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Results 401 - 450 of 2691
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Wang Jie - - 2012
PURPOSE: In drug discovery research the formation of soluble compound aggregates is a major cause of false positives, false negatives, and distorted values in High-Throughput Screening assays that measure either binding or functional activity. These aggregation-based artifacts lead to serious distortions in the SAR which are critical to successful lead ...
Hou Jingbo - - 2012
The neointimal tissue characteristics inside sirolimus-eluting stent (SES) were evaluated by optical coherence tomography (OCT) according to follow-up duration. One hundred and thirty-three Optical coherence tomography was performed in 96 patients with 143 SES which were retrospectively included and divided into 2 groups according to follow-up duration: Group 1, <24 months ...
Karppi Jouni - - 2012
Results from epidemiologic studies on the association between circulating carotenoid concentrations and the risk of prostate cancer are still inconsistent. We studied whether serum concentrations of carotenoids were associated with the risk of developing prostate cancer. The study population consisted of 997 middle-aged Finnish men (56.1 ± 6.6 yr) in ...
Leask Andrew - - 2012
Fibrosis is a major cause of end-stage renal disease (ESRD) a progressive loss in renal function that occurs over a period of months or years, is characterized by a decreased capability of the kidneys to excrete waste products. There is no specific treatment unequivocally shown to slow the worsening of ...
Hilger Alina - - 2012
The acronym VATER/VACTERL association is used to describe the non-random co-occurrence of vertebral defects (V), anorectal malformations (A), cardiac defects (C), tracheo-esophageal fistula with or without esophageal atresia (TE), renal malformations (R), and limb defects (L). We report a familial case of VATER/VACTERL association in which both the index case ...
Chudyk Anna M - - 2012
Osteoarthritis (OA) and hip fracture are two common musculoskeletal disorders associated with substantial societal and personal burden. The objective of this systematic review was to determine the association between hip or knee OA and risk of hip fractures in people aged 45 years and older as compared to people aged 45 years ...
Arora Amindra A - - 2012
Both basic science and clinical data indicate a strong role for allergy as a cause of eosinophilic esophagitis. As a result, one of the desired goals of therapy is identification and elimination of food antigens that trigger the allergic inflammatory pathway. Traditional methods for identification of causative food antigens include ...
Aschebrook-Kilfoy Briseis - - 2012
Nitrate and nitrite are precursors in the formation of N-nitroso compounds. We recently found a 40% increased risk of NHL with higher dietary nitrite intake and significant increases in risk for follicular and T-cell lymphoma. It is possible that these compounds also affect NHL prognosis by enhancing cancer progression in ...
Ma Yuanyuan - - 2012
Three xylose-fermenting recombinant Zymomonas mobilis strains containing different Peno-talB/tktA operon terminators were engineered. Each showed similar levels of foreign protein expression and xylose fermentation performance. Strain CP4-P2-1 was further used to compare the glucose/xylose co-fermentation under various cultivation environments to improve the efficiency of the process. Optimal co-fermentation was achieved ...
Ma Yanqin - - 2012
Epidemiological and experimental studies have demonstrated the atherogenic effects of environmental toxicant arsenic and fluoride. Inflammatory mechanism plays an important role in the pathogenesis of atherosclerosis. The aim of the present study is to determine the effect of chronic exposure to arsenic and fluoride alone or combined on inflammatory response ...
Nozu Ryo - - 2012
The three-spot wrasse (Halichoeres trimaculatus), which inhabits the coral reefs of Okinawa, changes sex from female to male. Sex change in this species is controlled by a social system. Oocytes disappear completely from the ovary, and male germ cells and somatic cells comprising testicular tissue arise a new during the ...
Dong Bin - - 2012
A novel high excited state energy transfer pathway to overcome the phonon quenching effect in rare-earth (RE) oxide upconversion (UC) materials is reported. In Er(Tm)-Yb oxide systems, an extraordinary enhancement of UC luminescence efficiency with four orders of magnitude is realized by Mo co-doping. The RE oxides with significant UC ...
Pickrell Joseph K - - 2012
Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported more than 10,000 mismatches between messenger RNA and DNA sequences from the same individuals, which they attributed to previously unrecognized mechanisms of gene regulation. We found that at least 88% of these sequence mismatches ...
Lee David R - - 2012
INTRODUCTION: Caring for people with dementia incurs significant stress for carers. Stress has been related to the duration of caring role, the number of weekly hours provided and severity of cognitive impairment. What remains less clear is the impact of neuropsychiatric symptoms and subtype of dementia on carer stress and ...
Lee Hye Rin - - 2012
Amyloid-β peptide (Aβ) deposits in the brain are critical in the neurotoxicity induced by Aβ. This study elucidates the underlying signaling pathway by which cilostazol protects HT22 neuronal cells from Aβ(1-40) (3-30 μM)-induced deterioration of cell proliferation, viability, and neurite elongation. Cilostazol rescued HT22 cells from the apoptotic cell death ...
Madan Nitin - - 2012
Madan N, Arnon R, Arnon R. Evaluation of cardiac manifestations in pediatric liver transplant candidates. Pediatr Transplantation 2012. © 2012 John Wiley & Sons A/S. Abstract:  Knowledge concerning the involvement of the cardiovascular system in children awaiting liver transplant is limited. Therefore, no guidelines have been established on evaluating this ...
Lorin-Nebel Catherine - - 2012
The effect of salinity was studied in natural populations of the black-chinned tilapia (Sarotherodon melanotheron) from West Africa. This euryhaline species colonizes nearly all coastal environments from bays to lagoons characterized by salinities ranging from fresh water to hypersaline water over 100 ‰. Individuals were sampled during the dry season at ...
Santovito Alfredo - - 2012
Endogenous nitric oxide (NO) is a molecule synthesized by endothelium nitric oxide synthase encoded by the ecNOS gene that plays an important role in regulating the systemic, cardiac and pulmonary circulation. Impairment in NO synthesis has been associated to many cardiovascular disorders, including coronary artery disease and hypertension. We investigated ...
Morin Jean-Benoît - - 2012
Sprint mechanics and field 100-m performances were tested in 13 subjects including 9 non-specialists, 3 French national-level sprinters and a world-class sprinter, to further study the mechanical factors associated with sprint performance. 6-s sprints performed on an instrumented treadmill allowed continuous recording of step kinematics, ground reaction forces (GRF), and ...
de la Torre Jack C - - 2012
Despite an archive of over 73,000 research papers published in the last two decades on the subject of Alzheimer's disease (AD), little clinical progress has been made relative to how people get sporadic AD and what can be done to help them avoid it. This review spotlights strategic steps that ...
Beaton Andrea - - 2012
Kaposiform hemangioendothelioma (KH) is a rare tumor of vascular origin that commonly affects the cutaneous tissues of the extremities. It can, however, affect the abdomen, thorax, head, or neck. Compared with juvenile hemangiomas, which tend to regress, KH tumors are locally aggressive and usually persist. Associated morbidity and mortality rates ...
Becker James T JT Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. - - 2012
Population-based studies face challenges in measuring brain structure relative to cognitive aging. We examined the feasibility of acquiring state-of-the-art brain MRI images at a community hospital, and attempted to cross-validate two independent approaches to image analysis. Participants were 49 older adults (29 cognitively normal and 20 with mild cognitive impairment ...
Gomes-Filho Isaac S - - 2012
Gerodontology 2012; doi: 10.1111/j.1741-2358.2012.00643.x Effect of osteoporosis on periodontal therapy among post-menopausal women Objective:  This intervention study aimed to investigate the effect of osteoporosis on periodontal condition among 48 post-menopausal women undergoing periodontal therapy. Material and methods:  The experimental group, which underwent non-surgical periodontal therapy, was composed of 16 women ...
Iwai Kazuro - - 2012
To clarify the long-term effect of immunotherapy, the effect of adoptive activated T lymphocyte immunotherapy on advanced lung cancer was evaluated in terms of survival time. In addition, the performance status of cancer patients under immunotherapy was examined. Over 5 × 10(9) alpha-beta T lymphocytes cultured ex vivo with an immobilized anti-CD3 ...
Hwang Shin - - 2012
Secure reconstruction of the right hepatic vein (RHV) is essential for successful implantation of a right-liver graft in living-donor liver transplantation (LDLT). To develop a reliable surgical technique for RHV reconstruction, we performed three concurrent studies as follows: a simulation study using a fluid-dynamics model experiment and a computational simulation ...
Hu Mingming - - 2012
Rosamine derivative , bearing macrocyclic ligand [15]aneNO(2)S(2) as receptor, was synthesized as an enhanced fluorescent chemosensor for Ag(+) in absolute aqueous solution. The fluorescence images in living cells show the potential application of . The difference of fluorescence enhancement process after binding with Ag(+)/Hg(2+) in acetonitrile/water solution was first proved ...
Gupta Preeya K - - 2012
BACKGROUND AND OBJECTIVE:To evaluate wound morphology and integrity using contrast-enhanced spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS:Eighteen patients (18 eyes) undergoing unilateral routine cataract surgery were enrolled. SD-OCT imaging of the corneal wound was performed immediately following cataract surgery and on postoperative day 1. A topical contrast agent, prednisolone ...
Jones Andrew Maxwell Phineas - - 2012
Dried male inflorescences of breadfruit (Artocarpus, Moraceae), are burned throughout Oceania to repel flying insects such as mosquitoes. We conducted this study to identify chemicals responsible for mosquito deterrence. Various crude extracts were evaluated and the most active, the volatile oil (VO), was used for bioassay guided fractionation. The VO ...
Wick Marius C - - 2012
A method to estimate the individual ankylosing spondylitis (AS) patient radiological progression of semi-quantitative magnetic resonance imaging (MRI) changes in the sacroiliac joints has not been described yet, which this study examines. Inflammatory disease activity and MRIs of the sacroiliac joints of 38 patients with recent onset established AS were ...
Lysdal Susan Hovmand - - 2012
Background. Occupational hand eczema is common in hairdressers, owing to excessive exposure to wet work and hairdressing chemicals. Objectives. To quantify occupational skin exposure and the use of protective gloves among hairdressers in Denmark. Methods. A register-based study was conducted comprising all graduates from hairdressing vocational schools from 1985 to ...
Mackey Aimee - - 2012
BACKGROUND: Breast-conserving surgery is often preferred to treat early-stage breast cancer. This method aims to minimize repeat excision and local recurrence rates. The ABLATE Registry expands this to multiple centers with a total accrual goal of 250. This video illustrates an intraoperative radiofrequency ablation (RFA) technique. METHODS: Sixteen women with ...
Shohat-Ophir G G Department of Anatomy, University of California, San Francisco, CA 94143-2822, USA. - - 2012
The brain's reward systems reinforce behaviors required for species survival, including sex, food consumption, and social interaction. Drugs of abuse co-opt these neural pathways, which can lead to addiction. Here, we used Drosophila melanogaster to investigate the relationship between natural and drug rewards. In males, mating increased, whereas sexual deprivation ...
Li Ling - - 2012
Electro-acupuncture (EA) at Fenglong acupoint (ST40) can lower the levels of serum cholesterol and triacylglycerols. To study the hepatic genes responsible for the cholesterol-lowering effect of EA, suppression subtractive hybridization combined with the switch mechanism at the 5'-end of RNA template cDNA synthesis and long-distance PCR were employed using hepatic ...
Yamasaki Fumie - - 2012
Two new isocoumarin glucosides, haworforbins A (1) and B (2), and a new chromone, haworforbin C (3), have been isolated from Haworthia cymbiformis. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Haworforbin C (3) exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated ...
Mattioli Laura L Pharmacognosy Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, Camerino, MC, Italy. - - 2012
Opioid addiction is a chronic, recurrent brain disease that is characterised by compulsive drug seeking and a high rate of relapse even after long periods of abstinence. Prevention of relapse is the primary goal of addiction treatment and is still the major limitation in drug therapy. The present study investigated ...
Zhang Xiao-Bin - - 2012
PURPOSE: Serum cystatin C is a promising new biomarker of glomerular filtration rate and cardiovascular events, but few studies focused on serum cystatin C levels in obstructive sleep apnea (OSA) patients. The aim of our study was to evaluate the association between serum cystatin C and OSA in younger men ...
Lee Jung Il - - 2012
We describe a patient with hand radiation injury that was caused by (192) Ir radiation source exposure. The cutaneous symptoms that appear after local radiation exposure follow a certain time pattern consisting of the prodromal, manifestation, subacute, chronic, and late stages. Although the clinical characteristics of each stage are well ...
Mahmoudi Morteza - - 2012
Because of their multifunctionality and unique magnetic properties, superparamagnetic iron oxide nanoparticles (SPIONs) have been recognized as very promising materials for various biomedical applications. The main difficulty with the use of SPIONs as multimodal bioimaging agents is their lack of fluorescence. Since cells can act as extremely efficient filters for ...
Noblin X - - 2012
Various plants and fungi have evolved ingenious devices to disperse their spores. One such mechanism is the cavitation-triggered catapult of fern sporangia. The spherical sporangia enclosing the spores are equipped with a row of 12 to 13 specialized cells, the annulus. When dehydrating, these cells induce a dramatic change of ...
Greene N P - - 2012
Our purpose was to elucidate effects of acute exercise and training on blood lipids-lipoproteins, and hsCRP in overweight/obese men (n=10) and women (n=8); age, BMI, body fat percentage, and VO(2)max were (mean±SEM): 45±2.5 yr, 31.9±1.4 kg·m(-2), 41.1±1.5%, and 25.2±1.3 mLO(2)·kg(-1) min(-1). Before exercise training subjects performed an acute exercise session ...
Rawlings David J DJ Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, USA. - - 2012
Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR) and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B cell responses, directly linking cell-intrinsic innate and adaptive immune programmes. Although most data regarding B cell-specific functions of the TLR signalling pathway have ...
Würbach Lydia - - 2012
PURPOSE: The chick embryo is a well-known economical in vivo model system and is widely applied in preclinical research, e.g., bone development studies. It is therefore surprising that no studies concerning the application of (18)F-fluoride microPET to bone metabolism have been reported so far. This may be due to motion ...
Hsiao Sheng-Mou - - 2012
INTRODUCTION AND HYPOTHESIS: Some lower urinary tract dysfunction (LUTD) subtypes may be associated with low-grade inflammation. This study aimed to investigate the role of serum C-reactive protein (CRP) levels in women with lower urinary tract symptoms (LUTS). METHODS: A total of 197 consecutive women with non-stress urinary incontinence (non-SUI) LUTS ...
Kitzmüller Gabriele - - 2012
The aim of this study is to illuminate the significance of the long-term influence of bodily changes on the perception of self after stroke by means of narrative interviews with 23 stroke survivors. A phenomenological-hermeneutic approach inspired by the philosophy of Merleau-Ponty and Ricoeur is the methodological framework. Zahavi's understanding ...
Van Langenhove Tim - - 2012
There is increasing evidence that frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) represent a continuum of neurodegenerative diseases. FTLD is complicated by ALS in a significant proportion of patients, and neuropsychological studies have demonstrated frontotemporal dysfunction in up to 50% of ALS patients. More recently, advances in neuropathology ...
Nordenfelt Lennart - - 2012
This article is a reply to Venkatapuram's critique in his article Health, Vital Goals, Capabilities, this volume. I take issue mainly with three critical points put forward by Venkatapuram with regard to my theory of health. (1) I deny that the contents of my vital goals are relative to each ...
Gao Zaifeng Z Department of Psychology, Zhejiang University, Hangzhou, People's Republic of - - 2013
EEG studies suggested that the N170 ERP and Gamma-band responses to faces reflect early and later stages of a multiple-level face-perception mechanism, respectively. However, these conclusions should be considered cautiously because EEG-recorded Gamma may be contaminated by noncephalic activity such as microsaccades. Moreover, EEG studies of Gamma cannot easily reveal ...
Petitpierre Blaise - - 2012
The assumption that climatic niche requirements of invasive species are conserved between their native and invaded ranges is key to predicting the risk of invasion. However, this assumption has been challenged recently by evidence of niche shifts in some species. Here, we report the first large-scale test of niche conservatism ...
Vaidya Alankar - - 2012
Pre-treatment is important step prior to enzymatic hydrolysis of ligno-cellulosic biomass in order to obtain renewable carbon source ca. glucose. Pinus radiata biomass including wood blocks, wood chips and steam exploded wood (SEW) were used to investigate the effect of fungal pre-treatment on glucose yield. Comparison was made using one ...
Barbanti Brodano G - - 2012
Spine fusion is the gold standard treatment in degenerative and traumatic spine diseases. The bone regenerative medicine needs (i) in vitro functionally active osteoblasts, and/or (ii) the in vivo induction of the tissue. The bone tissue engineering seems to be a very promising approach for the effectiveness of orthopedic surgical ...
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