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Wang Dasheng D Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, - - 2012
On the basis of our finding that the antitumor effect of 5-{4-[(1-methylcyclohexyl)methoxy]benzyl}thiazolidine-2,4-dione, a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)γ agonist, was, in part, attributable to its ability to block glucose uptake independently of PPARγ, we used its PPARγ-inactive analogue to develop a novel class of glucose transporter (GLUT) inhibitors. This lead ...
Hou Tingjun - - 2012
Determination of the binding specificity of SH3 domain, a peptide recognition module (PRM), is important to understand their biological functions and reconstruct the SH3-mediated protein-protein interaction network. In the present study, the SH3-peptide interactions for both class I and II SH3 domains were characterized by the intermolecular residue-residue interaction network. ...
Cohen-Karni Tzahi T School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, - - 2012
Nanostructures, which have sizes comparable to biological functional units involved in cellular communication, offer the potential for enhanced sensitivity and spatial resolution compared to planar metal and semiconductor structures. Silicon nanowire (SiNW) field-effect transistors (FETs) have been used as a platform for biomolecular sensors, which maintain excellent signal-to-noise ratios while ...
Chedraui Peter - - 2012
Background: The metabolic syndrome (METS) increases after the menopause which may enhance cardiovascular risk in part explained by a pro-inflammatory state. Objective: Measure nitric oxide (NO), tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) serum levels in postmenopausal women with and without the METS (Adult Treatment Panel III criteria). Methods: ...
Chailap Benjamat - - 2012
Two heteroditopic receptors based on a calix[4]arene crown ether containing amidoanthraquinone pendants in cone and 1,3-alternate conformations ( and , respectively) were synthesized. Photophysical properties of and were studied by UV-vis and fluorescence spectrophotometry in dried CH(3)CN. Both and showed the highest sensitivity towards F(-) through the appearance of a ...
Werheit H - - 2012
On the basis of the spectra of IR- and Raman-active phonons, the isotopic phonon effects in β-rhombohedral boron are analysed for polycrystalline (10)B- and (11)B-enriched samples of different origin and high-purity (nat)B single crystals. Intra- and inter-icosahedral B-B vibrations are harmonic, hence meeting the virtual crystal approximation (VCA) requirements. Deviations from the phonon ...
Florescu Marius C - - 2012
Cystic fibrosis (CF) patients have numerous infectious exacerbations requiring prolonged antibiotic treatments, some of which are nephrotoxic. Inhaled antibiotics can reach detectable serum levels. We studied the impact of chronic nephrotoxic antibiotic exposure on kidney function in CF population. We collected data retrospectively for 113 adult CF patients followed for ...
Iyer E Siva Subramaniam - - 2012
(2,2'-bipyridyl)-3-3'-diol (BP(OH)2) undergoes excited state intramolecular double proton transfer (ESIDPT). The photophysics of this molecule has been investigated, in the highly acidic water channels inside nafion membrane. The dianionic enolate form of the dye, which is formed only in alkaline conditions in neat aqueous solutions, is found to be present ...
Otto Claudia - - 2012
Hodgkin and Reed/Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL) show constitutive activation of nuclear factor (NF)-κB. Several genetic lesions contribute to this deregulated NF-κB activity. Here, we analysed two further NF-κB regulators for genetic lesions, the inhibitory factor TRAF3 and the key signalling component of the alternative NF-κB pathway, ...
Erdoğar Nazlı - - 2012
To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or polycaprolactone for the effective intravesical delivery of chemotherapeutic agent ...
Strioga Marius Martynas - - 2012
Mesenchymal stem/stromal cells (MSCs) comprise a heterogeneous population of cells with multilineage differentiation potential, the ability to modulate oxidative stress, and secrete various cytokines and growth factors that can have immunomodulatory, angiogenic, anti-inflammatory and anti-apoptotic effects. Recent data indicate that these paracrine factors may play the key role in MSC-mediated ...
Baker S H - - 2012
We describe the realization of a high moment state in fcc Fe nanoparticles through a controlled change in their atomic structure. Embedding Fe nanoparticles in a Cu(1-x)Au(x) matrix causes their atomic structure to switch from bcc to fcc. Extended x-ray absorption fine structure (EXAFS) measurements show that the structure in ...
Chodisetti Bhuvaneswari - - 2012
Gymnema sylvestre (CS 149), known to be a rich source of saponins and other valuable phytochemicals, has been analysed for antimicrobial activity. The chloroform extracts of aerial and root parts of G. sylvestre exhibited higher antimicrobial activity as compared to diethyl ether and acetone. The root extracts of chloroform have ...
Sebo Thomas J - - 2012
There is much concern expressed in the literature regarding the lack of predictive power of the thyroid fine needle aspiration/ biopsy (TFNAB) approach to defining the nature of clinically-detected thyroid nodules. This has been exacerbated in the past decade or more by the routine use of ultrasonography in examining the ...
Belfiori B - - 2012
Truffles are hypogeous ectomycorrhizal fungi belonging to the genus Tuber. Although outplanting of truffle-inoculated host plants has enabled the realization of productive orchards, truffle cultivation is not yet standardized. Therefore, monitoring the distribution of fungal species in different truffle fields may help us to elucidate the factors that shape microbial ...
Jin Kyung-Hwan - - 2012
The effect of atomic impurities including N, O, Na, Ti and Co on the surface states of the topological insulator (TI) Bi(2)Te(3) is studied using pseudopotential first principles methods. The robustness of the TI surface states is particularly investigated against magnetic and non-magnetic atomic adsorption by calculating the electronic band ...
Balaji Vijayam - - 2012
A randomized, open-label, parallel study was conducted to assess the efficacy and safety of premixed insulin aspart 30 (biphasic insulin aspart [BIAsp] 30) in managing gestational diabetes mellitus (GDM). A total of 323 women with GDM registered at a single center in India were randomly assigned to receive 6 U of ...
Yang Jiezuan - - 2012
The study was to determine the degree of clonal expansion of T cells in peripheral blood mononuclear cells (PBMCs) isolated from patients suffering from different clinical types of hepatitis B infection and to analyze the clinical relevance of the skewed T cell receptor beta variable (TCRBV). Sera and PBMCs were ...
Talati Sapan - - 2012
Fenoldopam is a dopamine-like receptor agonist that selectively increases renal medullary blood flow. Despite promising pathophysiology, randomized control trial failed to show benefit with intravenous infusion of fenoldopam in preventing CIN. The objectives of this study were to examine the efficacy of intra-renal fenoldopam in preventing CIN in high risk ...
Cary Lynnette H - - 2012
The detonation of a nuclear weapon or a nuclear accident represent possible events with significant exposure to mixed neutron/γ-radiation fields. Although radiation countermeasures generally have been studied in subjects exposed to pure photons (γ or X rays), the mechanisms of injury of these low linear energy transfer (LET) radiations are ...
Frost David M - - 2012
Abstract The aim of this study was to quantify joint compression and shear forces at L4/L5 during exercises used to overload the hips. Nine men performed 36 "walking" trials using two modalities: (1) sled towing and (2) exercise bands placed around the ankles. Participants completed forward, backward, and lateral trials ...
Dhami Manpreet K - - 2012
Scale insects are important ecologically and as agricultural pests. The majority of scale insect taxa feed exclusively on plant phloem sap, which is carbon-rich but deficient in essential amino acids. This suggests that, as seen in the related aphids and psyllids, scale insect nutrition might also depend upon bacterial symbionts, ...
Barbot V - - 2012
Modern dental chair units consist of a network of interconnected narrow-bore plastic tubes called dental unit waterlines (DUWL). The water delivered by those DUWL acts as both a coolant for a range of instruments and an irrigant during dental treatments. The quality of water is of considerable importance because both ...
Marklund Matti - - 2012
Alkylresorcinols (AR) have been established as short/medium-term biomarkers for whole grain (WG) wheat and rye intake; and AR metabolites, 3,5-dihydroxybenzoic acid and 3-(3,5-dihydroxyphenyl)-propanoic acid, have been suggested as complementary biomarkers to AR. The present study examined the medium-term reproducibility and relative validity of urinary AR metabolites as biomarkers for WG ...
Chan Bun - - 2012
We have assessed computational methodologies for calculating the rate constants for hydrogen abstraction by Cl(•) for a selection of 12 reactions. For the conventional approach of calculating higher-level [B2K-PLYP/aug'-cc-pV[(T+d),(Q+d)]Z] single-point energies at lower-level [BH&H-LYP/6-31+G(d,p)] stationary points, large deviations from experimental rate constants are found in a number of cases in ...
Al-Jumaily Mohammed - - 2012
Objective. We aimed to study a group of patients presenting with symptomatic longstanding overt ventriculomegaly in adults (LOVA) requiring treatment (endoscopic third ventriculostomy), and to study their long term neuropsychological status and functionality. Methods. Twenty patients were treated with endoscopic third ventriculostomy on presentation and were studied with neuropsychological assessments ...
Okamoto Nozomi - - 2012
OBJECTIVES: To investigate the relationship between swallowing problems and the number of remaining teeth in healthy elderly people. DESIGN: Cross-sectional. SETTING: Nara, Japan. PARTICIPANTS: Three thousand six hundred sixty-three male and female volunteers aged 65 and older who were living independently were analyzed. MEASUREMENTS: Swallowing problems were defined operationally using ...
Delforge Michel - - 2012
OBJECTIVES: The phase 3 VISTA study (http:\\ClinicalTrials.gov NCT00111319) in transplant-ineligible myeloma patients demonstrated superior efficacy with bortezomib-melphalan-prednisone (VMP; nine 6-week cycles) versus melphalan-prednisone (MP) but also increased toxicity. Health-related quality of life (HRQoL; exploratory endpoint) was evaluated using the European Organization for Research and Treatment of Cancer (EORTC) Quality of ...
Morita Mayuko - - 2012
Abstract An excessive accumulation of fat in the liver leads to chronic liver injury such as NAFLD (non-alcoholic fatty liver disease), which is an important medical problem affecting many populations worldwide. Oxidative stress has been implicated in the pathogenesis of NAFLD, but the exact nature of active species and the ...
Oyarzo Carolina - - 2012
Abstract Objective: To investigate whether the February 27(th) earthquake exposition was associated to adverse perinatal outcomes in Chilean pregnant women. Methods: We analyzed all deliveries occurred in 2009 (N=3,609) and 2010 (N=3,279) in a reference hospital in the area of the earthquake. Furthermore, we investigated pregnant women who gave birth ...
Brennan B J - - 2012
BACKGROUND: Amongst Caucasian, Hispanic and African Americans with genotype 1 hepatitis C virus (HCV), there is a wide variation in response to treatment with peginterferon alfa-2a (PEG-IFN alfa-2a) and ribavirin. AIM: To evaluate the pharmacokinetics (PK) of PEG-IFN alfa-2a and ribavirin among these three groups. METHODS: Forty-seven patients with genotype ...
Zacharias Norman - - 2012
The amplitudes of the most prominent component of auditory evoked magnetic fields and electrical potentials, the M100 and N100, recorded from the human scalp depend on the duration of the stimulus onset interval (SOI). Here, we show, using magnetoencephalography, that the SOI dependence of the M100 amplitude strongly depends upon ...
Xi Guangcheng - - 2012
Metal/semiconductor hybrid materials of various sizes and morphologies have many applications in areas such as catalysis and sensing. Various organic agents are necessary to stabilize metal nanoparticles during synthesis, which leads to a layer of organic compounds present in the interfaces between metal particles and semiconductor supports. Generally, high-temperature oxidative ...
Yin Huiyong - - 2012
Abstract Cardiolipin (CL) is a mitochondria-specific phospholipid and is critical for maintaining the integrity of mitochondrial membrane and mitochondrial function. CL also plays an active role in mitochondria-dependent apoptosis by interacting with cytochrome c (cyt c), tBid and other important Bcl-2 proteins. The unique structure of CL with four linoleic ...
Boyages Steven - - 2012
CONTEXT: Seasonal variation in 25-hydroxyvitamin D [25OHD] status and its relationship to gender, age, socioeconomic and geographic determinants in Australians has not been described in large biomedical sampling cohorts. OBJECTIVES: To analyse 25OHD levels in all primary tests undertaken consecutively in a two-year period to determine the prevalence of 25 ...
Luttenberger Katharina - - 2012
OBJECTIVES: To determine the efficacy of multimodal, nondrug therapy on symptoms of dementia and need for care in institutionalized individuals with degenerative dementia. DESIGN: Randomized, controlled, longitudinal trial. Data were analyzed using multiple linear regression. SETTING: Five German nursing homes. PARTICIPANTS: One hundred thirty-nine nursing home residents with primary degenerative ...
de Haan Hein A - - 2012
Background: The inability of individuals with Alcohol Use Disorders (AUD) to recognize and describe their feelings and cravings may be due to alexithymia. Previous researches have shown evidence for a negative influence of alexithymia on treatment outcomes in patients with AUD. Therefore, it was hypothesized that high alexithymic patients with ...
Dai Yan - - 2012
Carbon monoxide can adsorb specifically on Pd (111) to induce the formation of unique Pd nanostructures. In the co-presence of CO and H2, single-crystalline Pd tetrapod nanocrystals have now been successfully prepared. The Pd tetrapods are enclosed by (111) surfaces and are yielded through hydride formation. DFT calculations revealed that ...
Massin Nathalie - - 2012
CONTEXT: The androgen receptor (AR) is essential for the development and maintenance of the male phenotype, and for spermatogenesis. Mutations in the AR gene cause a wide variety of androgen insensitivity syndromes (AIS), ranging from complete feminization to phenotypic males with infertility. OBJECTIVE: We report the first birth achieved after ...
de Oliveira Gisele Lopes - - 2012
Context: Xanthosoma sagittifolium Schott. (Araceae) and Laportea aestuans (L.) Chew (Urticaceae) are two medicinal species used as food and to prevent and treat bone diseases, such as osteoporosis, in traditional Brazilian medicine. Objective: To investigate the free calcium concentration and further support the traditional use of these species as medicine. ...
Coskun Ramazan - - 2012
Context. We investigated the effects of endosulfan intoxication on pituitary functions in three patients. Methods. This is an observational case series including three patients with endosulfan intoxication. Patients were evaluated 3 months after the acute event. Results. Based on the baseline hormonal values and dynamic endocrine tests, one patient had ...
Foley1 2 K-R - - 2012
Purpose: The purpose of this review was to describe literature relating to transition for young people with an intellectual disability and identify gaps within the current knowledge base. Method: A narrative literature review was undertaken. Searches of databases Medline, CINAHL, PsycINFO, ERIC, ISI Web of Science and ProQuest 500 International ...
Sweetland Joanna - - 2012
Objective: The National Service Framework (NSF) for Long-Term Neurological Conditions (LTNC) highlights the need for vocational rehabilitation (VR) services in quality requirement 6. As a part of a review of this requirement, an extensive literature review was undertaken to identify, review and report on all relevant research undertaken in the ...
Long Wen - - 2012
We investigate the influence of edge chirality on the electronic transport in clean or disordered graphene ribbon junctions. By using the tight-binding model and the Landauer-Büttiker formalism, the junction conductance is obtained. In the clean sample, the zero-magnetic-field junction conductance is strongly chirality-dependent in both unipolar and bipolar ribbons, whereas ...
Sidana Jasmeen - - 2012
Context: Eucalyptus has been a source of a number of biologically active compounds. The anti-leishmanial activity of terpenoids from Eucalyptus loxophleba (Benth.) ssp. lissophloia (Myrtaceae) has not yet been investigated. Objective: Isolation of the terpenoidal constituents for evaluation of in vitro anti-leishmanial activity against the Leishmania donovani (Dd8 strain) promastigotes. ...
Michiels Joris - - 2012
The digestive function of low birth weight (LBW) pigs post-weaning has been poorly studied. Therefore, newborns from eleven hyperprolific sows were weighed, weaned at 27·2 d and fed a starter diet until sampling. Sampling was done between 18 and 28 d post-weaning. An LBW piglet (n 19) was defined as a piglet ...
Vrhovsek Urska - - 2012
Compelling evidence of the health benefits of phenolic compounds and their impact on food quality have stimulated the development of analytical methods for the identification and quantification of these compounds in different matrices in recent years. We have developed a targeted metabolomics method for the quantification of 135 phenolics, such ...
Gautier Alain - - 2012
CONTEXT: In men, obesity and the metabolic syndrome are accompanied by decreased testosterone levels, but little is known about the associations between visceral adipose tissue (VAT), VAT-related inflammation and sex steroids. OBJECTIVE: To examine the relative impact of VAT, abdominal subcutaneous adipose tissue (SAT) and interleukine-6 (IL-6), a marker of ...
Zhang Zhimin - - 2012
OBJECTIVES: To assess the relationship between body composition and fracture risk as determined by the FRAX® model in postmenopausal women in central south China. METHODS: A cross-sectional study was conducted in 779 women. Bone mineral density (BMD) of the left femur and total body composition were measured by dual X-ray ...
Gibbon-Walsh Kristoff - - 2012
Copper (Cu) in seawater can be determined by anodic stripping voltammetry using a vibrating gold microwire electrode (VGME) with a much lower limit of detection than using a mercury electrode, enabling detection of labile Cu at trace level. The possibility of pseudopolarography of Cu using the VGME is investigated here ...
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