, ...

The deprotonation and alkylation of 1-methylcyclohexa-2,5-diene-1-carboxylic acid has been investigated under a range of conditions. In all cases, the formation of compounds was found to be completely stereoselective, although compound was formed as an impurity when alkyl iodides were used as electrophiles, and doubly-alkylated compounds were formed in some cases ...

Background:   Clinical outcomes for patients treated in public and private hospitals may be different. Aim:   To compare the characteristics and outcomes of patients receiving dialysis at public and private hospitals in Queensland. Methods:   Incident adult dialysis patients in Queensland registered with the Australia and New Zealand Dialysis ...

The present investigation was designed to determine the efficacy of Bacopa monnieri (Brahmi; BM) to offset 3-nitropropionic acid (3-NPA) induced oxidative stress and mitochondrial dysfunction in dopaminergic (N27) cells and prepubertal mouse brain. Pretreatment of N27 cells with BM ethanolic extract (BME) significantly attenuated 3-NPA-induced cytotoxicity. Further, we determined the ...

Problems survivors face after intensive care unit (ICU) discharge begin while they are still in the ward, where many of their specific problems may run unrecognized, but they assume a heavy weight when they arrive at their homes and face several kind of limitations, from being unable to climb stairs ...

Additional Tachyarrhythmias in IST. Background: Symptom recurrence following sinus node modification (SNM) for inappropriate sinus tachycardia (IST) remains significant despite achieving acute procedural success. The impact of non-IST tachyarrhythmias on symptom recurrence remains poorly characterized. Objectives: The objective was to determine the prevalence and nature of additional tachyarrhythmias preceding and following ...

The comparison of the structural and magnetic properties of molecular nanomagnets (MNM) and magnetic nanoparticles (MNP) can be instructive to get a deeper understanding of the magnetic behavior on the intermediate scale between molecular and bulk objects. In this respect iron oxo based clusters are particularly interesting, since they provide ...

Off-label use of medicines is common. Because many off-label uses have not been carefully studied, it is important that postmarketing drug safety systems be able to identify, assess, and monitor adverse events that occur in the off-label setting. The full range of postmarketing surveillance and analysis tools can be utilized ...

Staphylococcal infections are common in veterinary dermatology patients, as are patients whose health status places them at increased risk of staphylococcal infection. The rapid emergence and dissemination of meticillin-resistant staphylococci has had significant impacts on management of infections and also increased concerns about transmission of staphylococci between animals, from animals ...

Abstract A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation, these prenyltransferases are categorized as cis- and ...

A series of O(2)-glycosylated diazeniumdiolate-based derivatives of oleanolic acid () were synthesized and their anti-human hepatocellular carcinoma (HCC) activities were evaluated. Compound selectively inhibited HCC, but not non-tumor liver cell proliferation. This inhibition was attributed to high levels of nitric oxide (NO) released in HCC cells. Importantly, exhibited low acute ...

We suggest copper nanoparticles as a CO(2) carrier by employing the ionic liquid BMIM(+)BF(4)(-) for facilitated transport membranes. The copper nanoparticles were prepared by dissociating the copper metal into the ionic liquid as a facile synthesis. The interactions between BF(4)(-) of the ionic liquid and the surface of copper nanoparticles ...

Restricted mean lifetime is often of direct interest in epidemiologic studies involving censored survival times. Differences in this quantity can be used as a basis for comparing several groups. For example, transplant surgeons, nephrologists, and of course patients are interested in comparing posttransplant lifetimes among various types of kidney transplants ...

A comparative computational study of the cooperative effect of hydrogen-, lithium- and halogen-bonding on model F-H and F-Li complexes with H(2)O was undertaken at the MP2/6-311++G(d,p) level of theory. The general trend of increased attraction or a positive cooperative effect on introduction of a third molecule to the F-H/LiOH(2) dimer ...

Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors.

The metal-organic framework Cu-BTC has been successfully synthesized as nanoparticles inside the mesopores of silica monoliths featuring a homogeneous macropore network enabling the use of Cu-BTC for continuous flow applications in liquid phase with low pressure drop. High productivity was reached with this catalyst for the Friedländer reaction.

  Propranolol has become the treatment of choice of large and complicated infantile hemangiomas. There is a controversy concerning the safety of systemic propranolol. Here we show that topical use of the beta-blocker timolol can also inhibit the growth and promote regression of infantile hemangiomas. In this case series we ...

Acid assists: The reaction of [{WO(O(2) )(2) }(2) (μ-O)](2-) with 0.5 equivalents of HNO(3) gave a tetranuclear peroxotungstate (1; see picture) that has a dramatically enhanced activity for the epoxidation of cyclooctene with H(2) O(2) compared to various peroxotungstates. The 1-catalyzed system was applicable to the selective oxidation of various ...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered as a possible therapeutic agent for cancer treatment. This is because of its selective cytotoxicity against various cancer cells without a detrimental effect on normal cells. However, recent studies have reported that the potential application of TRAIL in cancer therapy is ...

Significant efforts are under way to develop analytic surveillance systems that can leverage observational health-care data to monitor biopharmaceutical products. The systems are being designed to identify safety-related events in a postapproval setting, when the products are already on the market. An additional application of such a system would be ...

SiH bonds can be activated by organozinc and silylzinc compounds in the presence of minute amounts of radical initiators such as tBu(2) Hg or AIBN, yielding zinciosilanes in good yields. Activation of dihydridosilanes leads to geminal dizinciosilanes. Zincio-bridged disilyllithium compounds, which have three (1) and four metal-silicon bonds, were also ...

BACKGROUND: In patients with chronic hepatitis C virus (HCV) infection, the presence of peripheral blood cytopaenia may represent an obstacle to pegylated interferon and ribavirin treatment. AIMS: To evaluate the prevalence of anaemia, neutropaenia and thrombocytopaenia potentially limiting initiation of pegylated interferon and ribavirin treatment in patients with chronic HCV ...

  Hermansky-Pudlak syndrome (HPS) is a rare autosomal-recessive disorder characterized by oculocutaneous albinism, a hemorrhagic diathesis due to platelet dysfunction, and lysosomal ceroid accumulation that can cause a Crohn's-like granulomatous colitis and pulmonary fibrosis. We report peristomal and vulvar cutaneous involvement of the granulomatous colitis in HPS.

Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine-pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful ...

Telephone interviews and postal surveys may be a resource-efficient way of assessing health-related quality-of-life post-stroke, if they produce data equivalent to face-to-face interviews. This study explored whether telephone interviews and postal surveys of the Stroke and Aphasia Quality of Life Scale (SAQOL-39g) yielded similar results to face-to-face interviews. Participants included ...

Kava ('Awa) is a traditional water-based beverage in Pacific island communities, prepared from the ground root and stems of Piper methysticum. Kava use is associated with an ichthyotic dermatitis and delayed type hypersensitivity reactions. In the current study we collated preparative methodologies from cultural practitioners and recreational kava users in ...

Genetic factors underlying trait neuroticism, reflecting a tendency towards negative affective states, may overlap genetic susceptibility for anxiety disorders and help explain the extensive comorbidity amongst internalizing disorders. Genome-wide linkage (GWL) data from several studies of neuroticism and anxiety disorders have been published, providing an opportunity to test such hypotheses ...

The effect of Direct Healthcare Professional Communications (DHPCs) informing health-care providers of serious drug safety issues has been questioned. The aim of this study was to evaluate the impact of DHPCs on drug use. Nationwide dispensing data for the period 2000-2008 for new users of 46 drugs with one or ...

Background  A number of genetic conditions with associated intellectual disability and/or special educational needs have increasingly well-defined behavioural phenotypes. Thus, the concept of 'behavioural phenotype' and aetiology of intellectual disability may be important with regard to school-based interventions. Method  The evidence for distinctive cognitive and behavioural aspects of five of ...

Objective: This study investigated the question-behaviour effect of measuring intention in the interrogative or declarative form combined or not with a measure of moral norm. Design: A sample of 762 participants was randomised according to a 2 × 2 factorial design. Main outcome measures: Cognitions were assessed at the baseline, and physical ...

Annual ultrasound screening may detect small, node-negative breast cancers that are not seen on mammography. Magnetic resonance imaging (MRI) may reveal additional breast cancers missed by both mammography and ultrasound screening. To determine supplemental cancer detection yield of ultrasound and MRI in women at elevated risk for breast cancer. From ...

BACKGROUND: This article reports on patients with low rectal cancer treated with robot-assisted laparoscopic abdominoperineal resection. METHODS: Robot-assisted laparoscopic abdominoperineal resection was performed on seven patients in the General Surgery Clinic of Umraniye Training and Research Hospital between 2010 and 2011 by performing abdominal and perineal skin incisions using the ...

Sampling of mucosal antigens regulates immune responses but may also promote dissemination of mucosal pathogens. Lung dendritic cells (LDCs) capture antigens and traffic them to lung-draining lymph nodes (LDLNs) dependent on the chemokine receptor CCR7 (chemokine (C-C motif) receptor 7). LDCs also capture lung pathogens such as Bacillus anthracis (BA). ...

Arterial spin labelling (ASL) is increasingly available for noninvasive cerebral blood flow (CBF) measurement in stroke research. Here, a pseudo-continuous ASL technique (pCASL) was evaluated against (99m)Tc-D, L-hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) autoradiography in a rat stroke model. The (99m)Tc-HMPAO was injected (intravenously, 225 MBq) during pCASL acquisition. The pCASL and (99m)Tc-HMPAO autoradiography ...

This article provides a review of tobacco smoking using a hookah, an emerging threat to public health, especially among young adults. Knowledge deficits persist in regards to this form of smoking, because many perceive it as less harmful than cigarette smoking and little research is available. Knowledge about hookah smoking ...

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) represent useful models for studying multiple myeloma precursor disease, and for developing early intervention strategies. Administering a 4g dose of curcumin, we performed a randomised, double-blind placebo-controlled cross-over study, followed by an open-label extension study using an 8g dose ...

Menopause, a natural stage in a woman's reproductive life, is not an illness; yet some women experience severe enough symptoms to cause a breakdown in the body similar to illness or other major health disruptions. As part of a larger narrative analysis investigation of distress during menopause, this case study ...

Abstract Objective. To determine the safety and efficacy of anticoagulation treatment for portal vein thrombosis in cirrhosis patients with acute variceal bleeding, with patient eligibility determined by contrast ultrasonography findings. Materials and methods. This prospective study included 23 consecutive cirrhosis patients (63.8 ± 11.8 years old, 12 males and 11 ...

  Aquagenic wrinkling of the palms (AWP) is a cutaneous phenomenon marked by the transient formation of edematous, translucent papules and plaques on the palms and fingertips within minutes of water exposure. AWP is anecdotally reported in patients with cystic fibrosis (CF) and several studies have recently confirmed this association. ...

Antipsychotic medications can contribute to neurocognitive and motor impairments, but specific links to individualized pharmacological treatment regimens are unclear. In 68 participants with stabilized first-episode psychosis (FEP), we investigated the links between neuropsychological functions and an established anticholinergic potency index and a new D2 antagonist potency index developed in our ...

Recent reports suggest that the mortality rate of patients hospitalized with pneumonia has steadily declined. While this may be the result of advances in clinical care or improvements in quality, it may also represent an artifact of changes in diagnostic coding. To compare estimates of trends in hospitalizations and inpatient ...

The (Zn(0.95)Mn(0.05)S)(2)·L (L = hexylamine and octylamine) hybrids show the optimal Mn(2+) luminescence and their thin films were fabricated on the quartz substrate layer by layer by a spin coating method, which revealed the linear relationship of the UV optical absorption and the Mn(2+) luminescence intensity with the layer numbers.