Search Results
Results 151 - 200 of 2952
1 2 3 4 5 6 7 8 9 10 >
Gadó Klára - - 2012
AL amyloidosis is a systemic disease characterised by pathogenetic proteins produced by malignant plasma cells and the deposition of them in different organs of the body. Amyloidogenic protein is the light chain of the monoclonal immunoglobulin, which becomes water insoluble, precipitates and deposites in the extracellular space resulting damage of ...
Creighton Catherine M - - 2012
Objective-To compare the effect of xylazine bolus versus medetomidine constant rate infusion (MCRI) on serum cortisol and glucose concentrations, urine production, and anesthetic recovery characteristics in dorsally recumbent, spontaneously breathing, isoflurane-anesthetized horses. Design-Prospective, randomized crossover study. Animals-10 healthy Standardbreds. Procedures-Horses were premedicated with xylazine or medetomidine IV. Anesthesia was induced ...
Látos Melinda M Szegedi Tudományegyetem, Általános Orvostudományi Kar Magatartástudományi Intézet Szeged Szentháromság u. 5. 6720 Szegedi Tudományegyetem, Általános Orvostudományi Kar Sebészeti Klinika Szeged. - - 2012
Transplant patients' attitudes and representations related to their illness, their body, and the healing process have a significant impact on their recovery. The study involved 51 patients from the Department of Surgery, University of Szeged, Hungary. The primary aim was to examine the possible connections between emotional and mood factors, ...
Creighton Catherine M - - 2012
Objective-To compare the effects of xylazine bolus versus medetomidine constant rate infusion (MCRI) on cardiopulmonary function and depth of anesthesia in dorsally recumbent, spontaneously breathing, isoflurane-anesthetized horses. Design-Prospective, randomized crossover study. Animals-10 healthy adult Standardbreds. Procedures-Horses were premedicated with xylazine or medetomidine IV. Anesthesia was induced with diazepam and ketamine ...
Wernick Morena B - - 2012
Objective-To evaluate the agreement of blood pressure measurements and hypertension scores obtained by use of 3 indirect arterial blood pressure measurement devices in hospitalized dogs. Design-Diagnostic test evaluation. Animals-29 client-owned dogs. Procedures-5 to 7 consecutive blood pressure readings were obtained from each dog on each of 3 occasions with a ...
Koliscak Lindsey - - 2012
Purpose Published evidence on the incidence and predictors of venous thromboembolism (VTE) in patients with cirrhosis of the liver is reviewed. Summary The frequently observed phenomenon of elevated International Normalized Ratio (INR) values in patients with cirrhosis has led to a theory of "autoanticoagulation" and the assertion that such patients ...
Olivier Heather E - - 2012
Purpose The implementation of a pharmacist-managed clinic based on the Simplified Treatment Intervention to Control Hypertension (STITCH) algorithm is described, with insights on physician acceptance and implementation challenges. Summary After a medical records review indicating gaps in the follow-up care of emergency department (ED) patients found to have elevated blood ...
Kender Zoltán - - 2012
Transient or chronic hyperglycaemia increases the formation of intracellular reactive oxygen species and aldehydes. The accumulation of reactive aldehydes is implicated in the development of diabetic complications. Methylglyoxal, a glucose dependent α-dicarbonyl might be the most important reactive aldehyde in diabetes and its complications. Diabetes was the first disease in ...
Bos Alexandra Squires - - 2012
Objective-To determine accuracy, intermethod agreement, and inter-reviewer agreement for multisequence magnetic resonance imaging (MRI) and 2-view orthogonal myelography in small-breed dogs with first-time intervertebral disk (IVD) extrusion. Design-Prospective evaluation study. Animals-24 dogs with thoracolumbar IVD extrusion. Procedures-Each dog underwent MRI and myelography. Images obtained with each modality were independently evaluated ...
Kinyó Agnes - - 2012
Allopurinol is an effective urate lowering drug, which is usually well-tolerated with no adverse effects in most cases, but about 2% of the treated patients develop a skin rash, and patients may experience severe allopurinol-induced hypersensitivity syndrome. Aims: The aim of the authors was to summarize and present the clinical ...
Klosterman Emily S - - 2012
Case Description-An 8-year-old 12.2-kg (26.9-lb) spayed female American Cocker Spaniel was referred for evaluation of abdominal discomfort and a suspected intra-abdominal lipoma with possible invasion into the thorax. Clinical Findings-Physical examination revealed a tense abdomen, and the margins of a large abdominal mass could be appreciated. Abdominal imaging revealed a ...
Martello Jay L - - 2012
Purpose The pharmacology, pharmacokinetics, efficacy, safety, dosage, administration, adverse effects, and place in therapy of ecallantide, a kallikrein inhibitor for the treatment of hereditary angioedema (HAE), are reviewed. Summary Ecallantide is the first member of the kallikrein inhibitor class approved for the treatment of acute attacks of HAE. Ecallantide works ...
Lam Nathaniel K - - 2012
Case Description-A 5-year-old 8.6-kg (18.9-lb) spayed female Pug was evaluated because of chronic hematuria and recurrent urinary tract infections. Clinical Findings-Excretory urography, ultrasonography, and excretory CT urography were performed. Results indicated that the dog had bilateral hydronephrosis and hydroureter and suspected proximal ureteral stenosis. Retrograde ureteropyelography confirmed the presence of ...
Borchardt Stefan - - 2012
Objective-To evaluate the use of nonesterified fatty acids (NEFA) and β-hydroxybutyrate (BHBA) concentrations in pooled serum samples for herd-based detection of subclinical ketosis (SCK) in dairy cows after calving. Design-Cross-sectional study. Animals-1,100 dairy cows from 110 herds. Procedures-Blood samples were collected from 10 healthy cows/herd in the first week after ...
Radovic-Moreno Aleksandar F - - 2012
Bacteria have shown a remarkable ability to overcome drug therapy if there is a failure to achieve sustained bactericidal concentration or if there is a reduction in activity in situ. The latter can be caused by localized acidity, a phenomenon that can occur as a result of the combined actions ...
Higgins Khadine A KA Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, - - 2012
RcnR (resistance to cobalt and nickel regulator) is a 40-kDa homotetrameric protein and metalloregulator that controls the transcription of the Co(II) and Ni(II) exporter, RcnAB, by binding to DNA as an apoprotein and releasing DNA in response to specifically binding Co(II) and Ni(II) ions. Using X-ray absorption spectroscopy (XAS) to ...
Escudier Bernard - - 2012
In metastatic renal cell carcinoma (mRCC), many factors influence clinical decisions, including histology, tumour burden, prognostic factors, comorbidities, and the ability of the patient to tolerate treatment. Progression-free survival (PFS) durations reported from randomized trials of targeted therapies vary considerably, in part because of differences in patient characteristics. For first-line ...
Wang Xingbao - - 2012
Understanding the transformation mechanism and products of xenobiotics catalyzed by cytochrome P450 enzymes (CYPs) is vital to risk assessment. By density functional theory computation with the B3LYP functional, we simulated the reaction of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) catalyzed by the active species of CYPs (Compound I). The enzymatic and aqueous environments ...
Yang Kai - - 2012
A nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is nonco-valently functionalized with polyethylene glycol (PEG) by Z. Liu and co-workers on page 1868, obtaining a RGO-IONP-PEG nanocomposite which displays excellent physiological stability, strong NIR optical absorbance, and superpara-magnetic properties. This theranostic nanoprobe allows multimodal tumor imaging - in vivo ...
Nepal Dhriti - - 2012
Colloidal approaches to discrete plasmonic architectures offer numerous advantages with respect to lithography; however, scale-up, purity, and yield has been challenging. Reversibly controlling surface interactions throughout aqueous assembly affords methods that address these challenges. The false-color image illustrates the crude product of soluble, compositionally discrete Au nanorod (50 nm × ...
Ruffing Anne M - - 2012
The direct conversion of carbon dioxide into biofuels by photosynthetic microorganisms is a promising alternative energy solution. In this study, a model cyanobacterium, Synechococcus elongatus PCC 7942, is engineered to produce free fatty acids (FFA), potential biodiesel precursors, via gene knockout of the FFA-recycling acyl-ACP synthetase and expression of a ...
Kota Pradeep P Program in Cellular and Molecular Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7260, - - 2012
Limited proteolysis, accomplished by endopeptidases, is a ubiquitous phenomenon underlying the regulation and activation of many enzymes, receptors, and other proteins synthesized as inactive precursors. Serine proteases make up one of the largest and most conserved families of endopeptidases involved in diverse cellular activities, including wound healing, blood coagulation, and ...
Sun Dao-Cai DC Department of Implant Dentistry, School of Stomatology, Fourth Military Medical University, Xi'an, - - 2012
In order to understand the mechanisms of poor osseointegration following dental implants in type 2 diabetics, it is important to study the biological properties of alveolar bone osteoblasts isolated from these patients. We collected alveolar bone chips under aseptic conditions and cultured them in vitro using the tissue explants adherent ...
Alouche S R SR Departamento de Fisioterapia, Universidade Cidade de São Paulo, - - 2012
This study investigated the influence of cueing on the performance of untrained and trained complex motor responses. Healthy adults responded to a visual target by performing four sequential movements (complex response) or a single movement (simple response) of their middle finger. A visual cue preceded the target by an interval ...
Carmo A A AA Laboratório de Instrumentação para Biomecânica, Faculdade de Educação Física, Universidade Estadual de Campinas, SP, Brasil. - - 2012
The aim of this study was to analyze the alterations of arm and leg movements of patients during stroke gait. Joint angles of upper and lower limbs and spatiotemporal variables were evaluated in two groups: hemiparetic group (HG, 14 hemiparetic men, 53 ± 10 years) and control group (CG, 7 ...
Heldwein C G CG Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, RS, - - 2012
The objective of this study was to identify the possible involvement of the GABAergic system in the anesthetic effect of Lippia alba essential oil (EO). We propose a new animal model using silver catfish (Rhamdia quelen) exposed to an anesthetic bath to study the mechanism of action of EO. To ...
Rudd T R TR Istituto di Chimica e Biochimica, Milano, - - 2012
Heparan sulphate (HS) and the related polysaccharide, heparin, exhibit conformational and charge arrangement properties, which provide a degree of redundancy allowing several seemingly distinct sequences to exhibit the same activity. This can also be mimicked by other sulphated polysaccharides, both in overall effect and in the details of interactions and ...
Jonnalagadda Venkatadurga V Department of Chemistry, University at Buffalo, Buffalo, New York 14260, - - 2012
The E. coli isopentenyl diphosphate isomerase (IDI) catalyzed reaction of isopentenyl diphosphate (IPP) in D(2)O gives a 66% yield of dimethylallyl diphosphate labeled with deuterium at the (E)-methyl group (d-DMAPP) and a 34% yield of IPP labeled with 1 mol of deuterium at C-2 (d-IPP). This shows that the release ...
Breunig Fábio M - - 2012
Directional effects introduce a variability in reflectance and vegetation index determination, especially when large field-of-view sensors are used (e.g., Moderate Resolution Imaging Spectroradiometer - MODIS). In this study, we evaluated directional effects on MODIS reflectance and four vegetation indices (Normalized Difference Vegetation Index - NDVI; Enhanced Vegetation Index - EVI; ...
Mendanha S A SA Instituto de Física, Universidade Federal de Goiás, Goiânia, - - 2012
Electron paramagnetic resonance (EPR) spectroscopy of spin labels was used to monitor membrane dynamic changes in erythrocytes subjected to oxidative stress with hydrogen peroxide (H(2)O(2)). The lipid spin label, 5-doxyl stearic acid, responded to dramatic reductions in membrane fluidity, which was correlated with increases in the protein content of the ...
Stout E Paige EP Department of Chemistry and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, 92093, - - 2012
Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors.
Sachse Alexander - - 2012
The metal-organic framework Cu-BTC has been successfully synthesized as nanoparticles inside the mesopores of silica monoliths featuring a homogeneous macropore network enabling the use of Cu-BTC for continuous flow applications in liquid phase with low pressure drop. High productivity was reached with this catalyst for the Friedländer reaction.
Valette X - - 2012
BACKGROUND: During sepsis and septic shock, elevated plasma concentrations of brain natriuretic peptide (BNP) have been reported but may be related to several underlying mechanisms. The aim of the present experimental study was to investigate the effect of lipopolysaccharide (LPS), tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), interleukin 6 ...
Dunbar Robert C - - 2012
Rearranged: The attachment of gas-phase divalent metal ions which bind as strongly as Mg(2+) and transition-metal ions to the dipeptide PhePhe results in displacement of the amide proton by the newly characterized iminol tautomerization rearrangment. More weakly coordinating ions bind in the known charge-solvation mode. Infrared multiple-photon dissociation spectroscopy using ...
Eager David B - - 2012
In Australia trampolines contribute one quarter of all childhood play equipment injuries. The objective of this study was to gather and evaluate injury data from a non-traditional, 'soft-edged', consumer trampoline, where the design aimed to minimise injuries from the equipment and from falling off. The manufacturer of the non-traditional trampoline ...
Lee Yongjae - - 2012
High-pressure ion exchange of small-pore zeolite K-natrolite allows immobilization of nominally non-exchangeable aliovalent cations such as trivalent europium. A sample exchanged at 3.0(1) GPa and 250 °C contains about 4.7 Eu(III) ions per unit cell, which is equivalent to over 90 % of the K(+) cations being exchanged.
Parmelee Dean - - 2012
Team-based learning™ (TBL) is an instructional strategy developed in the business school environment in the early 1990s by Dr Michaelsen who wanted the benefits of small group learning within large classes. In 2001, a US federal granting agency awarded funds for educators in the health sciences to learn about and ...
Fotsch E J - - 2012
As labeling has become more complex, effective provider communication has become more difficult. Until the HITECH (Health Information Technology for Economic and Clinical Health) Act, which provided billions of federal payments to encourage the use of electronic health records (EHRs) and e-prescribing, adoption of EHRs was slow. Delivery of actionable ...
Bekö Sándor L - - 2012
Like most journals and newspapers worldwide Angewandte Chemie International Edition is printed with Pigment Red 57:1. M. U. Schmidt et al. report in their Communication (DOI: 10.1002/anie.201109082) that the actual shade of red depends on the hydration state and thus may change with the weather conditions. They solved the crystal ...
Muller Kate - - 2012
Background:  Hepatitis C treatment is successful in 40-80% of patients in drug sponsored registration trials. However, few studies have examined treatment outcomes in non-trial, routine clinical practice settings. Aims:  The aim of this study was to investigate the treatment outcomes and predictors of a sustained virological response in a routine ...
Yin Xuelai - - 2012
OBJECTIVES: Dental implant distractors (DID) are an efficacious means of simultaneously augmenting the vertical bony height together with the installation of dental implants. Little is known about their biomechanical properties and osteointegration ability in the free fibula flap, where the periosteum is invariably damaged during the multiple osteotomies required for ...
Weese Jeffrey Scott - - 2012
Staphylococcal infections are common in veterinary dermatology patients, as are patients whose health status places them at increased risk of staphylococcal infection. The rapid emergence and dissemination of meticillin-resistant staphylococci has had significant impacts on management of infections and also increased concerns about transmission of staphylococci between animals, from animals ...
Teng Kuo-Hsun - - 2012
Abstract A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation, these prenyltransferases are categorized as cis- and ...
Huang Zhangjian - - 2012
A series of O(2)-glycosylated diazeniumdiolate-based derivatives of oleanolic acid () were synthesized and their anti-human hepatocellular carcinoma (HCC) activities were evaluated. Compound selectively inhibited HCC, but not non-tumor liver cell proliferation. This inhibition was attributed to high levels of nitric oxide (NO) released in HCC cells. Importantly, exhibited low acute ...
Lee Jung Hyun - - 2012
We suggest copper nanoparticles as a CO(2) carrier by employing the ionic liquid BMIM(+)BF(4)(-) for facilitated transport membranes. The copper nanoparticles were prepared by dissociating the copper metal into the ionic liquid as a facile synthesis. The interactions between BF(4)(-) of the ionic liquid and the surface of copper nanoparticles ...
Zhang Min - - 2012
Restricted mean lifetime is often of direct interest in epidemiologic studies involving censored survival times. Differences in this quantity can be used as a basis for comparing several groups. For example, transplant surgeons, nephrologists, and of course patients are interested in comparing posttransplant lifetimes among various types of kidney transplants ...
McDowell Sean A C - - 2012
A comparative computational study of the cooperative effect of hydrogen-, lithium- and halogen-bonding on model F-H and F-Li complexes with H(2)O was undertaken at the MP2/6-311++G(d,p) level of theory. The general trend of increased attraction or a positive cooperative effect on introduction of a third molecule to the F-H/LiOH(2) dimer ...
Zhao Guixia - - 2012
Graphene oxide nanosheets have attracted multidisciplinary attention due to their unique physicochemical properties. Herein, few-layered graphene oxide nanosheets were synthesized from graphite using a modified Hummers method and were characterized by TEM, AFM, Raman spectroscopy, XPS, FTIR spectroscopy, TG-DTA and acid-base titrations. The prepared few-layered graphene oxide nanosheets were used ...
Han Zhi-Yong - - 2012
The hybrid Au(I)/Brønsted acid binary catalyst system enables enynes to serve as latent 1,3-silyloxydienes capable of participating in the first cascade hydrosiloxylation of enynyl silanol/asymmetric Diels-Alder reaction. A variety of polycyclic compounds bearing multi-stereogenic centers were obtained in high yields and excellent enantioselectivities from the relay catalytic cascade reaction between ...
Mizrahi Romina - - 2012
[(18)F]-FEPPA binds to the 18-kDa translocator protein (TSPO) and is used in positron emission tomography (PET) to detect microglial activation. However, quantitative interpretations of the PET signal with new generation TSPO PET radioligands are confounded by large interindividual variability in binding affinity. This presents as a trimodal distribution, reflecting high-affinity ...
1 2 3 4 5 6 7 8 9 10 >