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Huang Wei W Department of Orthopaedic Surgery, the First Affiliated Hospital of the General Hospital of PLA, Beijing, China. - - 2012
Sirtuin 1 (Sirt1) is the class III histone/protein deacetylase that interferes with the NF-κB signaling pathway, thereby has anti-inflammatory function. This study was undertaken to investigate whether Sirt1 could protect osteoblasts against TNF-α-induced injury in vitro. Murine osteoblastic cell line, MC3T3-E1, was used. Overexpress of Sirt1 protein in MC3T3-E1 cells ...
Ozono Hiroki - - 2012
Humans must coordinate approach-avoidance behaviours with the social cues that elicit them, such as facial expressions and gaze direction. We hypothesised that when someone is observed looking in a particular direction with a happy expression, the observer would tend to approach that direction, but that when someone is observed looking ...
Rachel Rivka A - - 2012
Cilia are highly specialized microtubule-based organelles that have pivotal roles in numerous biological processes, including transducing sensory signals. Defects in cilia biogenesis and transport cause pleiotropic human ciliopathies. Mutations in over 30 different genes can lead to cilia defects, and complex interactions exist among ciliopathy-associated proteins. Mutations of the centrosomal ...
Makkar Raj R - - 2012
Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known. We randomly assigned patients to transfemoral TAVR or to standard therapy (which often included balloon aortic valvuloplasty). Data ...
Mitkina Tatiana - - 2012
The oxidative coupling of sp(3) hybridized carbon atoms by photocatalysis is a valuable synthetic method as stoichiometric oxidation reagents can be avoided and dihydrogen is the only byproduct of the reaction. Cadmium sulfide, a readily available semiconductor, was used as a visible light heterogeneous photocatalyst for the oxidative coupling of ...
Rohn Susanne - - 2012
The rabies virus glycoprotein (RVG) peptide is known as a transfection reagent for systemic delivery of small interfering RNA (siRNA) into the brain. However, selective transfection of neuronal cells or specific brain regions remains a problem. In the present study, we show that the RVG peptide can efficiently be used ...
Dutton S E - - 2012
The magnetic properties of polycrystalline samples of Ba(3)Cu(3)In(4)O(12) (In-334) and Ba(3)Cu(3)Sc(4)O(12) (Sc-334) are reported. Both 334 phases have a structure derived from perovskite, with CuO(4) squares interconnected to form half-twist ladders along the c-axis. The Cu-O-Cu angles, ∼90°, and the positive Weiss temperatures indicate the presence of significant ferromagnetic (FM) ...
Perez-Mato J M - - 2012
Superspace symmetry has been for many years the standard approach for the analysis of non-magnetic modulated crystals because of its robust and efficient treatment of the structural constraints present in incommensurate phases. For incommensurate magnetic phases, this generalized symmetry formalism can play a similar role. In this context we review ...
Proctor Steven L - - 2012
Background: Substance use disorders (SUDs) are prevalent among female inmates. As the female state prison population continues to increase, describing the specific clinical and demographic characteristics of female prisoners remains of paramount importance to better define women's needs in the state prison system. Objectives: To determine the prevalence and patterns ...
Rouskas Konstantinos - - 2012
Melanocortin-4 receptor (MC4R) loss-of-function mutations are the commonest genetic cause of human monogenic obesity, so far. The contribution of MC4R coding mutations to severe obesity in the high-obesity prone Greek population has not been investigated to date. We determined the MC4R coding sequence of 510 obese and 469 lean control ...
Mattson Mark P - - 2012
The hallmark of the movement disorder Parkinson's disease (PD) is progressive degeneration of dopaminergic neurons. Mitochondrial dysfunction, impaired ubiquitin-mediated proteolysis of α-synuclein, and ER stress are each implicated in the complex and poorly understood sequence of events leading to dopaminergic neuron demise. In this issue of the JCI, Selvaraj et ...
Teunisse Jan-Pieter - - 2012
In this study, we compared neuropsychological tests and parent-based ratings of flexibility in a sample of children with autism spectrum disorders (ASD). We investigated the discriminant validity of the domain-specific flexibility measures by comparison with the domain general measures, general behavioral problems, general ASD-related traits, and general intelligence. Tests and ...
Gao Feng - - 2012
We here report an efficient and enhanced fluorescence energy transfer system between confined quantum dots by entrapping CdTe into the mesoporous silica shell (CdTe@SiO2) as donors and gold nanoparticles (AuNPs) as acceptors. At pH 6.50, the CdTe@SiO2-AuNPs assemblies coalesce to form larger clusters due to charge neutralization, leading to the ...
Banala Srinivas - - 2012
A hexafullereno-diporphyrinoid was obtained in a sequence of cycloaddition steps using porphyrins programmed for [4+2]-cycloaddition reactions and C(60)-fullerene.
Gitto Rosaria - - 2012
A series of arylsulfonamides has been synthesized and investigated for the inhibition of some selected human carbonic anhydrase isoforms. The studied compounds showed significant inhibitory effects in the nanomolar range towards druggable isoforms (hCA VII, hCA IX, and hCA XIV) (Ki values from 4.8 to 61.7 nM), whereas they generally ...
Wu Xin - - 2012
By designing a long and hydrophobic stilbeneboronic acid (STDBA) and allowing it to be included within the cavity of γ-cyclodextrin (γ-CyD) we succeeded in developing a fluorescent 2 : 2 STDBA-γ-CyD ensemble that shows a selective and sensitive response toward glucose in aqueous solutions, with satisfactory application in artificial urine samples.
Ma Cynthia X - - 2012
Patients with triple-negative breast cancer (TNBC) - defined by lack of estrogen receptor and progesterone receptor expression as well as lack of human epidermal growth factor receptor 2 (HER2) amplification - have a poor prognosis. There is a need for targeted therapies to treat this condition. TNBCs frequently harbor mutations ...
Iwanaga Kazunori - - 2012
Recently, the number of poorly water-soluble drug candidates has increased and has hindered the rapid improvement of new drugs with low intestinal absorption; however, the intestinal absorption of pH-dependent poorly water-soluble compounds is expected to be markedly improved by changing the pH in the vicinity of the absorption site. The ...
Weiland Silvia - - 2012
Research findings show that proposers make surprisingly fair offers in the ultimatum and dictator games, an observation that contradicts predictions of classical game theory. The present functional magnetic resonance imaging (fMRI) study examines brain activities of proposers that contribute to fair and unfair behaviors. We hypothesized that egoistic and altruistic ...
Hanfstein B - - 2012
In the face of competing first-line treatment options for CML, early prediction of prognosis on imatinib is desirable to assure favorable survival or otherwise consider the use of a second-generation tyrosine kinase inhibitor (TKI). A total of 1303 newly diagnosed imatinib-treated patients (pts) were investigated to correlate molecular and cytogenetic ...
Paik Young-Ki - - 2012
The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-HPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling ...
Zhao Juan - - 2012
Two novel trivacant Keggin-type polyoxometallate-based manganese carbonyl derivatives K(8)[(OC)(3)Mn(A-α-H(2)GeW(9)O(34))]·10H(2)O () and K(8)[(OC)(3)Mn(A-α-H(2)SiW(9)O(34))]·11H(2)O () have been synthesized by degradation of the metastable [γ-XW(10)O(36)](8-) (X = Ge(IV), Si(IV)) in CH(3)CN-H(2)O solvent (1 : 2, vol.) and structurally characterized by elemental analyses, IR spectra, thermogravimetric analysis, and single-crystal X-ray diffraction. X-ray diffraction analyses indicate that ...
Tanhuanpää Pirjo - - 2012
The first doubled haploid oat linkage map constructed at MTT Agrifood Research Finland was supplemented with additional microsatellites and Diversity Array Technology (DArT) markers to produce a map containing 1058 DNA markers and 34 linkage groups. The map was used to locate quantitative trait loci (QTLs) for 11 important breeding ...
Selvaraj Senthil S Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58201, - - 2012
Individuals with Parkinson's disease (PD) experience a progressive decline in motor function as a result of selective loss of dopaminergic (DA) neurons in the substantia nigra. The mechanism(s) underlying the loss of DA neurons is not known. Here, we show that a neurotoxin that causes a disease that mimics PD ...
Ren Rui-zhen RZ Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Ji'nan, - - 2012
Chemerin is a new adipokine involved in adipogenesis and insulin resistance. Since ethanol affects the insulin sensitivity that is closely associated with adipokines. The aim of this study was to investigate the effects of ethanol on chemerin in humans and rats. In the human study, 148 men who consumed alcohol ...
Wang Yujun - - 2012
Micelles assembled from amphiphilic poly(ethylene glycol)/poly(ε-caprolactone) (PEG/PCL) copolymers are promised as safe and effective drug delivery systems. They offer the potential to achieve high solubility of hydrophobic drugs, long blood circulation time and effective delivery to target organs. These advantages contribute to their application as vehicles of a broad variation ...
He Chong - - 2012
The arachidonic acid (AA) metabolic network produces key inflammatory mediators which have been considered as hallmark contributors in various inflammatory related diseases. Enzymes in this network, such as 5-lipoxygenase (5-LOX), cyclooxygenase (COX), leukotriene A(4) hydrolase (LTA4H) and prostaglandin E synthase (PGES), have been used as targets for anti-inflammatory drug discovery. ...
Wilsily Ashraf - - 2012
The ability of two common protected forms of amines (carbamates and sulfonamides) to serve as directing groups in Ni-catalyzed Suzuki reactions has been exploited in the development of catalytic asymmetric methods for cross-coupling unactivated alkyl electrophiles. Racemic secondary bromides and chlorides undergo C-C bond formation in a stereoconvergent process in ...
Hou Jared J - - 2012
InAs nanowires have been extensively studied for high-speed and high-frequency electronics due to the low effective electron mass and corresponding high carrier mobility. However, further applications still suffer from the significant leakage current in InAs nanowire devices arising from the small electronic bandgap. Here, we demonstrate the successful synthesis of ...
Devillers J - - 2012
A tight control of juvenile hormone (JH) titre is crucial during the life cycle of a holometabolous insect. JH metabolism is made through the action of enzymes, particularly the juvenile hormone esterase (JHE). Trifluoromethylketones (TFKs) are able to inhibit this enzyme to disrupt the endocrine function of the targeted insect. ...
Cui Jiaxi - - 2012
A small change in chemical structure causes a remarkable influence on the stereostructure stability and mutarotational rate of helical vinyl polymers bearing laterally attached p-terphenyl pendants with an achiral butoxy terminal and a chiral galactosyloxy terminal.
Ben Yahia Hamdi - - 2012
The new compounds Li(2-x)Na(x)Ni[PO(4)]F (x = 0.7, 1, and 2) have been synthesized by a solid state reaction route. Their crystal structures were determined from single-crystal X-ray diffraction data. Li(1.3)Na(0.7)Ni[PO(4)]F crystallizes with the orthorhombic Li(2)Ni[PO(4)]F structure, space group Pnma, a = 10.7874(3), b = 6.2196(5), c = 11.1780(4) Å and ...
Portela Raquel - - 2012
The photocatalytic efficiency of TiO2-SiMgOx plates to oxidise H2S was first evaluated in a flat laboratory reactor with 50 ml min-1 synthetic air containing 100 ppm H2S in the presence of humidity. The use of the photocatalyst-adsorbent hybrid material enhanced the photocatalytic activity in terms of pollutant conversion, selectivity and ...
Terol Amanda - - 2012
The present work describes the first attempt to use microwave reversed phase high performance liquid chromatography (MW-HPLC) to carry out the separation of organic compounds. Biotin and riboflavin were selected for the characterization of the new separation technique. Additional vitamins (nicotinamide, pyridoxine and thiamine) were used as reference compounds. In ...
Koudelka Tomas - - 2012
The effects of protein oxidation, for example of methionine residues, are linked to many diseases including those of protein misfolding such as Alzheimer's. Protein misfolding diseases are characterized by the accumulation of insoluble proteinaceous aggregates comprised mainly of amyloid fibrils. Amyloid-containing bodies known as corpora amylacea (CA) are also found ...
Huang Sherry - - 2012
Ultrasmall water-soluble silver nanoclusters are synthesized and their properties are investigated. The silver nanoclusters have high colloidal stability and show fluorescence in the red. This demonstrates that like gold nanoclusters also silver nanoclusters can be fluorescent.
Doni S - - 2012
In the past several years, industrial and agricultural activities have led to serious environmental pollution, resulting in a large number of contaminated sites. As a result, much recent research activity has focused on the application of bioremediation technologies as an environmentally friendly and economically feasible means for decontamination of polluted ...
Asano Yoshiaki - - 2012
A gable-type zinc phthalocyanine and a derived planar bis-phthalocyanine containing a shared anthracene unit have been synthesized and their spectroscopic properties examined. The former showed a split Q band, while the latter exhibited a red-shifted but unsplit Q band, as explained by exciton coupling theory and molecular orbital calculations.
Schmidt Bernd - - 2012
A sequence of acetamide directed oxidative Heck reaction and deacetylation-diazotation-Heck coupling allows the traceless removal of the acetamide group and its dual exploitation as a catalyst directing group and a leaving group.
Guo Zhen-Ni - - 2012
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system characterized by episodic and progressive neurologic dysfunction resulting from inflammatory and autoimmune reactions. The underlying pathogenesis of MS remains largely unclear. However, it is currently accepted as a T cell-mediated autoimmune disease. Among other clinical manifestations, ...
Copersino Marc L - - 2012
Neuropsychological impairment among patients with substance use disorders (SUDs) contributes to poorer treatment processes and outcomes. However, neuropsychological assessment is typically not an aspect of patient evaluation in SUD treatment programs because it is prohibitively time and resource consuming. In a previous study, we examined the concurrent validity, classification accuracy, ...
Wang Cheng - - 2012
Nowadays, biodegradable nanoscale preparations such as liposomes, micelles, nanoparticles (NPs), and solid lipid nanoparticles (SLN) have attracted increasing attention from major researchers. This article aims to review the absorption, pharmacokinetics, distribution properties and toxicity of the above-mentioned nanoscale preparations and the relative methodology. It may be significant for successful use ...
Bártfai Liza - - 2012
Abstract Objective. Vitamin E is frequently used for prevention/treatment of repeated or threatened abortion and threatened preterm delivery in Hungarian pregnant women though internationally this old-fashion method is not recommended. Methods. The rate of preterm birth of newborns in pregnant women with high dose (estimated daily dose 450 mg) vitamin E treatment ...
Schmidt-Hansen Mia - - 2012
Introduction. It has been suggested that the positive symptoms of acute schizophrenia are a consequence of a disruption of the process that produces latent inhibition (slower acquisition of conditioned responding after preexposure to the conditioned stimulus) and that this effect can be modelled by pro- and antipsychotic compounds in healthy ...
Ruan Jing - - 2012
Background/purpose: Skin ultrasound is a non-invasive technique widely used in the dermatological fields. Previous studies have indicated that ultrasound was able to measure nails depth. The use of ultrasound is particularly appropriate for the study of nail morphology because of the differences in tissue density. The objective of this present ...
Ivanová Monika M Institute for Heart Research, Slovak Academy of Sciences, Bratislava, - - 2012
To investigate the role of matrix metalloproteinases (MMPs) in the responses of rats to a prolonged doxorubicin (DOX) treatment. Male Wistar rats were used. DOX was administered by intraperitoneal injections of seven doses (cumulative dose was 15 mg/kg). Control animals were treated with saline. Tissue or plasma samples were collected ...
Chen Jun - - 2012
Objective: Phase transition of the lipid membrane is one of the most important properties of liposomes. The objective of this study was to investigate the influence of molar ratio of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and hydrogenated soy phosphatidylcholine (HSPC) on the phase transition temperature (T(m)) of the liposomes. Materials and methods: The ...
Bleijlevens Boris - - 2012
The Escherichia coli DNA repair enzyme AlkB is a 2-oxoglutarate (2OG) dependent Fe2+ binding dioxygenase that removes methyl lesions from DNA and RNA. To date, nine human AlkB homologues are known: ABH1 to ABH8 and the obesity-related FTO. Similar to AlkB, these homologues exert their activity on nucleic acids, although ...
Tuwairqi Waleed S - - 2012
To evaluate 1-year visual and topographic outcomes and safety and efficacy of corneal collagen cross-linking (CXL) combined with topography-guided photorefractive keratectomy (TG-PRK) to achieve near emmetropia in eyes with low-grade keratoconus. Twenty-two eyes from 15 patients (11 women, 4 men) were included in a prospective, nonrandomized, noncontrolled clinical study. Mean ...
Wang Jing - - 2012
In recent years, many researchers have paid more and more attentions on the use of Nanotechnology. Solid lipid nanoparticles (SLNs) are emerged as a promising alternation herein to emulsions, liposomes, microparticles and polymeric nanoparticles for their advantages. As promising drug carrier systems, SLNs are valuable for nanomedicine and have been ...
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