Search Results
Results 251 - 300 of 2294
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Hardmeier M - - 2012
The pharmacokinetics and pharmacodynamics of a highly concentrated cyclodextrin-based intranasal (i.n.) midazolam formulation containing the absorption-enhancer chitosan were studied in 12 healthy volunteers and compared with intravenous (i.v.) midazolam. The pharmacodynamic (PD) effects were assessed using quantitative electroencephalography (EEG). Maximal plasma concentrations of 63 and 110 ng/ml were reached at ...
Lin Chih-Hung - - 2012
This study is to characterize the sequential change in CD133 expression after preoperative chemoradiotherapy (CRT) in rectal cancer and its impact on postoperative prognosis. Forty-one patients with rectal cancer who had received CRT before surgery were selected retrospectively. In each case, immunohistochemical analysis was performed to compare CD133 expression in ...
Stodel Emma J - - 2012
Background: At times, preceptors struggle with aspects of resident education. Many are looking for more support and faculty development in this area. Aims: To address preceptors' needs for resources and provide a proactive framework for their teaching, the Academic Support Process (ASP) website was developed and evaluated. Preceptors' (N = 35) experiences ...
Kaida Kosuke - - 2012
"Flow" is a positive emotional state which typically occurs when a person perceives a balance between the challenges associated with a situation and his or her capabilities to accomplish these demands. While flow often occurs along with positive feelings and high introspective performance, only a few studies have investigated how ...
Jeanne M - - 2012
The analgesia nociception index (ANI) is an online heart rate variability analysis proposed for assessment of the antinociception/nociception balance. In this observational study, we compared ANI with heart rate (HR) and systolic blood pressure (SBP) during various noxious stimuli in anaesthetized patients. 15 adult patients undergoing laparoscopic appendectomy or cholecystectomy ...
Klotz Monika - - 2012
Context: The receptor tyrosine kinase MET contributes to a wide range of biological activities, including survival, proliferation, and metastasis, which play an important role in cancer progression. MET is frequently overexpressed or amplified in a range of malignancies. Therefore, MET is an attractive therapeutic target for treatment of cancer. BAY-853474 ...
Bianchi Federica - - 2012
A molecularly imprinted polymer with trinitrotoluene as the template molecule was synthesized and used as the novel coating for solid-phase microextraction of the nitroaromatic explosive 2,4,6-trinitrotoluene for its selective determination. The fiber was characterized in terms of coating thickness, morphology, intra- and inter-batch repeatability and extraction efficiency. An average thickness ...
Miki Takayuki - - 2012
Since diabetic cardiomyopathy was first reported four decades ago, substantial information on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances fatty acid metabolism, suppresses glucose oxidation, and modifies intracellular signaling, leading to impairments in multiple steps of excitation-contraction coupling, inefficient energy production, and increased susceptibility to ...
Lee Michelle H - - 2012
Barrett's esophagus is the precursor to esophageal adenocarcinoma, one of the most rapidly increasing cancers in the United States. Given the poor prognosis of late-stage adenocarcinoma, endoscopic surveillance is recommended for subjects with Barrett's esophagus to detect early neoplasia. Current guidelines recommend "random" four-quadrant biopsies taken every 1-2 cm throughout the ...
Sun Xing - - 2012
PURPOSE: We established a stable rat model of liver transplantation using Sprague-Dawley rats and Wistar rats in order to investigate the role of the IDO gene in acute rejection after rat liver transplantation. METHODS: IDO gene expression and IDO enzyme activity were quantified in liver syngeneic grafts and allografts using ...
Eschle D - - 2012
My hands are numb is a common complaint in primary care. Generally, carpal tunnel syndrome can be suspected. This case report explains typical aspects of clinical reasoning used by neurologists to confirm the diagnosis, and also provides some details of «red flags» based on history and examination. Additionally, a short ...
Chauhan Deepender - - 2012
To report the clinical findings and a novel method of removal of bee sting using an endoillumination light source the following methods were used: clinical presentation, slit-lamp photographs, serial endothelial images and surgical management of a case of retained bee sting in the cornea. The bee sting was surgically removed ...
Codner Gemma F - - 2012
Six major histocompatibility complex (MHC) classical class I genes have been identified in cattle, and up to three of these are expressed in variable combinations on different haplotypes. The origin and functional significance of this genetic complexity is unknown. However, an improved assembly of the cattle genome, an expanded database ...
Liu Chung-Pin - - 2012
Aims: This study determines whether KMUP-1 inhalation suppresses ovalbumine (OVA)-sensitized and -challenged peri-bronchial vascular inflammation and remodeling in mice. Methods and Results: After short-term KMUP-1 (1-5 mM, 30 min)-nebulization and L-NAME (12 mM, 15 min)-pretreatment, endothelial nitric oxide synthase (eNOS) and matrix metalloproteinases- 9 (MMP-9) expression in lung were measured ...
Boer Lonneke M - - 2012
BACKGROUND: In primary care, formal functional capacity testing is not always feasible. Guidelines for family practitioners suggest the use of dyspnoea scales to assess exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). AIMS: To examine whether the use of activity-based dyspnoea scales can substitute for actual functional capacity ...
Wild Andreas - - 2012
A poly(ethylene glycol) (PEG) decorated bis(terpyridine) zinc coordination polymer acts as an anion-responsive material in 100% aqueous solution. Depending on the binding and association constants to Zn(II), the addition of different anions leads to increased emission intensity and/or a shift of the emission wavelength. The sensor was addressed with a ...
Bosnić Dubravka - - 2012
PET/CT is starting to play an important role in evaluating fever of unknown origin (FUO), due to its ability to localize and delineate areas of high metabolic activity, such as neoplastic proliferation and inflammation, including vasculitis. We present a case of giant cell arteritis (GCA) in a 72-year-old female patient ...
Kayali Tamara - - 2012
Fredrik Svenaeus has applied Heidegger's concept of 'being-in-the-world' to health and illness. Health, Svenaeus contends, is a state of 'homelike being-in-the-world' characterised by being 'balanced' and 'in-tune' with the world. Illness, on the other hand, is a state of 'unhomelike being-in-the-world' characterised by being 'off-balance' and alienated from our own ...
Takeuchi Yoshinori - - 2012
A Japanese domestic long-hair cat of about 8 years of age was presented with vomiting and hematochezia and was found to have significant hypereosinophilia. Bone marrow aspiration revealed moderate increases of eosinophilic lineages. Histopathological examination revealed mild eosinophilic and epitheliotropic T-lymphocytic infiltrations in the duodenum. Although the cat remained asymptomatic ...
Velayos Benito - - 2012
AIMS: The aim of this work is to investigate the accuracy of the urea breath test (UBT) performed immediately after emergency endoscopy in peptic ulcer bleeding (PUB). METHODS: Urea breath test was carried out right after emergency endoscopy in patients with PUB. The accuracy of this early UBT was compared ...
McGregor Calum A - - 2012
Background: Junior doctors are frequently faced with making difficult clinical decisions and previous studies have shown that they are unprepared for some aspects of clinical decision making. Aim: To explore medical students' feelings and strategies when responsible for making clinical decisions and to obtain students' views of the effectiveness of ...
Claridge Mackonis Elizabeth - - 2012
Despite the long history of using cell cultures in vitro for radiobiological studies, there is to date no study specifically addressing the dosimetric implications of flask selection and exposure environment in clonogenic assays. The consequent variability in dosimetry between laboratories impedes the comparison of results. In this study we compare ...
Kawai Hideki - - 2012
Background: The differences in the coronary plaque characteristics between patients with mild chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] 30-59ml·min(-1)·1.73m(2)) and those without CKD (eGFR ≥60) by 320-row area detector computed tomography (CT) have not been studied. Methods and Results: We enrolled 487 patients undergoing coronary CT angiography ...
Barbosa-Cabrera E - - 2012
Genome analysis of Entamoeba histolytica predicts the presence of acetyl-CoA carboxylase. Using Western blot, histochemistry, and confocal microscopy, we demonstrated the presence of a biotin-containing protein in the cytoplasm of E. histolytica, with a molecular weight of 136 kDa and biotin-carboxylase activity. This protein probably corresponds to a transcarboxylase that catalyzes ...
Kamp Rachelle J A - - 2012
Within Problem-Based Learning successful learning depends on the quality of cognitive, social and motivational contributions students make to the tutorial group. But at the same time, not all students in PBL automatically contribute in a high quality manner, which might impede successful group functioning. This study investigated whether peer process ...
Guo Yanhui - - 2012
Ammine aluminium borohydride system is found to release >12 wt% pure H(2) below 120 °C via a combined strategy of changing the coordination number and adopting mixed cations.
Manassa R P - - 2012
Predation is known to influence the distribution of behavioural traits among prey individuals, populations and communities over both evolutionary and ecological time scales. Prey have evolved mechanisms of rapidly learning the identity of predators. Chemical cues are often used by prey to assess predation risk especially in aquatic systems where ...
Speck-Planche Alejandro - - 2012
Mycobacterium tuberculosis (MTB) is the principal pathogen which causes tuberculosis (TB), a disease that remains as one of the most alarming health problems worldwide. An active area for the search of new anti-TB therapies is concerned with the use computational approaches based on Chemoinformatics and/or Bioinformatics toward the discovery of ...
Zangenah S - - 2012
Capnocytophaga canimorsus and C. cynodegmi are gram negative bacteria that can be transmitted to humans from dogs or cats and cause serious infections. Routine bacteriological methods, including fermentation and phenotypic tests are insufficient to correctly identify C. canimorsus or C. cynodegmi. The aim of this study was to evaluate the ...
Kenney Mary Kay - - 2012
To examine national patterns of peer and parent interactive play opportunities that enhance early learning/socialization. Bivariate and multivariable analyses of cross-sectional data on 22,797 children aged 1-5 years from the National Survey of Children's Health 2007 were performed to determine the child, family, and neighborhood factors associated with four parent-initiated activities. ...
Zhang Kailiang - - 2012
Extensive data have shown that Wnt/beta-catenin signaling is associated with various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of Wnt/beta-catenin signaling in glioma, with particular focus on the expression signatures of the main components in Wnt/beta-catenin signaling, the role of key factors in Wnt/beta-catenin ...
Lakhdar Sami - - 2012
The imidazoles add to the CC-double bond of the iminium ion with rate constants as predicted by the equation log k = s(N)(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct account for the failure of imidazoles to take part in iminium-activated ...
Yamazaki Kazuhiro - - 2012
We report the case of a 68-year-old man with progressive heart failure due to effusive-constrictive pericarditis. During approximately 1 month, echocardiography revealed rapid progression from pericarditis with effusion without tamponade to pericardial thickening and diastolic dysfunction. Cardiac catheterization revealed that the pressure in the right heart chambers remained high after ...
Kar Susanta - - 2012
This study investigates the efficacy of carnosic acid (CA), a polyphenolic diterpene, isolated from the plant rosemary (Rosemarinus officinalis), on androgen-independent human prostate cancer PC-3 cells. CA induced anti-proliferative effects in PC-3 cells in a concentration- and time-dependent manner, which was due to apoptotic induction as evident from flow-cytometry, DNA ...
Liu Tian-Yu - - 2012
Chiral Lewis basic tertiary amines or phosphines can enable properly modified Morita-Baylis-Hillman (MBH) adducts to undergo asymmetric allylic substitutions with a wide range of nucleophiles. In addition, assisted by a Brønsted base, chiral Lewis bases can also catalytically convert modified MBH adducts into allylic ylides, which can be engaged in ...
Castorina Alessandro - - 2012
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas able to grow under conditions of metabolic stress caused by insufficient nutrients or oxygen. Both pituitary adenylate cyclase-activating polypeptide (PACAP) and activity-dependent neuroprotective protein (ADNP) have glioprotective potential. However, whether PACAP/ADNP signaling is involved in the resistance to cell death in MPNST ...
Bykov Dmytro - - 2012
Cytochrome c nitrite reductase catalyzes the six-electron, seven-proton reduction of nitrite to ammonia without release of any detectable reaction intermediate. This implies a unique flexibility of the active site combined with a finely tuned proton and electron delivery system. In the present work, we employed density functional theory to study ...
Zhang Bo - - 2012
An efficient TEMPO-catalyzed oxidative C-C bond formation with two Csp(3)-H bonds using molecular oxygen as the oxidant has been developed. The novel transformation provides a new strategy for the TEMPO-O(2) catalysis to construct C-C bonds. The advantages of this method include: (1) relatively mild and neutral conditions; (2) simplicity and ...
Dhariwala Fatema A - - 2012
The perception of toxicity to nitric oxide (NO) and irradiation (IR) by three different cell types has been studied. The three cell types are the macrophage like RAW264.7 cells, EL4 lymphoma cells, and splenocytes, which represent the different components of a tumor. These three cell types respond differently to NO ...
Hesham Abd El-Latif - - 2012
A thermophilic Bacillus strain ASU7 was isolated from soil sample collected from Assiut governorate in Upper Egypt on latex rubber-containing medium at 45 °C. Genetically, the 16S bacterial ribosomal RNA gene of the strain ASU7 was amplified by the polymerase chain reaction (PCR) and sequenced. The sequence of the PCR product ...
Rong Wei - - 2012
The aim of this study was to determine the therapeutic efficacy of starting naringin treatment 1 day after spinal cord injury (SCI) in rat and to investigate the underlying mechanism. SCI was induced using the modified weight-drop method in Sprague-Dawley rats. The SCI animals were randomly divided into three groups: vehicle-treated ...
De Carvalho Bruno R - - 2012
Calcific myonecrosis is a rare entity with only 57 cases reported in the English literature to date. It is a late complication of compartment syndrome of the limb and results in characteristic muscle necrosis with central liquefaction and peripheral calcification. This series presents a further two cases and consolidates the ...
Lin Tian - - 2012
Polycyclic aromatic hydrocarbons (PAHs) in 24 surface sediments from the Dahuofang Reservoir (DHF), the largest man-made lake in Northeast China, were measured. The results showed that the concentrations of 16 US EPA priority PAHs in the sediments ranged from 323 to 912 ng/g dry weight with a mean concentration of 592 ± 139 ng/g. ...
Munk Stig - - 2012
PURPOSE: Knee swelling after total knee arthroplasty may impair postoperative mobilisation and training, and as medical elastic compression stockings are well tolerated and effective to prevent oedema, haematoma and postoperative pain after venous surgery, we wanted to study whether this effect could be transferred to total knee arthroplasty surgery reducing ...
Chen Yue - - 2012
We reported a pulsed laser driven peristaltic pump for driving fluid in multilayer polydimethylsiloxane (PDMS) microchannels. By synchronizing the dynamics of deforming membrane valves with pulsed laser generated bubbles, a maximum pumping rate of 460 pl s(-1) has been achieved.
Voloshin Y Z - - 2012
The cycloaddition of the mono- and dichloroglyoximes to the cobalt(ii) bis-α-benzyldioximate afforded the cobalt(ii) mono- and dichloroclathrochelates in moderate yields (40-60%). These complexes undergo nucleophilic substitution of their reactive chlorine atoms with aliphatic amines, alcohols and thiolate anions. In the case of ethylenediamine and 1,2-ethanedithiol, only the macrobicyclic products with ...
Graf L - - 2012
Heritable thrombophilia as a concept in hemostasis has been continuously discovered parallel to the knowledge on physiology of bleeding disorders. Since the 1980s it has become increasingly popular to search for thrombophilia in patients with thromboembolism and their relatives. Although initially no direct evidence existed for any advantage for the ...
Geng Song - - 2012
The gas-phase N-alkyl-amino-cation affinities (NAACA) of archetypal anionic main-group element hydrides across the Periodic Table have been investigated by means of a modified G2(+) scheme. The reactions studied include R2NB --> R2N+ + B- (R = H, Me; B = XHn , n = 03, X = F, Cl, Br, ...
Işik Metin - - 2012
There are numerous causes of pulmonary cavitary lesions as infection (bacterial, parasitic and invasive fungal), Wegener granulomatosis (WG) and other vasculitis, sarcoidosis, malignancy, septic thromboembolism, airways disease (cystic bronchiectasis and bullae), pneumatoceles and traumatic parenchymal laceration. Herein, we present a case with perforated diverticulitis causing pulmonary cavitary lesions and a ...
Kramer Michael R - - 2012
Human papilloma virus (HPV) vaccination could substantially reduce the burden of cervical cancer by preventing HPV infection. This study uses the 2007 National Survey of Children's Health (NSCH) to estimate HPV vaccine coverage prevalence for US girls aged 12-17, the target group for vaccination. NSCH is a population-based telephone survey ...
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