Search Results
Results 451 - 500 of 2952
< 5 6 7 8 9 10 11 12 13 14 15 >
Liman N - - 2012
Apoptosis has been shown to be an important regulator of endometrium function. To clarify the regulation of apoptosis in the cat endometrium during the normal oestrus cycle, the expressions of the apoptosis-related proteins (Bcl-2 and Bax) and their correlation to the inhibitor of apoptosis protein Survivin were analysed using immunohistochemistry. ...
Kovacs Gabor G - - 2012
Aims: Frontotemporal lobar degeneration with Pick bodies (Pick's disease) is characterized by the presence of tau immunoreactive spherical structures in the cytoplasm of neurons. In view of confusion about the molecular pathology of Pick's disease, we aimed to evaluate the spectrum of tau pathology and concomitant neurodegeneration-associated protein depositions in ...
Hounjet Lindsay J - - 2012
CO(2) snapper: Compounds containing both acidic and basic P,N functionalities have been prepared. Of these, two amidophosphoranes containing highly reactive PN bonds within four-membered rings react rapidly with CO(2) , resulting in relief of ring strain. These compounds demonstrate the utility of phosphorus as a Lewis acid for small-molecule activation.
Šedová L - - 2012
Deficiency of fatty acid translocase Cd36 has been shown to have a major role in the pathogenesis of metabolic syndrome in the spontaneously hypertensive rat (SHR). We have tested the hypothesis that the effects of Cd36 mutation on the features of metabolic syndrome are contextually dependent on genomic background. We ...
Ong Wei Qiang - - 2012
In response to binding to amine and ammonium guests of varying types, a pyridine-based folding oligomer displays fingerprint regions in its (1)H NMR spectra that allow for the easy identification and classification of the bound guests.
Fidalgo A R - - 2012
BACKGROUND: The aim of this study is to investigate the effect of general anaesthesia induced by isoflurane with buprenorphine on hippocampus-dependent and neocortex-dependent memory, respectively, in mice, and in addition, to compare the effects of such anaesthesia on these memory processes with the effects induced by lipopolysaccharide (LPS) administration on ...
Lombardi V V Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, - - 2012
Dendritic cells (DCs) control the balance between protection against pathogens and tolerance to innocuous or self-antigens. Here, we demonstrate for the first time that mouse plasmacytoid DCs (pDCs) can be segregated into three distinct populations, exhibiting phenotypic and functional differences, according to their surface expression of CD8α or CD8β as ...
Nino Massimiliano - - 2012
  Obese adult patients have many dermatoses, such as skin tags, candida infection, cellulite, and intertrigo, but only limited data have been published on obese children and the barrier function of their skin. Sixty-five overweight and obese children (n = 40, BMI 85th-95th percentile; n = 25, BMI > 95th percentile) (aged 8-15; mean ...
Perry J - - 2012
Background  People with severe challenging behaviour are vulnerable to exclusion from local services and removal to out-of-area placements if locally available supported accommodation is insufficient to meet their needs. There are concerns about the high costs and potentially poorer outcomes of out-of-area placements but relatively little is known about how ...
Yano Hideto - - 2012
Background: The aim of the present study was to assess the effects of angiotensin II receptor blocker (ARB) on coronary plaque progression in patients with acute myocardial infarction (AMI) who received an angiotensin-converting enzyme inhibitor (ACEI). Methods and Results: After local ethics committee approval and obtaining of informed consent, 116 ...
Miro J M - - 2012
Eighty-four HCV/HIV-coinfected and 252-matched HCV-monoinfected liver transplant recipients were included in a prospective multicenter study. Thirty-six (43%) HCV/HIV-coinfected and 75 (30%) HCV-monoinfected patients died, with a survival rate at 5 years of 54% (95% CI, 42-64) and 71% (95% CI, 66 to 77; p = 0.008), respectively. When both groups ...
Bhat Shailen - - 2012
2'-Aminoacetophenone was chemoselectively alkylated with a range of substituted benzyl, heteroaryl alcohols to afford either the corresponding C- or N- alkylated products in good yield.
Bewernick Bettina H - - 2012
Deep brain stimulation (DBS) to the nucleus accumbens (NAcc-DBS) was associated with antidepressant, anxiolytic, and procognitive effects in a small sample of patients suffering from treatment-resistant depression (TRD), followed over 1 year. Results of long-term follow-up of up to 4 years of NAcc-DBS are described in a group of 11 ...
Frisk Per - - 2012
Frisk P, Arvidson J, Larsson M, Naessén T. Risk factors for cardiovascular disease are increased in young adults treated with stem cell transplantation during childhood. Abstract:  We measured risk factors for CVD in 18 patients at a median of 18.2 yr after SCT and in sex and age-matched controls. Three patients ...
Chen Zheng - - 2012
Electrical energy storage plays an increasingly important role in modern society. Current energy storage methods are highly dependent on lithium-ion energy storage devices and the expanded use of these technologies is likely to affect existing lithium reserves. The abundance of sodium makes Na-ion based devices very attractive as an alternative, ...
Caron W P - - 2012
Major advances in the field of carrier-mediated agents (CMAs) have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages over their small-molecule counterparts (solubility, duration of exposure, and delivery to the site of action are higher), these agents display substantial variability in systemic clearance (CL) and distribution, ...
Stuart Rhonda L - - 2012
INTRODUCTION:  The prevention and control of transmission of antimicrobial-resistant pathogens in Residential Aged Care Facilities (RACF) is an area that has been neglected yet has significant implications for health services. The aim of this study was to describe the prevalence and appropriateness of antibiotic use within five RACF associated with ...
Terwijn M - - 2012
Introduction:  Immunophenotypic detection of minimal residual disease (MRD) in bone marrow (BM) of acute myeloid leukaemia (AML) patients is of high prognostic relevance. Standard MRD percentage is assessed as a percentage of total white blood cells (WBCs) and is therefore highly dependent on WBC count. Peripheral blood (PB) contains more ...
Hota Kalpana B - - 2012
Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases and involves stabilization of transcription factors, hypoxia-inducible factor-1α (Hif-1α) and nuclear factor erythroid 2-related factor 2 (Nrf2) that mediate survival responses. On the contrary, release of cytochrome c into the cytosol during hypoxic stress triggers ...
Poon Peter Yam-Kau - - 2012
SUMMARY AT A GLANCE: While this is a single centre study, the size of the study population is not insignificant. The hypothesis is novel and provides room for another alternative biomarker for measuring outcomes in peritoneal dialysis, where current markers are less than satisfactory. ABSTRACT: Background Tumor necrosis factor-related apoptosis-inducing ...
Cho Youngjin - - 2012
Antifouling surfaces are critical for the good performance of functional materials in various applications including water filtration, medical implants, and biosensors. In this study, we synthesized amphiphilic triblock terpolymers (tri-BCPs, coded as KB) and fabricated amphiphilic nanofibers by electrospinning of solutions prepared by mixing the KB with poly(lactic acid) (PLA) ...
Poirier N - - 2012
Tolerance induction to alloantigens remains a major challenge in transplant immunology. Progress in the last decade of our understanding of T-cell activation has led to the development of new immunotherapeutic strategies to replace conventional immunosuppression which inhibits the immune system in a nonspecific way. In particular, positive and negative costimulatory ...
Feng Shengfei - - 2012
A polarization-independent optical sensor is created by fabricating a concentric gold ring grating with a period of 900 nm on the end facet of an optical fiber. The sensing function of this miniaturized device is realized by sending white light as a probe to the gold rings and collecting the ...
Edison E S - - 2012
Hemoglobinopathies are highly prevalent in Indian population. DNA analysis to detect causative mutations is required for identifying rare hemoglobin variants or when hematological results are discordant with the clinical phenotype. In this report, we describe a novel hemoglobin variant caused by a mutation in beta-globin gene, Codon 7 GAG→CAG (Glu→Gln) ...
- - 2013
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWAS mega-analysis for MDD. In the MDD discovery phase, we analyzed more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) ...
Berényi Agnes - - 2012
Inhibition of the local formation of estrogens seems to be an attractive strategy for pharmacological intervention in hormone-dependent disorders. The direct antiproliferative properties of ten nonsteroidal 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitors were investigated on human cancer cell lines of gynecological origin. The mechanism of the antiproliferative action was approximated ...
Liu Wanzhan W Medtronic, Inc., Minneapolis, Minnesota, - - 2013
In numerical analyses of radiofrequency (RF) fields for MRI, RF power is often permitted to radiate out of the problem region. In reality, RF power will be confined by the magnet bore and RF screen enclosing the magnet room. We present numerical calculations at different frequencies for various surface and ...
Zorrilla-Fontanesi Yasmín - - 2012
Improvement of strawberry (Fragaria × ananassa) fruit flavor is an important goal in breeding programs. To investigate genetic factors controlling this complex trait, a strawberry mapping population derived from genotype '1392', selected for its superior flavor, and '232' was profiled for volatile compounds over 4 years by headspace solid phase ...
Zaniew M - - 2012
Purpose: The aim of this study was to assess vitamin D status and bone density in steroid-treated children with glomerulopathies and to evaluate the effect of prophylactic vitamin D and calcium supplementation.Material and Methods: Retrospective analysis was performed on 55 children aged 4-18 yrs with glomerulopathies. The following data were ...
Giehl Maruí Weber Corseuil - - 2012
OBJECTIVE: To estimate the prevalence of the practice of leisure-time physical activity in older adults and to analyze its association with environment perception. METHODS: Cross-sectional population study conducted from September 2009 to June 2010 with 1.656 individuals aged 60 years or older, living in the urban zone of the city ...
Gogebakan Ayse - - 2012
Reduction in the synthesis or bioavailability of nitric oxide plays a significant role in the development of hypertension. Propolis is a resinous product collected by honeybees from various plant sources. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines. The aim of this study was to examine ...
Heering Johanna - - 2012
Triple-negative breast cancers (TNBCs) are especially refractory to treatment due to their negative hormone receptor and ErbB2/HER2 status. Therefore, the identification of cancer-associated deregulated signaling pathways is necessary to develop improved targeted therapies. Here we show that expression of the ceramide transfer protein CERT is reduced in TNBCs. CERT transfers ...
Chen Ke - - 2012
A series of enantiomerically pure 1,2-diester substituted P,N-ligands incorporating two chiral carbons in the backbone were generated in high yields and high stereoselectivity from acetylenedicarboxylate via initial hydrophosphination using diphenylphosphine followed by hydroamination with various primary and secondary amines. The reactions were activated and stereochemically controlled by the organopalladium complex ...
Rocha Marcelo M - - 2012
In this paper the influence of a secondary variable as a function of the correlation with the primary variable for collocated cokriging is examined. For this study five exhaustive data sets were generated in computer, from which samples with 60 and 104 data points were drawn using the stratified random ...
Chen Zhiyu Z Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, - - 2013
In vivo or ex vivo electron paramagnetic resonance imaging (EPRI) is a powerful technique for determining the spatial distribution of free radicals and other paramagnetic species in living organs and tissues. However, applications of EPRI have been limited by long projection acquisition times and the consequent fact that rapid gated ...
Haddad Ariz - - 2012
The enzyme cyclooxygenase-2 (COX-2) is rapidly and transiently up-regulated by a large variety of signals and implicated in pathologies such as inflammation and tumorigenesis. Although many signals cause COX-2 up-regulation, much less is known about mechanisms that actively down-regulate its expression. Here we show that the G protein-coupled receptor prostaglandin ...
Sridharan Sarup S - - 2012
Our "reservoir-wave approach" to arterial hemodynamics holds that measured arterial pressure should be considered to be the sum of a volume-related pressure (i.e., reservoir pressure, P(reservoir)) and a wave-related pressure (P(excess)). Because some have questioned whether P(reservoir) (and, by extension, P(excess)) is a real component of measured physiological pressure, it ...
Hamers Raph L - - 2012
Background. Human immunodeficiency virus type 1 (HIV-1) drug resistance may limit the benefits of antiretroviral therapy (ART). This cohort study examined patterns of drug-resistance mutations (DRMs) in individuals with virological failure on first-line ART at 13 clinical sites in 6 African countries and predicted their impact on second-line drug susceptibility.Methods. A total ...
Kasenda B - - 2012
BACKGROUND: High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL). We report long-term data of patients who were treated according to HCT-ASCT containing protocols. PATIENTS AND METHODS: We analyzed survival and relapse rates in 43 (<67 years) ...
Taylor Amanda R - - 2012
A 10 yr old domestic longhair presented with a 2.5 mo history of recurrent hematuria. Abdominal ultrasound examination demonstrated a thickened urinary bladder, abdominal lymphadenopathy, and a thickened and rounded spleen. Cytologic examination of fine-needle aspirate samples revealed Histoplasma capsulatum organisms in the urinary bladder wall and spleen. The cat ...
Dennick Reg - - 2012
Background: Although there is no single overarching theory of learning, there is a group of learning theories that shares some common elements which can provide useful guidance on a range of teaching and learning practices. Aim: This article aims to describe Constructivist, Experiential and Humanistic learning theories, to explain how ...
Hartmann Nils - - 2012
BACKGROUND: A challenge in age research is the absence of short-lived vertebrate model organisms. The turquoise killifish Nothobranchius furzeri has an exceptionally short lifespan of 4-10 months depending on the strain. Thus, it possesses the shortest known maximum lifespan of a vertebrate species that can be bred in captivity. RESULTS: ...
Gupta Abhishek Kumar - - 2012
A non-hydrolytic one pot sol-gel method has been used to synthesize mesoporous silica ionogels with the confined ionic liquid (IL) 1-ethyl 3-methyl imidazolium tetra fluoro-borate [EMIM][BF(4)]. The precursor for obtaining the SiO(2) matrix was tetraethyl orthosilicate (TEOS) and formic acid was used as a catalyst. These ionogels have been characterized ...
Sadeghi Mohsen - - 2012
Water inside carbon nanotubes as an example of nano-confined water has gained a noticeable attention, in both theoretical and applied aspects. Molecular simulation has played a major role in the studies in this field. Yet, there is a need for systematic study of simulation results and compilation of scientifically reliable ...
Kalager Mette - - 2012
Precise quantification of overdiagnosis of breast cancer (defined as the percentage of cases of cancer that would not have become clinically apparent in a woman's lifetime without screening) due to mammography screening has been hampered by lack of valid comparison groups that identify incidence trends attributable to screening versus those ...
Pozzoni Pietro P Department of Medicine, A. Manzoni Hospital, Lecco, Italy. - - 2012
Antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated diarrhea (CDAD) are common complications of antibiotic use. Probiotics were effective in preventing AAD and CDAD in several randomized controlled trials. This study was aimed at testing the effect of Saccharomyces boulardii on the occurrence of AAD and CDAD in hospitalized patients. A single-center, ...
Liu Chia-I - - 2012
Zaragozic acids (ZAs) belong to a family of fungal metabolites with nanomolar inhibitory activity toward squalene synthase (SQS). The enzyme catalyzes the committed step of sterol synthesis and has attracted attention as a potential target for antilipogenic and antiinfective therapies. Here, we have determined the structure of ZA-A complexed with ...
Koleva Rositsa I - - 2012
The transcription factor C/EBPα is a critical mediator of myeloid differentiation and is often functionally impaired in acute myeloid leukemia. Recent studies have suggested that oncogenic FLT3 activity disrupts wild-type C/EBPα function via phosphorylation on serine 21 (S21). Despite the apparent role of pS21 as a negative regulator of C/EBPα ...
Keddy Karen H - - 2012
Background. Systemic disease due to shigellae is associated with human immunodeficiency virus (HIV), malnutrition, and other immunosuppressed states. We examined the clinical and microbiologic characteristics of systemic shigellosis in South Africa, where rates of HIV infection are high.Methods. From 2003 to 2009, 429 cases of invasive shigellosis were identified through national laboratory-based ...
Paris S - - 2012
This study evaluated the influence of the penetration coefficient (PC) and ethanol addition on the penetration depth (PD) of experimental infiltrants into proximal caries lesions in primary molars. Caries lesions (n = 45) were randomly treated with 1 of 4 experimental infiltrants (PC63; PC185; PC204; PC391) for 5 min. Lesion ...
< 5 6 7 8 9 10 11 12 13 14 15 >