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Aul Raminder R University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester, Manchester, - - 2012
Lipopolysaccharide (LPS) is a TLR4 agonist which activates NFκB dependent cytokine production. We investigated LPS inhalation in healthy smokers as a model of COPD bacterial exacerbations. We studied safety, reproducibility, the translocation of the NFκB subunit p65 in sputum cells and changes in systemic biomarkers of inflammation. Twelve smokers inhaled ...
Kogure Takayuki T College of Medicine, Ohio State University, Columbus, OH, - - 2012
MicroRNAs (miRNAs) are small, regulatory non-coding RNAs that have potent effects on gene expression. Several miRNA are deregulated in cellular processes involved in human liver diseases and regulation of cellular processes. Recent studies have identified the involvement of miR-29 in hepatic fibrosis and carcinogenesis. Although several targets of miR-29 have ...
Wiseman Daniel H - - 2012
Acute megakaryoblastic leukemia is a rare variant of acute myeloid leukemia, whereby leukemic blasts display characteristic morphologic and phenotypic features indicating megakaryocytoid differentiation. A distinct entity characterized by the t(1;22)(p13;q13) translocation, resulting in the RBM15-MKL1 fusion oncogene, has been recently recognized. This is predominantly a disease afflicting infants and displays ...
George Sally L - - 2012
We report on the use of single-agent docetaxel (100 mg/m(2) in children >10 kg, 3.3 mg/kg in children <10 kg), given as a 1-hour infusion at 21-day intervals in 5 children with relapsed or refractory hepatoblastoma. One patient achieved complete remission of pulmonary metastases after 2 courses of docetaxel and ...
Tasian Sarah K SK Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of California, San Francisco School of Medicine, San Francisco, CA, USA. - - 2012
Diaphanospondylodysostosis (DSD) is a rare skeletal dysplasia syndrome resulting from disordered mesenchymal differentiation. Children with DSD generally die in utero or during the first month of life from severe thoracic insufficiency syndrome. An association of DSD with nephroblastomatosis has been observed, but the natural history of such nephroblastomatosis remains poorly ...
Kaur Manreena - - 2012
Mismatch negativity (MMN) and P3a are event-related potentials that index deviance detection and the orienting response, respectively. We have previously shown that the MMN/P3a complex is impaired in patients with schizophrenia and affective spectrum psychoses, which suggests that it may index a common pathophysiology and argues against the purported specificity ...
Lyddon Rebecca - - 2012
Dysfunction of glutamate neurotransmission has been implicated in the pathology of schizophrenia and bipolar disorder, and one mechanism by which glutamate signalling can be altered is through RNA editing of ionotropic glutamate receptors (iGluRs). The objectives of the present study were to evaluate the editing status of iGluRs in the ...
Broniowska Katarzyna A - - 2012
S-nitrosothiol formation and protein S-nitrosation is an important nitric oxide (NO)-dependent signaling paradigm that is relevant to almost all aspects of cell biology, from proliferation, to homeostasis, to programmed cell death. However, the mechanisms by which S-nitrosothiols are formed are still largely unknown, and there are gaps of understanding between ...
Cuneo K C - - 2012
Involvement of a cranial nerve caries a poor prognosis for many malignancies. Recurrent or residual disease in the trigeminal or facial nerve after primary therapy poses a challenge due to the location of the nerve in the skull base, the proximity to the brain, brainstem, cavernous sinus, and optic apparatus ...
Descovich M - - 2012
This paper investigates the dosimetric characteristics of stereotactic body radiotherapy (SBRT) treatment plans of spine patients in the prone position compared to the supine position. A feasibility study for treating spine patients in the prone position using a fiducial-less tracking method is presented. One patient with a multilevel spinal metastasis ...
Souter Melanie M Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, - - 2012
To determine whether a systemic immune response influences hearing thresholds and tissue response after cochlear implantation of hearing guinea pigs. Guinea pigs were inoculated with sterile antigen (Keyhole limpet hemocyanin) 3 weeks before cochlear implantation. Pure-tone auditory brainstem response thresholds were performed before implantation and 1 and 4 weeks later. ...
Pieterman Carolina R C - - 2012
To identify the optimal surgical strategy for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (pHPT). To describe the course of postoperative hypoparathyroidism and to assess whether genotype is associated with persistent/recurrent pHPT. Surgery is the preferred treatment in MEN1-related pHPT, but the surgical procedure of choice is still uncertain. ...
Harle Amelie S M AS Christie NHS Foundation Trust, Manchester Academic Health Science Centre, The University of Manchester, Manchester, - - 2012
This article summarizes the current understanding of cough in lung cancer, strategies for its management and highlights areas where further research is warranted.Cough is common, severe and distressing for many lung cancer patients. Currently few effective cough interventions exist for lung cancer patients. This review proposes some of the mechanisms ...
Collins Gregory T - - 2012
Dopamine D3-preferring agonists are commonly used to treat Parkinson's disease and restless leg syndrome; however, laboratory animal studies suggest that they may possess a moderate abuse potential. These studies aimed to compare the highly selective, full D3 agonist PF-592,379 to the less selective D3 agonist 7-OH-DPAT, and the indirect dopamine ...
Garstang Susan - - 2012
The Accreditation Council for Graduate Medical Education requires that training programs comprehensively evaluate residents in the six core Accreditation Council for Graduate Medical Education competencies. One of the ways we do this in our residency is by administering a nine-station Objective Structured Clinical Examination (OSCE) at the end of each ...
Raps M - - 2012
It takes many years to obtain reliable values for the risk of venous thrombosis of hormonal contraceptive users from clinical data. Measurement of activated protein C (APC) resistance via thrombin generation is a validated test for determining the thrombogenicity of hormonal contraceptives. Sex hormone-binding globulin (SHBG) might serve as a ...
Ji Wen-Tsai - - 2012
Arecoline, the major alkaloid of areca nut, has been shown to cause strong genotoxicity and is considered a potential carcinogen. However, the detailed mechanism for arecoline-induced carcinogenesis remains obscure. In this study, we noticed that the levels of p21 and p27 increased in two oral squamous cell carcinoma cell lines ...
Hussain Zubair Muhammad - - 2012
Traumatic brain injury (TBI) induces a cascade of primary and secondary events resulting in impairment of neuronal networks that eventually determines clinical outcome. The dynorphins, endogenous opioid peptides, have been implicated in secondary injury and neurodegeneration in rodent and human brain. To gain insight into the role of dynorphins in ...
Zhong Qian - - 2012
Bone marrow stem cells (BMSCs) have been shown to improve neurological function recovery in cerebral ischemia. Hypoxia-inducible factor-1 (HIF-1) α-AA is a more stable mutant form of HIF-1α, which is a crucial oxygen-sensitive regulator. To investigate the protective effects of HIF-1α-AA-modified BMSCs on neuron survival in cerebral ischemia models, we ...
Sule Gautam - - 2012
A major obstacle in the genetic therapy of inherited metabolic disease is host immune responses to the therapeutic protein. This is best exemplified by inhibitor formation in the protein therapy for hemophilia A. An approach to overcoming this is induction of immunological tolerance to the therapeutic protein. Tolerogenic dendritic cells ...
Chen Chunhai - - 2012
A deficiency of maternal thyroid hormones (THs) during pregnancy may have severe impacts on fetal brain development. However, the cellular targets of THs and their underlying mechanisms are still unclear. In this study, we found that maternal hypothyroidism during pregnancy in mice inhibited neurogenesis in the embryonic telencephalon and caused ...
Dahlin Rebecca L - - 2012
Flow perfusion culture is used in many areas of tissue engineering and offers several key advantages. However, one challenge to these cultures is the relatively low-throughput nature of perfusion bioreactors. Here, a flow perfusion bioreactor with increased throughput was designed and built for tissue engineering. This design uses an integrated ...
Chang Je Ho - - 2012
Previous studies regarding the risk for colorectal neoplasms in women with a prior diagnosis of gynecological cancer have revealed conflicting results. Therefore, we conducted a cross-sectional study to quantify the risk for colorectal neoplasms in patients with gynecological cancers. A total of 4613 women (including 27, 51 and 92 women ...
Mena Rajah - - 2012
ABSTRACT: Health physics is an important discipline with regard to understanding the effects of radiation on human health. This paper aims to illustrate the unique challenges presented to the health physicist or analyst of radiological data in a large-scale emergency.
Nanashima Atsushi - - 2012
Background/Aims: Surgical resection is a radical treatment option for pancreatic carcinoma (PC); however, it is still difficult to cure and patient prognosis is poor at this stage. Methodology: We examined the demographics, surgical records and outcome in 64 patients with hilar PC undergoing surgical resection. Results: Pancreatoduodenectomy (PD) was carried ...
Seckinelgin Hakan - - 2012
The article explores how the social construction of 'success' by program funders foregrounds the role of biomedicine in advancing health, with no attention to the wider social contexts that make it possible for poor people to use this medicine to advance their health. The article considers the impact of the ...
Casper M - - 2012
Aim  Biallelic MutY human homologue (MUTYH) germline mutations predispose to recessively inherited adenomatous polyposis, designated MUTYH-associated polyposis (MAP), and colorectal cancer (CRC). The hotspot mutations p.Y179C and p.G396D account for the majority of pathogenic variants of MUTYH in Caucasians. Our aim was to evaluate the prevalence of MUTYH mutations in ...
Gardini Andrea - - 2012
Background/Aims: Natural history of renal cell carcinoma includes metastases to the pancreas. The literature reports that selected patients may have benefits by pancreatic resection in terms of long term survival. We report patient outcome and considerations on immunotherapy approach. Methodology: From 2001 to 2010 eight patients underwent pancreatic resection for ...
Budzik Jean-François - - 2012
Entrapment neuropathies are a rare but presumably underdiagnosed cause of shoulder pain and painful instability. Radiologists must be aware of the clinical presentations and imaging features of these neuropathies because they may be the first to suggest these diagnoses. In this article, instead of a classical nerve-by-nerve approach, entrapment neuropathies ...
Chiu King-Wah - - 2012
Background: The cytochrome P450 (CYP) drug-metabolizing enzymes play an important role in cellular metabolism. Therapeutic failure or drug toxicity in the period after liver transplantation (LT) is influenced by the drug metabolizing capacity of the graft. The expression levels of CYP2C19 enzyme are often used as an indicator of the ...
Nanashima Atsushi - - 2012
Background/Aims: To identify the clinical significance of the omental wrapping (OW) technique after left hepatectomy to reduce bile leakage and delayed gastric emptying. We examined clinical and surgical parameters after left hepatectomy with or without biliary reconstruction in 79 patients. Methodology: This was a retrospective study of data from 14 ...
Schmieder Roland E - - 2012
Experts from the European Society of Hypertension prepared this position paper in order to summarize current evidence, unmet needs and practical recommendations on the application of percutaneous transluminal ablation of renal nerves [renal denervation (RDN)] as a novel therapeutic strategy for the treatment of resistant hypertension. The sympathetic nervous activation ...
Lygidakis Nikolaos J - - 2012
Background/Aims: HIPEC has been recently recommended as the 'new standard of care' for advanced ovarian cancer patients to treat residual disease, a recommendation based on the good results reported by many single institution studies. This study aims to elucidate whether cyto-reductive surgery for advanced stage IV ovarian cancer combined with ...
Cornish Flora - - 2012
The empowerment of marginalised communities to lead local responses to HIV/AIDS is a key strategy of funding agencies' globalised HIV/AIDS policies, given evidence that disempowerment is a root source of vulnerability to HIV. We report on two multi-level ethnographies at the interface between HIV prevention projects for sex workers in ...
Aveling Emma-Louise - - 2012
Interventions aiming to promote gender equality are a common feature of global HIV/AIDS policies. To develop effective interventions, it is important to understand how globally established concepts (e.g. 'gender') are (re)interpreted and legitimated locally. This paper examines what happens when the concept of 'gender' hits the local ground in the ...
Ayifuhan Ahan - - 2012
Background/Aims: The purpose of this study is to present the surgical treatment of hepatic alveolar echinococcosis and evaluate the treatment outcomes. Methodology: A retrospective analysis was made on 50 patients admitted between 2000 and 2008. All the patients were divided into two groups, 26 patients for the radical surgery group ...
Hwang Shin - - 2012
Liver resection can result in various types of bile duct injuries but their treatment is usually difficult and often leads to intractable clinical course. We present an unusual case of hepatic segment III duct (B3) injury, which occurred after left medial sectionectomy for large hepatocellular carcinoma and was incidentally detected ...
Tanguturi Varsha Keelara - - 2012
The clinical evaluation of athletes during symptom evaluation or pre-participation screening often involves interpretation of the 12-lead electrocardiogram (ECG). Differentiating abnormal ECG findings suggestive of underlying cardiovascular disease from benign findings caused by exercise-induced cardiac adaptations can be challenging, and recent clinical guidelines have been created for this purpose. One ...
Edna Tom-Harald - - 2012
Background/Aims: The aim of this study was to report the prevalence of anaemia in patients with cancer located in different anatomical segments of the colon and rectum and to assess possible risk factors for this anaemia. Methodology: The study included 1189 patients referred during 1980-2004 with a colorectal adenocarcinoma. Data ...
van Baal Mark C - - 2012
To determine the risk of recurrent biliary events in the period after mild biliary pancreatitis but before interval cholecystectomy and to determine the safety of cholecystectomy during the index admission. Although current guidelines recommend performing cholecystectomy early after mild biliary pancreatitis, consensus on the definition of early (ie, during index ...
Tursi A - - 2012
Aim  Inflammation occurs in diverticular disease (DD), but there is little information on inflammatory cytokines such as tumour necrosis factor α (TNF-α). The aim of this study was to assess TNF-α expression in DD and to see whether it is related to the severity of the disease. Method  Twenty-four patients ...
Yamanaka-Okumura Hisami - - 2012
The use of steatotic livers for transplantation is often associated with increased primary non-function. To reduce the risk of liver injury, steatosis of the donor liver in living donor liver transplantation (LDLT) was treated with restricted diet and exercise. A 21-year-old male donor, 167cm in height and 87kg in body ...
Imura Satoru - - 2012
Hemophagocytic syndrome (HPS) is a rare but serious complication that is associated with hypercytokinemia caused by activated T lymphocytes and macrophages in immunologically compromised patients. Living donor liver transplantation (LDLT) between adults has been performed to compensate for the shortage of available organs. There have been some reports of HPS ...
Czymek Ralf - - 2012
Background/Aims: Acute upper gastrointestinal bleeding (UGIB) that cannot be managed with conservative interventional techniques is a life-threatening condition. This study assesses patient outcome and the role of different risk factors. Methodology: We retrospectively analyzed data from 91 patients (58 men, 33 women) admitted between 2000 and 2009 and who underwent ...
Shaw Andrew D - - 2012
To assess the association of 0.9% saline use versus a calcium-free physiologically balanced crystalloid solution with major morbidity and clinical resource use after abdominal surgery. 0.9% saline, which results in a hyperchloremic acidosis after infusion, is frequently used to replace volume losses after major surgery. An observational study using the ...
Tamano Masaya - - 2012
Background/Aims: The degree of hepatic fibrosis is an important factor for prognosis and management of patients with chronic liver disease; however, liver biopsy is an invasive method of measuring fibrosis. Here, we investigated the diagnostic utility of liver stiffness, as measured by transient elastography in assessing hepatic fibrosis of viral ...
Ribeiro-Vaz Inês I Northern Pharmacovigilance Centre, Faculty of Medicine, University of Porto, Porto, Portugal. - - 2012
Spontaneous adverse drug reaction (ADR) reporting has been described as an efficient method to detect drug safety signals. However, under-reporting is a major issue undermining the effectiveness of spontaneous reports. Among hospitalized patients, ADRs are a particularly serious problem because these patients are often treated with more than one drug, ...
Hwang Shin - - 2012
It is important to perform intraoperative cholangiography (IOC) during liver resection in order to detect bile leaks, but its performance is not so simple during repeat hepatectomy. We describe the technique of antegrade intraoperative cholangiography not requiring hepatic hilar dissection during repeated hepatectomy. The patient was a 35-year-old female who ...
Beltran Luis S - - 2012
Internal causes of impingement are secondary to rotator cuff and capsular dysfunction and are categorized by the location of the impingement and the underlying pathophysiological or mechanical cause of the impingement. These include posterosuperior impingement, anterosuperior impingement, anterior impingement, and entrapment of the long head of the biceps tendon. The ...
Smith Daniel Jordan DJ Department of Anthropology, Brown University, Box 1921, 128 Hope Street, Providence, RI 02912, USA. - - 2012
Using two ethnographic case studies, the intersecting dynamics of inequality, morality, and corruption are examined as they play out in Nigerian AIDS NGOs. To the Nigerian public, local AIDS organizations are widely seen as conduits for corruption. But local opinions of particular NGOs and their leaders turn less on whether ...
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