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Abdelbary Ghada - - 2012
The aim of this work is to improve the oral bioavailability of poorly water soluble drug, simvastatin (SV) through combining the advantages of self-nanoemulsifying systems (SNEs) and tablets. Ternary phase diagram was constructed using Labrafil, Tween 80 and Transcutol, in order to evaluate self-nanoemulsification domain. The particle size distribution and ...
Wadden Katie P - - 2012
The purpose of this study was to investigate underlying mechanisms and neuromuscular recovery patterns following rapid and slow stretch-shortening cycle (SSC) movements performed to fatigue. Fourteen (10 moderately trained (MT) and four highly trained (HT)) subjects completed rapid and slow SSC movements to fatigue. The rapid SSC movement consisted of ...
Sperlich Billy - - 2012
Abstract We test the hypothesis that breathing oxygen-enriched air (F(I)O(2) = 100%) maintains exercise performance and reduces fatigue during intervals of maximal-intensity cycling. Ten well-trained male cyclists (age 25 ± 3 years; peak oxygen uptake 64.8 ± 6.2 ml · kg(-1) · min(-1); mean ± s) were exposed to either hyperoxic or normoxic air during the 6-min intervals between ...
Uzdin V M - - 2012
The magnetic response of itinerant electrons systems to an external magnetic field is investigated on the basis of a microscopic Hamiltonian from which the spin-polarized electronic structure is determined. The magnetic moment and grand thermodynamic potential of the d-electronic subsystem on a particular atomic site in the presence of the ...
Bae Donghyuck - - 2012
Context: Chamaecyparis obtusa Sieb. & Zucc., Endlicher (Cupressaceae) forest bathing or aromatherapy has been shown in various studies to have biological functions such as anticancer, antiallergies, antiinflammatory, and antioxidant activity. However, no reports exist on the pharmacological or biological activities of the essential oil of C. obtusa (EOCO) or its ...
Penn Alexandra S - - 2012
Co-operative behaviours, such as the production of public goods, are commonly displayed by bacteria in biofilms and can enhance their ability to survive in environmental or clinical settings. Non-cooperative cheats commonly arise and should, theoretically, disrupt co-operative behaviour. Its stability therefore requires explanation, but no mechanisms to supress cheating within ...
Merschjann C - - 2012
Thin films of chalcopyrite AgGaSe(2) have been successfully grown on glass and glass/molybdenum substrates using the technique of chemical close-spaced vapor transport. The high crystallinity of the samples is confirmed by grazing-incidence x-ray diffraction, scanning and transmission electron microscopy, and optical transmission/reflection spectroscopy. Here, two of the three expected direct ...
Kilic Sevtap - - 2012
Abstract Objective: To evaluate the intrauterine effect of cigarette smoke on cell death and DNA damage in follicular cells of fetal ovarian tissue. Methods: A prospective, randomized study was conducted with 25 female wistar-albino rats. The rats were randomized either to be exposed to cigarette smoke or to room air, ...
Doria Filippo - - 2012
Extended naphthalene diimides (NDIs) fused to 1,4-dihydropyrazine-2,3-dione, containing two solubilizing moieties, have been synthesized. Fluorescence spectra of the new NDIs were remarkably affected by pH, as the second deprotonation of the dihydropyrazinedione moiety (pK(a) 6.9) switched off the emission. Binding to a G-quadruplex folded oligonucleotide and stoichiometry were evaluated by ...
Ravikumar Madhumitha - - 2012
Platelet-mimetic synthetic hemostats are highly attractive in transfusion medicine. To this end, past research reports have described particles that either amplify platelet aggregation or mimic platelet adhesion. However, a construct design that effectively combines both functionalities has not been reported. Here, we describe the design of a liposomal construct simultaneously ...
Zheng Chunli - - 2012
Aim: The aim of this study was to investigate the feasibility of cationic biodegradable dextran microspheres loaded with bovine serum albumin (BSA) posterior to gel formation (postloading). Method: Positively charged microspheres were prepared by polymerization of hydroxylethyl methacrylate-derivatized dextran (dex-HEMA) and dimethyl aminoethyl methacrylate (DMAEMA) in an aqueous two-phase system ...
Lundgren Jennifer D - - 2012
The prevalence and familial patterns of night eating syndrome (NES) in families enrolled in the Québec Adipose and Lifestyle InvesTigation in Youth (QUALITY) study was examined. Families (n = 395; one child, mother, and father for whom at least one parent was obese or had abdominal obesity) completed the Night ...
Bingham P A - - 2012
The structure of iron phosphate glasses modified by additions of K(2)O and BaO, with nominal molar compositions [(1 - x)(0.6P(2)O(5)-0.4Fe(2)O(3))]xMe(y)O, where x = 0-0.4 in increments of 0.1; Me=K or Ba; and y = 1 or 2, has been investigated using neutron diffraction and x-ray diffraction techniques. Fitted coordination numbers for P-O and Fe-O showed a ...
Hostert C - - 2012
A systematic ab initio molecular dynamics study was carried out to identify valence electron concentration and size induced changes on structure, elastic and magnetic properties for Co(43)Fe(20)Ta(5.5)X(31.5) (X=B, Si, P, S). Short range order, charge transfer and the bonding nature are analyzed by means of density of states, Bader decomposition ...
Banan Mehdi - - 2012
Hydroxyurea (HU) is a drug used for the treatment of hemoglobinopathies. HU functions by up-regulating γ-globin transcription and fetal hemoglobin (HbF) production in erythroid cells. The K562 erythroleukemia cell line is widely used as a model system to study the mechanism of γ-globin induction by HU. However, transcription factors required ...
Pujari Bhalchandra S - - 2012
Using density functional theory we investigate a novel carbon allotrope 'SqC': a square planar material that can be more than tetracoordinated. Carbon atoms in this 2D square Bravais lattice form an unusual five-center four-electron bond with neighboring four carbon atoms (tetracoordination). Such an electron-deficient bonding leaves an empty orbital which ...
Glaves Rachel - - 2012
Nucleoside triphosphate hydrolysis is an essential component of all living systems. Despite extensive research, the exact modus and mechanism of this ubiquitous reaction still remain elusive. In this work, we examined the detailed hydrolysis mechanisms of a model nucleoside triphosphate in acidic and neutral solution by means of <i> ab ...
Kimura S-I - - 2012
We retrospectively investigated L-index, which evaluates both the intensity and duration of lymphopenia after allogeneic hematopoietic stem cell transplantation (HSCT) (n = 50). L-index was defined as the area over the lymphocyte curve during lymphopenia (absolute lymphocyte count < 700/μL). We calculated the L-index from the start of conditioning to day 30 - L-index(30) ...
Rowlands David S - - 2012
When ingested at high rates (1.8-2.4 g·min(-1)) in concentrated solutions, carbohydrates absorbed by multiple (e.g., fructose and glucose) vs. single intestinal transporters can increase exogenous carbohydrate oxidation and endurance performance, but their effect when ingested at lower, more realistic, rates during intermittent high-intensity endurance competition and trials is unknown. Trained cyclists ...
Chua Lee Suan - - 2012
A water extraction method has been used to extract plant proteins from the roots of Eurycoma longifolia harvested from Perak and Pahang, Malaysia. On the basis of the spectroscopic Bradford assay, Tongkat Ali Perak and Pahang contained 0.3868 and 0.9573 mg mL(-1) of crude protein, respectively. The crude proteins were separated by ...
van der Valk R J P - - 2012
BACKGROUND: Gene variants on chromosome 17q12-21 are associated with an increased risk of childhood-onset asthma, a risk known to be modified by environmental tobacco smoke (ETS). OBJECTIVES: To assess whether the association of rs2305480 on chromosome 17q12 in the GSDML gene with asthma-like symptoms in the first 4 years of life ...
Usui Takeshi - - 2012
OBJECTIVES: Epidemiologic studies indicate that soy intake has an important role in the prevention of age-related health problems. Daidzein, the principal isoflavone contained in soy, is converted to S-equol by the intestinal bacteria. Not all individuals, however, can produce S-equol, which is considered the most biologically active metabolite. We studied ...
Shide K - - 2012
Ten-Eleven-Translocation 2 (TET2) is an enzyme that catalyzes the conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5-hmC) and thereby alters the epigenetic state of DNA; somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies. To study the function of TET2 in vivo, we analyzed Ayu17-449 (TET2(trap)) mice, ...
van der Hooft Justin Johan Jozias - - 2012
In order to obtain more insight into the complex phenolic composition of tea, we applied advanced analytical approaches consisting of both LC-LTQ-Orbitrap Fourier Transformed (FT)-MS and LC-Time-of-Flight-(TOF)-MS coupled to Solid-Phase-Extraction-(SPE)-NMR. Based on the combined structural information from i) accurate mass fragmentation spectra, derived by using LC-Orbitrap FTMSn, and ii) proton-NMR ...
Rojas-Suarez José - - 2012
Abstract Objective: To evaluate women with hypertensive disorder admitted to critical care unit. Methods: This study was carried out in Cartagena, Colombia, between January 2006 and December 2009. Patients were divided into 4 groups; severe preeclampsia, eclampsia, HELLP syndrome and HELLP with eclampsia (HEEH). Result: A total of 217 cases ...
Puissegur M P - - 2012
B-cell acute lymphoblastic leukemia (B-ALL) is often associated with chromosomal translocations leading to the deregulation of proto-oncogenes. MicroRNAs can also be affected by chromosomal alterations and thus contribute to carcinogenesis. The microRNA, miR-125b-1, is overexpressed in B-ALL cases with the t(11;14)(q24;q32) translocation; therefore, we sought to determine the role of ...
Deshmukh Kirti - - 2012
Objective: The aim of the present investigation was to design and formulate appropriate form of glabridin, using microsponge drug delivery system. Method: Microsponges were prepared by emulsion solvent evaporation method and characterized by drug loading, infrared spectroscopy and scanning electron microscopy. In vitro diffusion studies of gel formulation were performed using ...
Dimopoulos Meletios A - - 2012
BACKGROUND: Multiple myeloma(MM) affects mainly elderly persons and since the population of octogenarians increases, it is common to treat patients ≥80 years of age. These patients are often not included in clinical trials, thus, there is limited data on their characteristics and treatment outcome. PATIENTS AND METHODS: We retrospectively analyzed ...
Valle Solange Oliveira Rodrigues - - 2012
Objective. To assess the reproducibility and validity of the International Study of Asthma and Allergies in Childhood (ISAAC) asthma written questionnaire (IAWQ) for 6- to 7-year-old children administered to their parents/caregivers through a telephone interview. Methods. Our study included 100 children selected from three health units in Rio de Janeiro, ...
Fu Hong-Xing - - 2012
Porosity asymmetric membrane capsules were prepared to study the relationship between the capsule formulation and drug release. Cellulose acetate (CA) and pore formers were used in the capsule shell formulation as the main semipermeable membrane material. The capsules were permeable to both water and dissolved solutes. Using sparingly soluble drug ...
Desai Divyakant - - 2012
Development of 0.1, 0.5, and 1.0 mg entecavir tablet formulations for the treatment of hepatitis B virus was challenging for content uniformity. Entecavir with pK(a) of 2.8 and 9.8 does not have sufficient solubility in acidic or alkaline medium or in common pharmaceutical solvents such as ethanol to dissolve the drug ...
Yi Yue-Neng - - 2012
Context: Chinese patent medicine Si-Mo-Tang oral liquid preparation (SMT) is composed of Aucklandia luppa Decne (Compositae), Citrus aurantium Linn (Rutaceae), Lindera aggregata (Sims) Kosterm (Lauraceae), and Areca catechu Linn (Arecaceae). Studies of SMT have been impeded due to the lack of quality control methods. Objective: This study aimed to simultaneously ...
Beta Jarek - - 2012
Abstract Objective: To examine the potential value of maternal serum level of ferritin in the first trimester of pregnancy in the prediction of spontaneous early preterm delivery. Methods: Maternal serum concentration of ferritin at 11-13 weeks' gestation was measured in a case-control study of singleton pregnancies delivering phenotypically normal neonates, ...
Er┼żen R - - 2012
BACKGROUND: There is no in vitro test to predict the induction of long-term tolerance in patients treated with venom immunotherapy (VIT). The aim of this study was to investigate whether immunotherapy-induced changes in basophil responsiveness reflect a state of protection and the induction of a tolerance. METHODS: Twenty-three patients with ...
Ikeda Andrea J - - 2012
Purpose: The objectives of this study were to compare three á priori alignment methods and evaluate them based on initial gait quality and further alignment changes required to optimize gait. Á priori alignment is requisite for monolimbs, transtibial prostheses in which the socket and pylon are made from one piece ...
Hall-Stoodley Luanne - - 2012
Biofilms associated with the human body, particularly in typically sterile locations, are difficult to diagnose and difficult to treat effectively due to their recalcitrance to conventional antibiotic therapy and host immune responses. The study of biofilms in medicine today requires a translational approach, with examination of clinically-relevant biofilms in the ...
Lai Wenxi - - 2012
A general master equation is derived to describe an electromechanical single-dot transistor in the Coulomb blockade regime. In the equation, Fermi distribution functions in the two leads are taken into account, which allows one to study the system as a function of bias voltage and temperature of the leads. Furthermore, ...
Kelly Brenna - - 2012
OBJECTIVES: To determine to what extent current practice promotes the goals of individuals who did not designate a surrogate while competent with respect to decision-making during periods of decisional incapacity. DESIGN: Systematic literature search for studies published in English and listed in PubMed, Scopus, Embase, CINAHL, or PsycINFO. Studies were ...
Strackharn Mathias - - 2012
Bottom up assembly of functional molecular ensembles with novel properties emerging from composition and arrangement of its constituents is a prime goal of nanotechnology. By Single-Molecule Cut-and-Paste we assembled binding sites for malachite green in a molecule-by-molecule assembly process from the two halves of a split aptamer. We show that ...
Bian Yangyang - - 2012
Complete coverage of all phosphorylation sites in a proteome is the ultimate goal for large-scale phosphoproteome analysis. However, only use of one protease trypsin for protein digestion cannot cover all phosphorylation sites, because not all tryptic phosphopeptides are detectable in MS. To further increase the phosphoproteomics coverage of Hela cell, ...
Kristensen Thomas - - 2012
It is presently accepted that the KIT D816V mutation is detectable in tissues with neoplastic mast cells in most patients with indolent systemic mastocytosis. In the present study, neoplastic mast cells were detected in bone marrow, but not in peripheral blood, by flow cytometry in all 25 included cases of ...
Kamezaki Yoshiko - - 2012
Stress-induced production of proinflammatory cytokines in the brain and periphery is associated with mental distress. In this study, we measured changes in levels of salivary cortisol and 50 circulating immune mediators in 28 4th-grade medical students (19 males and 9 females) 7 weeks before, 1 day before, immediately after, and ...
Szczepankiewicz Aleksandra - - 2012
Objectives. Asthma is a heterogenous complex disorder caused by chronic inflammation of the airways. The key issue in genetic association studies of complex disorders is the identification of multiple low-risk genes that individually have little impact on the phenotype, but in combination account for the clinical manifestation of asthma. Since ...
Markwick Arwen - - 2012
The comparative ability of the Montreal Cognitive Assessment (MoCA) and MMSE to detect mild cognitive difficulties was investigated in 107 older adults. The sensitivity of the MoCA to detect cognitive impairment with a cutoff score of <26 was investigated, as compared to the MMSE across all scores, and at a ...
Mongelli M - - 2012
Abstract Objective: To test the hypothesis that small or large for gestational age (SGA or LGA) newborns have anomalous crown rump length (CRL) growth rates in the 1(st) trimester. Methods: Prospective observational study. Women in the 1(st) trimester presenting to the Early Pregnancy Unit, between November 2006 and December 2010, ...
Tong Leung Viola Kit - - 2012
Abstract Objective: To assess the risk of intra-uterine death (IUD) after external cephalic version (ECV). Methods: In this retrospective cohort study, 1078 consecutive ECVs performed between January 1994 and March 2011 in an University teaching hospital were extracted from the computerized database to examine the risk of IUD after ECV. ...
Song Fanbo - - 2012
Inositol phosphates, as important second messengers of signal transduction, regulate many biological functions. However, cell penetration and phospholipase stability could be two main issues faced by inositol phosphate analogues used as lead compounds for drug discovery. Inositol phosphotriester analogues could be more beneficial to diffuse across plasma membrane. In this ...
Rosenthal Asher Deborah - - 2012
The scientific evaluation of depression's impact on mortality in hemodialysis (HD) patients has yielded mixed results, with the more recent, more rigorous studies detecting a significant relationship. In this study, 130 HD patients from an urban North American hospital were evaluated for depressive affect and then observed for up to ...
Ogden Lorraine G - - 2012
The National Weight Control Registry (NWCR) is the largest ongoing study of individuals successful at maintaining weight loss; the registry enrolls individuals maintaining a weight loss of at least 13.6 kg (30 lb) for a minimum of 1 year. The current report uses multivariate latent class cluster analysis to identify ...
Geldenhuys Werner J - - 2012
The blood-brain barrier (BBB) is a selectively permeable micro-vascular unit which prevents many central nervous system (CNS)-targeted compounds from reaching the brain. A significant problem in CNS drug development is the ability to model BBB permeability in a timely, reproducible and cost-effective manner. Through the years, several models have been ...
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