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Cooper Matthew A - - 2012
The meeting covered traditional topics such as high-content screening and assay development, as well as more contemporary, emergent areas involving novel screening platforms and technologies, strategies to deal with biosimilars and biologics, and natural product diversity. Notably, many talks challenged established screening practices and the use of 'combichem' small-molecule libraries. ...
Wang Jun-liang - - 2012
The widespread use of organophosphorus pesticides (OPs) poses a great threat to human health and has made the detection of OP residues in food an important task, especially in view of the fact that easy and rapid detection methods are needed. Because OPs have inhibitory effects on the activity of ...
Tomková Mária - - 2012
Background: The enzyme NADPH-P450 oxidoreductase (POR) is the main electron donor to all microsomal CYPs. The possible contribution of common POR variants to inter- and intra-individual variability in drug metabolism is of great pharmacogenetic interest. Aim: To search for POR polymorphic alleles and estimate their frequencies in a Jewish population. ...
Amaya-Villar Rosario - - 2012
The advances in burn care therapy have extended considerably the survival of seriously burned patients, exposing them to infectious complications, notably fungal infections. Due to the difficulty in the diagnosis of invasive mycoses and their high associated mortality rates, approaches to prophylactic or pre-emptive antifungal therapy in high-risk burned patients ...
Kayahan Hasan - - 2012
BACKGROUND: Data regarding early atherosclerosis and inflammatory bowel disease are limited and conflicting results are present. AIMS: The purpose of this study was to evaluate serological and sonographical evidence of subclinical vascular involvement in patients with inflammatory bowel disease. METHODS: Thirty-nine patients with inflammatory bowel disease (20 Crohn's disease, and ...
Elkoushy Mohamed A - - 2012
To assess the impact of pulsed fluoroscopy (PF) at a rate of 4 frames per seconds (fps) on the total fluoroscopy time during ureteroscopy (URS) and percutaneous nephrolithotomy (PCNL). A retrospective review of prospectively collected data was performed for consecutive patients undergoing URS and PCNL by a single surgeon between ...
Ingrosso Gianluca - - 2012
ABSTRACT: BACKGROUND: To assess interfraction translational and rotational setup errors, in patients treated with image-guided hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and positioned using stereotactic coordinates. METHODS: 37 patients with 47 brain metastases were treated with hypofractionated stererotactic radiotherapy. All patients were immobilized with a ...
Moore Gaea Schwaebe - - 2012
We sought to determine whether small-for-gestational age (SGA) and large-for-gestational age (LGA) birthweights increase autism risk. This was a retrospective cohort analysis comparing children with autism (n = 20,206) within a birth cohort (n = 5,979,605). Stratification by sex and birthweight percentile (SGA, <5th or 5-10th percentile; appropriate size for ...
Ahmed Fatima - - 2012
The purpose of this study was to determine the ability of orthodontists and orthodontic residents to identify nonorthodontic incidental findings and false positives in cone-beam computed tomography scans. Two groups of 10 cone-beam computed tomography scans containing equal numbers of scans with no, 1, or several abnormal nonorthodontic lesions were ...
Reagan John L - - 2012
Neutropenia is a common reason for hematology consultations in the inpatient and outpatient settings and is defined as an absolute neutrophil count less than 1500 cells/μL. Neutropenia varies in severity, with more profound neutropenia being associated with higher rates of infections and infection-related deaths. The causes for neutropenia are diverse ...
Balas Michele C - - 2012
Imagine working in an environment where all patients undergoing mechanical ventilation are alert, calm, and delirium free. Envision practicing in an environment where nonvocal patients can effectively express their need for better pain control, repositioning, or emotional reassurance. Picture an intensive care unit where a nurse-led, interprofessional team practices evidence-based, ...
Liu Peng - - 2012
Habitat selection of four sympatric pheasants (Syrmaticus ellioti, Lophura nycthemera, Pucrasia macrolopha and Bumbusicola thoracica) was studied in Guanshan National Nature Reserve, Jiangxi, China from October 2009 to November 2010. We measured seventeen ecological factors across 388 sites used by the four pheasants by direct observation in six transects. The ...
Dolmatch Bart L - - 2012
To review technical and 180-day clinical outcomes when stent grafts were used to treat dysfunctional arteriovenous (AV) hemodialysis access circuits. The FLUENCY Plus Stent Graft (Bard Peripheral Vascular, Tempe, Arizona) was used to salvage percutaneous transluminal angioplasty (PTA) technical failures and complications in AV access circuits over 2 years. There ...
Liu Tong - - 2012
Toll-like receptors (TLRs) are germline-encoded pattern-recognition receptors that initiate innate immune responses by recognizing molecular structures shared by a wide range of pathogens, known as pathogen-associated molecular patterns (PAMPs). After tissue injury or cellular stress, TLRs also detect endogenous ligands known as danger-associated molecular patterns (DAMPs). TLRs are expressed in ...
Tow Kenny Hey - - 2012
Relative intensity noise and frequency noise have been measured for the first time for a single-frequency Brillouin chalcogenide As<sub>38</sub>Se<sub>62</sub> fiber laser. This is also the first demonstration of a compact suspended-core fiber Brillouin laser, which exhibits a low threshold power of 22 mW and a slope efficiency of 26% for ...
Jang J K - - 2012
We demonstrate the passive suppression of stimulated Brillouin scattering in meter-length fiber-ring cavities through careful control of the fiber length. Experimentally we are able to demonstrate an over sixty-times increase in the Brillouin threshold of a 0.4 m fiber ring. This very simple suppression technique greatly simplifies the design of ...
Takahashi-Fujigasaki Junko - - 2012
Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive embryonic brain tumor predominantly seen in young children. The authors report an unusual case of a fourth ventricle AT/RT in an infant who survived for 26 years. The tumor was resected when the patient was 6 months of age, and radiation therapy (40-Gy ...
Aguilar Gerardo - - 2012
Critically ill patients with invasive candidiasis (IC) often suffer renal failure, which sometimes requires continuous renal replacement techniques (CRRT). Echinocandins are the first line treatment for IC in critically ill patients with mild or severe illness. Their elimination during CRRT should be negligible due to their pharmacokinetic and pharmacodynamic (PK/PD) ...
Nashed Angela - - 2012
Sleep bruxism (SB) is a movement disorder identified by grinding of teeth and rhythmic masticatory muscle activity (RMMA). RMMA is associated with body movements and cortical arousals. Increases in autonomic sympathetic activities that characterize sleep cortical arousal precede RMMA/SB. Based on these findings, this study examined whether RMMA/SB episodes are ...
Bharmal Nazleen - - 2012
There is limited information on the health status of South Asians. Our objective was to examine the delivery of clinical preventive services to South Asian adults. We used data from a 2001 mail survey to a nationwide sample of South Asians. We quantified the percentage of eligible adults who received ...
Bruns T - - 2012
A majority of patients with ulcerative colitis (UC) respond to medical therapy and remain in remission. However, approximately 20 % of UC patients experience severe relapses that require hospitalization. For these cases, intravenous corticosteroids are the established first-line treatment and 70 % of patients respond. Patients who do not respond ...
Barten Di-Janne J A - - 2012
OBJECTIVE: To determine the content validity, the construct validity, and the responsiveness of the Dutch McMaster Toronto Arthritis Patient Preference Questionnaire (MACTAR) in patients with osteoarthritis (OA) of the hip or knee. METHODS: The MACTAR comprises 2 parts: a transitional part and a status part. Content validity was investigated by ...
Valaviciene Rasa - - 2012
Hip fractures constitute a serious and common health problem from both individual and public health perspectives. Unified data collection and comparison between countries is recognised as an effective tool for care improvements. However, the variation in patients' demography, treatment methods and other local cultural aspects in different countries should be ...
el-Nahas Ahmed R - - 2012
To determine factors affecting the stone-free rate and complications of percutaneous nephrolithotomy (PNL) for treatment of staghorn stones. The computerized database of patients who underwent PNL for treatment of staghorn stones between January 2003 and January 2011 was reviewed. All perioperative complications were recorded and classified according to modified Clavien ...
Kestwal Rakesh M - - 2012
Vigna aconitifolia sprouts (Moth bean sprouts, MBS) were analyzed for their nutritional and antioxidant properties during sprouting. Sprouting for six days led to a 7.0 fold increase in fresh weight, 2.4 fold increase in soluble proteins, 3.0 fold increase in carbohydrates, and a 5.5 fold increase in mineral content. Phenolic ...
Ardon Monique S - - 2012
Ardon MS, Selles RW, Roebroeck ME, Hovius SE, Stam HJ, Janssen WG. Poor agreement on health-related quality of life between children with congenital hand differences and their parents. To determine agreement between children with congenital hand differences (CHDs) and their parents on health-related quality of life (HRQOL) and to explore ...
Brito Ciro José - - 2012
The aim of this study was to investigate the methods adopted to reduce body mass (BM) in competitive athletes from the grappling (judo, jujitsu) and striking (karate and tae kwon do) combat sports in the state of Minas Gerais, Brazil. An exploratory methodology was employed through descriptive research, using a ...
Liu Chang-Jing - - 2012
Phrynocephalus przewalskii is one kind of lizards inhabiting inclusively in the desert that has controversial viewpoints on its phylogeny. Based on mitochondrial ND2 gene of 119 samples from 12 geographic populations, we analyzed the effects of environmental factors on the variation of genetic diversity, as well as its relationship to ...
Hagert Elisabet - - 2012
The human thumb trapeziometacarpal (TM) joint is a unique articulation that allows stability during pinch and grip and great degrees of mobility. Because the saddle-shaped articulating surfaces of the TM joint are inherently unstable, joint congruity depends on the action of restraining ligaments and periarticular muscles. From other joints, it ...
Ma Qiufu Q Dana-Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. - - 2012
The somatic sensory system includes a variety of sensory modalities, such as touch, pain, itch, and temperature sensitivity. The coding of these modalities appears to be best explained by the population-coding theory, which is composed of the following features. First, an individual somatic sensory afferent is connected with a specific ...
Mendoza-Yero Omel - - 2012
We demonstrated a simple diffractive method to map the self-similar structure shown in squared radial coordinate of any set of circularly symmetric fractal plates into self-similar light pulses in the corresponding temporal domain. The space-to-time mapping of the plates was carried out by means of a kinoform diffractive lens under ...
Wang Bo - - 2012
Intravascular photoacoustic (IVPA) imaging can characterize atherosclerotic plaque composition on the basis of the optical absorption contrast between different tissue types. Given the high optical absorption of lipid at 1720 nm wavelength, an atherosclerotic rabbit aorta was imaged at this wavelength ex vivo using an integrated intravascular ultrasound (IVUS) and ...
Olsen Geary W - - 2012
The mortality of 2650 employees (93.4% males) in the mine and mill production of roofing granules at four plants was examined between 1945 and 2004. Hypotheses focused on diseases associated with exposure to silica: nonmalignant respiratory disease, lung cancer, and nonmalignant renal disease. Study eligibility required ≥ 1 year of ...
Potvin Olivier - - 2012
To examine in cognitively intact older men and women the associations between subjective sleep quality and 1-yr incident cognitive impairment. Prospective cohort study. General community. 1,664 cognitively intact individuals age 65 to 96 years. Sleep quality at baseline was measured using the Pittsburgh Sleep Quality Index (PSQI). Cognitive functioning was ...
Liu Mei - - 2012
To investigate optimal level of post-operation blood glucose control in infants with congenital heart disease (CHD). One hundred and two infants ≤1 year old undergoing open-heart surgery were randomly divided into three groups: intensive blood glucose control group (group A, n = 35), active blood glucose control group (group B, ...
Monticone Marco - - 2012
Although there is growing evidence in favour of the bio-psychosocial approach to the treatment of persistent neck pain, it is questioned whether treating psychological factors can improve patient perceptions of disability, pain and quality of life. This randomised, controlled study with 12 months' follow-up was conducted to evaluate the efficacy ...
Rietberg Matthew Rodney - - 2012
The sensory perception of water-in-oil emulsions containing a saline dispersed aqueous phase was investigated. Manipulating saltiness perception was achieved by varying the mass fraction aqueous phase (MFAP), initial salt load and surfactant concentration [(polyglycerol polyricinoleate (PgPr)] of the emulsions, with formulations based on a central composite design. Saltiness and emulsion ...
Nissen Mary Jo - - 2012
Radon is the second leading cause of lung cancer and it is recommended that all homes be tested for radon. Written surveys completed by 692 patients at two primary care clinics in the Minneapolis, MN, area revealed that only 24.7 % had ever tested their home. Testing rate was higher with ...
Shank S Brooke - - 2012
The purposes of this study were to quantify bone damage associated with insertion of 2 types of miniscrew implants and to relate the amount of bone damage to monocortical plate thickness. Nondrilling (n = 28) and self-drilling (n = 28) miniscrew implants (6 × 1.6 mm, Dentaurum, Newtown, Pa), and pilot holes ...
Suri Pradeep P Veterans Affairs Boston Healthcare System, Boston, MA, USA. - - 2012
To determine recurrence rates of lower-extremity radicular pain after nonsurgical treatment of acute symptomatic lumbar disk herniation (LDH), and to identify predictors of recurrence. Prospective inception cohort. Outpatient spine clinic. Patients (N=79) reporting resolution of radicular pain after magnetic resonance imaging confirmation of LDH. Individualized nonsurgical treatment tailored to the ...
Erguzel N - - 2012
Plasmin is involved in extracellular matrix remodeling by activating some matrix metallo-proteinases and degrading extracellular matrix; therefore component of fibrinolytic system such as tissue plasminogen activator and plasminogen activators inhibitors (PAI-1) might have a role in the pathogenesis of vascular remodeling. In our study we aimed to investigate the levels ...
Alsanosi Abdulrahman A - - 2012
To generate an Arabic version of the Dizziness Handicap Inventory (DHI), and to assess its reliability by applying it to a group of patients with vestibular disorders and control healthy subjects of Arabic origin. The Arabic version of the DHI was developed using the standard protocol for test translation. This ...
Ploch P - - 2012
A 35-year-old Kenian lady with advanced immunodeficiency due to HIV infection started on an antiretroviral therapy. Five months later, a severe colitis was diagnosed, however, no causal pathogen could be found. In order to avoid imminent perforation, a hemicolectomy became necessary, and immediately the symptoms and inflammation markers normalized rapidly. ...
Omair Mohammed A - - 2012
OBJECTIVE: To assess the effect of gastrointestinal (GI) manifestation on the quality of life in patients with systemic sclerosis (SSc). METHODS: The University of California, Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2 questionnaire was completed by 87 consecutive patients with SSc attending the scleroderma clinic at a single ...
Kaneko Shu - - 2012
An investigation by the Aroma Extract Dilution Analysis (AEDA) technique of the aroma concentrate from five different types of Japanese soy sauces, categorized according to Japan Agricultural Standards as Koikuchi Shoyu (KS), Usukuchi Shoyu (US), Tamari Shoyu (TS), Sai-Shikomi Shoyu (SSS), and Shiro Shoyu (SS), revealed 25 key aroma compounds. ...
Claessen Bimmer E - - 2012
Drug-eluting stents (DES) reduce the incidence of in-stent restenosis (ISR) after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). Whether the use of biomarkers might be of utility to identify patients who remain at risk for DES ISR after primary PCI has never been examined. A total of ...
Bansal Manish - - 2012
After single-ventricle palliation, patients have variable long-term functional outcomes. Cardiopulmonary exercise testing (CPET) is an assessment tool used to quantify functional outcome. Oxygen pulse kinetics during CPET, which can be an important indicator of dynamic changes in stroke volume reserve, has not been systematically studied in this population. This study ...
Loucks Eric B - - 2012
Education is inversely associated with coronary heart disease (CHD); however whether this is attributable to causal effects of schooling rather than potential confounders existing before school entry (eg, childhood intelligence, childhood economic circumstances, childhood chronic illness, parental mental health) remains unknown. We evaluated whether education is associated with 10-year CHD ...
Elliott Aaron M - - 2012
Cystic fibrosis (CF) is one of the most frequently diagnosed autosomal-recessive diseases in the Caucasian population. For general-population CF carrier screening, the American College of Medical Genetics (ACMG)/American College of Obstetricians and Gynecologists (ACOG) have recommended a core panel of 23 mutations that will identify 49-98% of carriers, depending on ...
Takeuchi Mikinobu - - 2012
Objective: There are mainly two surgical methods for lumbar foraminal stenosis, simple decompression of the extra-foraminal portion or decompression with fixation surgery. However the indication of either method is controversial. The aim of this study is to show our surgical method and results. Method: In six cases diagnosed as lumbar ...
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