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Results 301 - 350 of 2109
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Haerich Paul - - 2012
With the increased international emphasis on manned space exploration, there is a growing need to understand the impact of the spaceflight environment on health and behavior. One particularly important aspect of this environment is low-dose radiation. In the present studies, we first characterized the γ- and proton-irradiation dose effect on ...
Paduszyński Kamil - - 2012
We present the results of extensive study on novel approach of modeling of ionic liquids (ILs) and their mixtures with molecular compounds, incorporating perturbed-chain statistical associating fluid theory (PC-SAFT). The PC-SAFT was used to calculate thermodynamic properties of different homologous series of ILs based on bis(trifluormethylsulfonyl)imide anion ([NTf<sub>2</sub>]). First, pure ...
Kosugi Takahiro - - 2012
Conformational flexibility of proteins provides enzymes with high catalytic activity. Although the conformational flexibility is known to be pivotal for the ligand binding and release, its role in the chemical reaction process of the reactive substrate remains unclear. We determined a transition state of an enzymatic reaction in a psychrophilic ...
Koenig T - - 2012
Megavoltage imaging in image-guided radiotherapy usually suffers from the relatively small fraction of photons present in the energy range providing good soft tissue contrast, which corresponds to photon energies below 50 keV. As a consequence, comparatively high imaging doses are required to form low-noise images. Single-crystal targets can help to ...
Chrimes Adam F - - 2012
We demonstrate an active microfluidic platform that integrates dielectrophoresis for the control of silver nanoparticles spacing, as they flow in a liquid channel. By careful control of the nanoparticles spacing, we can effectively increase the surface-enhanced Raman scattering (SERS) signal intensity based on augmenting the number of SERS-active hot-spots, while ...
Philip Femi - - 2012
Background.  Atrial fibrillation (AF) is a common arrhythmia in adults with congenital heart disease (CHD). Long-term antiarrhythmic therapy (AAT) in these patients has significant shortcomings. The safety and efficacy of pulmonary vein antrum isolation (PVAI) for the treatment of AF in CHD is presently unknown. Hypothesis.  We hypothesized that PVAI ...
Bhupatiraju Charita - - 2012
Introduction. Bradykinin, a vasodilator by nature has been documented to have a protective role against hypertension and cardiovascular complications. Polymorphisms of bradykinin B2 receptor (BDKRB2) gene are reported to be predisposing factors for hypertension. Evaluation of the association between -58C>T and ±9 bp polymorphisms of BDKRB2 with essential hypertension (EHT) ...
Kato Jun - - 2012
Non-alcoholic steatohepatitis (NASH) is the hepatic manifestation of a metabolic syndrome characterized by accumulation of hepatic fat, inflammation and varying degrees of fibrosis. Angiotensin (AT)-II has been reported to play a role in the establishment of NASH. This study examined the effects of an AT-II receptor blocker, irbesartan, on NASH ...
Henderson Mark J - - 2012
Liquid N,N,N',N'-tetramethyl-ethane-1,2-diamine (tmeda) was intercalated into preprepared C(6)Li or C(12)Li. X-ray diffraction from the ternary compound indicates an identity period of 11.5 Å. The (13)C NMR line shifts show that tmeda molecules form a screen between the graphene planes and the lithium ions. Small-angle X-ray scattering showed that no higher ...
Koo Bonil - - 2012
Material design in terms of their morphologies other than solid nanoparticles can lead to more advanced properties. At the example of iron oxide we explored the electrochemical properties with an application as a cathode and anode of hollow nanoparticles. Such nanoparticles contain very high concentration of cation vacancies that can ...
Khan Munasib - - 2012
Juniperus excelsa Bieb. is used in folk medicine for lowering blood pressure (BP). Its BP-lowering effect, endothelium-dependent and endothelium-independent vasodilator effects, and cardio-modulatory effect are reported here. The crude extract of J. excelsa (Je.Cr) which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes, and tannins induced a ...
Henne Walter A - - 2012
EC20, a folate-targeted (99m)Tc based radioimaging agent with a high folate receptor (FR) binding affinity, has been used for both the diagnosis and the staging of FR positive malignancies (currently in phase III trials) and also for the localization of inflamed lesions characterized by the accumulation of FR+ macrophages. Because ...
McDonald Andrea M - - 2012
Objectives  To (i) document the incidence of multiplicity in Nigeria, (ii) compare healthcare utilization during pregnancy and at delivery for singleton and multiple pregnancies (iii)and investigate whether antenatal care modifies the relationship between multiplicity and likelihood of having skilled attendance. Methods  This observational study was a secondary analysis of the ...
Bortolatto Cristiani F - - 2012
Context: Organoselenium compounds have been described as antioxidant and neuroprotective agents. Objective: To evaluate the antioxidant action of 2,2'-dithienyl diselenide (DTDS) and its effects in brain monoamine oxidase (MAO) activity in vitro. Materials and methods: Assays for reactive species (RS), lipid peroxidation, protein oxidation, MAO A and B activities in ...
Ohkubo Tsuyako - - 2012
T-type voltage-gated Ca2+ channels have unique electrophysiological properties, suitable for generating Ca2+ oscillations and waves and thus controlling the proliferation of various tumor cells. In the present study, we investigated the role of Cav3.1, a candidate tumor suppressor gene, in neoplastic processes, and compared the differences between Cav3.1 with Cav3.2 ...
Shin Seung Han - - 2012
Background: Pleuropulmonary blastoma (PPB) is a rare and aggressive intrathoracic neoplasm that is associated with other dysplastic or neoplastic conditions. The prognosis, especially of type II (cystic and solid) and type III (solid) PPB, is poor. High-dose chemotherapy (HDC) and hematopoietic stem cell transplantation (HSCT) have been attempted to improve ...
Liu Yinglan - - 2012
The roles of inflammation-associated genes in the pathogenesis of endocervical polyps remain unclear. We thus compared the expression levels of 509 inflammation-associated genes between endocervical polyp tissues and endocervical canal membrane tissues using a gene microarray. Sixteen inflammation-related genes were differentially expressed in endocervical polyps compared with those of normal ...
Eno Louden Jennifer - - 2012
Persons with mental disorder are overrepresented in the criminal justice system. Once involved in the criminal justice system, offenders with mental disorder are more likely to return to custody while on probation than their nondisordered counterparts, often for breaking the rules of community supervision. Risk assessments and risk management strategies ...
McNulty C A M - - 2012
Most patients are prescribed Helicobacter pylori treatment without culture and antibiotic susceptibility testing, as current guidance recommends that patients with recurrent dyspepsia should be tested for H. pylori using a non-invasive breath or faecal antigen test. To determine the prevalence of H. pylori antibiotic resistance in patients attending endoscopy in ...
Morrongiello Barbara A - - 2012
Objective: Fire is a leading cause of unintentional injury and, although young children are at particularly increased risk, there are very few evidence-based resources available to teach them fire safety knowledge and behaviors. Using a pre-post randomized design, the current study evaluated the effectiveness of a computer game (The Great ...
Kishi Ryohei - - 2012
We develop novel calculation and analysis methods for the dynamic first hyperpolarizabilities β [the second-order nonlinear optical (NLO) properties at the molecular level] in the second harmonic generation based on the quantum master equation method combined with the ab initio molecular orbital (MO) configuration interaction method. As examples, we have ...
Whitmer Anson J - - 2012
Previous studies have demonstrated that individuals with major depressive disorder have difficulties switching attention from one task set to another. In the current study we examined whether ruminative thinking drives the switching deficits of depressed individuals. A secondary, more exploratory, goal of this study was to examine whether state rumination ...
Di Paola Rosanna - - 2012
Our primary aim in this study was to test the hypothesis that PEA, a member of the fatty acid ethanolamide family and an endogenous PPAR-α ligand, exerts anti-inflammatory effects on SAO shock, causing a severe form of circulatory shock and enhanced formation of ROS. SAO shock was induced by clamping ...
Gahr Maximilian - - 2012
In order to summarize current knowledge about the drug "Krokodil" a systematic review including a literature search of the databases PubMed, Embase, Scopus, and Google was conducted in December 2011. According to information acquired, "Krokodil" is a mixture of several substances and was first reported to have been used in ...
Goodwin David G - - 2012
Abstract We examined the effect of maternal Toxoplasma gondii infection on the behavior and neurotransmitter concentrations of congenitally infected CD-1 mice at 4 and 8 wk of age when latent tissue cysts would be present in their brains. Because of sex associated behavioral changes that develop during aging, infected female ...
Sharma Diksha - - 2012
The computational modeling of medical imaging systems often requires obtaining a large number of simulated images with low statistical uncertainty which translates into prohibitive computing times. We describe a novel hybrid approach for Monte Carlo simulations that maximizes utilization of CPUs and GPUs in modern workstations. We apply the method ...
Zanicotti Claudia Grott - - 2012
Abstract Depression is highly prevalent in patients with advanced cancer, commonly affecting quality of life. Considering the response delay with conventional antidepressants and the short life expectancy for these patients, treatments for Major Depressive Disorder (MDD) with faster onset of action are desirable. In this case report, a female patient ...
Thing Birthe Agergaard - - 2012
Cancer in the gallbladder is rare, and each year about 160 cases are registered in Denmark. Most malignant tumours in the gallbladder are adenocarcinomas. We present a rare case of signet ring cell carcinoma of the gallbladder. Signet ring cell carcinomas are particularly aggressive. The tumours are often disseminated at ...
Panek Michał - - 2012
Bronchial asthma is a disease of multifactorial etiology. The natural variability of the DNA sequence within the h-GR/NR3C1 gene affects both the conformation and the activity of glucocorticoid receptors. There are 2 major types of resistance to glucocorticoids (GCS)-resistant asthma failing to respond to treatment with high doses of inhaled ...
de Niet Judith - - 2012
Objective: Lifestyle programs can reduce the level of overweight in children; however, maintenance results and adherence to treatment are difficult to achieve. New technologies, such as the Short Message Service (SMS), might be a promising tool for enhancing interventions. The effect of an SMS approach aimed at improving treatment results ...
Eloy Jean Anderson - - 2012
Objective. The infratemporal fossa (ITF) has historically been one of the most difficult regions of the skull base to access surgically. Available open approaches are complex, are associated with high morbidity, and do not always afford optimal visualization. Endoscopic access to the ITF improves visualization for management of many sinonasal ...
Folven Erik - - 2012
The technologically important exchange coupling in antiferromagnetic/ferromagnetic bilayers is investigated for embedded nanostructures defined in a LaFeO3/La0.7Sr0.3MnO3 bilayer. Exploiting the element specificity of soft x-ray spectromicroscopy, we selectively probe the magnetic order in the two layers. A transition from perpendicular to parallel spin alignment is observed for these nanostructures, dependent ...
Wagner L - - 2012
Inhibitor of apoptosis (IAP) proteins are expressed at high levels in many cancers and therefore represent attractive targets for therapeutic intervention. Here, we report for the first time that the second mitochondria-derived activator of caspases (Smac) mimetic BV6 sensitizes glioblastoma cells toward Temozolomide (TMZ), the first-line chemotherapeutic agent in the ...
van Hamersveld Koen T - - 2012
Objective  To explore barriers to and solutions for effective implementation of obstetric audit at Saint Francis Designated District Hospital in Ifakara, Tanzania, where audit results have been disappointing 2 years after its introduction. Methods  Qualitative study involving participative observation of audit sessions, followed by 23 in-depth interviews with health workers and ...
Baron Riccardo - - 2012
LSD1 associated with its co-repressor protein CoREST is an exceptionally relevant target for anticancer epigenetic drugs. Hypotheses for the role of LSD1/CoREST as a multidocking site for chromatin and protein binding would require significant molecular flexibility and LSD1/CoREST large-amplitude conformational dynamics is currently unknown. Here, molecular dynamics simulation reveals that ...
Chen Zeng-Ping - - 2012
Particle size distribution and compactness have significant confounding effects on Raman signals of powder mixtures, which cannot be effectively modeled or corrected by traditional multivariate linear calibration methods such as partial least squares (PLS), and therefore greatly deteriorate the predictive abilities of Raman calibration models for powder mixtures. The ability ...
Ataguba John Ele-Ojo - - 2012
South Africa is considering major health service restructuring to move towards a universal system. This calls for understanding the challenges in the existing health system. The paper, therefore, comprehensively evaluates an aspect of current health system performance - the benefit incidence of health services. It seeks to understand how the ...
Hamid Abid - - 2012
The folate transport across the epithelial of the intestine, colon, kidney, and liver is essential for folate homeostasis. The relative localization of transporters in membranes is an important determinant for the vectorial flow of substrates across the epithelia. Folate deficiency is a highly prevalent vitamin deficiency in the world, and ...
Sun Jianfei - - 2012
Gold nanoshells currently attract increasing research interests due to the important role in many subjects. For practical applications, random arrangement of the nanoparticles is often unfavored so that the assembly of gold nanoshells is becoming a central issue. We here proposed to utilize time-variant magnetic field to direct the assembly ...
Raverot Véronique - - 2012
Background: Iodine deficiency (ID) remains common in Europe, and may be especially detrimental during pregnancy. The aim of our study was to assess iodine status and thyroid function in healthy pregnant women in the Lyon metropolitan area. Methods: In a cross-sectional study, healthy pregnant women (n=228) with no history of ...
Foster Nathaniel L - - 2012
In 4 experiments, we examined whether metacognitive beliefs about item memorability influence item-method directed forgetting. In Experiment 1, participants studied loud and quiet items, which were subsequently cued as to-be-remembered (TBR) or to-be-forgotten (TBF). Typically, the volume of stimuli does not influence recall, although loud items are judged as more ...
Ankola Anil V - - 2012
Abstract -  Aim: The aim of this study was to investigate the prevalence of dental trauma among primary school children aged 6-11 years in Belgaum, India.Materials and methods: A sample of 13 200 children from primary schools of Belgaum district was examined for dental trauma. WHO classification of dental trauma was used.Results: Total number of children ...
Koshevoy Igor O - - 2012
We report a homoleptic Au-Cu alkynyl cluster that represents an unexplored class of luminescent materials with stimuli-responsive photophysical properties. The bimetallic complex formulated as [Au2Cu2(C2OHC5H8)4]n efficiently self-assembles from Au(SC4H8)Cl, Cu(NCMe)4PF6 and 1-ethynylcyclopentanol in the presence of NEt3. This compound shows remarkably diverse polymorphism arising from the modulation of metallophilic interactions ...
Leary Dagmar Hajkova - - 2012
The large-scale identification and quantitation of proteins via nano-liquid chromatography (LC)-tandem mass spectrometry (MS/MS) offers a unique opportunity to gain unprecedented insight into the microbial composition and biomolecular activity of true environmental samples. However, in order to realize this potential for marine biofilms, new methods of protein extraction must be ...
Yildirim Nesligül - - 2012
Background. The aim of our study was to investigate the effect of white coat hypertension (WCH) to atrial conduction abnormalities by electrocardiographic P-wave analysis and echocardiographic electromechanical coupling (EMC) interval measurement. Methods. The study consisted of sex-, age-, and body mass index-matched 24 patients with WCH, 24 patients with sustained ...
Behrens Sarah - - 2012
Abstract In a recent article, Behrens and Vingron (J. Comput. Biol. 17/12, 2010) compute waiting times for k-mers to appear during DNA evolution under the assumption that the considered k-mers do not occur in the initial DNA sequence, an issue arising when studying the evolution of regulatory DNA sequences with ...
Akamatsu Hirofumi - - 2012
A comparative study of the crystal and electronic structure and magnetism of divalent europium perovskite oxides EuMO(3) (M = Ti, Zr, and Hf) has been performed on the basis of both experimental and theoretical approaches playing complementary roles. The compounds were synthesized via solid-state reactions. EuZrO(3) and EuHfO(3) have an ...
Unsworth Nash - - 2012
The present study examined individual differences in everyday attention failures. Undergraduate students completed various cognitive ability measures in the laboratory and recorded everyday attention failures in a diary over the course of a week. The majority of attention failures were failures of distraction or mind wandering in educational contexts (in ...
Yveborg Moa - - 2012
We are developing a photon-counting silicon strip detector with 0.4 × 0.5 mm(2) detector elements for clinical CT applications. Except for the limited detection efficiency of approximately 0.8 for a spectrum of 80 kVp, the largest discrepancies from ideal spectral behaviour have been shown to be Compton interactions in the detector ...
Hellman Urban - - 2012
Marked differences in phenotype in familial amyloid polyneuropathy (FAP) populations have been noted between but also within FAP populations. Initially, it was believed that patients with FAP, caused by the TTR V30M mutation, shared the same founder. However, recent studies have clearly shown that the V30M mutation in Sweden occurred ...
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