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Menne Jan - - 2012
We have previously demonstrated in the Randomized Olmesartan and Diabetes Microalbuminuria Prevention study that the angiotensin receptor blocker (ARB) olmesartan delays the onset of microalbuminuria in patients with type 2 diabetes. Now, we investigated the effect in the subpopulation with hypertension. Overall, 4020 patients with type 2 diabetes and hypertension ...
Salaverria Itziar - - 2012
Translocations involving immunoglobulin (IG) loci are the hallmarks of several subtypes of B-cell lymphoma. Common to these translocations is that cellular proto-oncogenes come under the influence of IG regulatory elements leading to deregulated expression. In case of a breakpoint in the IGH switch region, oncogene activation can take place on ...
Sanches Livia Rentas - - 2012
Undoubtedly, whole blood and vitreous humor have been biological samples of great importance in forensic toxicology. The determination of opiates and their metabolites has been essential for better interpretation of toxicological findings. This report describes the application of experimental design and response surface methodology to optimize conditions for enzymatic hydrolysis ...
Papaevangelou Vassiliki A - - 2012
Experimental results on evapotranspiration (ET), relevant to small on-site facilities are presented, derived from one-year controlled experiments in five pilot-scale horizontal subsurface flow (HSF) constructed wetlands (CW) used as lysimeters. The CW units operated in Northern Greece. They were rectangular tanks made of steel, with dimensions 3m long, 0.75m wide ...
Saeki Yuko - - 2012
A calcium gradient in skin epidermis is known to regulate epidermal differentiation. In cultures of human epidermal keratinocytes (NHEK), induction of calcium-dependent differentiation is associated with phosphorylation of ErbB receptors, including the epidermal growth factor receptor (EGFR). The activation of EGFR triggers the induction of activator protein 1 (AP-1) proteins ...
Beardsley James R - - 2012
The financial impact of an antimicrobial stewardship program in operation for more than 11 years was determined by calculating the reduction in antimicrobial expenditures minus program labor costs. Depending on the method of inflation adjustment used, the program was associated with average cost savings of $920,070 to $2,064,441 per year.
Han Gee-Bong - - 2012
In this study, the feasibility of an innovative upflow packed-bed reactor (UPBR) system using porous sulfur and lime ceramic media (CERAMED-L and CERAMED-SL) to remove nitrogen for wastewater treatment was evaluated. The specific lime dissolution rates for CERAMEDs in the UPBRs show an inverse proportion to pH and resulted in ...
Hwang Sam T - - 2012
The success of the adaptive immune system relies upon the transport of antigens by dendritic cells (DCs) from skin via lymphatic vessels to lymph nodes where DCs present antigen to T cells. Little is known about the requirements for so-called "reverse transmigration" (RT). Torzicky et al. in this issue demonstrate ...
O'Neill D - - 2012
Objectives: To describe systemic glucocorticoid usage in cats and dogs by three primary care -veterinary practices in England and to ascertain risk factors for clinical use. To evaluate consistency of prescribing patterns across clinics. To validate a merged database of primary veterinary clinical data as a functional tool for clinical ...
Vetander M - - 2012
Information about acute reactions to foods among children is limited. To describe the overall incidence of anaphylaxis in a paediatric emergency department (ED) setting and to describe reactions to foods in relation to sex and age, clinical characteristics and management. In a review of medical records, children with ED visits ...
Xie Kun - - 2012
Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) are a group of important persistent organic pollutants. In the present study, the three-dimensional holographic vector of atomic interaction field (3D-HoVAIF) method is used to describe the chemical structures of PCDD/Fs. After variable screening using a stepwise multiple regression (SMR) technique, the linear relationships among ...
Gullberg Rod G - - 2012
For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several established and well-documented methods are available to determine and report the ...
Hebert Courtney - - 2012
Objective. Healthcare providers need a better empiric antibiotic prescribing aid than the traditional antibiogram, which supplies no information on the relative frequency of organisms recovered in a given infection and which is uninformative in situations where multiple antimicrobials are used or multiple organisms are anticipated. We aimed to develop and demonstrate ...
Pavia P R - - 2012
A 14-year-old domestic shorthair cat presented with a 5-month history of urinary incontinence and inappro-priate elimination. Ultrasonography revealed a well-marginated, vascular mass of mixed echogenicity ex-tending from the dorsal wall of the urinary bladder into the lumen. Partial cystectomy was performed for re-moval of the urinary bladder mass; histopathological evaluation ...
Bellapart J - - 2012
Intensive care delirium is a well-recognized complication in critically ill patients. Delirium is an independent risk factor for death in the intensive care unit (ICU), leading to oversedation, increased duration of mechanical ventilation, and increased length of stay. Although there has not been a direct causal relationship shown between sleep ...
Jones Makoto - - 2012
Objective. To estimate avoidable intravenous (IV) fluoroquinolone use in Veterans Affairs (VA) hospitals. Design. A retrospective analysis of bar code medication administration (BCMA) data. Setting. Acute care wards of 128 VA hospitals throughout the United States. Methods. Data were analyzed for all medications administered on acute care wards between January 1, 2006, and December ...
Nakajima Hiroaki - - 2012
We recently reported that overexpression of the elastase NEP (neutral endopeptidase) by fibroblasts plays a pivotal role in the mechanism of UVB-induced skin wrinkling by degrading dermal elastic fibres. Since UVB does not penetrate to the dermis, we hypothesized that factors secreted by UVB-exposed keratinocytes in the epidermis trigger fibroblasts ...
McGowan John E - - 2012
Antimicrobial stewardship programs attempt to optimize prescribing of these drugs to benefit both current and future patients. Recent regulatory and other incentives have led to widespread adoption of such programs. Measurements of the success of these programs have focused primarily on process measures. However, evaluation of outcome measures will be ...
Torit Jirawan - - 2012
This study was to use the plants to remove phosphorus from domestic wastewater which contained high phosphorus concentration. Six higher plant species such as Crinum asiaticum L., Echinodorus cordifolius L., Spathiphyllum clevelandii Schott, Rhizophora apiculata Blume, Thalia dealbata J.fraser., Heliconia psittacorum L.f. were screened for phosphorus removal. Plants were grown ...
Standiford Harold C - - 2012
Background. An antimicrobial stewardship program was fully implemented at the University of Maryland Medical Center in July 2001 (beginning of fiscal year [FY] 2002). Essential to the program was an antimicrobial monitoring team (AMT) consisting of an infectious diseases-trained clinical pharmacist and a part-time infectious diseases physician that provided real-time monitoring ...
Zhao Cunyou - - 2012
To rapidly determine DNA methylation levels from a large number of biological or clinical samples, we have developed an accurate and sensitive method for high-throughput quantification of global methylation of 5'-Cm ( 5) CGG-3' sites in the genome, visualized by fluorescence polarization (FP) based measurement of DNA methylation (FPDM). In ...
Schroeder James W - - 2012
Prenatal exposure both to maternal psychiatric illness and psychiatric medication has been linked with adverse child outcomes that affect physiological, emotional and psychiatric development. Studies suggest that epigenetic mechanisms, such as DNA methylation, may facilitate these effects. In this report, we explore the association between maternal psychiatric illness and treatment ...
Minocherhomji Sheroy - - 2012
Most pathogenic mitochondrial DNA (mtDNA) mutations induce defects in mitochondrial oxidative phosphorylation (OXPHOS). However, phenotypic effects of these mutations show a large degree of variation depending on the tissue affected. These differences are difficult to reconcile with OXPHOS as the sole pathogenic factor suggesting that additional mechanisms contribute to lack ...
Gregory David J - - 2012
Our ability to selectively manipulate gene expression by epigenetic means is limited, as there is no approach for targeted reactivation of epigenetically silenced genes, in contrast to what is available for selective gene silencing. We aimed to develop a tool for selective transcriptional activation by DNA demethylation. Here we present ...
Mahoney Sarah E - - 2012
Rhabdomyosarcoma is the most common soft-tissue sarcoma in children. While cytogenetic abnormalities have been well characterized in this disease, aberrant epigenetic events such as DNA hypermethylation have not been described in genome-wide studies. We have analyzed the methylation status of 25,500 promoters in normal skeletal muscle, and in cell lines ...
Yang Pei-Ming - - 2012
CD1d is a MHC class-like molecule that presents glycolipids to natural killer T (NKT) cells, then regulates innate and adaptive immunity. The regulation of CD1d gene expression in solid tumors is still largely unknown. Gene expression can be epigenetically regulated by DNA methylation and histone acetylation. We found that histone ...
Falluel-Morel Anthony - - 2012
Mercury is an environmental toxicant that can disrupt brain development. However, although progress has been made in defining its neurotoxic effects, we know far less about available therapies that can effectively protect the brain in exposed individuals. We previously developed an animal model in which we defined the sequence of ...
Hiraki Teruyuki - - 2012
The aim of this study was to investigate the effect of vagus nerve stimulation (VNS) on infarct volume and neurological recovery up to 3 weeks following transient focal cerebral ischemia. Transient ischemia was produced by filament occlusion of the proximal middle cerebral artery (MCA) in rats. The right vagus nerve ...
Zhu Jie - - 2012
Persistent changes in behavior and psychological function that occur as a consequence of exposure to drugs of abuse are thought to be mediated by the structural plasticity of specific neural circuits such as the brain's dopamine (DA) system. Changes in dendritic morphology in the nucleus accumbens (NAc) accompany drug-induced enduring ...
Willer Cristen J - - 2012
We review the main findings from genome-wide association studies (GWAS) for levels of HDL-cholesterol, LDL-cholesterol and triglycerides, including approaches to identify the functional variant(s) or gene(s). We discuss study design and challenges related to whole genome or exome sequencing to identify novel genes and variants. GWAS have detected approximately 100 ...
Moriwaki Shinichi - - 2012
We describe an unusual xeroderma pigmentosum (XP) patient with a mutation in XP complementation group G, representing only the third reported Japanese XP-G patient. A 40-year-old men (XP3HM), born from consanguineous parents experienced sun sensitivity and pigmentary changes of sun-exposed skin since childhood. He developed a squamous cell carcinoma on ...
Davis Megan E - - 2012
This study aimed to determine the feasibility of using likelihood of inadequate therapy (LIT), a parameter calculated by using pathogen frequency and in vitro susceptibility for determination of appropriate empiric antibiotic therapy for primary bloodstream infections. Our study demonstrates that LIT may reveal differences in traditional antibiograms.
Van Aller Glenn S - - 2012
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes ...
Ganten M K - - 2012
A proven criterion for assessing tumor response is the increase in tumor size. Unlike most tumors, lymph nodes are normal anatomical structures and can be measured even when benign. The International Working Group (IWG) criteria for lymphomas therefore combine morphological with functional (positron emission tomography PET) and biopsy (bone marrow ...
Stroupe Christopher C Department of Molecular Physiology and Biological Physics and Center for Membrane Biology, University of Virginia, Charlottesville, VA 22908, USA. - - 2012
A previous report described lipid mixing of reconstituted proteoliposomes made using lipid mixtures that mimic the composition of yeast vacuoles. This lipid mixing required SNARE {SNAP [soluble NSF (N-ethylmaleimide-sensitive factor)-attachment protein] receptor} proteins, Sec18p and Sec17p (yeast NSF and α-SNAP) and the HOPS (homotypic fusion and protein sorting)-Class C Vps ...
Glance Laurent G LG Department of Anesthesiology, University of Rochester School of Medicine, Rochester, NY 14642, USA. - - 2012
To develop a 30-day mortality risk index for noncardiac surgery that can be used to communicate risk information to patients and guide clinical management at the "point-of-care," and that can be used by surgeons and hospitals to internally audit their quality of care. Clinicians rely on the Revised Cardiac Risk ...
Almeida Rimple D RD Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), School of Clinical Sciences, University of Nottingham, Nottingham, - - 2012
5-hydroxymethyl-cytosine (5-hmC) is a cytosine modification that is relatively abundant in mammalian pre-implantation embryos and embryonic stem cells (ESC) derived from mammalian blastocysts. Recent observations imply that both 5-hmC and Tet1/2/3 proteins, catalyzing the conversion of 5-methyl-cytosine to 5-hmC, may play an important role in self renewal and differentiation of ...
Doupé David P DP Department of Physiology, Development and Neuroscience, The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, - - 2012
In the 1970s, studies of tissue architecture and cell proliferation were used to formulate a new model of epidermal homeostasis. This asserted that the tissue was maintained by long-lived, slow-cycling, self-renewing stem cells that generate a short-lived population of transit amplifying (TA) cells, which undergo terminal differentiation after a set ...
Rivenbark Ashley G AG Department of Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The - - 2012
An obstacle in the treatment of human diseases such as cancer is the inability to selectively and effectively target historically undruggable targets such as transcription factors. Here, we employ a novel technology using artificial transcription factors (ATFs) to epigenetically target gene expression in cancer cells. We show that site-specific DNA ...
Balakrishnan Anita A Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA. - - 2012
Short bowel syndrome remains a condition of high morbidity and mortality, and current therapeutic options carry significant side effects. To identify new treatments we focused on postresection changes in microRNAs--short noncoding RNAs, which suppress target genes--and suggest a previously undiscovered role for microRNA-125a (mir-125a) in intestinal adaptation. Rats underwent either ...
Akilov Oleg E OE Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15213, USA. - - 2012
Failure to execute an apoptotic programme is one of the critical steps and a common mechanism promoting tumorogenesis. Immediate early responsive gene 3 (IER3) has been shown to be upregulated in several cancers. IER3 is a stress-induced gene, which upregulation leads to reduction in production of reactive oxygen species (ROS) ...
Donde Aneesh A Human Exposure Laboratory, Division of Occupational and Environmental Medicine, University of California San Francisco, San Francisco, CA, - - 2012
Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants. To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise. We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that ...
Byrne A M AM Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, - - 2012
Glucocorticoid-induced TNF receptor-related protein ligand (GITRL), a ligand for the T cell co-stimulatory molecule GITR, is expressed by keratinocytes and involved in chemokine production. The expression of GITRL in skin inflammation remains unknown. This study investigated cytokine regulation of keratinocyte GITRL expression. Glucocorticoid-induced TNF receptor expression was evaluated in cytokine-treated ...
Viardot A A Klinik für Innere Medizin III, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland. - - 2012
Malignant lymphomas are the most common cancers of the hematopoietic system. The treatment is usually cytotoxic chemotherapy after the appearance of symptoms in indolent lymphoma and immediately in aggressive lymphoma. Local therapy, such as radiotherapy is sometimes required in addition to systemic treatment. By the introduction of targeted therapies the ...
Esquivel-Rodríguez Juan J Department of Computer Science, Purdue University, West Lafayette, Indiana 47907, - - 2012
A novel computational method for fitting high-resolution structures of multiple proteins into a cryoelectron microscopy map is presented. The method named EMLZerD generates a pool of candidate multiple protein docking conformations of component proteins, which are later compared with a provided electron microscopy (EM) density map to select the ones ...
Kunisue Tatsuya - - 2012
Benzophenone (BP)-type UV filters are widely used in a variety of personal care products for the protection of skin and hair from UV irradiation. Despite the estrogenic potencies of BP derivatives, few studies have examined the occurrence of these compounds in human matrices. Furthermore, associations among exposure to these compounds ...
Wu Pan - - 2012
4-Oxalocrotonate tautomerase (4-OT), a member of tautomerase superfamily, is an essential enzyme in the degradative metabolism pathway occurring in the Krebs cycle. The proton transfer process catalyzed by 4-OT has been explored previously using both experimental and theoretical methods; however, the elaborate catalytic mechanism of 4-OT still remains unsettled. By ...
Masutomi Kosuke K Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, - - 2012
All-trans retinal is a potent photosensitizer that is released in photoreceptor outer segments by the photoactivated visual pigment following the detection of light. Photoreceptor outer segments also contain high concentrations of polyunsaturated fatty acids, and are thus particularly susceptible to oxidative damage such as that initiated by light via a ...
Burgos Emmanuel S ES Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, United - - 2012
S-Adenosyl-L-homocysteine hydrolase (SAHH) catalyzes the reversible conversion of S-adenosyl-L-homocysteine (SAH) to adenosine (ADO) and L-homocysteine, promoting methyltransferase activity by relief of SAH inhibition. SAH catabolism is linked to S-adenosylmethionine metabolism, and the development of SAHH inhibitors is of interest for new therapeutics with anticancer or cholesterol-lowering effects. We have developed ...
Boyer Nicholas P NP Department of Ophthalmology, Medical University of South Carolina, Charleston, SC, - - 2012
Lipofuscin is a fluorescent material with significant phototoxic potential that accumulates with age in the retinal pigment epithelium (RPE) of the eye. It is thought to be a factor in retinal degeneration diseases. The most extensively characterized lipofuscin component, N-retinylidene-N-retinylethanolamine (A2E), has been proposed to be a byproduct of reactions ...
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