Search Results
Results 351 - 400 of 3126
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Raish Mohammad - - 2012
OBJECTIVE: The aim of this study was to identify novel genes following genomic DNA copy number changes using a genome-wide array-based comparative genomic hybridization (array-CGH) analysis in uterine leiomyosarcoma (ULMS). METHODS: Genomic DNA copy number changes were analyzed in 15 cases of ULMS from St Mary's Hospital of the Catholic ...
Touré Abdoulaye - - 2012
Abstract To identify the risk factors associated with presentation for care with CD4 cell count ≤200 cells/mm(3) and death in HIV-infected patients in Lyon, France. Data were analyzed on participants from mid-1992 to December 2006 in the Lyon section of the French Hospital Database on HIV Infection. Patients were stratified ...
Kakita Naruyasu - - 2012
Regulatory T cells (Tregs) play pivotal roles in cancer-induced immunoediting. Increment of CD25(high+) FOXP3(+) natural Tregs has been reported in patients with hepatocellular caricinoma (HCC); however, the involvement of other type of Tregs remain elusive. We aimed to clarify whether FOXP3(-) Tregs are increased and functionally suppressive or not in ...
Faucheron J-L - - 2012
Stapled haemorrhoidopexy is a well recognized alternative to haemorrhoidectomy, and is associated with reduced pain and earlier return to normal activity. This paper reports all published cases of life-threatening sepsis following stapled haemorrhoidopexy, identifies causative factors and makes recommendations. A systematic review of the literature was performed by searching the ...
Tercek Michael T - - 2012
Recent efforts by the United States Department of the Interior (DOI) have the potential to make climate zones the basic geographic units guiding monitoring and resource management programs in the western U.S. We evaluated a new National Park Service approach for delineating climate zones that will likely be a model ...
Saarinen J T - - 2012
Background and purpose:  We studied the impact of the location of the thrombus (internal carotid artery, proximal M1 segment, distal M1 segment, M2 segment, and M3 segment of the middle cerebral artery) in predicting the clinical outcome of patients treated with intravenous thrombolytic therapy (<3 h) in a retrospective cohort. Methods:  ...
Wang Na - - 2012
Distant metastasis is one of the leading causes of lung cancer death. Detecting the early-stage molecular alternations in primary tumors, such as gene expression differences, provides a "prognostic" value to the precaution of tumor metastasis. The aim of this article is to screen and identify the metastasis-related genes in human ...
Chattopadhyay M K - - 2012
We have studied the temperature and magnetic field dependence of the electrical resistivity of GdCu(6) and have co-related the results with the temperature dependence of heat capacity and magnetization. The magnetoresistance of GdCu(6) is found to be positive both in the paramagnetic and antiferromagnetic regimes. Within the antiferromagnetic regime, the ...
Ryan Anjanette - - 2012
Abstract The present study investigated the association between therapist dispositional mindfulness and therapist self-affiliation, the therapeutic alliance, and treatment outcome. Total therapist mindfulness was associated with therapist self-affiliation, r=.413, p<.05. Therapist mindfulness was positively correlated with therapist ratings of the working alliance, r=.456, p<.05, though only the Act with Awareness ...
Zhang B - - 2012
In this study, we explore the population genetics of the Russian wheat aphid (RWA) (Diuraphis noxia), one of the world's most invasive agricultural pests, in north-western China. We have analysed the data of 10 microsatellite loci and mitochondrial sequences from 27 populations sampled over 2 years in China. The results confirm ...
Wu Chang-Chin - - 2012
Patients sustaining bony fractures frequently require the application of bone graft substitutes to fill the bone defects. In the meantime, anti-osteoporosis drugs may be added in bone fillers to treat osteoporosis, especially in postmenopausal women and the elderly. The effects of zoledronate-impregnated calcium phosphate cement (ZLN/CPC) on ovariectomized (OVX) rats ...
Tilleul Patrick - - 2012
CONTEXT: Temozolomide (TMZ) is approved for the treatment of high-grade gliomas such as glioblastoma (GBM) multiforme and refractory anaplastic astrocytoma, but it is also used in indications not mentioned in the summary of product characteristics (SPC). The main objective of this study was to evaluate the conformity of TMZ prescriptions ...
Sabin Andrew T AT Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA. - - 2012
Normal sensory perception requires the ability to detect and identify patterns of activity distributed across the receptor surface. In the visual system, the ability to perceive these patterns across the retina improves with training. This learning differs in magnitude for different trained stimuli and does not generalize to untrained spatial ...
Zaytoun Osama M - - 2012
Study Type - Disagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Many patients undergo serial biopsy with a low rate of detection of prostate cancer, and the rate of detection declines as more biopsies are pursued. Furthermore, the clinical significance of ...
Michel Erich - - 2012
Production of sufficient amounts of human proteins is a frequent bottleneck in structural biology. Here we describe an Escherichia coli-based cell-free system which yields mg-quantities of human proteins in N-terminal fusion constructs with the GB1 domain, which show significantly increased translation efficiency. A newly generated E. coli BL21 (DE3) RIPL-Star ...
Hanssen K E - - 2012
The aim of this work was to study the effect of training volume on activation of satellite cells. Healthy untrained men were randomly assigned into two groups. The 3L-1UB group (n = 10) performed three-set leg exercises and single-set upper body exercises, and the 1L-3UB group (n = 11) performed single-set leg exercises and ...
Vacheva Anna - - 2012
It has recently been shown that pathogens with a limited capacity for sessile growth (like some Escherichia coli O157 strains) can benefit from the presence of other bacteria and form mixed biofilms with companion strains. This study addresses the question whether pathogens may influence attached growth of E. coli non-pathogenic ...
Gawrońska-Szklarz Barbara - - 2012
Pantoprazole is metabolized by cytochrome P450 2 C19, which shows genetic polymorphism. The effect of CYP2C19 polymorphism on single-dose pharmacokinetics of oral pantoprazole in healthy volunteers was evaluated. Pantoprazole pharmacokinetics was determined in 32 healthy volunteers after a 40-mg single oral dose of the drug. Carriers of CYP2C19*2/*2 (n = ...
Tian Lei - - 2012
The potential for self-reactive T cells to cause autoimmune disease is held in check by Foxp3(+) regulatory T cells (Tregs), essential mediators of peripheral immunological tolerance. Tregs have the capacity to suppress multiple branches of the immune system, tightly controlling the different subsets of effector T cells across multiple different ...
Men Shuang - - 2012
The surface chemistry of a series of four pyrrolidinium based ionic liquids, [C(n)C(1)Pyrr][Tf(2)N] where n = 4-10, is investigated by angle resolved X-ray photoelectron spectroscopy (ARXPS). The importance of sample purity is demonstrated and the stability of the ionic liquids under X-ray irradiation investigated. It is apparent that the surface ...
Kalhan Satish C - - 2012
Methionine and folate are the key components of one carbon metabolism, providing the methyl groups for numerous methyl transferase reactions via the ubiquitous methyl donor, s-adenosyl methionine. Methionine metabolism is responsive to nutrient intake, is regulated by several hormones and requires a number of vitamins (B12, pyridoxine, riboflavin) as co-factors. ...
Carlsson Anja M - - 2012
SUMMARYIn order to quantify the impact of parasites on host population dynamics, experimental manipulations that perturb the parasite-host relationship are needed but, logistically, this is difficult for wild hosts. Here, we describe the use of a delayed-release anthelmintic delivery system that can be administered when the hosts can be captured ...
Morishige Tomohiro - - 2012
It has gradually become evident that nanomaterials, which are widely used in cosmetics, foods, and medicinal products, could induce substantial inflammation. However, the roles played by the physical characteristics of nanomaterials in inflammatory responses have not been elucidated. Here, we examined how particle size and surface modification influenced the inflammatory ...
Suhodolčan Lovro - - 2012
PURPOSE: To evaluate the in vitro biomechanical characteristics of patellar tendon ligaments (BTB) when stored as fresh frozen or as glycerol cryopreserved allografts. METHODS: Seventy patellar tendons were harvested from 35 cadaveric human donors and randomly assigned into seven groups. Grafts in group FRESH were mechanically tested within 2 h of ...
VAN Mossel C - - 2012
VAN MOSSEL C., LEITZ L., SCOTT S., DAUDT H., DENNIS D., WATSON H., ALFORD M., MITCHELL A., PAYEUR N., COSBY C., LEVI-MILNE R. & PURKIS M.E. (2012) European Journal of Cancer Care Information needs across the colorectal cancer care continuum: scoping the literature Because cancer care requires a multifaceted approach, ...
Wei Shihu - - 2012
To verify the anti-inflammatory potency of iridoids, three iridoids (two natural, loganic acid: LA; geniposide: GE; and an artefact, 7(S)-n-butyl morroniside: BM) were investigated in vitro on the inhibition of superoxide generation in human neutrophils. All compounds showed inhibitory effect on fMLP-induced superoxide generation in a concentration-dependent manner with the following ...
Ridruejo Ezequiel - - 2012
Currently, five nucleos(t)ide analogs (NAs) are approved for the treatment of chronic hepatitis B (CHB) infection. They are lamivudine, adefovir dipivoxil, telbivudine, entecavir (ETV) and tenofovir disoproxil fumarate (TDF). Two of them, ETV and TDF, are recommended as first-line treatment options. Their main advantages include excellent tolerability, antiviral potency and ...
Nachum-Biala Yaarit - - 2012
A compelling and extensive epidemiological literature documents the strong association of inadequate status of folate, vitamin B12, and to a lesser degree vitamin B6, with increased risk of neurodegenerative and cerebrovascular disease. Mildly elevated plasma total homocysteine, which is biochemically related to low status of these B-vitamins, is similarly associated ...
Wilson Lisa B LB Department of Psychiatry, University of Colorado Denver, Aurora, CO 80045, - - 2013
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders. Twin studies have provided heritability estimates as high as 90% for idiopathic ASD. Further evidence for the spectrum's heritability is provided by the presence of the broad autism phenotype (BAP) in unaffected first-degree relatives. Language ability, specifically phonological processing, is proposed to ...
Abbas Richat - - 2012
PURPOSE: Neratinib, a potent, low-molecular-weight, orally administered, irreversible, pan-ErbB receptor tyrosine kinase inhibitor has antitumor activity in ErbB2 + breast cancer. The objective of this study was to characterize the onset, severity, and duration of diarrhea after administration of neratinib 240 mg once daily (QD) and 120 mg twice daily (BID) for ≤14 days in ...
Louis E D ED G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA. - - 2012
Patients with essential tremor (ET) and Parkinson's disease (PD) may exhibit overlapping clinical features. Also, a growing number of non-motor features are being documented in ET. Color vision abnormalities, although well known to occur in PD, have not been studied extensively in ET. We assessed color vision in ET cases ...
Thyssen Jacob P - - 2012
Background. Chromium-tanned leather footwear, which releases >3 ppm hexavalent Cr(VI), may pose a risk of sensitizing and eliciting allergic dermatitis. Objectives. To determine the content and potential release of chromium in leather footwear and to discuss the prevention of chromium contact allergy and dermatitis. Methods. Sixty pairs of leather shoes, ...
Kwon Beom-June - - 2012
Dyssynchrony is common in asymptomatic patients with hypertension. We sought to investigate the impact of antihypertensive treatment on dyssynchrony in patients with hypertension. A total of sixty patients who had uncomplicated hypertension that had never been treated (treatment-naïve hypertensive patients) underwent echocardiographic evaluations of left ventricular (LV) dyssynchrony at baseline ...
Zaleski-Ejgierd Patryk - - 2012
An initial observation of the formation of WH under pressure from W gaskets surrounding hydrogen in diamond anvil cells led to a theoretical study of tungsten hydride phases. At P = 1 atm no stoichiometry is found to be stable with respect to separation into the elements, but as the pressure is raised ...
Avalos Marta - - 2012
We adapt the least absolute shrinkage and selection operator (lasso) and other sparse methods (elastic net and bootstrapped versions of lasso) to the conditional logistic regression model and provide a full R implementation. These variable selection procedures are applied in the context of case-crossover studies. We study the performances of ...
Florentin Matilda - - 2012
Statins, the mainstay of lipid-lowering therapy, are among the most commonly used drugs due to their beneficial effects in cardiovascular morbidity and mortality. Simvastatin, one of the most well-studied statins, is available in several generic forms both as monotherapy and with ezetimibe and is frequently prescribed worldwide. Despite its overall ...
Asher A J - - 2012
SUMMARYHumans are infected by 2 genetic assemblages (A and B) of Giardia duodenalis, a protozoan parasite that causes gastro-intestinal disease. Sub-assemblages AI, AII, BIII and BIV are commonly identified in human cases. Detection requires amplification of G. duodenalis loci. Subsequent DNA sequencing or restriction fragment length polymorphism (RFLP) identifies sub-assemblages ...
Ljøstad U - - 2012
Purposes:  To chart clinical, laboratory, and psychometric profiles in patients who attribute their complaints to chronic Lyme disease. Methods:  We assessed the patients by clinical examination, laboratory tests, and questionnaires measuring fatigue, depression, anxiety, health-related quality of life, hypochondriasis, and illness perceptions. Results:  We found no evidence of ongoing Borrelia ...
Yu Chien-Tai - - 2012
A cross-sectional study was conducted to investigate the prevalence, types, and risk factors associated with anal HPV infection among HIV-infected men in outpatient clinics at an AIDS designated hospital in Taiwan. Anal swabs were collect and PCR (polymerase chain reaction) was used to analyze the types of anal HPV infection. ...
Janaswamy Srinivas S Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907-2009, USA. - - 2012
Nutraceuticals are important due to their inherent health benefits. However, utilization and consumption are limited by their poor water solubility and instability at normal processing and storage conditions. Herein, we propose an elegant and novel approach for the delivery of nutraceuticals in their active form using hydrocolloid matrices that are ...
Blakely Tony - - 2012
Relative survival and excess mortality approaches are commonly used to estimate and compare net survival from cancer. These approaches are based on the assumption that the underlying (non-cancer) mortality rate of cancer patients is the same as that of the general population. This assumption is likely to be violated particularly ...
Naitoh Itaru - - 2012
Abstract Objective. Autoimmune pancreatitis (AIP) needs to be differentiated from pancreatic cancer (PC). We aimed to clarify the findings specific for AIP by comparing the clinical differences between mass-forming AIP and PC. Material and methods. We retrospectively compared 36 patients with mass-forming AIP and 60 with PC without metastasis regarding ...
Barnes Geoffrey D - - 2012
Venous thromboembolism (VTE) carries significant morbidity and mortality and affects a large portion of hospitalized patients. VTE prophylaxis is rated by the Agency for Healthcare Research and Quality as the most effective of 79 patient safety practices it assessed in 2001. Since 1997, Blue Cross Blue Shield of Michigan/Blue Care ...
Bene Judit - - 2012
L-carnitine supplementation is extensively used in patients on maintenance hemodialysis (HD) to improve dialysis-related clinical symptoms. In a series of studies, we investigated the dynamics of carnitine pool in carnitine-supplemented HD patients; here we report dramatic decrease with special changes of the ester profile due to interruption of the exogenous ...
Meyers Arthur B - - 2012
Gadoxetate disodium (Gd-EOB-DTPA) is a hepatobiliary MRI contrast agent widely used in adults for characterization of liver tumors and increasingly used in children. Hepatoblastoma is the most common primary hepatic malignancy of childhood. In this review, we describe our experience with this agent both before and after initiating therapy in ...
Faupel-Badger Jessica M - - 2012
A history of a preeclamptic pregnancy has been associated with subsequent increased risk of cardiovascular disease in the mother and decreased risk of breast cancer in both the mother and offspring. The concentrations of steroid sex hormones, angiogenic factors, and other proteins during pregnancy are important components of the in ...
Chien Su-Chen - - 2012
Objectives: To compare intensiveness of use of child preventive health services (CPHS) between cross-cultural immigrant families and native-born families in Taiwan and to explore factors associated with differences in intensiveness of CPHS use. Design: Cross-cultural immigrant families were defined as families where the mother was an immigrant from another southeast ...
Arnold Jennifer E - - 2012
In this article, we examine the hypothesis that acoustic variation (e.g., reduced vs. prominent forms) results from audience design. Bard et al. (Journal of Memory and Language 42:1-22, 2000) have argued that acoustic prominence is unaffected by the speaker's estimate of addressee knowledge, using paradigms that contrast speaker and addressee ...
Yu Hsu-Sheng - - 2012
The present study aimed to experimentally confirm that long-term alcohol drinking causes a high risk of oral and esophageal cancer in aldehyde dehydrogenase 2 (ALDH2)-deficient individuals. Aldh2 knockout mice, an animal model of ALDH2-deficiency, were treated with 8% ethanol for 14 months. Levels of acetaldehyde-derived DNA adducts were increased in ...
Carlson Robert W RW Eastern Cooperative Oncology Group, Boston, MA, USA. - - 2012
EGFR signalling pathways appear involved in endocrine therapy resistance in breast cancer. This trial estimates the antitumor efficacy and toxicity of the EGFR tyrosine kinase inhibitor gefitinib in combination with anastrozole or fulvestrant in postmenopausal hormone receptor positive breast cancer. Subjects with estrogen receptor and/or PgR positive, metastatic breast cancer ...
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