Search Results
Results 51 - 100 of 5079
1 2 3 4 5 6 7 8 9 10 >
Mercer Ryan G - - 2012
Production of the gene transfer agent of Rhodobacter capsulatus, RcGTA, is dependent upon several cellular regulatory systems, including a putative phosphorelay involving the CtrA and CckA proteins. These proteins are also involved in flagellar motility in R. capsulatus. The interactions of proteins in this system are best understood in Caulobacter ...
Detoni Cassia Britto - - 2012
It is desirable and challenging to prevent E-resveratrol (E-RSV) from photoisomerizing to its Z-configuration to preserve its biological and pharmacological activities. The aim of this research was to evaluate the photostability of E-RSV-loaded supramolecular structures and the skin penetration profile of chemically and physically stable nanoestructured formulations. Different supramolecular structures ...
Avrahami-Moyal Liat L Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, - - 2012
We investigated the genetic causes of ethanol tolerance by characterizing mutations selected in Saccharomyces cerevisiae W303-1A under the selective pressure of ethanol. W303-1A was subjected to three rounds of turbidostat, in a medium supplemented with increasing amounts of ethanol. By the end of selection, the growth rate of the culture ...
Belenky Inna - - 2012
Acetohydroxy acid synthase (AHAS; EC 2.2.1.6) is a thiamin diphosphate (ThDP)-dependent decarboxylase-ligase that catalyzes the first common step in the biosynthesis of branched-chain amino acids. In the first stage of the reaction, pyruvate is decarboxylated and the reactive intermediate hydroxyethyl-ThDP carbanion/enamine is formed. In the second stage, the intermediate is ...
Guan Shenheng S Department of Pharmaceutical Chemistry and Mass Spectrometry Facility, University of California, San Francisco, California 94158-2517, USA. - - 2012
Protein turnover studies on a proteome scale based on metabolic isotopic labeling can provide a systematic understanding of mechanisms for regulation of protein abundances and their transient behaviors. At this time, these large-scale studies typically utilize a simple kinetic model to extract protein dynamic information. Although many high-quality, protein isotope ...
Li Jingyi J Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, - - 2012
Mammals employ large numbers of odorant receptors to sample and identify volatile chemicals in the environment. These receptors are thought to vary not only in specificity for particular odorants, but also in breadth of tuning. That is, some odorant receptors are narrowly focused on a few closely related structures, while ...
Mann Monica K - - 2012
A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the pathogenesis of EAE through the production of anti-myelin antibodies that contribute to demyelination. On the contrary, ...
Hong E S ES Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, - - 2012
Individuals requiring insulin therapy for type 2 diabetes often require escalation of their regimen to achieve glycaemic control. Optimal management strategies for uncontrolled type 2 diabetes would improve glycaemic control without hypoglycaemia and weight gain. This study compared the efficacy and tolerability of adding sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, ...
Angoa-Pérez Mariana M Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, - - 2012
Neuropsychiatric disorders characterized by behavioral disinhibition, including disorders of compulsivity (e.g. obsessive-compulsive disorder; OCD) and impulse-control (e.g. impulsive aggression), are severe, highly prevalent and chronically disabling. Treatment options for these diseases are extremely limited. The pathophysiological bases of disorders of behavioral disinhibition are poorly understood but it has been suggested ...
Noguez Jaime H - - 2012
Entomopathogenic nematodes survive in the soil as stress-resistant infective juveniles that seek out and infect insect hosts. Upon sensing internal host cues, the infective juveniles regurgitate bacterial pathogens from their gut that ultimately kill the host. Inside the host, the nematode develops into a reproductive adult and multiplies until unknown ...
Clarke T-K - - 2012
Genetic factors are believed to account for 30-50% of the risk for cocaine and heroin addiction. Dynorphin peptides, derived from the prodynorphin (PDYN) precursor, bind to opioid receptors, preferentially the kappa-opioid receptor, and may mediate the aversive effects of drugs of abuse. Dynorphin peptides produce place aversion in animals and ...
Huard Jérémy - - 2012
During liver regeneration, quiescent hepatocytes re-enter the cell cycle to proliferate and compensate for lost tissue. Multiple signals including hepatocyte growth factor, epidermal growth factor, tumor necrosis factor α, interleukin-6, insulin and transforming growth factor β orchestrate these responses and are integrated during the G(1) phase of the cell cycle. ...
Liu Jiawang J Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, United - - 2012
To discover new selective mechanism-based P450 inhibitors, eight 7-ethynylcoumarin derivatives were prepared through a facile two-step synthetic route. Cytochrome P450 activity assays indicated that introduction of functional groups in the backbone of coumarin could enhance the inhibition activities toward P450s 1A1 and 1A2, providing good selectivity against P450s 2A6 and ...
Laing Brian M BM Department of Medicinal Chemistry and Molecular Pharmacology and Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47907, - - 2012
The ability of packaging RNA (pRNA) from the phi29 DNA packaging motor to form nanoassemblies and nanostructures has been exploited for the development of the nascent field of RNA nanotechnology and subsequent applications in nanomedicine. For applications in nanomedicine, it is necessary to modify the pRNA structure for the conjugation ...
Borgert Andrew A Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, - - 2012
Mucin glycoproteins present a complex structural landscape arising from the multiplicity of glycosylation patterns afforded by their numerous serine and threonine glycosylation sites, often in clusters, and with variations in respective glycans. To explore the structural complexities in such glycoconjugates, we used NMR to systematically analyze the conformational effects of ...
Nadithe Venkatareddy V Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84108, - - 2012
The objective of this study was to investigate the efficiency of multifunctional poly(ethylene glycol)-based hemoglobin conjugates crosslinked with antioxidant enzymes for their ability to protect an oxygen carrier (hemoglobin) and insulin secreting islets from the combination of hypoxic and free radical stress under simulated transplantation conditions. In this study, RINm5F ...
Hu Jing J Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina 27599-7431, United - - 2012
Bioremediation is one of the commonly applied remediation strategies at sites contaminated with polycyclic aromatic hydrocarbons (PAHs). However, remediation goals are typically based on removal of the target contaminants rather than on broader measures related to health risks. We investigated changes in the toxicity and genotoxicity of PAH-contaminated soil from ...
Sivaramakrishnan Santhosh S Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158-2517, - - 2012
CYP125 from Mycobacterium tuberculosis catalyzes sequential oxidation of the cholesterol side-chain terminal methyl group to the alcohol, aldehyde, and finally acid. Here, we demonstrate that CYP125 simultaneously catalyzes the formation of five other products, all of which result from deformylation of the sterol side chain. The aldehyde intermediate is shown ...
Zhan Changyou - - 2012
The E3 ubiquitin ligase MDM2 functions as a crucial negative regulator of the p53 tumor suppressor protein by antagonizing p53 transactivation activity and targeting p53 for degradation. Cellular stress activates p53 by alleviating MDM2-mediated functional inhibition, even though the molecular mechanisms of stress-induced p53 activation still remain poorly understood. Two ...
Dennis Allison M - - 2012
Intracellular pH (pH(i)) plays a critical role in the physiological and pathophysiological processes of cells, and fluorescence imaging using pH-sensitive indicators provides a powerful tool to assess the pH(i) of intact cells and subcellular compartments. Here we describe a nanoparticle-based ratiometric pH sensor, comprising a bright and photostable semiconductor quantum ...
GÅ‚owacka Iwona E - - 2012
The 1,3-dipolar cycloaddition of diethyl 2-azidoethyl-, 3-azidopropyl-, 2-azido-1-hydroxyethyl-, 3-azido-2-hydroxypropylphosphonates with selected N-propargyl nucleobases gave a series of the phosphonylated 1,2,3-triazole acyclonucleosides in which the phosphonate residue and nucleobases were linked by three- and four-carbon chains. Under standard conditions (TMSBr, ethanol), all synthesized O,O-diethylphosphonates were transformed into the respective phosphonic acids. ...
Ashton Kathleen S - - 2012
Isolated limb perfusion and isolated limb infusion are surgical interventions that provide high-dose regional chemotherapy to patients experiencing a recurrence of melanoma in an extremity. Nurses may be unfamiliar with these treatment options, as they are not available in all hospitals; however, the number of people diagnosed with melanoma is ...
Tian Mohan - - 2012
The purpose of this study was to assess the correlations between the maximum standardized uptake value (SUVmax) of colorectal carcinoma and hepatocyte growth factor (HGF), vascular endothelial growth factor C (VEGF-C), and their respective receptors using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT). Fluorine-18-FDG PET/CT scans were performed on ...
Gosselin Gilbert - - 2012
Previous studies have suggested that percutaneous coronary intervention (PCI) decreases long-term mortality in patients with silent myocardial ischemia (SMI), but whether PCI specifically decreases mortality when added to intensive medical therapy is unknown. We performed a post hoc analysis of clinical outcomes in patients in the COURAGE trial based on ...
Belle Loic - - 2012
Whether academic hospitals provide better quality of care for patients with acute myocardial infarction is widely debated. The aim of this study was to compare processes of care and mortality between academic and nonacademic hospitals in the contemporary era of acute myocardial infarction management. We analyzed the original data from ...
Ohta Kazuhide - - 2012
Aims: To further elucidate the clinical relevance of T-cell abnormalities in minimal change nephrotic syndrome (MCNS), and to predict the consequences of MCNS, we studied T-cell receptor (TCR) diversity by analyzing CDR3 size distribution and the frequency of Vβ repertoire usage. Methods: Participants comprised 36 pediatric patients with MCNS. 18 ...
Martorell Jaime - - 2012
Case Description-A 5-year-old 2.23-kg (4.91-lb) spayed female Lop rabbit (Oryctolagus cuniculus) was evaluated because of a history of lethargy, polyuria, and polydipsia of 1 month's duration. The referring veterinarian made a presumptive diagnosis of hypercalcemia of unknown etiology on the basis of a plasma total calcium concentration of 14.0 mg/dL. ...
Nielsen Einar E - - 2012
Few species worldwide have attracted as much attention in relation to conservation and sustainable management as Pacific salmon. Most populations have suffered significant reductions, many have disappeared, and even entire evolutionary significant units (ESUs) are believed to have been lost. Until now, no 'smoking gun' in terms of direct genetic ...
Harding Pg - - 2012
Objectives  To compare two approaches to performing the inferior alveolar nerve block in the horse and to evaluate the consistency of described topographical landmarks. Design  Experimental cadaver model. Methods  Eleven cadaver heads were positioned to mimic a standing sedated horse and the position of the mandibular foramen approximated. The vertical ...
Liu Jian - - 2012
The 2  '-deoxy-2  '-fluoro-2  '-C-methyluridine nucleotide prodrug, PSI-7851 and its single diastereomer PSI-7977 have displayed potent antiviral activity against hepatitis C virus in clinical trials, and PSI-7977 is currently in Phase III studies. As part of our SAR study of the 2  '-deoxy-2  '-fluoro-2  '- C-methyl class of nucleosides, we prepared the cyclopentyl carbocyclic uridine analog ...
Winborn Mark - - 2012
This paper examines the influence of familiarity on the progress of analysis. It is proposed that familiarity is a particular aspect of the intersubjective field which emerges over time and begins to shape and influence the behaviours, perceptions, thoughts, and feelings of the participants. It is also proposed that states ...
Barnes D R - - 2012
Abstract.  Barnes DR, Antoniou AC (Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK). Unravelling modifiers of breast and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: update on genetic modifiers (Review). J Intern Med 2012; 271: 331-343 Pathogenic mutations in the tumour suppressor genes BRCA1 and BRCA2 ...
Whitman Steven - - 2012
Although the racial disparity in breast cancer mortality is widely discussed there are no studies that analyze this phenomenon at the city level. We used national death files, abstracting those cases for which the cause was malignant neoplasm of the breast (ICD-10=C50) for the numerators and American Community Survey data ...
Macaluso Fabio Salvatore - - 2012
The current standard of care (SoC) for chronic hepatitis C, i.e. the combination of a pegylated-interferon (PEG-IFN) with ribavirin (RBV), may activate underlying autoimmune conditions. Particularly, interferon (IFN) has been known to induce or exacerbate autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) in hepatitis C virus patients. We describe ...
Sundstrom Shana M - - 2012
  The cross-scale resilience model states that ecological resilience is generated in part from the distribution of functions within and across scales in a system. Resilience is a measure of a system's ability to remain organized around a particular set of mutually reinforcing processes and structures, known as a regime. ...
Usami Shin-ichi - - 2012
CDH23 mutations and the 1555A>G mitochondrial mutation were identified among our series of electric acoustic stimulation (EAS) patients, confirming that these genes were important in hearing loss with involvement of high frequency. Successful hearing preservation as well as good outcomes from EAS indicated that patients with this combination of mutations ...
Swinton Paul A - - 2012
ABSTRACT: Swinton, PA, Stewart, AD, Lloyd, R, Agouris, I, and Keogh, JWL. Effect of load positioning on the kinematics and kinetics of weighted vertical jumps. J Strength Cond Res 26(4): 906-913, 2012-One of the most popular exercises for developing lower-body muscular power is the weighted vertical jump. The present study ...
Mans Christoph - - 2012
Case Description-3 female African spurred tortoises (Geochelone sulcata) of various body weights (0.22, 0.77, and 2.86 kg [0.48, 1.69, and 6.29 lb]) were examined because of reduced food intake and lack of fecal output. Owners reported intermittent tenesmus in 2 of the tortoises. Clinical Findings-Physical examinations revealed no clinically important ...
Crutsinger Gregory M - - 2012
In ecology, there is an increasing amount of research dedicated to understanding how intraspecific genetic diversity can extend beyond the population level to influence the assembly of communities and the functioning of ecosystems. In this issue of Molecular Ecology, Koh et al. (2012) take this exploration to a new level using ...
Chou Kun-Ta - - 2012
Patients with sleep apnea have been reported to be associated with increased prevalence of deep vein thrombosis (DVT) in some papers, which were criticized for either a small sample size or lack of a prospective control. Our study strived to explore the relationship of sleep apnea and the subsequent development ...
Kester Laura M - - 2012
The obesity epidemic has resulted in more young people having high-risk profiles for the development of type 2 diabetes. Screening to promote earlier diagnosis and treatment of type 2 diabetes is of significant importance, as untreated disease leads to metabolic, microvascular, and macrovascular complications. However, the choice of screening methodology ...
Li Jianbo - - 2012
Aim: To explore the relationship between plasma total homocysteine concentration and diabetic nephropathy in patients with Type 2 diabetes. Methods: Chinese patients with Type 2 diabetes (n = 183) were enrolled in a cross-sectional hospital based study. Early diabetic nephropathy status was documented by presence of microalbuminuria. Plasma total homocysteine ...
Izzo Mm - - 2012
Objective  Compare real-time reverse transcription polymerase chain reaction (qRT-PCR), a commercially available enzyme-linked immunosorbent assay (ELISA) and lateral flow immunochromatography assay (LAT) for the detection of rotavirus and coronavirus in faecal samples collected from diarrhoeic calves. Design  Prospective survey. Method  Samples were tested at two separate facilities using a commercial ...
Su Chun-Yan - - 2012
Objective: Peritonitis is still one of the major causes of peritoneal dialysis (PD) patients' dropout. In the present study, we analyzed the relationship between gastrointestinal (GI) problems and peritonitis in our CAPD patients. Methods: It is a prospective observational study. In December, 2008, 158 patients on continuous ambulatory peritoneal dialysis ...
Jackson Ae - - 2012
Financial effect of bovine Johne's disease · Detection of rotavirus and coronavirus in calf faeces · Canine vector-borne diseases · Parvovirus in the bone marrow of cats · Toxoplasmosis in flying foxes · Poxvirus infection in common ringtails · Inferior alveolar nerve blocks in horses · Chewing disease in grazing horses.
Tjiong Linda - - 2012
This quasi-experimental study compares manual compression and use of hemostatic patch in achieving hemostasis after femoral sheath removal. Patients who agreed to participate were randomly assigned to either control group or study. A majority of the patients (75.3%, n=67) had a diagnostic procedure, and 24.7%, (n=22) had an interventional procedure. ...
Moir Melinda L - - 2012
  Translocation, introduction, reintroduction, and assisted migrations are species conservation strategies that are attracting increasing attention, especially in the face of climate change. However, preventing the extinction of the suite of dependent species whose host species are threatened is seldom considered, and the effects on dependent species of moving threatened ...
Pettersen Svein A - - 2012
ABSTRACT: Pettersen, SA and Mathisen, GE. Effect of short burst activities on sprint and agility performance in 11- to 12-year-old boys. J Strength Cond Res 26(4): 1033-1038, 2012-There are limited data on how coordinative sprint drills and maximal short burst activities affects children's sprint and agility performance. The purpose of ...
Meisel Jane L - - 2012
Psychosocial distress is common after a diagnosis of breast cancer. Little is known about the psychosocial adjustment of women living long term with metastatic breast cancer. We conducted a cross-sectional survey of women living with metastatic breast cancer for 5 years or longer. The survey included demographic and medical history, ...
Ceylan Mehmet Fatih - - 2012
Aims:  Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder with an etiopathogeny not fully understood. According to the prevailing view, the main factors contributing to the disorder are prefrontal dopamine deficiency and central dopaminergic dysfunction, but the factors/mechanisms involved in the brain dysfunction and its consequences are not well known. We ...
1 2 3 4 5 6 7 8 9 10 >