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Kitamura Ryoji - - 2012
The aim of this study was to confirm the expression profile of cytokeratin (CK)17 in comparison with that of CK13 in oral squamous cell carcinoma (OSCC) and leukoplakia and to clarify an association of CK17 with the OSCC differentiation. The expression of CK17 and CK13 was immunohistochemically examined in 105 ...
Thomson Wendy L - - 2012
Umbilical hernias occur frequently in children but complications are very rare and thus surgery is not routinely indicated. In this literature review, we report 19 cases of spontaneous evisceration of abdominal contents through umbilical hernias. Precipitating causes included umbilical ulceration or sepsis, crying, respiratory infection, intussusception and ascites. Management involved ...
Valente Luísa M P - - 2012
We investigated postprandial changes in transcript abundance following a single satiating meal in juvenile Atlantic salmon (Salmo salar L.) (about 70 g body mass) following fasting for 1 week at 12°C. The expression of twenty-three growth-related genes was determined in fast myotomal muscle using quantitative real-time PCR at the following postprandial ...
Hu Xiangqian X Department of Chemistry, Duke University, Durham, NC 27708, - - 2012
We reformulate the density fragment interaction (DFI) approach [Fujimoto and Yang, J. Chem. Phys., 2008, 129, 054102.] to achieve linear-scaling quantum mechanical calculations for large molecular systems. Two key approximations are developed to improve the efficiency of the DFI approach and thus enable the calculations for large molecules: the electrostatic ...
Seet Emily L - - 2012
Abstract Objective: The purpose of this study was to compare the risk of adverse neonatal outcomes between women with placenta accreta and placenta increta or percreta. Methods: This was a single institution retrospective cohort study of women with abnormal placentation (placenta accreta, increta, and percreta) who delivered from 1982-2002. Cases ...
Yin Cheng - - 2012
Abstract Rebleeding leads to lots of patients' disability and mortality after spontaneous subarachnoid hemorrhage (SAH), but the risk factors of rebleeding have not been fully understood. More evidence showed apolipoprotein E (apoE protein, APOE gene) influenced the outcome of spontaneous SAH. In this study, we aimed to investigate the relationship ...
Coetzee Jacorien - - 2012
Simple mixed anhydrides are known to pose synthetic difficulties relating to their thermal lability and ways to stabilise such mixed anhydride systems by relying on either electronic or steric effects were therefore explored. Thus, a series of acyloxyphosphines and acylphosphites derived from either propanoic acid or phenylacetic acid were prepared ...
Leung Cindy W CW Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. - - 2012
A high prevalence of food insecurity has persisted in the USA for the past two decades. Previous studies suggest that the association between food insecurity and obesity may vary by gender and race/ethnicity. We examined whether food insecurity was associated with BMI and obesity within gender and racial/ethnic groups in ...
Kingsbury Sarah R - - 2012
AimTo explore general practitioners' (GPs) management of osteoarthritis (OA). BACKGROUND: OA represents a large burden on primary care. Little is known about GPs' current management of OA, especially influences on their prescribing quality care and the barriers they face while doing so. METHODS: A total of 1006 GPs were randomly ...
Taylor Jennifer P - - 2012
OBJECTIVE: To assess the nutritional quality of lunchtime food consumption among elementary-school children on Prince Edward Island according to the source of food consumed (home v. school). DESIGN: Students completed a lunchtime food record during an in-class survey. Dietary adequacy was assessed by comparing median micronutrient intakes with one-third of ...
Lorenzi Julio C C - - 2012
Abstract The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here the expression of the miRNAs miR-15a/16-1 in PBMC, CD4(+) and CD8(+) ...
Rotolo Jimmy J Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center (MSKCC), New York, New York, - - 2012
Radiation gastrointestinal (GI) syndrome is a major lethal toxicity that may occur after a radiation/nuclear incident. Currently, there are no prophylactic countermeasures against radiation GI syndrome lethality for first responders, military personnel, or remediation workers entering a contaminated area. The pathophysiology of this syndrome requires depletion of stem cell clonogens ...
Roskell Ns - - 2012
Abstract Objectives: Previous systematic reviews and meta-analyses of treatments in relapsing-remitting multiple sclerosis (RRMS) derived their findings from either placebo-controlled studies only or separately from head-to-head and comparative studies. The purpose of this study is to compare annualized relapse rates (ARR) of fingolimod versus all of the commonly used first-line ...
Czirr Eva - - 2012
While immune responses in neurodegeneration were regarded as little more than a curiosity a decade ago, they are now increasingly moving toward center stage. Factors driving this movement include the recognition that most of the relevant immune molecules are produced within the brain, that microglia are proficient immune cells shaping ...
Perera A - - 2012
The development of molecular methods is becoming a promising field in the analysis of parasite fauna in wildlife species. This is especially useful in the case of parasite species where developmental larval stages are difficult to assess using standard methods. In this study we screened for the presence of parasitic ...
Cornelis Tom - - 2012
Context. Bortezomib is a proteasome inhibitor with excellent antimyeloma activity. The most frequent toxic side effects are gastrointestinal, neuropathy and thrombocytopenia. The liver was not considered an important target organ for toxicity until one case of bortezomib-induced severe hepatitis was reported in a patient with multiple myeloma. Case report. We ...
Cerveri Pietro - - 2012
The results of recent studies concerning statistical bone atlases and automated shape analysis are promising with a view to widening the use of surface models in orthopedic clinical practice, both in pre-operative planning and in the intra-operative stages. In this domain, automatic shape analysis is strongly advocated because it offers ...
Deka Lopamudra - - 2012
Immune-mediated thrombocytopenic purpura (ITP), one of the common causes of thrombocytopenia, is characterized by morphologic alterations in megakaryocytes in the bone marrow. Few studies have explored morphometric measurements of megakaryocytes in bone marrow trephine biopsies. Quantitative morphometric analysis of megakaryocytes in bone marrow aspirate smears is lacking in the available ...
Yuan Qinghong - - 2012
The reaction between a metal cluster Al13(-) and an inorganic molecule HI involves charge transfer and density functional calculations has deficiency to estimate the activation barrier due to the self-interaction error. Coupled-cluster calculation with single and double excitation (CCSD) based on spin-unrestricted Hartree-Fock wavefunction can improve the calculated barrier and ...
Hancock Ruth - - 2012
In England, Local Authorities (LAs) contribute to the care home fees of two-thirds of care home residents aged 65+ who pass a means test. LAs typically pay fees below those faced by residents excluded from state support. Most proposals for reform of the means test would increase the proportion of ...
Nolan Christine - - 2012
AimThis qualitative study explored the professional and practice-based factors affecting the role legitimacy and adequacy of practice nurses in managing obese patients. BACKGROUND: There are strong clinical, financial and practical reasons for tackling obesity in UK general practice. Although practice nurses may seem to be in an ideal position to ...
Sansone Francesco - - 2012
Guanidinium groups were introduced through a spacer at the lower rim of calix[4]arenes in the cone conformation to give new potential nonviral vectors for gene delivery. Several structural modifications were explored, such as presence or absence of a macrocyclic scaffold, lipophilicity of the backbone, length of the spacer, nature of ...
Lin Yu-Yu - - 2012
Dysregulation of canonical Wnt signaling is thought to play a role in colon carcinogenesis. β-Catenin, a key mediator of the pathway, is stabilized upon Wnt activation and accumulates in the nucleus, where it can interact with the transcription factor T cell factor (TCF) to transactivate gene expression. Normal colonic epithelia ...
Bouhrara Mustapha - - 2012
Understanding and monitoring deformation and water content changes in meat during cooking is of prime importance. We show the possibilities offered by Nuclear Magnetic Resonance Imaging (MRI) for the in situ dynamic measurement of deformation fields and water content mapping during beef heating from 20 to 75 °C. MRIs were ...
Tian Shan Xi - - 2012
Positive-negative photoion pairs can be formed in the photoexcitation of molecules in the broad energy range from vacuum ultraviolet to soft X-ray. Synchrotron radiation is the most suitable photon source and state-of-the-art mass spectrometry techniques have been successfully applied in the experimental studies of such ion-pair photodissociation dynamics. This perspective ...
He Meng M The Department of Cardiology, Biomedical Research Therapy Center, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, - - 2012
To investigate the influences of breviscapine, a flavonoid extracted from Erigeron breviscapus, on the proliferation and migration of vascular smooth muscle cells (VSMCs) cultured in a high glucose medium and the underlying mechanisms. VSMCs were isolated from thoracic aortas of male Sprague-Dawley rats and cultured in vitro. Cell proliferation was ...
Hanke Conni - - 2012
A new system for dielectrophoretic cell capture on permeable polyester membranes is presented. Conventional photolithographic techniques were used to fabricate gold microelectrodes on a polyester membrane. The characterization of the microelectrodes showed that there were no differences regarding roughness, permeability, and hydrophilicity of the membrane before and after processing. Finally, ...
Cook R J RJ University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA. - - 2012
Desmoplastic small round cell tumor of the peritoneum (DSRCTP) is a rare, frequently fatal tumor. This retrospective study, based on CIBMTR registry data, describes the largest reported cohort of DSRCTP patients who have undergone Auto-SCT. The probabilities of disease-free survival (DFS) at 1 year for patients in CR and not ...
Zanoni Ivan - - 2012
Inflammation is a multistep process triggered when innate immune cells - for example, DCs - sense a pathogen or injured cell or tissue. Edema formation is one of the first steps in the inflammatory response; it is fundamental for the local accumulation of inflammatory mediators. Injection of LPS into the ...
Zinaman Michael - - 2012
Abstract Background: The likelihood of conception is increased if intercourse is timed to coincide with the fertile period (5 days prior to ovulation). However, to be effective, this requires good awareness of the day of ovulation. The aim of this study was to examine the accuracy of women's perceived ovulation ...
Paterson Nicole D - - 2012
Luteinizing hormone (LH) is believed to play a role in follicle maturation during the natural cycle. However, the need for co-treatment with recombinant LH (rLH) for controlled ovarian stimulation is controversial. The primary objective of our study was to determine if pregnancy rates are improved when rLH is used in ...
Rotaru Aurelian - - 2012
We studied the spin state dependence of the electrical conductivity of the spin crossover compound [Fe(Htrz)(2)(trz)](BF(4)) (Htrz = 1H-1,2,4-triazole) by means of dc electrical measurements. The low spin state is characterized by higher conductance and lower thermal activation energy of the conductivity, when compared to the high spin state.
Nylander Alyssa A Department of Neurology and Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, - - 2012
Multiple sclerosis (MS) is a multifocal demyelinating disease with progressive neurodegeneration caused by an autoimmune response to self-antigens in a genetically susceptible individual. While the formation and persistence of meningeal lymphoid follicles suggest persistence of antigens to drive the continuing inflammatory and humoral response, the identity of an antigen or ...
Cade Je - - 2012
OBJECTIVE: Nutritionists in the UK are at the start of an exciting time of professional development. The establishment of the Association for Nutrition in 2010 has presented an opportunity to review, revitalize and expand the UK Voluntary Register of Nutritionists. In the UK and elsewhere, there is a need for ...
Kaloriti Despoina D School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, - - 2012
Pathogenic microbes exist in dynamic niches and have evolved robust adaptive responses to promote survival in their hosts. The major fungal pathogens of humans, Candida albicans and Candida glabrata, are exposed to a range of environmental stresses in their hosts including osmotic, oxidative and nitrosative stresses. Significant efforts have been ...
Berglund Sean P - - 2012
Porous, nanostructured BiVO(4) films are incorporated with Mo and W by simultaneous evaporation of Bi, V, Mo, and W in vacuum followed by oxidation in air. Synthesis parameters such as the Bi : V : Mo : W atomic ratio and deposition angle are adjusted to optimize the films for photoelectrochemical (PEC) water oxidation. Films synthesized ...
Jääskeläinen Pertti - - 2012
Background. Hypertrophic cardiomyopathy (HCM) is predominantly caused by a large number of various mutations in the genes encoding sarcomeric proteins. However, two prevalent founder mutations for HCM in the alpha-tropomyosin (TPM1-D175N) and myosin-binding protein C (MYBPC3-Q1061X) genes have previously been identified in eastern Finland. Objective. To assess the prevalence of ...
Ransohoff Richard M - - 2012
Immune responses in the CNS are common, despite its perception as a site of immune privilege. These responses can be mediated by resident microglia and astrocytes, which are innate immune cells without direct counterparts in the periphery. Furthermore, CNS immune reactions often take place in virtual isolation from the innate/adaptive ...
Cairrão Elisa E Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal. - - 2012
The sex hormones 17β-estradiol (βES) and progesterone (PRG) induce rapid non-genomic vasodilator effects which could be protective for the cardiovascular system. The purpose of this study was to analyze the mechanisms underlying their vasodilator effect in rat aortic smooth muscle preparations. Endothelium-denuded aorta artery rings were prepared from male Wistar ...
Olas Beata - - 2012
The antiplatelet and antioxidative activity of polyphenolic fraction isolated from aerial parts of Tribulus pterocarpus in blood platelets stimulated by thrombin was studied. Thrombin as a strong physiological agonist induces the enzymatic peroxidation of endogenous arachidonic acid, the formation of different reactive oxygen species, including superoxide anion radicals ([Formula: see ...
Barber Anthony - - 2012
ABSTRACT Sleep disturbances are common in patients with Parkinson's disease (PD). These disturbances can primarily affect the patient's quality of life and may worsen the symptoms of PD. Among the multiple sleep disturbances in PD patients, there has been a marked growing interest in Rapid Eye Movement Sleep Behavior Disorder ...
Wang Hong-Ju - - 2012
Abstract The previous studies suggested that some subpopulations of T lymphocytes against CNS antigens, such as myelin basic protein (MBP), are neuroprotective. But there were few reports about the effect of these T cells on axon regeneration. In this study, the neonatally thymectomied (Tx) adult rats which contain few T ...
Hu Jingjing - - 2012
Abstract Objectives: To investigate the association of 1082G>A(RsaI) (rs1256049) and 1730A>G(AluI) (rs4986938) single nucleotide polymorphisms(SNPs), respectively- located on estrogen receptor beta (ESR2) gene with recurrent spontaneous abortion in chinese population. Methods: The study group consisted of 196 patients with recurrent spontaneous abortion and 182 fertile women as control. Two functional ...
Kakasi B - - 2012
Fluorochromes in combination with flow cytometry can be used for laboratory assessment of semen quality in humans and domestic animals. Some studies have reported the potential toxicity of these fluorochromes toward the cells analyzed, but not toward the laboratory technician who operates the analytical instrument. We tested the genotoxic potential ...
Hong Yun-Chul - - 2012
Oxidative stress may be affected by lead exposure as well as antioxidants, yet little is known about the interaction between dietary antioxidants and blood lead levels (BLL) on oxidative stress level. We investigated the interaction between dietary antioxidants and BLL on oxidative stress level. As part of the Biomarker Monitoring ...
Kiritsi Dimitra - - 2012
Spontaneous gene repair, also called revertant mosaicism, has been documented in several genetic disorders involving organs that undergo self-regeneration, including the skin. Genetic reversion may occur through different mechanisms, and in a single individual, the mutation can be repaired in various ways. Here we describe a disseminated pattern of revertant ...
Yun Dong-Jin - - 2012
The hafnium silicate and aluminum oxide high-k dielectrics were deposited on stainless steel substrate using atomic layer deposition process and octadecyltrichlorosilane (OTS) and polystyrene (PS) were treated improve crystallinity of pentacene grown on them. Besides, the effects of the pentacene deposition condition on the morphologies, crystallinities and electrical properties of ...
Lithovius Raija - - 2012
Objective. We estimated trends in prescription medication costs in out-patients with type 1 diabetes by various stages of diabetic nephropathy (DN), before the development of end-stage renal disease, between 1995 and 2005. Methods. Patients with normo- (n = 1,334), micro- (n = 206), and macroalbuminuria (n = 365) were identified ...
Cao Yuanning - - 2012
Abstract Background: Maternal diabetes causes neural tube defects (NTDs) in the embryos via activating protein kinase Cs (PKCs), which regulate programmed cell death (apoptosis). The aims of this study are to investigate the role of pro-apoptotic PKCδ in NTD formation and the underlying mechanisms. Methods: PKCδ heterozygous (pkcδ(+/-)) female mice ...
Patel Rinkal - - 2012
Disease resistance prediction using genotypic data has been widely pursued in animal as well as plant research, mostly in cases where genotypic data can be readily available for a large number of subjects. With the evolution of SNP marker genotyping technology and the consequent cost reduction for genotyping thousands of ...
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