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Asciutto Eliana K EK Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282-1530, - - 2012
Removal of substrate (+)-camphor from the active site of cytochrome P450(cam) (CYP101A1) results in nuclear magnetic resonance-detected perturbations in multiple regions of the enzyme. The (1)H-(15)N correlation map of substrate-free diamagnetic Fe(II) CO-bound CYP101A permits these perturbations to be mapped onto the solution structure of the enzyme. Residual dipolar couplings ...
Wang Dasheng D Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, - - 2012
On the basis of our finding that the antitumor effect of 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}thiazolidine-2,4-dione, a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)γ agonist, was, in part, attributable to its ability to block glucose uptake independently of PPARγ, we used its PPARγ-inactive analogue to develop a novel class of glucose transporter (GLUT) inhibitors. This lead ...
Hou Tingjun - - 2012
Determination of the binding specificity of SH3 domain, a peptide recognition module (PRM), is important to understand their biological functions and reconstruct the SH3-mediated protein-protein interaction network. In the present study, the SH3-peptide interactions for both class I and II SH3 domains were characterized by the intermolecular residue-residue interaction network. ...
Cohen-Karni Tzahi T School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, - - 2012
Nanostructures, which have sizes comparable to biological functional units involved in cellular communication, offer the potential for enhanced sensitivity and spatial resolution compared to planar metal and semiconductor structures. Silicon nanowire (SiNW) field-effect transistors (FETs) have been used as a platform for biomolecular sensors, which maintain excellent signal-to-noise ratios while ...
Marklund Matti - - 2012
Alkylresorcinols (AR) have been established as short/medium-term biomarkers for whole grain (WG) wheat and rye intake; and AR metabolites, 3,5-dihydroxybenzoic acid and 3-(3,5-dihydroxyphenyl)-propanoic acid, have been suggested as complementary biomarkers to AR. The present study examined the medium-term reproducibility and relative validity of urinary AR metabolites as biomarkers for WG ...
Luttenberger Katharina - - 2012
OBJECTIVES: To determine the efficacy of multimodal, nondrug therapy on symptoms of dementia and need for care in institutionalized individuals with degenerative dementia. DESIGN: Randomized, controlled, longitudinal trial. Data were analyzed using multiple linear regression. SETTING: Five German nursing homes. PARTICIPANTS: One hundred thirty-nine nursing home residents with primary degenerative ...
de Haan Hein A - - 2012
Background: The inability of individuals with Alcohol Use Disorders (AUD) to recognize and describe their feelings and cravings may be due to alexithymia. Previous researches have shown evidence for a negative influence of alexithymia on treatment outcomes in patients with AUD. Therefore, it was hypothesized that high alexithymic patients with ...
Gibbon-Walsh Kristoff - - 2012
Copper (Cu) in seawater can be determined by anodic stripping voltammetry using a vibrating gold microwire electrode (VGME) with a much lower limit of detection than using a mercury electrode, enabling detection of labile Cu at trace level. The possibility of pseudopolarography of Cu using the VGME is investigated here ...
Abdelbary Ghada - - 2012
The aim of this work is to improve the oral bioavailability of poorly water soluble drug, simvastatin (SV) through combining the advantages of self-nanoemulsifying systems (SNEs) and tablets. Ternary phase diagram was constructed using Labrafil, Tween 80 and Transcutol, in order to evaluate self-nanoemulsification domain. The particle size distribution and ...
Wadden Katie P - - 2012
The purpose of this study was to investigate underlying mechanisms and neuromuscular recovery patterns following rapid and slow stretch-shortening cycle (SSC) movements performed to fatigue. Fourteen (10 moderately trained (MT) and four highly trained (HT)) subjects completed rapid and slow SSC movements to fatigue. The rapid SSC movement consisted of ...
Sperlich Billy - - 2012
Abstract We test the hypothesis that breathing oxygen-enriched air (F(I)O(2) = 100%) maintains exercise performance and reduces fatigue during intervals of maximal-intensity cycling. Ten well-trained male cyclists (age 25 ± 3 years; peak oxygen uptake 64.8 ± 6.2 ml · kg(-1) · min(-1); mean ± s) were exposed to either hyperoxic or normoxic air during the 6-min intervals between ...
Barbot V - - 2012
Modern dental chair units consist of a network of interconnected narrow-bore plastic tubes called dental unit waterlines (DUWL). The water delivered by those DUWL acts as both a coolant for a range of instruments and an irrigant during dental treatments. The quality of water is of considerable importance because both ...
Breccia Massimo - - 2012
Acute promyelocytic leukemia (APL), the most rapidly fatal leukemia only two decades ago, has been converted into the most frequently curable leukemia by the advent of all-trans retinoic acid (ATRA) and its combination with anthracycline-based chemotherapy. More recently, arsenic trioxide (ATO) has been shown to be the most effective single ...
Long Wen - - 2012
We investigate the influence of edge chirality on the electronic transport in clean or disordered graphene ribbon junctions. By using the tight-binding model and the Landauer-Büttiker formalism, the junction conductance is obtained. In the clean sample, the zero-magnetic-field junction conductance is strongly chirality-dependent in both unipolar and bipolar ribbons, whereas ...
Sidana Jasmeen - - 2012
Context: Eucalyptus has been a source of a number of biologically active compounds. The anti-leishmanial activity of terpenoids from Eucalyptus loxophleba (Benth.) ssp. lissophloia (Myrtaceae) has not yet been investigated. Objective: Isolation of the terpenoidal constituents for evaluation of in vitro anti-leishmanial activity against the Leishmania donovani (Dd8 strain) promastigotes. ...
Kristensen Thomas - - 2012
It is presently accepted that the KIT D816V mutation is detectable in tissues with neoplastic mast cells in most patients with indolent systemic mastocytosis. In the present study, neoplastic mast cells were detected in bone marrow, but not in peripheral blood, by flow cytometry in all 25 included cases of ...
Lai Wenxi - - 2012
A general master equation is derived to describe an electromechanical single-dot transistor in the Coulomb blockade regime. In the equation, Fermi distribution functions in the two leads are taken into account, which allows one to study the system as a function of bias voltage and temperature of the leads. Furthermore, ...
Kelly Brenna - - 2012
OBJECTIVES: To determine to what extent current practice promotes the goals of individuals who did not designate a surrogate while competent with respect to decision-making during periods of decisional incapacity. DESIGN: Systematic literature search for studies published in English and listed in PubMed, Scopus, Embase, CINAHL, or PsycINFO. Studies were ...
Coskun Ramazan - - 2012
Context. We investigated the effects of endosulfan intoxication on pituitary functions in three patients. Methods. This is an observational case series including three patients with endosulfan intoxication. Patients were evaluated 3 months after the acute event. Results. Based on the baseline hormonal values and dynamic endocrine tests, one patient had ...
Foley1 2 K-R - - 2012
Purpose: The purpose of this review was to describe literature relating to transition for young people with an intellectual disability and identify gaps within the current knowledge base. Method: A narrative literature review was undertaken. Searches of databases Medline, CINAHL, PsycINFO, ERIC, ISI Web of Science and ProQuest 500 International ...
Penn Alexandra S - - 2012
Co-operative behaviours, such as the production of public goods, are commonly displayed by bacteria in biofilms and can enhance their ability to survive in environmental or clinical settings. Non-cooperative cheats commonly arise and should, theoretically, disrupt co-operative behaviour. Its stability therefore requires explanation, but no mechanisms to supress cheating within ...
Merschjann C - - 2012
Thin films of chalcopyrite AgGaSe(2) have been successfully grown on glass and glass/molybdenum substrates using the technique of chemical close-spaced vapor transport. The high crystallinity of the samples is confirmed by grazing-incidence x-ray diffraction, scanning and transmission electron microscopy, and optical transmission/reflection spectroscopy. Here, two of the three expected direct ...
Sweetland Joanna - - 2012
Objective: The National Service Framework (NSF) for Long-Term Neurological Conditions (LTNC) highlights the need for vocational rehabilitation (VR) services in quality requirement 6. As a part of a review of this requirement, an extensive literature review was undertaken to identify, review and report on all relevant research undertaken in the ...
Valle Solange Oliveira Rodrigues - - 2012
Objective. To assess the reproducibility and validity of the International Study of Asthma and Allergies in Childhood (ISAAC) asthma written questionnaire (IAWQ) for 6- to 7-year-old children administered to their parents/caregivers through a telephone interview. Methods. Our study included 100 children selected from three health units in Rio de Janeiro, ...
Fu Hong-Xing - - 2012
Porosity asymmetric membrane capsules were prepared to study the relationship between the capsule formulation and drug release. Cellulose acetate (CA) and pore formers were used in the capsule shell formulation as the main semipermeable membrane material. The capsules were permeable to both water and dissolved solutes. Using sparingly soluble drug ...
Desai Divyakant - - 2012
Development of 0.1, 0.5, and 1.0 mg entecavir tablet formulations for the treatment of hepatitis B virus was challenging for content uniformity. Entecavir with pK(a) of 2.8 and 9.8 does not have sufficient solubility in acidic or alkaline medium or in common pharmaceutical solvents such as ethanol to dissolve the drug ...
Yi Yue-Neng - - 2012
Context: Chinese patent medicine Si-Mo-Tang oral liquid preparation (SMT) is composed of Aucklandia luppa Decne (Compositae), Citrus aurantium Linn (Rutaceae), Lindera aggregata (Sims) Kosterm (Lauraceae), and Areca catechu Linn (Arecaceae). Studies of SMT have been impeded due to the lack of quality control methods. Objective: This study aimed to simultaneously ...
Beta Jarek - - 2012
Abstract Objective: To examine the potential value of maternal serum level of ferritin in the first trimester of pregnancy in the prediction of spontaneous early preterm delivery. Methods: Maternal serum concentration of ferritin at 11-13 weeks' gestation was measured in a case-control study of singleton pregnancies delivering phenotypically normal neonates, ...
Rojas-Suarez José - - 2012
Abstract Objective: To evaluate women with hypertensive disorder admitted to critical care unit. Methods: This study was carried out in Cartagena, Colombia, between January 2006 and December 2009. Patients were divided into 4 groups; severe preeclampsia, eclampsia, HELLP syndrome and HELLP with eclampsia (HEEH). Result: A total of 217 cases ...
Puissegur M P - - 2012
B-cell acute lymphoblastic leukemia (B-ALL) is often associated with chromosomal translocations leading to the deregulation of proto-oncogenes. MicroRNAs can also be affected by chromosomal alterations and thus contribute to carcinogenesis. The microRNA, miR-125b-1, is overexpressed in B-ALL cases with the t(11;14)(q24;q32) translocation; therefore, we sought to determine the role of ...
Tong Leung Viola Kit - - 2012
Abstract Objective: To assess the risk of intra-uterine death (IUD) after external cephalic version (ECV). Methods: In this retrospective cohort study, 1078 consecutive ECVs performed between January 1994 and March 2011 in an University teaching hospital were extracted from the computerized database to examine the risk of IUD after ECV. ...
Wlotko Edward W EW Beckman Institute, University of Illinois, Urbana, Illinois 61801, USA. - - 2012
Contextual information influences multiple aspects of language comprehension extended over time. To determine how age-related changes impact normal comprehension, effects of contextual strength were examined with event-related potentials. Increased contextual constraint facilitated semantic processing (reduced N400s). Effects were smaller and delayed for older adults, and sensitivity to contextual information was ...
Song Fanbo - - 2012
Inositol phosphates, as important second messengers of signal transduction, regulate many biological functions. However, cell penetration and phospholipase stability could be two main issues faced by inositol phosphate analogues used as lead compounds for drug discovery. Inositol phosphotriester analogues could be more beneficial to diffuse across plasma membrane. In this ...
Mateo Maria Gracia - - 2012
The lamivudine (3TC) + stavudine (d4T) combination is still widely used as part of first-line therapy for HIV-1-infected patients in low-resource countries. This review is intended to assess the benefits and risks in terms of safety of d4T + 3TC-based combination antiretroviral therapy (ART) for the treatment of HIV-1 infection. ...
Strackharn Mathias - - 2012
Bottom up assembly of functional molecular ensembles with novel properties emerging from composition and arrangement of its constituents is a prime goal of nanotechnology. By Single-Molecule Cut-and-Paste we assembled binding sites for malachite green in a molecule-by-molecule assembly process from the two halves of a split aptamer. We show that ...
Bian Yangyang - - 2012
Complete coverage of all phosphorylation sites in a proteome is the ultimate goal for large-scale phosphoproteome analysis. However, only use of one protease trypsin for protein digestion cannot cover all phosphorylation sites, because not all tryptic phosphopeptides are detectable in MS. To further increase the phosphoproteomics coverage of Hela cell, ...
Erdoğar Nazlı - - 2012
To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or polycaprolactone for the effective intravesical delivery of chemotherapeutic agent ...
Strioga Marius Martynas - - 2012
Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with multilineage differentiation potential, the ability to modulate oxidative stress, and secrete various cytokines and growth factors that can have immunomodulatory, angiogenic, anti-inflammatory and anti-apoptotic effects. Recent data indicate that these paracrine factors may play the key role in MSC-mediated ...
Baker S H - - 2012
We describe the realization of a high moment state in fcc Fe nanoparticles through a controlled change in their atomic structure. Embedding Fe nanoparticles in a Cu(1-x)Au(x) matrix causes their atomic structure to switch from bcc to fcc. Extended x-ray absorption fine structure (EXAFS) measurements show that the structure in ...
Al-Jumaily Mohammed - - 2012
Objective. We aimed to study a group of patients presenting with symptomatic longstanding overt ventriculomegaly in adults (LOVA) requiring treatment (endoscopic third ventriculostomy), and to study their long term neuropsychological status and functionality. Methods. Twenty patients were treated with endoscopic third ventriculostomy on presentation and were studied with neuropsychological assessments ...
Okamoto Nozomi - - 2012
OBJECTIVES: To investigate the relationship between swallowing problems and the number of remaining teeth in healthy elderly people. DESIGN: Cross-sectional. SETTING: Nara, Japan. PARTICIPANTS: Three thousand six hundred sixty-three male and female volunteers aged 65 and older who were living independently were analyzed. MEASUREMENTS: Swallowing problems were defined operationally using ...
Glaves Rachel - - 2012
Nucleoside triphosphate hydrolysis is an essential component of all living systems. Despite extensive research, the exact modus and mechanism of this ubiquitous reaction still remain elusive. In this work, we examined the detailed hydrolysis mechanisms of a model nucleoside triphosphate in acidic and neutral solution by means of <i> ab ...
Kimura S-I - - 2012
We retrospectively investigated L-index, which evaluates both the intensity and duration of lymphopenia after allogeneic hematopoietic stem cell transplantation (HSCT) (n = 50). L-index was defined as the area over the lymphocyte curve during lymphopenia (absolute lymphocyte count < 700/μL). We calculated the L-index from the start of conditioning to day 30 - L-index(30) ...
Rowlands David S - - 2012
When ingested at high rates (1.8-2.4 g·min(-1)) in concentrated solutions, carbohydrates absorbed by multiple (e.g., fructose and glucose) vs. single intestinal transporters can increase exogenous carbohydrate oxidation and endurance performance, but their effect when ingested at lower, more realistic, rates during intermittent high-intensity endurance competition and trials is unknown. Trained cyclists ...
Chua Lee Suan - - 2012
A water extraction method has been used to extract plant proteins from the roots of Eurycoma longifolia harvested from Perak and Pahang, Malaysia. On the basis of the spectroscopic Bradford assay, Tongkat Ali Perak and Pahang contained 0.3868 and 0.9573 mg mL(-1) of crude protein, respectively. The crude proteins were separated by ...
Chedraui Peter - - 2012
Background: The metabolic syndrome (METS) increases after the menopause which may enhance cardiovascular risk in part explained by a pro-inflammatory state. Objective: Measure nitric oxide (NO), tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) serum levels in postmenopausal women with and without the METS (Adult Treatment Panel III criteria). Methods: ...
Deshmukh Kirti - - 2012
Objective: The aim of the present investigation was to design and formulate appropriate form of glabridin, using microsponge drug delivery system. Method: Microsponges were prepared by emulsion solvent evaporation method and characterized by drug loading, infrared spectroscopy and scanning electron microscopy. In vitro diffusion studies of gel formulation were performed using ...
Dimopoulos Meletios A - - 2012
BACKGROUND: Multiple myeloma(MM) affects mainly elderly persons and since the population of octogenarians increases, it is common to treat patients ≥80 years of age. These patients are often not included in clinical trials, thus, there is limited data on their characteristics and treatment outcome. PATIENTS AND METHODS: We retrospectively analyzed ...
Florescu Marius C - - 2012
Cystic fibrosis (CF) patients have numerous infectious exacerbations requiring prolonged antibiotic treatments, some of which are nephrotoxic. Inhaled antibiotics can reach detectable serum levels. We studied the impact of chronic nephrotoxic antibiotic exposure on kidney function in CF population. We collected data retrospectively for 113 adult CF patients followed for ...
Iyer E Siva Subramaniam - - 2012
(2,2'-bipyridyl)-3-3'-diol (BP(OH)2) undergoes excited state intramolecular double proton transfer (ESIDPT). The photophysics of this molecule has been investigated, in the highly acidic water channels inside nafion membrane. The dianionic enolate form of the dye, which is formed only in alkaline conditions in neat aqueous solutions, is found to be present ...
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