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Smith Kristen - - 2012
The past two decades have seen the extensive privatisation and marketisation of health care in an ever reaching number of developing countries. Within this milieu, medical tourism is being promoted as a rational economic development strategy for some developing nations, and a makeshift solution to the escalating waiting lists and ...
Lee L Y - - 2012
Introduction:  Hepatitis C virus (HCV) affects approximately 3% of the world population. The current standard of care for treatment of HCV is a combination of pegylated interferon and ribavirin. Approximately 10% of patients will stop treatment and 30% of patients require dose reduction because of side effects. For genotype 1 ...
Przewoznik Margarethe - - 2012
During inflammation and in transplantable tumor models, natural killer (NK) cells are recruited to pathologic tissues and activated to produce proinflammatory cytokines favoring adaptive immune responses of the T-helper type 1 (Th1) type. Interferon (IFN)-γ is needed to induce chemokines that attract NK cells in transplanted tumors. Nothing, however, is ...
Labbé Annie-Claude - - 2012
BACKGROUND:: In resource-poor settings, control of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) among female sex workers (FSWs) is difficult. We sought to determine whether periodical antibiotic treatment (PAT) might be effective in controlling these infections among West African FSWs. Secondary objectives were to determine the impact of PAT on ...
Cannata Aldo - - 2012
The choice of cardioplegic solution for myocardial preservation in heart transplantation (HT) remains debated. We analysed our experience with three different cardioplegic solutions in adult HT performed during past 5 years, in terms of non-immunological intraoperative biventricular graft failure (BVF) and in-hospital mortality. A total of 133 patients underwent HT ...
de Carvalho Carla C C R - - 2012
Microbial cells, under moist conditions, are able to adhere to surfaces and to form structured communities embedded in a matrix of extracellular polymeric substances (EPS). In industrial environments, biofilms can cause heat and mass transfer limitations whilst in medical facilities they can be a source of contamination and proliferation of ...
Tesiram Yasvir A - - 2012
The aims of this study were (1) to determine nuclear magnetic resonance spectroscopic characteristics and metabolite profiles of serum samples from patients with pancreatic cancer compared with noncancerous control samples and (2) to ascertain if the accuracy of metabolite identification by 1D spectra can be improved upon by confirmation of ...
Chung Christina K - - 2012
: Previous studies in other medical specialties have shown a significant percentage of publications represented in residency applications are not actually published. A comprehensive evaluation of applicants to plastic surgery residency over an extended period has not been previously reported in the literature. The purpose of our study was to ...
Herranz M - - 2012
Aim: To analyse association between preoperative hyperprolactinemia serum levels and clinical and biological features of breast tumors. Methods: Serum levels of prolactin were measured in 253 women with invasive breast cancer. Clinical and biological parameters analysed were age, size, lymph node involvement, distant metastasis and immunohistochemical expression of estrogen receptor, ...
Heusch Gerd - - 2012
Activation of coronary vascular α-adrenoceptors results in vasoconstriction which competes with metabolic vasodilation during sympathetic activation. Epicardial conduit vessel constriction is largely mediated by α(1)-adrenoceptors; the constriction of the resistive microcirculation largely by α(2)-adrenoceptors, but also by α(1)-adrenoceptors. There is no firm evidence that α-adrenergic coronary vasoconstriction exerts a beneficial ...
Cohen I Glenn - - 2012
A growing literature examines descriptive and normative questions about medical tourism such as: How does it operate? What are its effects? Are home country patients or their governments failing in moral duties by engaging in or permitting medical tourism? By contrast, much less has been written on the regulatory dimension: ...
Schatorjé E J H - - 2012
Immunophenotyping of blood lymphocyte subpopulations is an important tool in the diagnosis of immunological and haematological diseases. Paediatric age-matched reference values have been determined for the major lymphocyte populations, but reliable reference values for the more recently described T lymphocyte subpopulations, like different types of memory T lymphocytes, recent thymic ...
Orrù Christina D - - 2012
The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils from recombinant PrP (Sen) has served as the basis for several relatively rapid and highly sensitive tests for prion diseases. These tests include rPrP-PMCA (rPMCA), standard quaking-induced conversion (S-QuIC), amyloid seeding assay (ASA), real-time QuIC ...
Guy Rebecca - - 2012
: Since 2000, infectious syphilis notifications have increased substantially among Australian gay men. We describe testing at a frequency lower than guidelines recommend. : We examined data from a cross-sectional survey of gay men in 5 Australian cities in 2010. We used logistic regression to identify correlates of no lifetime ...
Page William F - - 2012
: While population-based seroprevalence studies of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are widespread, seroincidence studies are largely limited to select or high-risk populations. The US military offers a potential population to derive national seroincidence rate estimates for young adults (ages 18-29). : We used banked, ...
Bisson Nicolas - - 2012
Pak1 is a member of the PAK family of serine/threonine kinases that are downstream effectors of Rac1 and Cdc42 small GTPases and are implicated in cytoskeleton reorganization. Early expression of Pak1 in Xenopus embryos is tissue restricted, suggesting a role in organogenesis and in cranial neural crest (CNC) cell migration. ...
Pereira Clifford - - 2012
: Gunshot wounds (GSWs) to the face are an infrequent occurrence outside of a war zone. However, when they occur, they constitute a significant reconstructive challenge. We present our 10-year experience at an urban level I trauma center to define the patterns of injury, assess the morbidity and mortality, and ...
Bortoluzzi Marcelo Carlos - - 2012
Objective:  To investigate whether smoking has adverse effects in simple exodontia. Methods:  A single-centre, prospective study of postoperative inflammatory complications in simple exodontia was performed. All procedures were conducted under similar and sterile conditions. Postoperative complications (PCs) in exodontia were classified as alveolar osteitis (AO) or alveolar infection (AI) and ...
Blackstock Oni J - - 2012
: Female Veterans comprise 12% of Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans, the largest proportion of women to serve of any prior cohort. We sought to determine the sex-specific risk of using a Veterans Health Administration (VHA) homeless program among OEF/OIF Veterans and to identify factors associated with increased ...
Mori Yasuhisa - - 2012
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are known as incretins to stimulate insulin secretion. The aims of this study were to investigate the postoperative β-cell function and hormonal responses of GLP-1 and GIP after pancreatoduodenectomy (PD) and distal pancreatectomy (DP). Oral glucose tolerance tests were performed in 34 ...
Satterwhite Thomas S - - 2012
: Reconstruction of abdominal wall defects is a challenging problem. Often, the surgeon is presented with a patient having multiple comorbidities, who has already endured numerous unsuccessful operations, leaving skin and fascia that are attenuated and unreliable. Our study investigated preoperative, intraoperative, and postoperative factors and techniques during abdominal wall ...
Bansal Parikshit - - 2012
Laboratory dialysis, one of the most widely used techniques in biological research is truly a ' gateway technology' . The analogy is to that of a ' gate' of a building through which everybody has to pass, even though they may wish to go to different departments. Similarly, researchers may ...
Laurence Vincent G - - 2012
Pixie ear is a condition in which the posterior edge of the helix extends straight down to the cheek-jaw intersection, without sweeping back up anteriorly to form a lobe. It occurs congenitally, but more commonly is a postoperative condition, following facelift surgery. Over the years, a handful of methods have ...
Chaoyi Ma - - 2012
Background:  Chinese dental technicians play a significant role in the globalised market of dental prosthesis fabrication, but this subject has not been investigated in detail. The demand for dental prostheses increases as individuals pay increasing attention to their oral health. Therefore, it is important to investigate the status of Chinese ...
Huo Lin - - 2012
Several replication-initiation proteins are assembled stepwise onto replicators to form pre-replicative complexes (pre-RCs) to license eukaryotic DNA replication. We performed a yeast functional proteomic screen and identified the Rix1 complex members (Ipi1p-Ipi2p/Rix1-Ipi3p) as pre-RC components and critical determinants of replication licensing and replication-initiation frequency. Ipi3p interacts with pre-RC proteins, binds ...
McArdle Adrian - - 2012
: The debate on how to create ideal facial proportions-once the remit of artists and sculptors-has been reignited during the past 5 decades, with the emergence of aesthetic facial surgery. Classic ideals exist, but few individuals actually satisfy these criteria. Aesthetic ideals are culturally and temporally variable. For centuries, the ...
Maharani Diah A - - 2012
Objective:  One of the goals of Indonesian health policy is 'Health for All'; this includes dental health care. Therefore, it is important to continually evaluate and dynamically assess the effects of government policies, particularly whether these policies promote or obstruct social justice. This study is intended to describe the need ...
Peled Anne Warren - - 2012
: Immediate expander-implant breast reconstruction has been associated with postoperative complications, including infection and wound-healing problems. In extreme cases, these issues can lead to expander-implant loss. Little is known about the long-term reconstructive outcomes for patients who develop major complications threatening their expander-implant reconstructions. : A review of all patients ...
Kruger Estie - - 2012
Objectives:  New Zealand is a country with a relatively small population (4 million people) distributed unevenly over a relatively large land area. Adult oral health services in New Zealand are almost all delivered through a market-driven, private practice model and are funded directly by patient payments. Little attention has been given ...
Alt Stefan - - 2012
Field distributions of the simulation with the virtual family phantom. The SAR distribution through the center of the body is shown in (a). Exposure is almost completely concentrated in the imaging gap. The excitation field B +1 is shown within two coronal slices through the body (b,c). The central signal void ...
Oliveira-Cunha Melissa - - 2012
Pancreatic and periampullary cancers have a high incidence of activating KRAS mutations. The aim of this study was to determine the incidence of KRAS and EGFR mutations in pancreatic and periampullary cancers and their relationship with survival. One hundred patients undergoing pancreaticoduodenectomy or pancreatic biopsy for cancer were recruited. Samples ...
Sisó Silvia - - 2012
Prion diseases exhibit different disease phenotypes in their natural hosts and when transmitted to rodents, and this variability is regarded as indicative of prion strain diversity. Phenotypic characterization of scrapie strains in sheep can be attempted by histological, immunohistochemical and biochemical approaches, but it is widely considered that strain confirmation ...
Howell Neil J - - 2012
To determine the predictors of post-operative renal function following adult cardiac surgery, and to assess the influence of this on late survival. Prospectively collected data were analysed on 8032 patients who underwent coronary artery bypass grafting, valve surgery or combined procedures from 1 January 1998 until 31 December 2008, who ...
Romero Manuel - - 2012
Numerous bacterial functions, such as virulence and biofilm formation, are controlled by a cell densitydependent communication mechanism known as Quorum Sensing (QS), in which small diffusible molecules are released, allowing bacteria to coordinate their behavior once a minimal effective quorum has been reached. The interference with these signaling systems, also ...
Alfonso Fernando - - 2012
Disclosure of potential conflicts of interest (COI) is used by biomedical journals to guarantee credibility and transparency of the scientific process. COI disclosure, however, is not systematically nor consistently dealt with by journals. Recent joint editorial efforts paved the way towards the implementation of uniform vehicles for COI disclosure. This ...
Cha Yong Hoon - - 2012
Though tumor suppressor p53 and the canonical Wnt cascade have been extensively studied for the last 30 years, due to their important physiological roles, the two signaling pathways have been largely considered independent. Recently, the miR-34 family was found to directly link p53 and Wnt, revealing the tight connection between ...
Sadeghi Masoumeh - - 2012
Introduction:  The number of scientific papers is a conventional metric for the measurement of a country's research performance in a particular area. Objective:  To evaluate the trend in Iranian publications of dental research results in peer-reviewed international scientific journals over the period 1999-2009, using national and international databases, and to ...
Lo Yi-Chun - - 2012
: New human immunodeficiency virus (HIV) diagnoses in the St. Louis metropolitan area, MO, occur predominantly among men who have sex with men (MSM). The Centers for Disease Control and Prevention recommends HIV testing at least annually for sexually active MSM. We examined prevalence and factors associated with recent HIV ...
Endress Ryan - - 2012
: Staged breast reconstruction with implants and human acellular cadaveric dermis offers advantages of precise expander positioning, higher initial expander fill volumes, and improved outcomes. This study reports breast reconstruction using fetal bovine acellular dermal matrix (FBADM). The high type III collagen content of FBADM may allow for more rapid ...
Rafsanjani Mehrnaz S Ohadi - - 2012
During the past epoch we have gone through the remarkable progress in plant gene transformation technology. The production of transgenic plants is considered as a valuable tool in plant research and the technology is extensively applied in phytomedicines and agricultural research. Gene transformation in plants is normally carried out by ...
Harding Shane M - - 2012
During the DNA damage response (DDR), chromatin modifications contribute to localization of 53BP1 to sites of DNA double-strand breaks (DSBs). 53BP1 is phosphorylated during the DDR, but it is unclear whether phosphorylation is directly coupled to chromatin binding. In this study, we used human diploid fibroblasts and HCT116 tumor cells ...
Mandava Anitha - - 2012
Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA), or Herlyn-Werner-Wunderlich syndrome, is a rare Mullerian duct anomaly with uterus didelphys, unilateral obstructed hemivagina, and ipsilateral renal agenesis. Patients with this anomaly usually present after menarche with pelvic pain and/or a mass and rarely, in later years, with primary infertility. Strong suspicion ...
Tuite Ashleigh R - - 2012
: Rates of Chlamydia trachomatis (CT) infection in Canada have been increasing since the mid-1990s. We sought to estimate the burden of CT in this population. : We developed an age- and sex-structured mathematical model parameterized to reproduce trends in CT prevalence between 1991 and 2009 in the Canadian population ...
Haga Kristin - - 2012
To assess the clinical utility of the Gold Standards Framework Prognostic Indicator Guide (GSF) and the Seattle Heart Failure Model (SHF) to identify patients with chronic heart failure (CHF) in the last year of life. An observational cohort study of 138 community based ambulatory patients with New York Heart Association ...
Agrawal Pallavi - - 2012
Objectives:  For decades there has been increasing focus on the development of clinically acceptable, more sensitive and specific methods for the accurate and non-invasive diagnosis and prognosis of periodontitis. There are several well-known inherent drawbacks to current clinical procedures. The purpose of this article is to summarise some of the ...
Roosta Neda - - 2012
This commentary raises an important issue that has not been sincerely considered in the field of dermatology, which is the vital role of hairdressers-a group that makes daily observations of the general populations' scalp and neck-in the detection of head and neck melanomas in the general population. We note several ...
White Douglas A E - - 2012
: Implementing national recommendations for syphilis screening is not feasible in the emergency department (ED) setting. The purpose of this study was to determine the syphilis screening rate among ED patients tested for gonorrhea and chlamydia (GC/CT) and the syphilis prevalence among those who were tested. : A 1-year retrospective ...
Lee Gordon K - - 2012
Reconstruction of the cervical esophagus can be fraught with a variety of complications, such as fistula formation or stricture. Additional complicating factors may include local tumor recurrence, failed prior reconstruction, partial or total flap necrosis, and compromised tissues in an irradiated field. Once complications occur, the chance of a successful ...
Mohammadi Zahed - - 2012
Objectives:  To compare the antibacterial effect of AH-26, white-coloured mineral trioxide aggregate (WMTA) and CPM sealer against Staphylococcus aureus and Streptococcus mutans after 24 h and 1 week. Materials and methods:  All materials were prepared according to the manufacturers' directions immediately before testing. The antibacterial effect of each agent was determined by ...
Harding Alexander S - - 2012
: No single laboratory test is both sensitive and specific to diagnose neurosyphilis. Several major clinical guidelines suggest that negative cerebrospinal fluid (CSF) treponemal-specific antibody tests rule out the diagnosis of neurosyphilis. Our aim was to systematically review the literature and describe the performance of treponemal-specific CSF antibody tests when ...
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