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Wickenden A - - 2012
Ion channels are targets of many therapeutically useful agents, and worldwide sales of ion channel-targeted drugs are estimated to be approximately US$12 billion. Nevertheless, considering that over 400 genes encoding ion channel subunits have been identified, ion channels remain significantly under-exploited as therapeutic targets. This is at least partly due ...
Lynch J P - - 2012
The aim of this study was to investigate the effects of inoculating 3 contrasting lactic acid bacteria on the fermentation profile, estimated nutritive value, and aerobic stability of corn ears and stover produced under marginal growing conditions. Ears and stover were separated from whole-crop corn plants obtained from 3 replicate ...
Papachristou Evangelos - - 2012
The arteriovenous fistula is the preferred vascular access for hemodialysis patients because of its low complication rate and lower costs, but it still has unacceptable failure rates. Krishnamoorthy et al. implicate the geometry of the fistula in the temporal and spatial variations occurring in two of the most important parameters ...
Hoshino Yuichi - - 2012
Japan has already rushed in the Super-aged society, and up to 5 million aged people presumably are under the support-demanding condition. In 2007, Japanese Orthopedic Association advocated the new concept "Locomotive Syndrome" in order to make all the nation people realize an importance of locomotive organ. "Locomo Index 25" is ...
Dubuc J - - 2012
The objectives were to identify risk factors for and to quantify the effect of postpartum anovulation on reproductive performance in dairy cows. Data from 2,178 Holstein cows in 6 commercial herds enrolled in a randomized clinical trial were used. Data on periparturient disease incidence, calving history, and body condition score ...
Zoropogui Anthony - - 2012
The pathogenic strain Nocardia cyriacigeorgica GUH-2 was isolated from a fatal human nocardiosis case, and its genome was sequenced. The complete genomic sequence of this strain contains 6,194,645 bp, an average G+C content of 68.37%, and no plasmids. We also identified several protein-coding genes to which N. cyriacigeorgica's virulence can ...
Kaliamoorthy Kousalya - - 2012
To evaluate the drug utilization of third generation cephalosporins using core drug use indicators in various wards of Sri Ramachandra Hospital. Third generation cephalosporins are the most commonly prescribed broad spectrum antibiotic even before the culture sensitivity results arrives. Hence this study was undertaken to study the drug utilization evaluation ...
Khalid Shamaila - - 2012
Iron deficiency anemia (IDA) affects not only the hematological parameters but also disturb the oxidative balance of body. In pregnancy, this is much more considerable as oxidative stress is considered to be one of the physiological changes during this period. This study aims to observe the effect of daily iron ...
Dissanayake M - - 2012
The main aim of the study was to assess the effect of microparticulation at low pH on the functionality of heat-denatured whey proteins (WP). Spray-dried, microparticulated WP (MWP) powders were produced from 7% (wt/wt) WP dispersions at pH 3, acidified with citric or lactic acid, and microfluidized with or without ...
Saini V - - 2012
Surveillance of antimicrobial use and resistance is needed to manage antimicrobial resistance in bacteria. In this study, data were collected on antimicrobial use and resistance in Staphylococcus aureus (n=562), isolated from intramammary infections and (sub)clinical mastitis cases on 89 dairy farms in 4 regions of Canada [Alberta, Ontario, Québec, and ...
Hussain Abid - - 2012
The present study was conducted to formulate and evaluate flurbiprofen transdermal gel. A standard calibration curve was constructed to obtain a regression line equation to be used for finding out the concentration of drug in samples. Olive oil was used as penetration enhancer and was added in different concentrations to ...
- - 2012
The ISFA wishes to acknowledge the following 2012 Corporate Sponsors.
Lander Flemming - - 2012
The aim of the present study was to establish if social inequalities in early childhood, particularly living in a socially and economically deprived neighbourhood, are predictive of later unemployment. A cohort was established in 1987. It consists of 8-9 year-old children living in a socially deprived suburb who were followed ...
Cecchinato A - - 2012
The aim of this study was to investigate sources of variation of milk coagulation properties (MCP) of buffalo cows. Individual milk samples were collected from 200 animals in 5 herds located in northern Italy from January to March 2010. Rennet coagulation time (RCT, min) and curd firmness after 30min from ...
Nam Seong-Hyeuk - - 2012
Lactobacillus fructivorans is important in the generation of particular flavors and in other ripening processes associated with fermented food. Here, we present the draft genome sequence of the type strain Lactobacillus fructivorans KCTC 3543 (1,373,326 bp, with a G+C content of 38.9%), which consists of 5 scaffolds. The genome sequence ...
Dreher Mark L - - 2012
The pistachio is a nutrient-dense nut with a heart-healthy fatty-acid profile as well as protein, dietary fiber, potassium, magnesium, vitamin K, γ-tocopherol, and a number of phytochemicals. The pistachio's unique green and purple kernel color is a result of its lutein and anthocyanin content. Among nuts, pistachios contain the highest ...
Brick Nerys - - 2012
To assess the effectiveness of noninvasive interventions.
Marner Lisbeth - - 2012
The communication among neurons is the prerequisite for the working brain. To understand the cellular, neurochemical, and structural basis of this communication, and the impacts of aging and disease on brain function, quantitative measures are necessary. This thesis evaluates several quantitative neurobiological methods with respect to possible bias and methodological ...
Martinez-Martin Pablo - - 2012
Caregivers of Parkinson's disease patients face responsibilities stemming from providing assistance to a person, usually a family member, who suffers a progressively disabling disease characterized by both motor and nonmotor symptoms. These circumstances impact on the physical, emotional and psychosocial aspects of the caregivers' lives and, therefore, on their quality ...
Post A E - - 2012
Selective precipitation is a common method for the isolation of β-casein, using the different calcium sensitivities of the individual caseins and the selective solubility of β-casein at a low temperature. In previous studies, it has been indicated that the β-casein yield depends on the physicochemical characteristics of the casein raw ...
Stevenson J S - - 2012
The objective of this research was to increase the proportion of cows with at least 1 functional corpus luteum (CL) and elevated progesterone at the onset of the timed artificial insemination (TAI) protocol. Postpartum Holstein cows in one herd were stratified by lactation number at calving (September 2009 through August ...
Börner V - - 2012
The availability of different single nucleotide polymorphism (SNP) chips and the development of imputation algorithms allow for multistage dairy cattle breeding schemes applying various genomic selection strategies. These SNP genotypes yield genomically estimated breeding values (GEBV) with different accuracies at different costs. Thus, the optimum allocation of investments to different ...
Saghir Muhammad Rashad - - 2012
Medicinal plants play a key role in preventing various diseases. Hyperlipidemia is a major contributor to the pathogenesis of cardiovascular diseases. The purpose of the present study was to assess the effect of aqueous extract of Carum carvi seeds in diet induced hyperlipidemia in rats. 2% cholesterol diet were given ...
Marin Alicia - - 2012
Abstract The recovery of potentially pathogenic microorganisms (PPMs) from bronchial secretions is associated with a local inflammatory response in COPD patients. The objective of this study was to determine the relationships between bronchial colonisation and both bronchial and systemic inflammation in stable COPD. In COPD patients recruited on first admission ...
Zhong Yazhen - - 2012
Common herpes viruses such as Epstein-Barr virus (EBV) cause infection and disease after hematopoietic cell transplantation (HCT). Post-transplantation lymphoproliferative disorder following allogeneic HCT is a rare but life-threatening disease, mostly associated with EBV-infected B cells. Anti-CD20 monoclonal antibodies (e.g., rituximab) target normal and infected B cells and further suppress the ...
Naaby-Hansen Søren - - 2012
This is a review of ten previously published studies of the human sperm proteome. Proteins expressed on the sperm cell surface were identified and characterized by a combination of vectorial labelling with radioiodine and biotin, PI-PLC treatment, two-dimensional gel electrophoresis, immuno and lectin blotting procedures, affinity overlay assays with radioactive ...
Carod-Artal Francisco Javier - - 2012
Post-stroke health-related quality of life (HRQoL) reflects a comprehensive view of subjective health and a measure of a person's perceived physical, mental and social health following stroke. Generic scales may enable comparisons between groups of patients with a diverse range of conditions, although they may underestimate the effect of stroke ...
Baneyx Guillaume - - 2012
Interactions between co-administered medicines can reduce efficacy or lead to adverse effects. Understanding and managing such interactions is essential in bringing safe and effective medicines to the market. Ideally, interaction potential should be recognized early and minimized in compounds that reach late stages of drug development. Physiologically based pharmacokinetic models ...
Weiss W P - - 2012
Various diet formulation strategies were evaluated to alleviate milk fat depression using a corn milling product (CMP) that contained approximately 28% crude protein, 34% neutral detergent fiber (NDF), and 12% starch (dry basis). The control diet comprised mostly corn silage, alfalfa silage, corn grain, and soybean meal and contained approximately ...
Brouwer Michael S M - - 2012
Here we report the draft genome sequence of Clostridium difficile strain CD37, the first nontoxigenic strain sequenced. Every sequenced strain of Clostridium difficile has been shown to contain multiple different mobile genetic elements. The draft genome sequence of strain CD37 reveals the presence of two putative conjugative transposons.
Hines Lisa E - - 2012
In October 2009, a 2-day, multistakeholder, national conference was held in Rockville, Maryland, to discuss and propose methods to improve the drug-drug interaction (DDI) evidence base and its evaluation and integration into clinical decision support (CDS) systems. The conference featured participants representing consumers, health care providers, those responsible for relevant ...
- - 2012
Faced with a high rate of unemployment and an increase in uninsured patients, Lee Memorial Health system in Ft. Myers, FL sponsored a community-wide effort to provide health care options for unfunded patients. Triage Center provides post-acute medical care for the homeless. Salvation Army operates 10-bed respite unit that provides ...
Naeem A - - 2012
We evaluated expression of 50 genes encoding enzymes involved in metabolism, cellular growth, and various transporters in ruminal epithelium tissue when calves were fed conventional milk replacer (MR) and starter (control) or enhanced MR and enhanced starter. Male Holstein calves were fed reconstituted control MR [20% crude protein (CP), 20% ...
Petrofsky Jerrold S - - 2012
Most studies of the skin and how it responds to local heat have been conducted with either water, thermodes, or dry heat packs. Very little has been accomplished to look at the interaction between air humidity and temperature on skin temperature and blood flow. With variable air temperatures and humidity's ...
Skarżyński Henryk - - 2012
Communication is an integral part of human behaviour. Communication disorders are associated mainly with impairment in hearing, vision, and/or speech, which influences the ability to receive, comprehend, produce, and express verbal, nonverbal, and graphic information. When unrecognized and unmanaged, these very often "invisible" conditions can have a significant detrimental effect ...
Mohammadi Jamshid - - 2012
Phytotherapy has been achieved to maintain glycemic control in patients with diabetes mellitus. The present study was conducted to evaluate the antihyperglycemic properties of the Juglans regia leaf extract in streptozotocin-nicotinamide induced diabetic rats. Nicotinamide was injected intraperitonealy (i.p.) 15 min before the injection of Streptozotocin (i.p.). One week after ...
Watanabe Toshifumi - - 2012
For a society with an aging population, it is important to extend healthy life expectancy. Knee arthroplasty is one of the most successful and beneficial treatments for osteoarthritic knees, helping the elderly improve their activities of daily life. Previous reports have proved health-related quality of life improves dramatically with this ...
Göbel Uta - - 2012
With this first "regular" issue of Biotechnology Journal we would like to highlight that we invite you all to send us your best articles in the focus areas of BTJ - systems and synthetic biology, nanobiotech and medicine. It features the best of the latest in biotechnology, with several articles ...
Bromage Daniel I - - 2012
Percutaneous coronary intervention (PCI) of small vessels can be complicated by technically difficult access to the target lesion, an increased risk of major adverse cardiac events and in-stent restenosis requiring repeat revascularization. Conventional management of such lesions is with drug-eluting stent implantation; however, these have only partly attenuated the problem. ...
Kimoto-Nira H - - 2012
Many milk fermentations use mixed cultures of lactic acid bacteria. To select a new mixed starter culture, 100 acid-producing bacterial strains were isolated from raw cow milk. Of these, 13 strains identified as belonging to the genera Lactococcus, Lactobacillus, Leuconostoc, or Weissella (based on phenotypic and genotypic tests) were assessed ...
Ramsey K Wong - - 2012
Monozygotic twins with discordant karyotypes are rare. We report a case of monozygotic twins discordant for trisomy 13 by amniocyte karyotypes. Ultrasound revealed multiple congenital anomalies in Twin A (47,XY,+13), none in Twin B (46,XY), and monochorionic-diamniotic placentation. Zygosity testing performed both prenatally and after birth supported monozygosity. Twin A ...
Jans Christoph - - 2012
Streptococcus infantarius subsp. infantarius, a member of the Streptococcus bovis/Streptococcus equinus complex, is highly prevalent in artisanal dairy fermentations in Africa. Here the complete genome sequence of the dairy-adapted S. infantarius subsp. infantarius CJ18 strain--a strain predominant in traditionally fermented camel milk (suusac) from Kenya--is presented.
Baker Julien S - - 2012
The aim of this study was to investigate differences in blood lactate accumulation following 10 and 20 sec of maximal cycle ergometer exercise. Body mass, stature, and age of the group was determined prior to testing (82.57 ± 5.94 kg 177 ± 5.94 cm and 21.42 ± 1.61 yrs, respectively). ...
Miyata Hitomi - - 2012
Rapid amelioration of hypercholesterolemia in nephrotic syndrome (NS) using low density lipoprotein-apheresis (LDL-A) sometimes leads to NS remission, along with improvement of impaired biodefense system; however, the mechanism of how LDL-A affects NS is still unknown. We studied IFN-γ production under IL-12 stimulation for 24 h in whole blood from 30 ...
Lange Peter - - 2012
Our goal was to estimate the number of individuals with chronic obstructive pulmonary disease (COPD) in the Capital Region of Denmark and the need of resources required to implement the regional management programme for COPD. We examined a total of 45,970 participants from the Copenhagen General Population Study (CGPS) using ...
Winkler B - - 2012
Claw horn disorders are one of the main causes of lameness in dairy cows globally. This study aimed to develop material testing techniques to assess changes in the mechanical properties of bovine claw horn (BCH) and to compare these mechanical properties with existing methods of assessing claw horn disorders during ...
Giaginis Constantinos - - 2012
The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that contributes to tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of RCAS1 expression in human benign and malignant thyroid lesions. RCAS1 protein expression was ...
De P Campos Ualace - - 2012
The aim of this study was to investigate the effects of sub-clinical alterations on the amplitudes and slopes of the DPOAE input-output responses from subjects with previous history of middle ear dysfunction. The study included 15 subjects with and 15 subjects without a history of otitis media in the last ...
Regelmann Molly O - - 2012
Hyperthyroidism has been associated with liver function abnormalities; however, cholestasis as the presenting feature of adolescent Graves' disease has not been previously reported. The patient was a 17-year-old girl who presented with severe cholestasis and was found to have Graves' disease. She also had a positive hepatitis A immunoglobulin M ...
Teixeira Vivian de Oliveira Nunes - - 2012
Approximately 66% of the patients with rheumatoid arthritis (RA) have significant loss of cell mass (rheumatoid cachexia), mainly of skeletal muscle (rheumatoid sarcopenia). Sarcopenia is defined as muscle wasting associated with functional impairment. Patients with RA possess significant reduction in muscle strength, caused by muscle protein wasting, and loss of ...
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