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Mangner Norman - - 2012
Introduction: Mice that lack both the transcription factor MyoD and dystrophin display a more pronounced myopathic phenotype when compared with mdx mice. No data on skeletal muscle function and the impact of exercise training are available. Methods: Six-month-old wild-type, mdx, myoD(-/-) , mdx:myoD(+/-) , and mdx:myoD(-/-) mice were randomly assigned ...
Adegbola Richard A - - 2012
Pneumonia kills more children than any other disease-more than HIV/AIDS, malaria, and measles combined. Introduction of vaccines against pneumococcus and Haemophilus influenzae type b (the most important causes of severe pneumonia in young children), increasing resistance to antibiotics, and changes in HIV prevalence will likely change patterns of pneumonia etiology ...
Thombare Nandkishore S - - 2012
Crop losses due to bacterial pathogens are a major global concern. Most of the available pesticides for these pathogens suffer from various drawbacks such as complicated synthesis, high cost, high toxicity, pesticide resistance and environmental hazards. To overcome these drawbacks, the present study was undertaken to find a potent bactericide. ...
Holdoway A - - 2012
How to cite this article: Holdoway A. & Sanders D.S. (2012) The Inaugural Digestive Disorders Federation Meeting: a collaborative and multidisciplinary approach to medical and nutrition education? J Hum Nutr Diet. 25, 101-102.
Gnanaraj J - - 2012
The method that we use has an initial cost (£150) and uses fewer materials for dressing daily than other methods. It is easy to use at the extremities and is effective in preventing amputation in some diabetics.
Bernstein Harold S - - 2012
Congenital heart disease occurs in 1% of liveborn infants, making it the most common birth defect worldwide. Many of these children develop heart failure. In addition, both genetic and acquired forms of dilated cardiomyopathy are a significant source of heart failure in the pediatric population. Heart failure occurs when the ...
Dubey Nazneen - - 2012
Purpose: Neuroendocrine tumors often present a diagnostic and therapeutic challenge. We have aimed to synthesize and develop biodegradable nanoparticles of somatostatin analogue, octreotide for targeted therapy of human neuroendocrine pancreatic tumor. Methods: Direct solid phase peptide synthesis of octreotide was done. Octreotide loaded PCL/PEG nanoparticles were prepared by solvent evaporation ...
Wu Yang - - 2012
In this study, the dissipation of two antibiotics, sulfamethoxazole (SMX) and trimethoprim (TRM), in three soils under both aerobic and anaerobic conditions are evaluated. Under aerobic conditions, SMX dissipated rapidly through biodegradation but TRM was more persistent. Within the first 20 days in biologically active soils, >50% of the SMX ...
Alfieri Alex - - 2012
We present an outstanding example of successful prehistoric double trephination dating between 2700 and 2200 BC, most likely to the Corded Ware culture, at the end of the Neolithic Age. The particularity of this case is the presence of a double trephination, one frontal over the sinus sagittal superior and ...
Martinez M N - - 2012
Martinez, M. N., Fahmy, R. The scientific basis for establishing solubility criteria for veterinary species. J. vet. Pharmacol. Therap. 35 (Suppl. 1), 81-86. The relationship between factors influencing the in vitro and in vivo drug solubilization is highly dependent upon the physiology of the individual animal species and the physico-chemical ...
Glower Donald - - 2012
The Endovascular Valve Edge-to-Edge Repair Study (EVEREST II) is a prospective, multicenter, randomized controlled trial comparing percutaneous repair with the MitraClip device to mitral valve (MV) surgery in the treatment of mitral regurgitation. The present study analyzed the patient characteristics and treatment effects on mitral repair versus replacement. Of 279 ...
Daikeler Thomas - - 2012
Autologous hematopoietic stem cell transplantation (HSCT) has been used to treat severe and refractory autoimmune diseases (ADs) in children and adults for more than 15 years. The aim of this treatment is to restore tolerance through an intense lymphodepleting conditioning, and many patients have achieved lasting remissions. However, HSCT is ...
Nauck M A - - 2012
Liraglutide is a once-daily human glucagon-like peptide-1 analogue used in the treatment of type 2 diabetes (T2D). It has been prospectively investigated in a series of multinational, randomised, controlled phase 3 trials (the Liraglutide Effect and Action in Diabetes programme), as well as in an additional direct head-to-head study with ...
Garber A J - - 2012
The glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide is indicated as an add-on to oral antidiabetic drug regimens in subjects with type 2 diabetes. Herein, the results of clinical trials assessing the efficacy, safety and tolerability of liraglutide when used in combination with either one or two oral antidiabetic therapies are ...
Blonde L - - 2012
The two classes of incretin-related therapies, dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1 RAs), have become important treatment options for patients with type 2 diabetes. Sitagliptin, saxagliptin, vildagliptin and linagliptin, the available DPP-4 inhibitors, are oral medications, whereas the GLP-1 RAs-twice-daily exenatide, once-weekly exenatide and once-daily liraglutide-are ...
Gough S C L - - 2012
Liraglutide, a once-daily glucagon-like peptide-1 receptor agonist, is approved for use as monotherapy in the USA and Japan (but not in Europe or Canada) and in combination with selected oral agents (all regions) for the treatment of patients with type 2 diabetes. Guidance from local advisory bodies is emerging on ...
Vilsbøll T - - 2012
The glucagon-like peptide-1 receptor agonists (GLP-1 RAs) liraglutide and exenatide can improve glycaemic control by stimulating insulin release through pancreatic β-cells in a glucose-dependent manner. GLP-1 receptors are not restricted to the pancreas; therefore, GLP-1 RAs cause additional non-glycaemic effects. Preclinical and clinical trial data suggest a multitude of additional ...
Bohlin Kajsa - - 2012
There is mounting evidence that early continuous positive airway pressure (CPAP) from birth is feasible and safe even in very preterm infants. However, many infants will develop respiratory distress syndrome (RDS) and require surfactant treatment. Combining a non-invasive ventilation approach with a strategy for surfactant administration is important, but questions ...
Avecilla Scott T - - 2012
New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced into the market for venous thromboembolic prophylaxis and for stroke prevention in atrial fibrillation. While dabigatran has been approved for use without the need for routine therapeutic monitoring, there are clinical scenarios in which ...
Auchincloss Amy H - - 2012
Understanding the impact of place on health is a key element of epidemiologic investigation, and numerous tools are being employed for analysis of spatial health-related data. This review documents the huge growth in spatial epidemiology, summarizes the tools that have been employed, and provides in-depth discussion of several methods. Relevant ...
DeLuca Andrea N - - 2012
The Pneumonia Etiology Research for Child Health (PERCH) project has the potential to provide a highly valuable resource of biospecimens that may be used to inform future studies on the causes of pneumonia. Designing a biorepository for this complex project was done in collaboration with a wide range of experts ...
Reynolds Charles F CF - - 2012
Randomized trials for selective and indicated prevention of depression in both mixed-aged and older adult samples, conducted in high-income countries (HICs), show that rates of incident depression can be reduced by 20-25% over 1-2 years through the use of psychoeducational and psychological interventions designed to increase protective factors. Recurrence of ...
Li Jianghong J Institute for Community Research, Hartford, Connecticut 06106, USA. - - 2012
Project RAP (Risk Avoidance Partnership) trained 112 active drug users to become peer health advocates (PHAs). Six months after baseline survey (N(bl) = 522), 91.6% of PHAs and 56.6% of community drug users adopted the RAP innovation of giving peer intervention, and 59.5% of all participants (N(6m) = 367) were ...
Stewart Katharine E KE Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. - - 2012
This manuscript describes lessons learned in the development and implementation of a clinical behavioral trial to reduce sexual risk among African-American cocaine users in rural Arkansas, from the perspectives of a multidisciplinary investigative team and community staff members with a history as local drug users who served as "translators." Recommendations ...
Cox David J DJ Centre for the Developing Brain, Imperial College London and MRC Clinical Sciences Centre, London, - - 2012
There is significant uncertainty regarding the optimal circulatory management of preterm infants, with research in the field limited by the paucity of safe, reproducible biomarkers of circulatory function. This review discusses the physiology and pathophysiology of circulatory function in preterm infants, describes the mode of action and evidence for and ...
Stegger M M Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, - - 2012
The recent finding of a new mecA homologue, mecA(LGA251) , with only 70% nucleotide homology to the conventional mecA gene has brought the routine testing for mecA as a confirmatory test for methicillin-resistant Staphylococcus aureus (MRSA) into question. A multiplex PCR was designed to differentiate mecA(LGA251) from the known mecA ...
Gilani Zunera Z Department of Epidemiology, Bloomberg School of Public Health, Baltimore, MD 21205, USA. - - 2012
The Pneumonia Etiology Research for Child Health (PERCH) project is the largest multicountry etiology study of childhood pneumonia since the Board on Science and Technology in International Development studies of the 1980s. However, it is not the only recent or ongoing pneumonia etiology study, and even with seven sites, it ...
Levine Orin S OS Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. - - 2012
The Pneumonia Etiology Research for Child Health (PERCH) project is a 7-country, standardized, comprehensive evaluation of the etiologic agents causing severe pneumonia in children from developing countries. During previous etiology studies, between one-quarter and one-third of patients failed to yield an obvious etiology; PERCH will employ and evaluate previously unavailable ...
Turner Gareth D H GD Mahidol-Oxford Research Unit, and Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. - - 2012
The diagnosis of etiology in severe pneumonia remains a challenging area. Postmortem lung tissue potentially increases the sensitivity of investigations for identification of causative pathogens in fatal cases of pneumonia and can confirm antemortem microbiological diagnoses. Tissue sampling allows assessment of histological patterns of disease and ancillary immunohistochemical or molecular ...
Grant Lindsay R LR Department of International Health, Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. - - 2012
In most settings, sputum is not routinely collected for microbiological diagnosis from children with lower respiratory disease. To evaluate whether it is feasible and diagnostically useful to collect sputum in the Pneumonia Etiology Research for Child Health (PERCH) study, we reviewed the literature on induced sputum procedures. Protocols for induced ...
Hammitt Laura L LL Department of International Health, International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA. - - 2012
Pneumonia is the leading cause of childhood death in the developing world. Higher-quality etiological data are required to reduce this mortality burden. We conducted a case-control study of pneumonia etiology among children aged 1-59 months in rural Kenya. Case patients were hospitalized with World Health Organization-defined severe pneumonia (SP) or ...
Hicheri Y Y Service d'Hématologie Clinique, Assistance Publique-Hopitaux de Paris, Hôpital Henri Mondor, University Paris Est-Créteil, 51 Av. Maréchal de Lattre de Tassigny, Créteil, - - 2012
Invasive fungal infections (IFIs) are a major cause of morbidity and mortality in haematopoietic stem cell transplant (HCT) recipients and patients with haematological malignancies. Early treatment initiation is vital for improving survival, but is hampered by difficulties in timely diagnosis. Prophylaxis with a broad-spectrum antifungal, such as voriconazole, has the ...
Orosi Piroska P Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Népegészségügyi Kar Debrecen Nagyerdei krt. 98. 4032. - - 2012
Influenza vaccination is the most effective way of influenza prevention. The vaccination rate is low worldwide. In Hungary, the vaccine is free of charge to health care workers and, therefore, the low vaccination rate is unaccountable. In this study, the authors wanted to explore those factors which influence the refusal ...
Szabó György G Háziorvosi Szolgálat Enese Szabadság u. 18. 9143. - - 2012
The determination of carbohydrate deficient transferrin (CDT) concentration is primarily used in social security studies as a proof of regular alcohol consumption exceeding the amount of 60 grams per day. The present study was performed to investigate into how carbohydrate deficient transferrin CDT values in serum are affected by the ...
Radu Oana M OM Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, - - 2012
We assessed 103 resected gastroesophageal adenocarcinomas for HER2 amplification by fluorescence in situ hybridization (FISH) and 2 commercial immunohistochemical assays. Of 103, 30 (29%) were FISH-amplified. Both immunohistochemical assays had greater than 95% concordance with FISH. However, as a screening test for FISH amplification, the Ventana Medical Systems (Tucson, AZ) ...
Robinson-Papp Jessica J Department of Neurology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1052, New York, New York 10029, USA. - - 2012
Human immunodeficiency virus (HIV)-infected patients commonly develop distal symmetric polyneuropathy (DSP). Age, ethnicity, and toxic exposures may influence the risk. In this study we examined the association between substance use, antiretrovirals, ethnicity, and incident neuropathy in an HIV-infected cohort. Data were obtained from the National NeuroAIDS Tissue Consortium (NNTC), an ...
Allet Lara L Department of Physiotherapy, University of Applied Sciences of Western Switzerland, Geneva, Switzerland. - - 2012
Changes occur in muscles and nerves with aging. In this study we explore the relationship between unipedal stance time (UST) and frontal plane hip and ankle sensorimotor function in subjects with diabetic neuropathy. UST, quantitative measures of frontal plane ankle proprioceptive thresholds, and ankle and hip motor function were tested ...
Rouviere Clement C Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, P.O. Box 3975, Atlanta, Georgia 30302-3975, - - 2012
The purpose of this study was to test the hypothesis that malignant hyperthermia model mice (RyR1Y522S/wt) are more vulnerable to exercise-induced muscle injury and fatigability and adapt less to run training. After 6 weeks of voluntary wheel running, we measured anterior crural muscle fatigability, muscle injury, and cytochrome oxidase (COX) ...
Malinowski Kathleen T KT Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, - - 2012
To investigate the effect of tumor site, measurement precision, tumor-surrogate correlation, training data selection, model design, and interpatient and interfraction variations on the accuracy of external marker-based models of tumor position. Cyberknife Synchrony system log files comprising synchronously acquired positions of external markers and the tumor from 167 treatment fractions ...
Narayanaswami Pushpa P Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, TCC-8, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. - - 2012
The current practice of single-fiber electromyography (SFEMG) requires that 20 fiber pairs with normal jitter be collected to exclude myasthenia gravis (MG). We applied principles of futility analysis from clinical trials in an attempt to reduce that requirement. We utilized conditional power futility analysis to assess the probability of an ...
Gaias Larissa M LM Bowdoin College, Brunswick, Maine, - - 2012
Cross-cultural differences in temperament were investigated between infants (n = 131, 84 Finns), children (n = 653, 427 Finns), and adults (n = 759, 538 Finns) from the United States of America and Finland. Participants from both cultures completed the Infant Behavior Questionnaire, Childhood Behavior Questionnaire and the Adult Temperament ...
Lee Won Hee WH School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, - - 2012
Blood-brain barrier (BBB) disruption is one of the major consequences of radiation-induced normal tissue injury in the central nervous system. We examined the effects of whole-brain irradiation on matrix metalloproteinases (MMPs)/tissue inhibitors of metalloproteinases (TIMPs) and extracellular matrix (ECM) degradation in the brain. Animals received either whole-brain irradiation (a single ...
Schiefer Isaac T - - 2012
Furoxans (1,2,5-oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents adjacent to the furoxan ring system led to modulation of reactivity toward bioactivation, studied by HPLC-MS/MS analysis of reaction products. Attenuated reactivity unmasked the cytoprotective actions of NO in contrast to the ...
Schlippe Yollete V Guillen - - 2012
There is a great demand for the discovery of new therapeutic molecules that combine the high specificity and affinity of biologic drugs with the bioavailability and lower cost of small molecules. Small, natural-product-like peptides hold great promise in bridging this gap; however, access to libraries of these compounds has been ...
St Helen Gideon G Center for Tobacco Control Research and Education, University of California, San Francisco, California, - - 2012
Our study objectives were (1) to investigate the selectivity of polycyclic aromatic hydrocarbon (PAH) metabolites for tobacco smoke exposure and (2) to determine half-lives of PAH metabolites in smokers. There were 622 participants from the United States (US) and Poland, and of these, 70% were smokers. All subjects provided spot ...
Buchman Jennifer S - - 2012
Class D β-lactamases pose an emerging threat to the efficacy of β-lactam therapy for bacterial infections. Class D enzymes differ mechanistically from other β-lactamases by the presence of an active-site N-carboxylated lysine that serves as a general base to activate the serine nucleophile for attack. We have used site-saturation mutagenesis ...
Bordiga Matteo M Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale A. Avogadro, Novara, Italy. - - 2012
Over forty-five complex free oligosaccharides (of which several are novel) have been isolated and chemically characterized by gas chromatography and high resolution and high mass accuracy matrix-assisted laser desorption/ionization mass spectrometry (MALDI-FTICR MS) in red and white wines, Grignolino and Chardonnay, respectively. Oligosaccharides with a degree of polymerization between 3 ...
Mamonova Tatyana T Laboratory for G Protein-Coupled Receptor Biology, Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, - - 2012
The Na(+)/H(+) exchange regulatory factor-1 (NHERF1) is a scaffolding protein that possesses two tandem PDZ domains and a carboxy-terminal ezrin-binding domain (EBD). The parathyroid hormone receptor (PTHR), type II sodium-dependent phosphate cotransporter (Npt2a), and β2-adrenergic receptor (β2-AR), through their respective carboxy-terminal PDZ-recognition motifs, individually interact with NHERF1 forming a complex ...
Andreeva Daria V - - 2012
A sonodesigned metal-based sponge can form as a surface layer on metal capsules with the possibility of multicomponent loading and time-resolved release. The capsules can be loaded with active agents, such as corrosion inhibitors, vitamins and drugs, enzymes, DNA fragments, or antibodies. The porous layer is continuous with the bulk ...
Liu Qi - - 2012
The image features a method for determining molecular configurations in motion, which combines time-resolved tunneling spectroscopy and density functional theory (DFT) calculations. It has been successfully applied to two typical molecular systems, tetra-tert-butyl zinc phthalocyanine and iron phthalocyanine, with molecular rotation and lateral diffusion on the Au(111) surface. The energy ...
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