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Blumer Steven L - - 2012
BACKGROUND:: Adenocarcinoma of the colon is rare in pediatric patients and thus not much is known about its clinical and imaging characteristics. OBSERVATIONS:: We present 4 adolescents with an average age of 15 years who present with several month histories of significant weight loss and abdominal pain. All had an ...
Pereira Elaine Maria - - 2012
We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management ...
Huang Xiaojun - - 2012
BACKGROUND: This multicenter, randomized, open-label phase 3 study compared the efficacy and safety of micafungin and itraconazole in prophylaxis of invasive fungal infections (IFI) in neutropenic patients undergoing hematopoietic stem cell transplantation in China. METHODS: Micafungin (50mg/day i.v.) or itraconazole (5mg/kg/day p.o.) was administered for ≤ 42 days. The primary ...
Langley Joanne M - - 2012
BACKGROUND: Concern arose in 2010 that reactogenicity, particularly febrile seizures, to influenza A/H1N1-containing 2010-2011 trivalent seasonal inactivated influenza vaccine (TIV) could occur in young children who had been previously immunized and/or infected with the pandemic strain. We conducted a pre-season study of 2010-2011 TIV safety and immunogenicity in children 12-59 ...
Stelzeneder David - - 2012
OBJECTIVE: The aim of this study was to evaluate differences in damage patterns assessed using MRI between hips with femoroacetabular impingement (FAI) and developmental dysplasia of the hip (DDH) as well as to correlate MRI findings with delayed Gadolinium enhanced MRI of cartilage (dGEMRIC) and with patient pain. DESIGN: This ...
Li Qiurong - - 2012
OBJECTIVE:: To investigate the role of sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate (S1P) signaling in inflammatory response in severe acute pancreatitis (SAP). BACKGROUND:: SAP is an acute inflammatory process of the pancreas, which may lead to systemic inflammatory response syndrome and multiorgan dysfunction syndrome. SphK1 and its product S1P have been ...
Chabardès Stéphan - - 2012
Because of its reversibility and adaptability, deep brain stimulation (DBS) has recently gained interest in psychiatric disorders, such as obsessive compulsive disorders (OCD) and depression. In OCD, DBS is now an alternative procedure to lesions of fascicles such as the anterior capsule, that link the orbito frontal cortex, the cingulum ...
Shang Fujun - - 2012
Increasing evidence has shown that inflammation is involved in pressure overload-induced cardiac remodeling. Monocyte chemoattractant protein-1 (MCP-1) plays a pivotal role in the inflammatory process. However, the mechanisms underlying the upregulation of MCP-1 expression remain poorly understood. In the present study, we examined the hypothesis that an increased production of ...
Papeo Liuba - - 2012
Sensorimotor representations in the brain encode the sensory and motor aspects of one's own bodily activity. It is highly debated whether sensorimotor representations are the core basis for the representation of action-related knowledge and, in particular, action words, such as verbs. In this review, we will address this question by ...
Huang Shuai - - 2012
There has been an urgent need for an effective and efficient upper limb rehabilitation method for poststroke patients. We present a Micro-Sensor-based Upper Limb rehabilitation System for poststroke patients. The wearable motion capture units are attached to upper limb segments embedded in the fabric of garments. The body segment orientation ...
Esquenazi Alberto - - 2012
OBJECTIVE: This study aimed to provide clinical injection data and real-world patient-reported and clinical outcomes for the chemodenervation and neurolytic treatment of muscle overactivity including spasticity in patients with traumatic brain injury and stroke. DESIGN: This study used a prospective multicenter observational design. The participants were 487 patients with stroke ...
Yates Patsy - - 2012
PURPOSE OF REVIEW: The study provides a review of current evidence about the role of complex nonpharmacological strategies in managing the multidimensional components of the breathlessness experience for individuals with life-limiting conditions. RECENT FINDINGS: Evidence continues to demonstrate the significant impact of breathlessness on patients' quality of life, day-to-day activity, ...
Barrett Sean P - - 2012
Both nicotine and various non-nicotine smoking factors are believed to contribute to tobacco addiction but their relative roles remain incompletely understood. This study aimed to help clarify these roles by examining acute interactions between nicotine and denicotinized tobacco (DT). During two randomized blinded sessions, the effects of a quick-release 4 ...
Elliott Robert E - - 2012
OBJECTIVE: Since its original description by Magerl and Seeman in 1986, C1-2 fusion via transarticular screw (TAS) fixation has been successfully used on thousands of patients. Reviewed published series describing C1-2 posterior instrumented fusions, summarizing clinical and radiographic outcomes of patients treated with TAS. METHODS: Online databases were searched for ...
Luo Limei - - 2012
Bone disease is a common clinical problem after kidney transplantation. To date, studies investigating the effects of tacrolimus (TAC) on bone metabolism in vivo or vitro yielded conflicting data. This study was carried out to discuss the relationship between TAC blood concentrations and bone metabolism status in kidney transplant recipients. ...
Li Zhengrong - - 2012
The phosphatase of regenerating liver-3 (PRL-3) gene is associated with metastasis in gastric cancer, and is believed to play a causative role by promoting tumor cell motility, invasion, and metastasis, but little is known of the mechanisms involved. We previously reported that PRL-3 expression is significantly higher in the tissues ...
Craig Orla - - 2012
BACKGROUND & AIMS: Magnetic resonance and ultrasonography have increasing roles in the initial diagnosis of Crohn's disease, but computed tomography (CT) with positive oral contrast agents is most frequently used to identify those with acute extramural complications. However, CT involves exposure of patients to radiation. We prospectively compared the diagnostic ...
Kluger Nicolas N Department of Dermatology, Institute of Clinical Medicine, University of Helsinki, Skin and Allergies Hospital, Helsinki, Finland. - - 2012
The introduction in the dermis of exogenous pigments and dyes to obtain a permanent design (tattooing) represents a unique in-vivo situation, where a large amount of metallic salts and organic dyes remain in the skin for the lifetime of the bearer. The potential local and systemic carcinogenic effects of tattoos ...
Yao Qingxia - - 2012
Here we describe the cloning and expression of Pekin duck IL-10 (duIL-10) and a six exon-five intron structure of an IL-10 gene. Two transcripts encoding duIL-10 with an alternately spliced 3'UTR, and a transcript lacking exon 5 with a novel coding sequence for its C-terminus (duIL-10ΔE5) were isolated from splenocytes. ...
Bittersohl Bernd - - 2012
OBJECTIVE: To evaluate T2* values in various histological severities of Osteoarthritis (OA). METHOD: Magnetic resonance imaging (MRI) and T2* mapping including a 3D double-echo steady-state (DESS) sequence for morphological cartilage assessment and a 3D multiecho data image combination (MEDIC) sequence for T2* mapping were conducted in 21 human femoral head ...
Marino Ralph J - - 2012
OBJECTIVE: This study aimed to describe the development, internal consistency, and validity of the Capabilities of Upper Extremity Test (CUE-T) for persons with tetraplegia. DESIGN: This study used a cross-sectional sample of adults with spinal cord injury. CUE-T items and procedures were developed based on the CUE Questionnaire. Thirty adults ...
Stupak Daniel Paul - - 2012
Upper gastrointestinal (GI) dysmotility, an entity commonly found in the intensive care unit setting, can lead to insufficient nutrient intake while increasing the risk of infection and mortality. Further, overcoming the altered motility with early enteral feeding is associated with a reduced incidence of infectious complications in intensive care unit ...
Wieland Markus - - 2012
Synthetic biology has made significant leaps over the past decade, and it now enables rational and predictable reprogramming of cells to conduct complex physiological activities. The bases for cellular reprogramming are mainly genetic control components affecting gene expression. A huge variety of these modules, ranging from engineered fusion proteins regulating ...
Mouzaki Marialena - - 2012
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease in adults and children and is currently the third most common indication for liver transplantation in North America. Its pathogenesis is thought to be secondary to multiple "hits" derived from the dietary components, adipose tissue, immune system, ...
Ray-Coquard Isabelle - - 2012
Each year, 13,000 newly gynecologic cancers are diagnosed in France. Gynecologic cancers were specifically heterogeneous (localisations, histologic subgroups, age class, etc). This work was delineated for a national call dedicated to gynecologic cancers. This review reports the major needs in terms of scientific research dedicated to gynecologic cancers in the biologic, ...
Nayar Preethy - - 2012
BACKGROUND:: Over the last couple of decades, hospitals in the United States are facing pressures to maximize performance in terms of production efficiency and quality. An increasing emphasis on value-based purchasing on the part of third-party payers as well as the prevalence of pay for performance initiatives create an imperative ...
Zhou Zhou - - 2012
OBJECTIVE: This study aimed to assess cough effectiveness after a stroke and to propose a bedside screening test. DESIGN: Patients who had had ischemic hemispheric stroke were recruited and followed up for 2 mos. Maximum phonation time (MPT) was assessed during the first 10 days. Aspiration was evaluated on days ...
Sañudo Borja - - 2012
OBJECTIVE: This study aimed to evaluate the immediate effects of a 6-mo combined exercise program on quality-of-life, physical function, depression, and aerobic capacity in women with fibromyalgia syndrome and to determine the impact of repeated delivery of the intervention. DESIGN: Forty-one women with fibromyalgia were randomly assigned to a training ...
Panthani Matthew G - - 2012
Semiconductor nanocrystals are promising materials for low-cost large-area electronic device fabrication. They can be synthesized with a wide variety of chemical compositions and size-tunable optical and electronic properties as well as dispersed in solvents for room-temperature deposition using various types of printing processes. This review addresses research progress in large-area ...
Gill Simone V - - 2012
ABSTRACT: The objective of this study was to evaluate how weight classification relates to meeting task constraints. Using a cross-sectional design, three-dimensional motion data were collected while children crossed obstacles of various heights. Twelve normal-weight (≥5th and <85th percentile on growth charts) and 12 overweight or obese (≥85th percentile on ...
Bach John R - - 2012
OBJECTIVE: This work describes and correlates plateau/maximum observed vital capacity (VC) with spinal muscular atrophy (SMA) severity and prognosis for autonomous breathing. DESIGN: SMA severity was correlated with VC, onset, paradoxical breathing, age at definitive dependence on continuous mechanical ventilation (DDCV), and age at first respiratory hospitalization and gastrostomy. RESULTS: ...
Perchiacca Joseph M - - 2012
The ability of antibodies to bind to target molecules with high affinity and specificity has led to their widespread use in diagnostic and therapeutic applications. Nevertheless, a limitation of antibodies is their propensity to selfassociate and aggregate at high concentrations and elevated temperatures. The large size and multidomain architecture of ...
Clark James H - - 2012
In the current climate of several interrelated impending global crises, namely, climate change, chemicals, energy, and oil, the impact of green chemistry with respect to chemicals and biofuels generated from within a holistic concept of a biorefinery is discussed. Green chemistry provides unique opportunities for innovation via product substitution, new ...
Lee Myung Mo - - 2012
OBJECTIVE: The purpose of this study was to evaluate the effects of the mirror therapy program on upper-limb motor recovery and motor function in patients with acute stroke. DESIGN: Twenty-six patients who had an acute stroke within 6 mos of study commencement were assigned to the experimental group (n = ...
van Koppen Arianne - - 2012
Chronic kidney disease (CKD) is a major health care problem. New interventions to slow or prevent disease progression are urgently needed. We studied functional and structural effects of infusion of healthy and CKD bone marrow cells (BMCs) in a rat model of established CKD. CKD was induced by 5/6 nephrectomy ...
Zhang Peng - - 2012
Disorders in cholesterol metabolism are critical in development of atherosclerosis and are related to acute myocardial infarction (AMI). The liver is one of the most important organs that balances cholesterol metabolism. In order to investigate whether Nur77 is capable of regulating cholesterol metabolism in HepG2 cells and to demonstrate the ...
Chen Jieli - - 2012
Background: Human placenta-derived adherent (PDA001) cells are mesenchymal-like stem cells isolated from postpartum human placenta. In this study, we tested whether intravenously-infused PDA001 improves neurological functional recovery after stroke in rats. In addition, potential mechanisms underlying the PDA001-induced neuroprotective effect were investigated.Methods: Young adult male rats (2-3 months) were subjected ...
Duchez Pascale - - 2012
We recently developed a clinical grade ex vivo cord blood expansion procedure enabling a massive amplification of hematopoietic progenitors without any loss of stem cell potential. This procedure, based on Day 14 liquid cultures of cord blood CD34+ cells, in medium Macopharma HP01 and in presence of Stem Cell Factor ...
D'Urso Pietro I - - 2012
An altered expression of microRNAs (miRNAs) contributes both to the development of cancer and to the progression of the disease. Malignant tumours and tumour cell lines have widespread deregulated expressions of miRNAs compared to normal tissues. In this study, we investigated the expression profiles of 340 mammalian miRNAs in 93 cases ...
Vernon Robert B - - 2012
We have developed a bioengineered implant (BI) to evaluate strategies to promote graft survival and function in models of islet transplantation in mice. The BI, sized for implantation within a fold of intestinal mesentery, consists of a disk-shaped, polyvinyl alcohol sponge infused with a type I collagen hydrogel that contains ...
Kozlova Elena N - - 2012
Transplantation of stem or progenitor cells is an attractive strategy for cell replacement therapy. However, poor long-term survival and insufficiently reproducible differentiation to functionally appropriate cells in vivo still present major obstacles for translation of this methodology to clinical applications. Numerous experimental studies have revealed that the expression of just ...
Ueki Hideo - - 2012
A novel transcriptional system was developed that can robustly enhance cancer-specific gene expression. In the system, hTERT promoter-driven gene expression was enhanced by an advanced two-step transcriptional amplification (TSTA). This construct was used to develop a novel system for detection of bladder cancer cells. The current study evaluated the advanced ...
Sato Akinori - - 2012
Our previous study showed that the combination of a histone deacetylase (HDAC) inhibitor and an HIV protease inhibitor is effective against renal cancer cells. Because HDAC inhibition disrupts the chaperon function of heat shock protein (HSP) 90, we hypothesized that the combination of 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of HSP90, and ...
Cestari Andrea - - 2012
This study tested the technical feasibility and short-term perioperative outcomes of the novel da Vinci Single-Site Instrumentation platform for the treatment of upper ureteropelvic junction obstruction (UPJO) in a selected group of patients. Nine patients underwent robotic laparoendoscopic single-site (R-LESS) pyeloplasty using a new single-site platform for UPJO at our ...
Ganzer Roman - - 2012
Many authors advocate a high anterior incision during nerve-sparing radical prostatectomy (RP) to improve potency results. Despite a growing number of studies describing autonomic nerves in the ventrolateral position of the prostate, little is known about their quality and their role in erectile function. The intention of this study was ...
Xu Junji - - 2012
Jaw osteoradionecrosis (ORN) is a common and serious complication of radiation therapy for head and neck cancers. Bone marrow mesenchymal stromal cells (BMMSCs) are multipotent postnatal stem cells and have been widely used in clinical therapies. In the present study, we generated the mandibular ORN model in swine using a ...
Han Namshik - - 2012
Clinically, our ability to predict disease outcome for patients with early stage lung cancer is currently poor. To address this issue, tumour specimens were collected at surgery from non-small cell lung cancer (NSCLC) patients as part of the European Early Lung Cancer (EUELC) consortium. The patients were followed-up for three years post-surgery ...
Rocco Giuliana Di - - 2012
Presently, orthotopic liver transplant is the major therapeutic option for patients affected by primary liver diseases. This procedure is characterized by major invasive surgery, scarcity of donor organs, high costs, and lifelong immunosuppressive treatment. Transplant of hepatic precursor cells represents an attractive alternative. These cells could be used either for ...
Choi Yeong Min - - 2012
Cytochrome P450 1A1 (CYP1A1) is a member of the cytochrome p450 enzyme family, which is involved in the metabolisms of carcinogenic metabolites, such as benzo(a)pyrene. In this study, we identified miR-892a as a negative regulator of CYP1A1 expression. Luciferase assays revealed a sequence in the 3'-untranslated region of CYP1A1 that ...
Sher Falak - - 2012
In multiple sclerosis (MS), a chronic inflammatory relapsing demyelinating disease, failure to control or repair damage leads to progressive neurological dysfunction and neurodegeneration. Implantation of neural stem cells (NSCs) has been shown to promote repair and functional recovery in the acute experimental autoimmune encephalomyelitis (EAE) animal model for MS; the ...
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