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Results 401 - 450 of 2109
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Peng Xin-Wen - - 2012
Xylan-rich hemicelluloses-based hydrogel was developed as a novel porous bioadsorbent by graft copolymerization of acrylic acid (AA) and xylan-rich hemicelluloses for adsorption of heavy metal ions (Pd2+, Cd2+, and Zn2+) from aqueous solutions. The chemical structure, the interaction between the hydrogel and metal ions and the porous structure of xylan-rich ...
Moritsugu Kei - - 2012
Molecular functions of intrinsically disordered proteins (IDPs) or intrinsically disordered regions (IDRs), such as molecular recognition and cellular signaling, are ascribed to dynamic changes in the conformational space in response to binding of target molecules. Sortase, a transpeptitase in Gram-positive bacteria, has an IDR in a loop which undergoes a ...
Dittrich Christian - - 2012
Pemetrexed/cyclophosphamide was evaluated as first-line treatment for patients with locally advanced/metastatic breast cancer. In this randomized phase II study (NCT00190671), therapy consisted of either 600 mg/m(2) (P600) or 1,800 mg/m(2) (P1800) pemetrexed, followed by 600 mg/m(2) cyclophosphamide, every 21 days; 103 females (42 P600; 61 P1800) were enrolled. P600 was ...
Li Xiaomao - - 2012
In recent years, it has been reported that CHFR may be a useful biomarker for chemotherapeutic response to microtubule inhibitors in some tumor cells. The purpose of the present study was to test the hypothesis and to elucidate the underlying mechanism in endometrial cancer cells. First, we effectively inhibited CHFR ...
Barazzuol Lara - - 2012
High-linear-energy transfer radiation offers superior biophysical properties over conventional radiotherapy and may have a great potential for treating radioresistant tumors, such as glioblastoma. However, very little pre-clinical data exists on the effects of high-LET radiation on glioblastoma cell lines and on the concomitant application of chemotherapy. This study investigates the ...
Etminan Mahyar - - 2012
There have been several published reports of inflammatory ocular adverse events, mainly uveitis and scleritis, among patients taking oral bisphosphonates. We examined the risk of these adverse events in a pharmacoepidemiologic cohort study. We conducted a retrospective cohort study involving residents of British Columbia who had visited an ophthalmologist from ...
Mudge Alison Mary - - 2012
Background: residents of aged care are old, frail and frequently require hospital management of intercurrent illness, but hospital outcomes are poor. OBJECTIVE: to identify the impact of an interdisciplinary care model on medical inpatients admitted from residential aged care (RAC). DESIGN: pre-planned subgroup analysis of controlled trial. SETTING: general medical ...
Rucker Richard P - - 2012
A method for highly selective anti-Markovnikov hy-droamination of terminal alkenes is reported. The one-pot procedure involves hydroboration of alkenes, followed by novel electrophilic amination of the alkyl boranes catalyzed by a NHC-Cu complex. Terminal alkenes are successfully transformed into tertiary alkyl amines in the presence of a variety of functional ...
Lamsa Anne A Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, - - 2012
Bacillus subtilis SDP is a peptide toxin that kills cells outside the biofilm to support continued growth. We show that purified SDP acts like endogenously produced SDP; it delays sporulation, and the SdpI immunity protein confers SDP resistance. SDP kills a variety of Gram-positive bacteria in the phylum Firmicutes, as ...
Heller Stephen T - - 2012
Carbonylimidazole derivatives have been found to be highly active acylation reagents for esterification and amidation in the presence of pyridinium salts. These reactions are thought to involve both Brønsted acid and nucleophilic catalysis. This mode of activation has been applied to the synthesis of difficult to access oxazolidinones, as well ...
Chaw Cheng Shu - - 2012
This study was aimed to investigate the effects of molar ratio of cholesterol to Span 60 and stabilizers (Solutol HS 15 or dicetyl phosphate (DCP)) on the entrapment of methylene blue, a model hydrophilic drug. The niosomes were prepared by the film hydration method and characterized for drug entrapment efficiency ...
Sahu Biswamitra - - 2012
This paper seeks to answer the question of how Muslim women interpret and negotiate religion in order to realise their reproductive aspirations. A close reading of lived experiences of 32 Muslim women from a varied educational background yields a wider perspective of the different interpretations of reproductive norms employed by ...
Reddy C D - - 2012
Precise positioning and packing of nanoscale building blocks is essential for the fabrication of many nanoelectro-mechanical devices. Carrying out such manipulations at the nanoscale still remains a challenge. Here we propose the use of graphone domain arrays embedded in a graphene sheet as a template to precisely position and pack ...
Yilmaz Y - - 2012
BACKGROUND: The role of excess fructose intake in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) has recently received increasing attention, but the pathophysiology of this relationship has been only partly elucidated. AIM: To provide an overview of the potential role played by fructose in the pathogenesis of NAFLD by ...
Frampton James E - - 2012
This article reviews the pharmacology, therapeutic efficacy and tolerability profile of intramuscularly injected onabotulinumtoxinA (onaBoNTA; BOTOX®) for headache prophylaxis in adults with chronic migraine, with a focus on UK labelling for the drug. The pharmacological actions of onaBoNTA include a direct antinociceptive (analgesic) effect; while not fully understood, the mechanism ...
Sissa Cristina - - 2012
A joint experimental and theoretical work is presented on two quadrupolar D-π-A-π-D chromophores characterized by the same bulky donor (D) group and two different central cores. The first chromophore, a newly synthesized species with a malononitrile-based acceptor (A) group has a V-shaped structure that makes its absorption spectrum very broad, ...
Lysaker Paul H - - 2012
Self-stigma is a barrier to the recovery of persons with schizophrenia. Little is known about whether participation in rehabilitation is naturalistically linked to declines in self-stigma, and if so, what is correlated with changes in self-stigma. The current study examined in a quasi-experimental design the rate of change of self-stigma ...
Lin Zhibin - - 2012
Many-body Green function analysis and first-order perturbation theory are used to quantify the influence of size, surface reconstruction and surface treatment on exciton transport between small silicon quantum dots. Competing radiative processes are also considered in order to determine how exciton transport efficiency is influenced. The analysis shows that quantum ...
Akdeniz Celal - - 2012
Blocked premature atrial contractions can cause bradycardia by resetting sinoatrial node and prolonging the RR intervals. Herein, we report the management of a patient with frequent premature atrial contractions in bigeminal pattern. The patient presented with symptomatic bradycardia and was successfully treated with propafenone.
Palmer Matthew A - - 2012
Wells ("The psychology of lineup identifications," Journal of Applied Social Psychology, 1984, 14, 89-103) proposed that a blank lineup (an initial lineup of known-to-be-innocent foils) can be used to screen eyewitnesses; witnesses who chose from a blank lineup (initial choosers) were more likely to make an error on a second ...
Hohwü Lena - - 2012
The aim of the study was to evaluate the impact of general practitioners (GPs) follow-up of unvaccinated girls in the Danish Human Papillomavirus catch-up vaccination programme. Telephone interviews were conducted with the GPs to explore their follow-up procedure. The girls were divided into two groups: 1) girls contacted by their ...
van Oostwaard Mf - - 2012
Please cite this paper as: van Oostwaard M, Langenveld J, Bijloo R, Wong K, Scholten I, Loix S, Hukkelhoven C, Vergouwe Y, Papatsonis D, Mol B, Ganzevoort W. Prediction of recurrence of hypertensive disorders of pregnancy between 34 and 37 weeks of gestation: a retrospective cohort study. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03312.x ...
Koksaldi Motor Vicdan - - 2012
Background and Aims: Many studies have focused on the role of pathogen infection in hypertension (HT). It has been postulated that increased vascular tonus in HT is basically related to the imbalance between vasodilator, such as nitric oxide (NO), and vasoconstrictor, such as endothelin-1 (ET-1), substances secreted by endothelium. The ...
Yudanov Vladislav V - - 2012
The possibility of the multichannel stochastic model to adequately describe all principal regularities observed in thermal electron transfer kinetics has been demonstrated. The most important are (i) the model predicts the solvent controlled regime in the Marcus normal region and its almost full suppression in the Marcus inverted region as ...
Galisteo-Lopez Juan - - 2012
Hybrid metallodielectric systems where dielectric components are combined with metals supporting surface plasmons are able to spatially redistribute the electromagnetic field intensity within its volume through hybrid photonic-plasmonic modes. While most of the work done recently in this kind of systems has been focused on the way such redistribution takes ...
Szondy Klara - - 2012
The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC cells was significantly decreased in ...
Lipps Ferdinand - - 2012
We investigate the nature of the solvent motions giving rise to the rapid temperature dependence of protein picoseconds motions at 220 K, often referred to as the protein dynamical transition. The interdependence of picoseconds dynamics on hydration and temperature is examined using terahertz time domain spectroscopy to measure the complex ...
Haapala Irja - - 2012
OBJECTIVE: To examine 21-year longitudinal changes in dietary habits and their associations with age and marital status among women aged 50-60 years at baseline. DESIGN: Prospective, longitudinal study of a cohort in the FINMONICA population-based risk factor survey with clinical assessments in 1982, 1992 and 2003. Dietary habits were assessed ...
Flamm Robert K - - 2012
The Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE) surveillance program is a sentinel resistance monitoring system designed to track the activity of ceftaroline and comparator agents. In the United States, a total of 8,434 isolates were collected during the 2010 surveillance program from 65 medical centers distributed across the nine census ...
Maclean Leann L - - 2012
Cronobacter dublinensis (formerly Enterobacter sakazakii) HPB 3169 is a pathogenic Gram-negative bacterium that produces a smooth-type lipopolysaccharide in which the antigenic O-polysaccharide component was determined to be a repeating pentasaccharide unit composed of l-rhamnose; 2-acetamido-2-deoxy-d-glucose; 3,6-dideoxy-3-(R)-3-hydroxybutyramido-d-glucose; and 3-deoxy-manno-oct-2-ulosonic acid in the respective molar ratio 2:1:1:1. Chemical and 2D NMR analyses ...
De Jong Kim - - 2012
Abstract Providing outcome monitoring feedback to therapists seems to be a promising approach to improve outcomes in clinical practice. This study aims to examine the effect of feedback and investigate whether it is moderated by therapist characteristics. Patients (n=413) were randomly assigned to either a feedback or a no-feedback control ...
Li Keyan - - 2012
By incorporating the solvent effect into the Born effective radius, an electronegativity scale of metal ions in aqueous solution with the most common oxidation states and hydration coordination numbers has been proposed in terms of the effective ionic electrostatic potential. It is found that the metal ions in aqueous solution ...
Heijmans J - - 2012
Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ...
Cho Y S - - 2012
A modified InChI (International Chemical Identifier) string scheme, yaInChI (yet another InChI), is suggested as a method for including the structural information of a given molecule, making it straightforward and more easily readable. The yaInChI theme is applicable for checking the structural identity with higher sensitivity and generating three-dimensional (3-D) ...
Tho Dau Quang DQ Oxford University Clinical Research Unit Vietnam, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, - - 2012
HIV-associated tuberculous meningitis (TBM) has high mortality. Aside from the devastating impact of multidrug resistance (MDR) on survival, little is understood about the influence of other bacterial factors on outcome. This study examined the influence of Mycobacterium tuberculosis drug resistance, bacterial lineage, and host vaccination status on outcome in patients ...
Yu Xiang - - 2012
The misfolding and aggregation of amyloid-ß (Aß) peptides into amyloid fibrils in solution and on the cell membrane has been linked to the pathogenesis of Alzheimer's disease. Although it is well known that the presence of different surfaces can accelerate the aggregation of Aß peptides into fibrils, surface-induced conformation, orientation, ...
Kellen David - - 2012
Traditional approaches within the framework of signal detection theory (SDT; Green & Swets, 1966), especially in the field of recognition memory, assume that the positioning of response criteria is not a noisy process. Recent work (Benjamin, Diaz, & Wee, 2009; Mueller & Weidemann, 2008) has challenged this assumption, arguing not ...
Kumar Puneet P Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84102, - - 2012
An easy and expeditious route to substituted piperidines is described. A Ni-phosphine complex was used as catalyst for [4 + 2] cycloaddition of 3-azetidinone and alkynes. The reaction has broad substrate scope and affords piperidines in excellent yields and excellent regioselectivity. In the reaction of an enantiopure azetidinone, complete retention ...
Guaraldi Federica - - 2012
Pituitary antibodies have been reported with greater frequency in patients with Hashimoto's thyroiditis than in healthy controls, although there is significant variability in the strength of the association and the methodologies used. We designed a nested case-control study to characterize the prevalence of pituitary antibodies at the time of the ...
Else-Quest Nicole M - - 2012
The self-conscious emotions (SCE) of guilt, shame, pride, and embarrassment are moral emotions, which motivate adherence to social norms and personal standards and emerge in early childhood following the development of self-awareness. Gender stereotypes of emotion maintain that women experience more guilt, shame, and embarrassment but that men experience more ...
Moonoosawmy Kevin R - - 2012
A sol-gel chemistry approach is employed to generate meso-porous and macro-porous brookite thin films using Ag ions as dopant species whose thermal stability are well above previously reported literature values for thin films. The Ag ions not only induce the formation of brookite but also participate towards its enhanced thermal ...
Adunsky Abraham - - 2012
Aim:  To study possible differences in rehabilitation outcomes of patients with hip fracture, with and without atrial fibrillation. Methods:  A retrospective cohort study comprising 1114 patients, divided into three groups: patients with sinus rhythm, paroxysmal atrial fibrillation or chronic atrial fibrillation. All patients underwent a standard orthogeriatric care comprising surgical ...
Rydell-Törmänen Kristina - - 2012
Pulmonary fibrosis is a hallmark of several systemic diseases such as systemic sclerosis. Initiation and early development is not well characterized, as initiation usually is unnoticed in patients, yet fibrosis has been considered a late event, occurring after an inflammatory phase. By utilizing an animal model, the starting point can ...
Williams Kathy - - 2012
Novel oral regimens composed of new drugs with potent activity against Mycobacterium tuberculosis and no cross-resistance with existing agents are needed to shorten and simplify treatment for both drug-susceptible and drug-resistant tuberculosis. As part of a continuing effort to evaluate novel drug combinations for treatment-shortening potential in a murine model, ...
Gordon Rachel A RA Institute of Government and Public Affairs, University of Illinois at Chicago, 815 West Van Buren St., Suite 525, Chicago, IL 60607, USA. - - 2013
The Early Childhood Environment Rating Scale-Revised (ECERS-R) is widely used to associate child care quality with child development, but its validity for this purpose is not well established. We examined the validity of the ECERS-R using the multidimensional Rasch partial credit model (PCM), factor analyses, and regression analyses with data ...
Fisher David M - - 2012
Team mental models (TMMs) have received much attention as important drivers of effective team processes and performance. Less is known about the factors that give rise to these shared cognitive structures. We examined potential antecedents of TMMs, with a specific focus on team composition variables, including various facets of personality ...
Nar Meryem - - 2012
In this study, we have synthesised (3,4-dihydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone and a series of its derivatives (5, 13-16) and tested the ability of these compounds to inhibit two metalloenzyme human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, hCA I and hCA II. The synthesised compounds showed inhibitory effect on hCA I and hCA II ...
Kasper Frederikke - - 2012
Cystic tumour of the atrioventricular node (CTAVN) is a rare type of cardiac tumour. We report a case of a previously healthy nine year-old girl, presenting with syncope caused by complete AV block. Despite intensive treatment, she died of multiple organ failure after two days. Infectious and congenital AV block ...
Ohkubo Tsuyako - - 2012
T-type voltage-gated Ca2+ channels have unique electrophysiological properties, suitable for generating Ca2+ oscillations and waves and thus controlling the proliferation of various tumor cells. In the present study, we investigated the role of Cav3.1, a candidate tumor suppressor gene, in neoplastic processes, and compared the differences between Cav3.1 with Cav3.2 ...
Bijleveld Erik E Department of Psychology, Utrecht University, Utrecht, the Netherlands. - - 2012
When in pursuit of rewards, humans weigh the value of potential rewards against the amount of effort that is required to attain them. Although previous research has generally conceptualized this process as a deliberate calculation, recent work suggests that rudimentary mechanisms-operating without conscious intervention-play an important role as well. In ...
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