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Beaumont David R - - 2012
Abstract Ciclosporin is used to treat severe atopic dermatitis (AD) where conventional therapy is either ineffective or inappropriate. Response to treatment is variable and the factors determining responsiveness are currently unclear. The aim of this study was to determine which children with severe AD are most responsive. A cohort of ...
Dey Bipasha - - 2012
DNA-binding proteins control various cellular processes such as recombination, replication and transcription. This review is aimed to summarize some of the most commonly used techniques to determine DNA-protein interactions. In vitro techniques such as footprinting assays, electrophoretic mobility shift assay, southwestern blotting, yeast one-hybrid assay, phage display and proximity ligation ...
Stepan Jan J - - 2012
The aim of this study was to calculate rates of hospitalization for hip fracture and the incidence of hip fractures in the Czech Republic over a period of 29 years. A second aim was to use the most recent data to populate a FRAX(®) model for the assessment of fracture probability ...
Farges Marie-Chantal - - 2012
Prospective studies have indicated an age-related impairment of the immune response. Carotenoids have been hypothesised to enhance immune cell function. The aim of the present study was to describe the age-related effects and the impact of in vivo dietary carotenoid depletion and repletion on specific and non-specific immunity. A total ...
Reuter Gábor - - 2012
The family Astroviridae consists of two genera, Avastrovirus and Mamastrovirus whose members are associated with gastroenteritis in avian and mammalian hosts, respectively. In this study, we report the first detection of astrovirus from fecal specimens of wild boars (Sus scrofa) using viral metagenomics and complete genome sequencing. The wild boar ...
Touchefeu Y - - 2012
Radiovirotherapy is defined as the use of viruses to deliver radioisotopic treatment into infected cells. Oncolytic viruses are able to selectively target and kill cancer cells. The combination of oncolytic viruses and radiation therapies can have synergistic antitumour properties. Viruses may act as radiosensitizers, and radiations can increase viral oncolytic ...
Paize Fauzia - - 2012
The sublingual microcirculation can be visualised in real time using sidestream dark-field (SDF) imaging. Endothelial activation mediated through adhesion molecules may alter flow patterns in the microcirculation. We studied sublingual microcirculatory disturbances in children with meningococcal disease (MCD) and simultaneously measured plasma levels of adhesion molecules. Twenty children admitted to ...
Holman N - - 2012
The study aimed to explore the variation in recorded incidence of lower limb amputation in England. The incidences of amputations in adults with and without diabetes were determined from hospital episode statistics over 3 years to 31 March 2010 and compared between the 151 Primary Care Trusts (PCTs) in England. ...
Faber Mette T - - 2012
Background. A number of epidemiological studies have examined the association between use of dairy products and risk of ovarian cancer, but results are conflicting. Using data from a large Danish population-based case-control study we here further examined the association between dairy consumption, lactose, and calcium and risk of overall ovarian ...
Saito Nozomi - - 2012
Ruthenium-catalyzed cyclization of 1,6-allenynes occurs via the addition of heteroatom nucleophiles to ruthenacyclopentenes, providing functionalized 1,2-bisalkylidenecyclopentanes in a highly regio- and stereoselective manner.
Cao Guoxin - - 2012
The effect of the nucleus on the cell mechanical behavior was investigated based on the dynamic indentation response of cells under a spherical tip. A "two-component" cell model (including cytoplasm and nucleus) is used, and the dynamic indentation behavior is studied by a semiempirical method, which is established based on ...
Mahesh Kumar Palanisamy - - 2012
The present study was carried out on Solanum xanthocarpum fruit extract and copepods Mesocyclops thermocyclopoides, which were assessed for the control of dengue vector, Aedes aegypti, under laboratory conditions. The medicinal plants were collected from the outskirts of Bharathiar University, Coimbatore, Tamil Nadu, India. The shade-dried fruit materials were extracted ...
Valverde Israel - - 2012
A 2-year-old boy with hypoplastic left heart syndrome and previous hemi-Fontan palliation surgery was referred for cardiovascular magnetic resonance evaluation because of progressive cyanosis. This case report illustrates the advantages of non-invasive four-dimensional magnetic resonance imaging for comprehensive identification and quantification of venovenous collaterals in patients with palliated hemi-Fontan staged ...
Nabika Toru - - 2012
The stroke-prone spontaneously hypertensive rat (SHRSP) is a unique genetic model of severe hypertension and cerebral stroke. SHRSP, as well as the spontaneously hypertensive rat, the parental strain of SHRSP, has made a tremendous contribution to cardiovascular research. However, the genetic mechanisms underlying hypertension and stroke in these rats have ...
Suschinsky Kelly D - - 2012
Sexual concordance refers to the degree to which two aspects of human sexual arousal (genital response and self-reported sexual arousal) correspond with each other. Researchers have consistently reported a sex difference in sexual concordance: The relationship between genital responses and reported feelings of sexual arousal in men is positive and ...
Li Chunguang - - 2012
Water-dispersible Re(3+) doped CeF(3) colloidal nanocrystals with well controllable morphology and high crystallinity have been successfully synthesized through a solvothermal process. The TEM images illustrate that the Re(3+) doped CeF(3) nanocrystals are rectangular (or cubic) with a mean diameter of ∼10 nm. The excellent dispersibility in some of the polar ...
Shen Yang - - 2012
We developed a method to fabricate an array of silver non-planar nano-arc-gaps via inverted hemispherical colloidal lithography and shadow metal evaporation methods. It is found that there is a localized surface plasmon mode which results in extraordinary optical transmission. The electric field is strongly localized at the nano-arc-gap region and ...
Gerlinger Marco M Cancer Research UK London Research Institute, London, United - - 2012
Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites. We characterized ...
Wang Ruitao - - 2012
Huntington's disease (HD) is a hereditary neurodegenerative disorder resulting from the expansion of a polyglutamine tract in the huntingtin protein. The expansion of cytosine-adenine-guanine repeats results in neuronal loss in the striatum and cortex. Mutant huntingtin (HTT) may cause toxicity via a range of different mechanisms. Recent studies indicate that ...
Saponaro Concetta - - 2012
Upregulation of inflammatory responses in the brain is associated with a number of neurodegenerative diseases. Microglia are activated in neurodegenerative diseases, producing pro-inflammatory mediators. Critically, lipopolysaccharide (LPS)-induced microglial activation causes dopaminergic neurodegeneration in vitro and in vivo. The signaling mechanisms triggered by LPS to stimulate the release of pro-inflammatory mediators ...
Jongjaroenprasert Wallaya - - 2012
Several lines of evidence have pointed out that genetic components have roles in thyrotoxic hypokalemic periodic paralysis (TTPP). In this study, for the first time we performed genome-wide association study (GWAS) in male hyperthyroid subjects in order to identify genetic loci conferring susceptibility to TTPP. We genotyped 78 Thai male ...
Banerjee Sambuddha - - 2012
Neisseria gonorrhoeae is an obligate pathogen that hijacks iron from the human iron transport protein, holo-transferrin (Fe(2)-Tf), by expressing TonB-dependent outer membrane receptor proteins, TbpA and TbpB. Homologous to other TonB-dependent outer membrane transporters, TbpA is thought to consist of a β-barrel with an N-terminal plug domain. Previous reports by ...
Rix Thomas Andersen - - 2012
Abstract Objectives: To assess the validity of the diagnoses of atrial fibrillation (AF) and atrial flutter (AFL) for men and women recorded in the Danish National Patient Registry, and to assess the relative distribution of AF and AFL. Design: Review of medical records for incident cases of AF and/or AFL ...
Sun Ye - - 2012
Michelia maudiae Dunn. is a Magnoliaceae species threatened by habitat destruction and over-exploitation. Genetic diversity and differentiation, population contribution to total diversity and allelic/haplotypic richness, and the relative importance of pollen- and seed-mediated gene flow were investigated in nine populations (192 individuals) of M. maudiae using nuclear and chloroplast microsatellites ...
Bille Marie-Louise Bastholm - - 2012
Abstract Objective. Root resorption, impaired tooth eruption and early tooth loss have been described in relation to diseases that involve defects in the RANK-RANKL-OPG-expression. The aim of the present immunhistochemical study was to localize and compare the reactions for RANK and membrane-bound RANKL along root surfaces and in the periodontal ...
Peddireddy Vidyullatha - - 2012
Objective: The present investigation was taken up to evaluate the 8-oxo-7,8-dihydro-2'-deoxyguanosine and malondialdehyde as markers of oxidative stress, the levels of antioxidants and the correlations between these oxidative stress markers and antioxidants in lung cancer patients. Methods: The study included 222 patients (158 men and 64 women, age ranging from ...
Albiin Nils N Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Medical Imaging and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. - - 2012
To evaluate the efficacy of three dose levels of the oral hepatobiliary manganese-based magnetic resonance imaging (MRI) contrast agent CMC-001, and assess its safety profile and patient acceptability. After ethics committee approval, 32 healthy volunteers (males/females: 18/14) were included. Liver MRI was performed before and 3 h after ingestion of ...
Helldén A - - 2012
PURPOSE: The influence of the cytochrome P450 enzyme CYP2D6 in the metabolism of the novel dopaminergic stabilizer pridopidine was investigated in healthy Swedish Caucasians. METHODS: Six extensive metabolizers (EM) and six poor metabolizers (PM) of debrisoquine were given a single oral dose of pridopidine (EM, 50 mg; PM, 25 mg). RESULTS: The ...
Miyake Hiroyuki - - 2012
A diastereomer pair of left- and right-handed square planar Pd(ii) complexes was synthesized from a single chiral ligand as kinetic and thermodynamic products. Helicity inversion between the diastereomers occurred rapidly under thermal and microwave irradiation conditions.
Chan Symphorosa Shing Chee - - 2012
INTRODUCTION AND HYPOTHESIS: We performed an investigation of symptoms, quality of life (QOL), and factors affecting women's treatment choice of pelvic organ prolapse (POP). METHODS: Three hundred and eight women presenting with POP were assessed by Pelvic Floor Distress Inventory (PFDI), Pelvic Floor Impact Questionnaire (PFIQ), Short Form-36 (SF-36), Pelvic ...
Zhang Liping - - 2012
Yak metallothioneins (BgMTs) are cysteine-rich metal-chelating proteins with highly conserved cysteine residues in their amino acid sequences. The 3D structures of the Cd(7)-BgMTs reconstructed by molecular modeling included two domains: the β-domain with M(3)(S(cys))(9) metal-thiolate clusters and the α-domain with M(4)(S(cys))(11) metal-thiolate clusters. An unusual variant was found at position ...
Louriz Maha - - 2012
PURPOSE: To report determinants and outcomes associated with decisions to deny or to delay intensive care unit (ICU) admission in critically ill patients. METHODS: An observational prospective study over a 6-month period. All adult patients triaged for admission to a medical ICU were included prospectively. Age, gender, reasons for requesting ...
Bentham James R - - 2012
OBJECTIVE: To describe endovascular stent placement using partially covered stents to preserve flow in head and neck vessels. BACKGROUND: Endovascular stent placement has become established as a first-line therapy for native coarctation of the aorta or re-coarctation in older children and adults. Increasingly covered stents are becoming the preferred option ...
Sattar N - - 2012
This commentary aims to move the debate regarding the adoption of HbA(1c) for diagnosis of type 2 diabetes forwards by highlighting the need to avoid addressing irrelevant questions, in particular, comparison of individuals diagnosed with different diagnostic criteria. Instead, we provide a list of important future questions, including whether adoption ...
Zhang Cui - - 2012
Abstract Objective. The objective of this study was to determine the effect of laminarin on the expression of kidney endoplasmic reticulum molecular chaperones (GRP78 and GRP94) in rats with renal interstitial fibrosis. Material and methods. A renal interstitial fibrosis model in rats was developed by unilateral ureteral obstruction (UUO). Rats ...
Yokokawa Miki - - 2012
BACKGROUND: Advancing age is a strong risk factor for the development of atrial fibrillation (AF). However, its impact on the left atrial (LA) substrate in patients is not well defined. METHODS: Forty-seven patients underwent catheter ablation of persistent AF. Bipolar electrograms from the LA were recorded for voltage analysis. The ...
Marangoz Abdullah Hilmi - - 2012
The aim of this study was to investigate the interaction between nitric oxide (NO) and acetylcholine (ACh) in penicillin-induced experimental epilepsy. Adult male Wistar rats weighing 220 ± 35 g were used in the experiments. The epileptiform activity was induced by microinjection of penicillin (200 IU/1 μl) into the left sensorymotor cortex. Electrocorticogram was recorded ...
Silveira Paulo Cesar Lock - - 2012
It has been demonstrated that reactive oxygen species (ROS) formation and oxidative damage markers are increased after muscle damage. Recent studies have demonstrated that low-level laser therapy (LLLT) modulates many biochemical processes mainly those related to reduction of muscular injures, increment of mitochondrial respiration and ATP synthesis, as well as ...
Lazarevic Bato - - 2012
Nutritionally relevant levels of genistein, the predominant isoflavone in soyabean associated with lower risk of prostate cancer (PCa), may modulate the expression of prostate tissue biomarkers associated with cancer prediction and progression. A phase 2 placebo-controlled, randomised, double-blind clinical trial was conducted in forty-seven Norwegian patients before prostatectomy. Intervention was ...
Hwang Ki-Eun - - 2012
Although tuberculosis can affect various organs and tissues, the lung is the site most commonly involved. Extrapulmonary tuberculosis (EPTB) involves relatively inaccessible and variable sites and is consequently often overlooked by clinicians. The ear is a notably very rare site of EPTB, and the diagnosis is difficult because of the ...
Breitwieser Christian - - 2012
Steady-state somatosensory evoked potentials (SSSEPs) have been elicited applying vibro-tactile stimulation to all fingertips of the right hand. Nine healthy subjects participated in two sessions within this study. All fingers were stimulated 40 times with a 200-Hz carrier frequency modulated with a rectangular signal. The frequencies of the rectangular signal ...
Young Laura K - - 2012
Protein Z-dependent protease inhibitor (ZPI) is a plasma inhibitor of factor (F)Xa and FXIa. In an earlier study, five mutations were identified within the ZPI gene of venous thrombosis patients and healthy controls. Two of these were nonsense mutations and three were missense mutations in important regions of the protein. ...
Reichert Elena - - 2012
Lignin is a component of lignocellulosic biomass and a promising matrix for recovering important renewable aromatic compounds. We present a new approach of electro-oxidative cleavage of lignin, dissolved in a special protic ionic liquid, using an anode with particular electro-catalytic activity. As appropriate ionic liquid triethylammonium methanesulfonate was identified, synthesised, ...
Arai Ryoichi - - 2012
To probe the potential for activity in unevolved amino acid sequence space, we created a 3rd generation combinatorial library of de novo 4-helix bundle proteins. The "artificial superfamily" of helical bundles was designed using binary patterning of polar and nonpolar residues, and expressed in Escherichia coli from a library of ...
Sun Nian-Kang - - 2012
In the present study, we observed that the Golgi-SNARE GS28 forms a complex with p53 in HEK293 cells. Given that p53 represents a tumor suppressor involved in sensitivity to various chemotherapeutic drugs, we examined whether GS28 may be implicated in resistance to the DNA-damaging drug cisplatin, whereas no sensitization effect ...
Postow Michael A MA Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, - - 2012
The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, ...
Zhou Ming - - 2012
The integration of a biosensor employing a DNAzyme logic system within a biofuel cell is presented. The self-powered DNAzyme logic biosensor conforms with INH logic operation and generates power output in accordance with a truth table. The new concept of logic-activated DNAzyme by the input signals has wide-ranging implications in ...
Chung Christopher P - - 2012
INTRODUCTION AND HYPOTHESIS: We assessed the incidence of and risk factors for developing urinary tract infection (UTI) after uterosacral ligament suspension (USLS). METHODS: Retrospective analysis of patients undergoing USLS in 2008-2009 was performed. Postoperative UTI was defined as a positive urine culture within 1 month following surgery. Factors analyzed were ...
Evans Rachel C - - 2012
The synthesis of photoluminescent conjugated polymer silica ionogels using sol-gel chemistry is described. Cooperative self-assembly of an ionic liquid, the silica precursor and poly(9,9-dioctylfluorene) (PFO) via hydrogen bonding and π-stacking interactions drives formation of the PFO β-phase.
Seung Ong Ping - - 2012
Tuberculosis (TB) remains a global burden despite extensive efforts to control it. TB arthritis commonly manifest as monoarthritis of weight-bearing joints. We report a rare presentation of osteoarticular TB involving multiple small joints of the hands, which mimicked rheumatoid arthritis (RA). Magnetic resonance imaging showed tenosynovitis. The patient was initially ...
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