Search Results
Results 101 - 150 of 3134
1 2 3 4 5 6 7 8 9 10 >
Wieczorek Mark A - - 2012
The Moon possesses strong magnetic anomalies that are enigmatic given the weak magnetism of lunar rocks. We show that the most prominent grouping of anomalies can be explained by highly magnetic extralunar materials from the projectile that formed the largest and oldest impact crater on the Moon: the South Pole-Aitken ...
Fritzsche C - - 2012
Background: Patients with autoimmune inflammatory diseases (AID) account for 13-36% of Pneumocystis pneumonia (PCP) cases in human immunodeficiency virus (HIV)-negative patients. Up to 88% of PCP cases in HIV-negative patients are associated with prior steroid treatment. Pulmonary colonization with Pneumocystis in HIV-negative patients is associated with corticosteroid therapy in up ...
Radu Beatrice Mihaela - - 2012
The formation of advanced glycation end products is one of the major factors involved in diabetic neuropathy, aging, and neurodegenerative diseases. Reactive carbonyl compounds, such as methylglyoxal (MG), play a key role in cross-linking to various proteins in the extracellular matrix, especially in neurons, which have a high rate of ...
Yuan Jun - - 2012
FAT10, as a small ubiquitin-like modifier, plays an important role in various cellular processes, including mitosis, immune response, and apoptosis, the dys-regulation of which may arise tumorigenesis. Therefore, the aim of this study was to examine the expression of FAT10 at gene and protein levels in glioma samples with different ...
Hall Susan - - 2012
PURPOSE: To explore experiences and support needs of people with colorectal cancer, with a focus on identifying opportunities for primary care interventions. METHODS: We conducted a new qualitative analysis of an existing dataset, comprising semi-structured interview transcripts from 39 people with colorectal cancer from across the UK, interviewed in 2001-2002 ...
Miskowiak Kamilla - - 2012
Background: Cognitive dysfunction in unipolar disorder (UD) and bipolar disorder (BD) may persist into remission and affect psychosocial function. Executive and memory deficits during remission may be more pronounced in BD than UD. However, patients' subjective experience of cognitive difficulties is poorly understood, and it is unclear whether BD and ...
Luo Simin - - 2012
Chondroid cell from human adipose-derived stem cells (ADSCs) has emerged as an alternative treatment option for articular cartilage defects. Herein, we successfully compared ADSCs, normal chondrocytes, and chondroid cells. The comparative study of ADSCs and chondroid cells revealed type II collagen (COL II) and glycosaminoglycans expression of chondroid cells were ...
Shanmughapriya S - - 2012
We sought to analyse the presence of human papillomavirus (HPV), Chlamydia trachomatis and cytomegalovirus (CMV) infection in women with epithelial ovarian carcinomas. Polymerase chain reaction (PCR)-based detection of microbial infections was carried out. A total of 39 tissue samples were analysed with consensus and type-specific primers for HPV, primers specific ...
Sariali Elhadi - - 2012
Proximal cementless fixation using anatomic stems reportedly increases femoral fit and avoids stress-shielding. However, thigh pain was reported with the early stem designs. Therefore, a new anatomic cementless stem design was based on an average three-dimensional metaphyseal femoral shape. However, it is unclear whether this stem reduces the incidence of ...
Duch J - - 2012
AIM: The aim of this paper was to prospectively evaluate FDG PET/CT in the assessment of metabolic response to neoadjuvant chemotherapy and correlation with tumor cellularity in locally advanced breast cancer. METHODS: Images were acquired with a PET/CT scanner in 50 patients at baseline and after completion of treatment, just ...
Chapurlat R D - - 2012
We have examined the effect of oral monthly ibandronate on distal radius and tibia microarchitecture with high-resolution peripheral quantitative tomography compared with placebo, in women with osteopenia, and found that ibandronate did not significantly affect trabecular bone but improved cortical density and thickness at the tibia. METHODS: We have examined ...
Yang Hui - - 2012
(S)-Proline-catalyzed nitro-Michael additions of aldehydes and ketones to β-nitrostyrene were investigated computationally (MP2/6-311+G**//M06-2X/6-31G**). Contrary to what is usually assumed in organocatalysis, the lowest-energy transition states of proline-catalyzed nitro-Michael reactions do not necessarily involve the carboxylic acid group of the proline moiety directing the incoming nitroalkene to the same face through ...
Atesok Kivanc - - 2012
PURPOSE: The purpose of this article was to analyze the results of studies in the literature, which evaluated the use of endothelial progenitor cells (EPCs) as a cell-based tissue engineering strategy. METHODS: EPCs have been successfully used in regenerative medicine to augment neovascularization in patients after myocardial infarction and limb ...
Farrugia Audrey - - 2012
High-resolution melting (HRM) analysis is a recently developed molecular technique proved to be applicable for detection of genetic variation, notably in sudden cardiac death. In certain circumstances, especially in postmortem genetic investigations, the formalin-fixed and paraffin-embedded (FFPE) tissues are the only DNA source available. The present study aimed to develop ...
Manji A - - 2012
BACKGROUND: There is no consensus on whether therapeutic intensity can be reduced safely in children with low-risk febrile neutropenia (FN). Our primary objective was to determine whether there is a difference in efficacy between outpatient and inpatient management of children with low-risk FN. Our secondary objective was to compare oral ...
Nummenmaa Lauri - - 2012
Faces and bodies convey important information for the identification of potential sexual partners, yet clothing typically covers many of the bodily cues relevant for mating and reproduction. In this eye tracking study, we assessed how men and women viewed nude and clothed, same and opposite gender human figures. We found ...
Leva L - - 2012
AIM: The aim of the study was to assess the reproducibility (R) and variability of quantitative parameters derived from Cedars-Sinai QGS software for phase analysis of G-SPECT in 39 coronary artery disease (CAD) patients with or without severe heart-failure (HF). METHODS:Phase standard deviation (s) and entropy (e) are global parameters ...
Maier Michael W - - 2012
BACKGROUND: This prospective study evaluated the development of proprioception over the course of 3 years after shoulder arthroplasty. METHODS: Twenty-one patients were enrolled who underwent total shoulder arthroplasty (n = 10) or hemiarthroplasty (HEMI) (n = 11) for shoulder osteoarthritis. All patients were examined 1 day before the operation, 6 months and 3 years after surgery in a ...
Yoshida S - - 2012
The main histological change in rheumatoid arthritis (RA) is the villous proliferation of synovial lining cells, an important source of cytokines and chemokines, which are associated with inflammation. The aim of this study was to evaluate gene expression in the microdissected synovial lining cells of RA patients, using those of ...
Verzola Daniela - - 2012
Progressive chronic kidney disease (CKD) is common in lysinuric protein intolerance (LPI), a primary inherited aminoaciduria characterized by massive Lysine excretion in urine. However, by which mechanisms Lysine may cause kidney damage to tubule cells is still not understood. This study determined whether Lysine overloading of human proximal tubular cells ...
Brownson Dale A C - - 2012
We explore the use of graphene modified electrodes towards the electroanalytical sensing of various analytes, namely dopamine hydrochloride, uric acid, acetaminophen and p-benzoquinone via cyclic voltammetry. In line with literature methodologies and to investigate the full-implications of employing graphene in this electrochemical context, we modify electrode substrates that exhibit either ...
Nadour M - - 2012
The antioxidant properties of phenolic compounds from olive pulp (PCO) of chamlal variety and those of individual phenolic compounds were evaluated and compared with that of vitamin C (Vit C). The antioxidant activity was measured by the tests of iron reduction and scavenging hydrogen peroxide (H(2)O(2)). Results showed that all ...
Rybalov M - - 2012
AIM: This study focuses on the potential role of [11C]choline positron emission tomography (PET) for the intraprostatic tumor characterization and localization in recurrent prostate cancer after EBRT. METHODS: This retrospective study was conducted in patients who were being followed up after EBRT for histological proven prostate cancer. We selected the ...
Corti M A M - - 2012
Corynebacterium ulcerans is mainly known for its ability to cause animal infections. Some strains of C. ulcerans produce diphtheria toxin, which can cause life-threatening cardiopathies and neuropathies in humans. Human cutaneous C. ulcerans infection is a very rare disease that mimics classical cutaneous diphtheria. We present a very rare case ...
Tessari Alessia A Department of Psychology, University of Bologna, Viale Berti Pichat 5, 40127 Bologna, Italy. - - 2012
There is evidence suggesting that viewing hands triggers automatic access to the Body Structural Description, a visual-spatial representation of human body parts configuration. Hands, however, have a special representational status within the brain because of their significance for action and cognition. We tested whether feet, less important in gestural and ...
Eberhardt Frank - - 2012
BACKGROUND: Atrioventricular (AV) interval optimization is often deemed too time-consuming in dual-chamber pacemaker patients with maintained LV function. Thus the majority of patients are left at their default AV interval. OBJECTIVE: To quantify the magnitude of hemodynamic improvement following AV interval optimization in chronically paced dual chamber pacemaker patients. PATIENTS ...
Braciale Thomas J - - 2012
Recent years have seen several advances in our understanding of immunity to virus infection of the lower respiratory tract, including to influenza virus infection. Here, we review the cellular targets of viruses and the features of the host immune response that are unique to the lungs. We describe the interplay ...
Schwartz Seth J - - 2012
The longitudinal effects among self and identity processes, and between these processes and internalizing symptoms, are not well understood. As a result, the present study was designed to ascertain the over-time effects among identity commitment, reconsideration of commitments, and self-concept clarity, as well as to map the interplay of these ...
Mocumbi Ana O H - - 2012
Intracardiac masses in the young occur in some conditions that are prevalent in Africa. Although usually non-malignant, they may present with refractory heart failure and other complications that can be fatal. In the majority of cases, the aetiologic differentiation can be achieved by careful history, physical examination, basic laboratory tests, ...
Nandi Sumon - - 2012
Hip and knee arthroplasties are widely performed and vascular disease among patients having these procedures is common. Clopidogrel is a platelet inhibitor that decreases the likelihood of thrombosis. It may cause intraoperative and postoperative bleeding, but its discontinuation increases the risk of vascular events. There is currently no consensus regarding ...
Kim Jungwook - - 2012
Self-actuating materials capable of transforming between three-dimensional shapes have applications in areas as diverse as biomedicine, robotics, and tunable micro-optics. We introduce a method of photopatterning polymer films that yields temperature-responsive gel sheets that can transform between a flat state and a prescribed three-dimensional shape. Our approach is based on ...
Pulido J S - - 2012
To describe the histological findings of birdshot chorioretinopathy. DESIGN/PARTICIPANT: This is a case study of a single patient who has both birdshot chorioretinopathy and ciliochoroidal melanoma. A 55-year-old woman who was HLA-A29 positive and had birdshot chorioretinopathy had a large ciliochoroidal melanoma (T4b N0 M0) and underwent enucleation. Using histopathology, ...
Lerner-Ellis Jordan P - - 2012
This commentary is based on the key note address given by Jordan Lerner-Ellis at the annual symposium of the Society for the Study of Inborn Errors of Metabolism, held in Geneva, Switzerland in August 2011. The content of the address was developed from a series of discussions with seven clinicians ...
Yuzawa Sayaka - - 2012
Pancreatic adenocarcinoma is a lethal disease that often develops a desmoplastic reaction in tumor stroma. In general, desmoplasia is thought to promote tumor growth. However, its molecular pathology and prognostic potential have not been fully investigated. Here, we investigate 26 cases of pancreatic ductal adenocarcinoma and examine the clinicopathological association ...
Laverrière M M Instituto de Investigaciones Biotecnológicas IIB-INTECH, Universidad Nacional de San Martín - CONICET, Buenos Aires, - - 2012
Metacaspases are distant relatives of animal caspases present in plants, fungi and protozoa. At variance with caspases, metacaspases exhibit stringent specificity for basic amino-acid residues and are absolutely dependent on millimolar concentrations of calcium. In the protozoan parasite Trypanosoma cruzi, metacaspases have been suggested to be involved in an apoptosis-like ...
Krishnan Marimuthu - - 2012
An analytical approach is developed for reconstructing site-specific methyl-bearing protein side-chain conformational energy surfaces from NMR methyl axis order parameters (O<sup>2</sup><sub>axis</sub>). Application of an enhanced sampling algorithm (adaptive biasing force) to molecular dynamics simulation of a protein, calcium-bound calmodulin, reveals a non-linear correlation between O<sup>2</sup><sub>axis</sub> and the populations of rotamer ...
Wen-Jun Liu - - 2012
We investigated the role of homeobox B4 (HOXB4) mRNA/protein expression induced by human cytomegalovirus (HCMV) and/or all-trans retinoic acid (ATRA) in proliferation and committed differentiation of human cord blood hematopoietic stem cells (HSCs) into colony-forming-units of T-lymphocyte (CFU-TL) and erythroid (CFU-E) progenitors in vitro. Twelve cord blood samples were collected ...
Belew Sileshi - - 2012
An experimental study to investigate the susceptibility pattern of Haemonchus contortus to commonly used anthelmintics (albendazole, tetramisole, ivermectin, and triclobendazole) was conducted between June and September 2009. Adult H. contortus parasites were collected from a total of 30 sheep slaughtered at Jimma municipal abattoir. The anthelmintics were assessed for egg ...
Maimon Shimon - - 2012
BACKGROUND: Flow diverters are recently developed stent-like endovascular devices developed to treat complex and non-coilable aneurysms. SILK is a type of flow diverter that has been used for nearly 3 years. Only sparse data about it are available. We would like to share our experience with this device. METHODS: Twenty-eight patients ...
Berger Burkhard - - 2012
We attempted to quantitatively determine the chimeric state in a total of 162 buccal swabs from 77 adult recipients aged 19-74 (median 50 years) after allogeneic hematopoietic cell transplantation by estimating the chimeric recipient/donor DNA ratios through analysis of 15 autosomal short tandem repeat markers. From each individual between one and ...
Teitelbaum Aaron M - - 2012
PURPOSE: The delivery of drugs to the brain is a major obstacle in the design and development of useful treatments for malignant glioma. Previous studies by our laboratory have identified a series of 9-amino acridine compounds that block the catalytic cycle of topoisomerase II resulting in apoptosis and cell death ...
Yau Thomas - - 2012
The combination of bevacizumab (B) and erlotinib (E) has shown promising clinical outcomes as the first-line treatment of advanced HCC patients. We aimed to evaluate the efficacy and safety of using combination of B + E in treating advanced HCC patients who had failed prior sorafenib treatment. Eligible advanced HCC patients with ...
Martorana Alessandro - - 2012
The dysfunction of cholinergic neurons is a typical hallmark in Alzheimer's disease (AD). In animal models of AD, fragments of amyloid beta protein (Aβ) and Tau protein are thought to interfere with central cholinergic transmission, specifically with synthesis and release of acetylcholine. Thus, we aimed to investigate whether the cerebrospinal ...
Chahroudi Ann A Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, - - 2012
Many species of African nonhuman primates are naturally infected with simian immunodeficiency viruses (SIVs) in the wild and in captivity. In contrast to HIV-infected humans, these natural SIV hosts typically do not develop AIDS, despite chronic infection with a highly replicating virus. In this Review, we discuss the most recent ...
Kuang Guanglin - - 2012
Cannabinoid receptor-1 (CB(1)) is widely expressed in the central nervous system and plays a vital role in regulating food intake and energy expenditure. CB(1) antagonists such as Rimonabant have been used in clinic to inhibit food intake, and therefore reduce body weight in obese animals and humans. To investigate the ...
Freeman N J - - 2012
We used data from two troops of free-ranging vervet monkeys (Chlorocebus aethiops) to assess the proposition that the conspicuous chest rubbing observed in this species constitutes scent-marking behavior. Our data indicate that chest-rubbing behavior is associated with higher-ranking males who are more likely to do so during the breeding season ...
Narita Masato - - 2012
BACKGROUND: Indocyanine green (ICG) retention is a validated test of hepatic function in patients with chronic liver disease. The underlying mechanism for the impairment of ICG retention in patients undergoing chemotherapy for colorectal liver metastases (CLM) remains unclear. We sought to elucidate the mechanism for impairment of ICG retention in ...
Dostálek Jiří - - 2012
Dry grasslands are one of the most species rich and endangered types of vegetation in Europe. In the Czech Republic, dry grasslands are mainly of anthropogenic origin and were formed as a result of grazing after the clear-cutting of thermophilous oak woods. Gradual changes in the farming landscape throughout the ...
Amini Ami R - - 2012
Large area or critically sized bone defects pose a serious challenge in orthopaedic surgery, as all current treatment options present with shortcomings. Bone tissue engineering offers a more promising alternative treatment strategy. However, this approach requires mechanically-stable scaffolds that support homogenous bone formation throughout the scaffold thickness. Despite advances in ...
Kikuchi Masahiro - - 2012
BACKGROUND: The purpose of this study was to investigate the possibility of early survival prediction after completion of one cycle of neoadjuvant chemotherapy (NAC) by positron emission tomography (PET)/computed tomography (CT) with (18)F-fluorodeoxyglucose (FDG). METHODS: Fifty-seven patients with advanced head and neck squamous cell carcinoma (HNSCC) underwent FDG-PET/CT scans twice, ...
1 2 3 4 5 6 7 8 9 10 >