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Chodisetti Bhuvaneswari - - 2012
Gymnema sylvestre (CS 149), known to be a rich source of saponins and other valuable phytochemicals, has been analysed for antimicrobial activity. The chloroform extracts of aerial and root parts of G. sylvestre exhibited higher antimicrobial activity as compared to diethyl ether and acetone. The root extracts of chloroform have ...
Sebo Thomas J - - 2012
There is much concern expressed in the literature regarding the lack of predictive power of the thyroid fine needle aspiration/ biopsy (TFNAB) approach to defining the nature of clinically-detected thyroid nodules. This has been exacerbated in the past decade or more by the routine use of ultrasonography in examining the ...
Belfiori B - - 2012
Truffles are hypogeous ectomycorrhizal fungi belonging to the genus Tuber. Although outplanting of truffle-inoculated host plants has enabled the realization of productive orchards, truffle cultivation is not yet standardized. Therefore, monitoring the distribution of fungal species in different truffle fields may help us to elucidate the factors that shape microbial ...
Jin Kyung-Hwan - - 2012
The effect of atomic impurities including N, O, Na, Ti and Co on the surface states of the topological insulator (TI) Bi(2)Te(3) is studied using pseudopotential first principles methods. The robustness of the TI surface states is particularly investigated against magnetic and non-magnetic atomic adsorption by calculating the electronic band ...
Balaji Vijayam - - 2012
A randomized, open-label, parallel study was conducted to assess the efficacy and safety of premixed insulin aspart 30 (biphasic insulin aspart [BIAsp] 30) in managing gestational diabetes mellitus (GDM). A total of 323 women with GDM registered at a single center in India were randomly assigned to receive 6 U of ...
Yang Jiezuan - - 2012
The study was to determine the degree of clonal expansion of T cells in peripheral blood mononuclear cells (PBMCs) isolated from patients suffering from different clinical types of hepatitis B infection and to analyze the clinical relevance of the skewed T cell receptor beta variable (TCRBV). Sera and PBMCs were ...
Mongelli M - - 2012
Abstract Objective: To test the hypothesis that small or large for gestational age (SGA or LGA) newborns have anomalous crown rump length (CRL) growth rates in the 1(st) trimester. Methods: Prospective observational study. Women in the 1(st) trimester presenting to the Early Pregnancy Unit, between November 2006 and December 2010, ...
Frost David M - - 2012
Abstract The aim of this study was to quantify joint compression and shear forces at L4/L5 during exercises used to overload the hips. Nine men performed 36 "walking" trials using two modalities: (1) sled towing and (2) exercise bands placed around the ankles. Participants completed forward, backward, and lateral trials ...
van der Valk R J P - - 2012
BACKGROUND: Gene variants on chromosome 17q12-21 are associated with an increased risk of childhood-onset asthma, a risk known to be modified by environmental tobacco smoke (ETS). OBJECTIVES: To assess whether the association of rs2305480 on chromosome 17q12 in the GSDML gene with asthma-like symptoms in the first 4 years of life ...
Chailap Benjamat - - 2012
Two heteroditopic receptors based on a calix[4]arene crown ether containing amidoanthraquinone pendants in cone and 1,3-alternate conformations ( and , respectively) were synthesized. Photophysical properties of and were studied by UV-vis and fluorescence spectrophotometry in dried CH(3)CN. Both and showed the highest sensitivity towards F(-) through the appearance of a ...
Chan Bun - - 2012
We have assessed computational methodologies for calculating the rate constants for hydrogen abstraction by Cl(•) for a selection of 12 reactions. For the conventional approach of calculating higher-level [B2K-PLYP/aug'-cc-pV[(T+d),(Q+d)]Z] single-point energies at lower-level [BH&H-LYP/6-31+G(d,p)] stationary points, large deviations from experimental rate constants are found in a number of cases in ...
Kamezaki Yoshiko - - 2012
Stress-induced production of proinflammatory cytokines in the brain and periphery is associated with mental distress. In this study, we measured changes in levels of salivary cortisol and 50 circulating immune mediators in 28 4th-grade medical students (19 males and 9 females) 7 weeks before, 1 day before, immediately after, and ...
Szczepankiewicz Aleksandra - - 2012
Objectives. Asthma is a heterogenous complex disorder caused by chronic inflammation of the airways. The key issue in genetic association studies of complex disorders is the identification of multiple low-risk genes that individually have little impact on the phenotype, but in combination account for the clinical manifestation of asthma. Since ...
Markwick Arwen - - 2012
The comparative ability of the Montreal Cognitive Assessment (MoCA) and MMSE to detect mild cognitive difficulties was investigated in 107 older adults. The sensitivity of the MoCA to detect cognitive impairment with a cutoff score of <26 was investigated, as compared to the MMSE across all scores, and at a ...
Uzdin V M - - 2012
The magnetic response of itinerant electrons systems to an external magnetic field is investigated on the basis of a microscopic Hamiltonian from which the spin-polarized electronic structure is determined. The magnetic moment and grand thermodynamic potential of the d-electronic subsystem on a particular atomic site in the presence of the ...
Bae Donghyuck D Jeollanamdo Institute of Natural Resources Research, Jeollanamdo 529-851, - - 2012
Chamaecyparis obtusa Sieb. & Zucc., Endlicher (Cupressaceae) forest bathing or aromatherapy has been shown in various studies to have biological functions such as anticancer, antiallergies, antiinflammatory, and antioxidant activity. However, no reports exist on the pharmacological or biological activities of the essential oil of C. obtusa (EOCO) or its effects ...
Weisberg E E Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, - - 2012
Acute myeloid leukemia (AML) progenitors are frequently characterized by activating mutations in the receptor tyrosine kinase Fms-like tyrosine kinase-3 (FLT3). Protein tyrosine kinases are integral components of signaling cascades that have a role in both FLT3-mediated transformation as well as viability pathways that are advantageous to leukemic cell survival. The ...
Ogden Lorraine G - - 2012
The National Weight Control Registry (NWCR) is the largest ongoing study of individuals successful at maintaining weight loss; the registry enrolls individuals maintaining a weight loss of at least 13.6 kg (30 lb) for a minimum of 1 year. The current report uses multivariate latent class cluster analysis to identify ...
Talati Sapan - - 2012
Fenoldopam is a dopamine-like receptor agonist that selectively increases renal medullary blood flow. Despite promising pathophysiology, randomized control trial failed to show benefit with intravenous infusion of fenoldopam in preventing CIN. The objectives of this study were to examine the efficacy of intra-renal fenoldopam in preventing CIN in high risk ...
Geldenhuys Werner J - - 2012
The blood-brain barrier (BBB) is a selectively permeable micro-vascular unit which prevents many central nervous system (CNS)-targeted compounds from reaching the brain. A significant problem in CNS drug development is the ability to model BBB permeability in a timely, reproducible and cost-effective manner. Through the years, several models have been ...
Kilic Sevtap - - 2012
Abstract Objective: To evaluate the intrauterine effect of cigarette smoke on cell death and DNA damage in follicular cells of fetal ovarian tissue. Methods: A prospective, randomized study was conducted with 25 female wistar-albino rats. The rats were randomized either to be exposed to cigarette smoke or to room air, ...
Doria Filippo - - 2012
Extended naphthalene diimides (NDIs) fused to 1,4-dihydropyrazine-2,3-dione, containing two solubilizing moieties, have been synthesized. Fluorescence spectra of the new NDIs were remarkably affected by pH, as the second deprotonation of the dihydropyrazinedione moiety (pK(a) 6.9) switched off the emission. Binding to a G-quadruplex folded oligonucleotide and stoichiometry were evaluated by ...
Hostert C - - 2012
A systematic ab initio molecular dynamics study was carried out to identify valence electron concentration and size induced changes on structure, elastic and magnetic properties for Co(43)Fe(20)Ta(5.5)X(31.5) (X=B, Si, P, S). Short range order, charge transfer and the bonding nature are analyzed by means of density of states, Bader decomposition ...
Banan Mehdi - - 2012
Hydroxyurea (HU) is a drug used for the treatment of hemoglobinopathies. HU functions by up-regulating γ-globin transcription and fetal hemoglobin (HbF) production in erythroid cells. The K562 erythroleukemia cell line is widely used as a model system to study the mechanism of γ-globin induction by HU. However, transcription factors required ...
Pujari Bhalchandra S - - 2012
Using density functional theory we investigate a novel carbon allotrope 'SqC': a square planar material that can be more than tetracoordinated. Carbon atoms in this 2D square Bravais lattice form an unusual five-center four-electron bond with neighboring four carbon atoms (tetracoordination). Such an electron-deficient bonding leaves an empty orbital which ...
Usui Takeshi - - 2012
OBJECTIVES: Epidemiologic studies indicate that soy intake has an important role in the prevention of age-related health problems. Daidzein, the principal isoflavone contained in soy, is converted to S-equol by the intestinal bacteria. Not all individuals, however, can produce S-equol, which is considered the most biologically active metabolite. We studied ...
Shide K - - 2012
Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state of DNA; somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies. To study the function of TET2 in vivo, we analyzed Ayu17-449 (TET2(trap)) mice, ...
Delforge Michel - - 2012
OBJECTIVES: The phase 3 VISTA study (http:\\ClinicalTrials.gov NCT00111319) in transplant-ineligible myeloma patients demonstrated superior efficacy with bortezomib-melphalan-prednisone (VMP; nine 6-week cycles) versus melphalan-prednisone (MP) but also increased toxicity. Health-related quality of life (HRQoL; exploratory endpoint) was evaluated using the European Organization for Research and Treatment of Cancer (EORTC) Quality of ...
Morita Mayuko - - 2012
Abstract An excessive accumulation of fat in the liver leads to chronic liver injury such as NAFLD (non-alcoholic fatty liver disease), which is an important medical problem affecting many populations worldwide. Oxidative stress has been implicated in the pathogenesis of NAFLD, but the exact nature of active species and the ...
Oyarzo Carolina - - 2012
Abstract Objective: To investigate whether the February 27(th) earthquake exposition was associated to adverse perinatal outcomes in Chilean pregnant women. Methods: We analyzed all deliveries occurred in 2009 (N=3,609) and 2010 (N=3,279) in a reference hospital in the area of the earthquake. Furthermore, we investigated pregnant women who gave birth ...
Ravikumar Madhumitha - - 2012
Platelet-mimetic synthetic hemostats are highly attractive in transfusion medicine. To this end, past research reports have described particles that either amplify platelet aggregation or mimic platelet adhesion. However, a construct design that effectively combines both functionalities has not been reported. Here, we describe the design of a liposomal construct simultaneously ...
Zheng Chunli - - 2012
Aim: The aim of this study was to investigate the feasibility of cationic biodegradable dextran microspheres loaded with bovine serum albumin (BSA) posterior to gel formation (postloading). Method: Positively charged microspheres were prepared by polymerization of hydroxylethyl methacrylate-derivatized dextran (dex-HEMA) and dimethyl aminoethyl methacrylate (DMAEMA) in an aqueous two-phase system ...
Lundgren Jennifer D - - 2012
The prevalence and familial patterns of night eating syndrome (NES) in families enrolled in the Québec Adipose and Lifestyle InvesTigation in Youth (QUALITY) study was examined. Families (n = 395; one child, mother, and father for whom at least one parent was obese or had abdominal obesity) completed the Night ...
Bingham P A - - 2012
The structure of iron phosphate glasses modified by additions of K(2)O and BaO, with nominal molar compositions [(1 - x)(0.6P(2)O(5)-0.4Fe(2)O(3))]xMe(y)O, where x = 0-0.4 in increments of 0.1; Me=K or Ba; and y = 1 or 2, has been investigated using neutron diffraction and x-ray diffraction techniques. Fitted coordination numbers for P-O and Fe-O showed a ...
Dai Yan - - 2012
Carbon monoxide can adsorb specifically on Pd (111) to induce the formation of unique Pd nanostructures. In the co-presence of CO and H2, single-crystalline Pd tetrapod nanocrystals have now been successfully prepared. The Pd tetrapods are enclosed by (111) surfaces and are yielded through hydride formation. DFT calculations revealed that ...
Massin Nathalie - - 2012
CONTEXT: The androgen receptor (AR) is essential for the development and maintenance of the male phenotype, and for spermatogenesis. Mutations in the AR gene cause a wide variety of androgen insensitivity syndromes (AIS), ranging from complete feminization to phenotypic males with infertility. OBJECTIVE: We report the first birth achieved after ...
de Oliveira Gisele Lopes - - 2012
Context: Xanthosoma sagittifolium Schott. (Araceae) and Laportea aestuans (L.) Chew (Urticaceae) are two medicinal species used as food and to prevent and treat bone diseases, such as osteoporosis, in traditional Brazilian medicine. Objective: To investigate the free calcium concentration and further support the traditional use of these species as medicine. ...
van der Hooft Justin Johan Jozias - - 2012
In order to obtain more insight into the complex phenolic composition of tea, we applied advanced analytical approaches consisting of both LC-LTQ-Orbitrap Fourier Transformed (FT)-MS and LC-Time-of-Flight-(TOF)-MS coupled to Solid-Phase-Extraction-(SPE)-NMR. Based on the combined structural information from i) accurate mass fragmentation spectra, derived by using LC-Orbitrap FTMSn, and ii) proton-NMR ...
Yin Huiyong - - 2012
Abstract Cardiolipin (CL) is a mitochondria-specific phospholipid and is critical for maintaining the integrity of mitochondrial membrane and mitochondrial function. CL also plays an active role in mitochondria-dependent apoptosis by interacting with cytochrome c (cyt c), tBid and other important Bcl-2 proteins. The unique structure of CL with four linoleic ...
Boyages Steven - - 2012
CONTEXT: Seasonal variation in 25-hydroxyvitamin D [25OHD] status and its relationship to gender, age, socioeconomic and geographic determinants in Australians has not been described in large biomedical sampling cohorts. OBJECTIVES: To analyse 25OHD levels in all primary tests undertaken consecutively in a two-year period to determine the prevalence of 25 ...
Er┼żen R - - 2012
BACKGROUND: There is no in vitro test to predict the induction of long-term tolerance in patients treated with venom immunotherapy (VIT). The aim of this study was to investigate whether immunotherapy-induced changes in basophil responsiveness reflect a state of protection and the induction of a tolerance. METHODS: Twenty-three patients with ...
Rosenthal Asher Deborah D Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, New York 11203-2098, - - 2012
The scientific evaluation of depression's impact on mortality in hemodialysis (HD) patients has yielded mixed results, with the more recent, more rigorous studies detecting a significant relationship. In this study, 130 HD patients from an urban North American hospital were evaluated for depressive affect and then observed for up to ...
Otto Claudia - - 2012
Hodgkin and Reed/Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) show constitutive activation of nuclear factor (NF)-κB. Several genetic lesions contribute to this deregulated NF-κB activity. Here, we analysed two further NF-κB regulators for genetic lesions, the inhibitory factor TRAF3 and the key signalling component of the alternative NF-κB pathway, ...
Dhami Manpreet K - - 2012
Scale insects are important ecologically and as agricultural pests. The majority of scale insect taxa feed exclusively on plant phloem sap, which is carbon-rich but deficient in essential amino acids. This suggests that, as seen in the related aphids and psyllids, scale insect nutrition might also depend upon bacterial symbionts, ...
Brennan B J - - 2012
BACKGROUND: Amongst Caucasian, Hispanic and African Americans with genotype 1 hepatitis C virus (HCV), there is a wide variation in response to treatment with peginterferon alfa-2a (PEG-IFN alfa-2a) and ribavirin. AIM: To evaluate the pharmacokinetics (PK) of PEG-IFN alfa-2a and ribavirin among these three groups. METHODS: Forty-seven patients with genotype ...
Zacharias Norman - - 2012
The amplitudes of the most prominent component of auditory evoked magnetic fields and electrical potentials, the M100 and N100, recorded from the human scalp depend on the duration of the stimulus onset interval (SOI). Here, we show, using magnetoencephalography, that the SOI dependence of the M100 amplitude strongly depends upon ...
Xi Guangcheng - - 2012
Metal/semiconductor hybrid materials of various sizes and morphologies have many applications in areas such as catalysis and sensing. Various organic agents are necessary to stabilize metal nanoparticles during synthesis, which leads to a layer of organic compounds present in the interfaces between metal particles and semiconductor supports. Generally, high-temperature oxidative ...
Michiels Joris - - 2012
The digestive function of low birth weight (LBW) pigs post-weaning has been poorly studied. Therefore, newborns from eleven hyperprolific sows were weighed, weaned at 27·2 d and fed a starter diet until sampling. Sampling was done between 18 and 28 d post-weaning. An LBW piglet (n 19) was defined as a piglet ...
Vrhovsek Urska - - 2012
Compelling evidence of the health benefits of phenolic compounds and their impact on food quality have stimulated the development of analytical methods for the identification and quantification of these compounds in different matrices in recent years. We have developed a targeted metabolomics method for the quantification of 135 phenolics, such ...
Gautier Alain - - 2012
CONTEXT: In men, obesity and the metabolic syndrome are accompanied by decreased testosterone levels, but little is known about the associations between visceral adipose tissue (VAT), VAT-related inflammation and sex steroids. OBJECTIVE: To examine the relative impact of VAT, abdominal subcutaneous adipose tissue (SAT) and interleukine-6 (IL-6), a marker of ...
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