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Miraglia Roberto - - 2012
The present paper describes the first reported successful use of a single session of percutaneous alcohol sclerotherapy for the treatment of an excluded segmental biliary duct in a fivemonth-old left lateral liver recipient. A concomitant stricture of the hepaticojejunostomy was also successfully treated using standard percutaneous balloon dilatation. The patient ...
Li Ziyuan - - 2012
The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance.
Kato Tatsuya - - 2012
Abstract We examined the genotoxic effects of multi-walled carbon nanotubes (MWCNTs) using in vitro and in vivo assays. MWCNTs significantly induced micronuclei in A549 cells and enhanced the frequency of sister chromatid exchange (SCE) in CHO AA8 cells. When ICR mice were intratracheally instilled with a single dose (0.05 or ...
Schnute Mark E - - 2012
Sphingosine kinase is the major source of the bioactive lipid and GPCR agonist sphingosine-1-phosphate (S1P). S1P promotes cell growth, survival and migration and is a key regulator of lymphocyte trafficking. Inhibition of S1P signaling has been proposed as a strategy for treatment of inflammatory diseases and cancer. Here we describe ...
Niegel Claudia - - 2012
Fast capillary electrophoresis (CE) hyphenated to time-of-flight mass spectrometry (TOF-MS) of four organoarsenic species (glycerol oxoarsenosugar, sulfate oxoarsenosugar, arsenobetaine, arsenocholine) are presented using short length CE capillaries under high electric field strengths of up to 1.3 kV cm(-1) with small inner diameter (ID). The separation of arsenosugars by CE is demonstrated ...
Tsujimoto Hironori - - 2012
BACKGROUND: Recently, novel intracorporeal esophagojejunostomy using a linear stapler after laparoscopic total gastrectomy (LTG) was reported and termed as the overlap method. In this study, we evaluated the feasibility and safety of the overlap method for esophagojejunostomy or esophagogastrostomy after LTG or laparoscopic proximal gastrectomy (LPG), respectively. METHODS: Twenty-five patients ...
Bird J E - - 2012
Plasma kallikrein is a multifunctional serine protease involved in contact activation of coagulation. Deficiency in humans is characterised by prolonged activated partial thromboplastin time (aPTT); however, the balance between thrombosis and haemostasis is not fully understood. A study of plasma kallikrein-deficient mice revealed increased aPTT, without prolonged bleeding time. Prekallikrein ...
Geula Shay - - 2012
Structural studies place the VDAC N-terminal region within the channel pore. Biochemical and functional studies, however, reveal that the N-terminal domain is cytoplasmically exposed. Here, the location and translocation of the VDAC1 N-terminal domain, and its role in voltage-gating and as a target for anti-apoptotic proteins, were addressed. Site-directed mutagenesis ...
Fan Meikun - - 2012
The fabrication and on-chip integration of surface-enhanced Raman scattering (SERS) optrodes are presented. In the optrode configuration, both the laser excitation and the back-scattered Raman signal are transmitted through the same optical fiber. The SERS-active component of the optrode was fabricated through the self-assembly of silver nanoparticles on the tip ...
Cho Yool - - 2012
INTRODUCTION: Over time, the need for anatomic anterior cruciate ligament (ACL) to restore normal kinematics and postoperative function of the knee has been accepted. The purpose of this study was to compare the sagittal alignment of reconstructed ACL, which is performed between transtibial (TT) technique and accessory anteromedial (AAM) portal ...
Kranaster Laura - - 2012
Objectives. Electroconvulsive therapy (ECT) is an effective and safe option in the treatment of affective disorders and schizophrenia. One parameter known to influence ECT treatment efficacy is the choice of narcotic, and ketamine has emerged as an interesting alternative to conventional anaesthetics like barbiturates since it does not negatively influence ...
Cui Kai - - 2012
In natural conditions, culms of developing Moso bamboo, <i>Phyllostachys heterocycla</i> var. <i>pubescens</i>, reach their final height of more than ten meters within a short period of two to four months. To study this phenomenon, bamboo culm material collected from different developmental stages and internodes was analyzed. Histological observations indicated that ...
Kulathunga D G R S - - 2012
Arginine kinase (AK) is a member of the phosphagen kinase family. AK plays a major role in cellular energy metabolism in invertebrates including nematodes. In the present study, we performed the direct immunofluorescence test to determine the immunolocalization of AK in different stages of the life cycle (eggs, larvae, and ...
Chen Yan - - 2012
A polycation-selective polymeric membrane electrode using dinonylnaphthalene sulfonate as an ion exchanger has been developed as a protamine controlled-release system for potentiometric detection of heparin. The incorporation of tetradodecylammonium tetrakis(4-chlorophenyl)borate as a lipophilic salt in the membrane dramatically improves the sensor's selectivity towards protamine over sodium ions via influencing the ...
Turpeinen Anu M - - 2012
Lifestyle intervention is recommended as the primary treatment for mild hypertension and hypercholesterolemia. We studied the effects of a spread containing bioactive milk peptides IPP and VPP, as well as plant sterols, on cardiovascular risk factors in 104 hypertensive, hypercholesterolemic subjects in a randomised, placebo-controlled double-blind intervention. Middle-aged subjects consumed ...
Shi-Yi Liu - - 2012
PURPOSE: To evaluate retrospectively the incidence, predictive factors, and management of acute pancreatitis which develops following placement of duodenal stents in patients with malignant gastroduodenal obstruction. MATERIALS AND METHODS: Among 242 patients with symptomatic malignant gastroduodenal obstruction successfully treated with duodenal stent placement, acute pancreatitis occurred in 10 patients (4.1%) ...
Beaumont David R - - 2012
Abstract Ciclosporin is used to treat severe atopic dermatitis (AD) where conventional therapy is either ineffective or inappropriate. Response to treatment is variable and the factors determining responsiveness are currently unclear. The aim of this study was to determine which children with severe AD are most responsive. A cohort of ...
Dey Bipasha - - 2012
DNA-binding proteins control various cellular processes such as recombination, replication and transcription. This review is aimed to summarize some of the most commonly used techniques to determine DNA-protein interactions. In vitro techniques such as footprinting assays, electrophoretic mobility shift assay, southwestern blotting, yeast one-hybrid assay, phage display and proximity ligation ...
Kitai Ryuhei - - 2012
The aims of this study were to determine the diagnostic utility of the serum levels of the soluble interleukin 2 receptor (sIL-2R) as a tumor marker of primary central nervous system lymphoma (PCNSL) and to investigate the cellular source of sIL-2R using immunohistochemical staining. The serum sIL-2R levels of 37 ...
Das Gunajyoti - - 2012
Codon degeneracy is a key feature of the genetic code, explained by Crick (J Mol Biol 19:548-555, 1966) in terms of imprecision of base pairing at the codon third position (the wobble position) of the codon-anticodon duplex. The Crick wobble rules define, but do not explain, which base pairs are ...
Sciacca Beniamino - - 2012
A nanostructured porous silicon chip functionalized with dichlorofluorescein is employed as a nanoreactor to respond to Reactive Oxygen Species (ROS) and to real-time studying redox reactions.
Bensaci J - - 2012
Enterocyte is one of the main sites of amino acids metabolism and particularly of the citrulline biosynthesis. Working at the cellular scale and applying ordinary differential equations (ODEs) formalism, we have built a mathematical model of the enterocytic glutamine to citrulline conversion in the fasting state. This model enables us ...
Nordlund Marianne S - - 2012
Progastrin-releasing peptide (proGRP) is a promising serum tumor marker for small cell lung cancer (SCLC). We have tested assay specificity and performed a correlation study between a recently developed time-resolved immunofluorometric assay (TR-IFMA) for proGRP and the established Advanced Life Science Institute (ALSI) ELISA method. Between-method correlation and comparison of ...
Howells Fleur M - - 2012
A certain level of arousal is required for an individual to perform optimally, and the locus coeruleus norepinephrine (LC-NE) system plays a central role in optimizing arousal. Tonic firing of LC-NE neurons needs to be held within a narrow range of 1-3 Hz to facilitate phasic firing of the LC-NE neurons; ...
Piff Paul K - - 2012
How do extreme degrees of positive emotion-such as those characteristic of mania-influence emotion perception? The present study investigated how mania proneness, assessed using the Hypomanic Personality Scale, influences the perception of emotion via touch. Using a validated dyadic interaction paradigm for communicating emotion through touch (Hertenstein, Keltner, App, Bulleit, & ...
Soylu Fatma Nur - - 2012
Accurate local staging of prostate cancer is essential for patient management decisions. Conventional and evolving magnetic resonance imaging (MRI) techniques, such as diffusion-weighted imaging, dynamic contrast-enhanced MRI, and MR spectroscopy, are promising techniques in prostate cancer imaging. In this article, we will review the current applications of conventional and advanced ...
Basen Timo - - 2012
The accumulation of cyanobacterial biomass may severely affect the performance of aquatic consumers. Here, we investigated the role of sterols in determining the food quality of cyanobacteria for the invasive clam Corbicula fluminea, which has become a common benthic invertebrate in many freshwater ecosystems throughout the world. In standardized growth ...
Cetin Emel Oyku - - 2012
The Eudragit RL 100 and propylene glycol (PG) membranes with and without cholesteryl oleyl carbonate (COC) were prepared by the solvent casting method to pioneer a novel application of a thermo-sensitive drug delivery system. After that, the properties of these membranes were investigated by thermal, scanning, and porosity studies. Drug ...
McCanlies Erin C - - 2012
Both self-report and industrial hygienist (IH) assessed parental occupational information were used in this pilot study in which 174 families (93 children with ASD and 81 unaffected children) enrolled in the Childhood Autism Risks from Genetics and Environment study participated. IH results indicated exposures to lacquer, varnish, and xylene occurred ...
Ruiz-Casares Mónica - - 2012
Access to health care for undocumented migrant children and pregnant women confronts human rights and professional values with political and institutional regulations that limit services. In order to understand how health care professionals deal with these diverging mandates, we assessed their attitudes toward providing care to this population. Clinicians, administrators, ...
Gupta Richa - - 2012
Type II restriction endonucleases (REs) are highly sequence-specific compared with other classes of nucleases. PD-(D/E)XK nucleases, initially represented by only type II REs, now comprise a large and extremely diverse superfamily of proteins and, although sharing a structurally conserved core, typically display little or no detectable sequence similarity except for ...
Galdiero Stefania - - 2012
Glycoprotein H (gH) of the herpes simplex virus type 1 is involved in the complex mechanism of membrane fusion of the viral envelope with host cells. The virus requires four glycoproteins (gB, gD, gH, gL) to execute fusion and the role played by gH remains mysterious. Mutational studies have revealed ...
Baumert Jens - - 2012
Elevated fibrinogen levels are strongly and consistently associated with incident coronary heart disease (CHD). A possible causal contribution of fibrinogen in the pathway leading to atherothrombotic cardiovascular disease complications has been suggested. However, for implementation in clinical practice, data on validity and reliability, which are still scarce, are needed that ...
Li Yulin - - 2012
Discrete DNA decorations of Pt nanoparticles (PtNPs) are realized for the first time, which provide a valence control over the quasi-molecular self-assembly of Au-Pt bimetallic heteronanostructures with DNA as the guide.
Steinberg Anna - - 2012
Nitric oxide (NO) is an important molecule in headache pathophysiology. NO regulates vascular tone and acts as a potent vasodilator, and thus participates in regulating blood flow. NO is also considered to play a role in processing sensory information and pain sensitization. In this article, we review the role of ...
Ling Irene - - 2012
Imidazolium functionalized carboxylic acid forms a multi-component material with p-sulfonatocalix[4]arene and aquated lanthanide ions, stabilising dinuclear metal complexes for Y(3+) and Gd(3+). These have the simplest binding of two bridging carboxylates between the two metal centres (Y(3+)), or the same arrangement along with the simplest binding of one carboxylate bridging ...
Roberts Christine C - - 2012
A thin flow-focusing microfluidic channel is evaluated for generating monodisperse liquid droplets. The microfluidic device is used in its native state, which is hydrophilic, or treated with OTS to make it hydrophobic. Having both hydrophilic and hydrophobic surfaces allows for creation of both oil-in-water and water-in-oil emulsions, facilitating a large ...
Kim Jane S - - 2012
Contrast-enhanced magnetic resonance angiography (MRA) using time-resolved imaging is a relatively new and increasingly popular technique. We will describe the technique utilized at our institution, Time-Resolved Imaging of Contrast Kinetics (TRICKS; GE Healthcare, Milwaukee, WI), and the parameters that can be adjusted to optimize the exam. We will review key ...
Krause-Utz A - - 2012
BACKGROUND: Emotion dysregulation, characterized by heightened emotional arousal and increased emotional sensitivity, is a core feature of borderline personality disorder (BPD). Although current theories emphasize the disruptive potential of negative emotions on cognitive functioning in BPD, behavioral and neurobiological data on this relationship are still lacking.MethodUsing functional magnetic resonance imaging ...
Kuller Lewis H - - 2012
Excess total and cardiovascular morbidity and mortality remain very high among those with type 2 diabetes versus those without diabetes. Clinical trials to lower blood glucose have been disappointing probably because the participants were too late in the natural history of diabetes and already had extensive vascular disease. Insulin resistance ...
Marcus Stuart G - - 2012
The Patient Protection and Affordable Care Act signed into law in March 2010, has led to sweeping changes to the US health care system. The ensuing pace of change in health care regulation is unparalleled and difficult for physicians to keep up with. Because of the extraordinary challenges that have ...
Ramm Olga - - 2012
INTRODUCTION AND HYPOTHESIS: Uterine morcellation during laparoscopy for pelvic floor repair has prompted adoption of uterine screening tests by some surgeons. We report a case series of uterine malignancy incidentally diagnosed at the time of pelvic floor surgery. METHODS: We reviewed records from patients undergoing hysterectomy for pelvic organ prolapse ...
Norvilitis Jill M - - 2012
Although there is growing concern about the issue of credit card debt among college students in China, little research has examined attitudes to money and debt among that group. The present study compared financial self-confidence, perceived financial wellbeing, attitudes to debt, and parent education about money and debt in 410 ...
Abbassian A H - - 2012
We introduce a modified-firing-rate model based on Hebbian-type changing synaptic connections. The existence and stability of solutions such as rest state, bumps, and traveling waves are shown for this type of model. Three types of kernels, namely exponential, Mexican hat, and periodic synaptic connections, are considered. In the former two ...
Furuichi Kengo - - 2012
BACKGROUND: Acute kidney injury (AKI) is a critical condition for kidney and other remote organs, including the lung. However, available treatments for AKI are limited. In this study, we explored the effect of adipose-derived mesenchymal cells on a mouse model of AKI. METHODS: Adipose-derived mesenchymal cells were isolated from mouse ...
van Rappard Dominique C - - 2012
Abstract To provide an overview of the current evidence regarding off-label treatment of hidradenitis suppurativa with TNF-alpha inhibitors, a systematic search was performed in MEDLINE, EMBASE, and CENTRAL. Any type of original article concerning hidradenitis suppurativa patients treated with infliximab, etanercept and/or adalimumab was included. No language restriction was applied. ...
Mazloum-Ardakani Mohammad - - 2012
A novel carbon paste electrode modified with nanosized mesoporous MCM-41 was prepared, and used as an electrochemical sensor to study the electro oxidation of levodopa (LD), carbidopa (CD) and their mixtures. Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of LD and CD has been explored at ...
Ichimura Koichi - - 2012
The isocitrate dehydrogenase 1 (IDH1) or 2 (IDH2) genes are mutated in 50-80% of astrocytomas, oligodendrogliomas or oligoastrocytomas of grades II and III, and secondary glioblastomas; they are, however, seldom mutated in primary glioblastomas and never in other types of glioma. Gliomas with IDH1/2 mutations always harbor either TP53 mutations ...
Glöckler Martin - - 2012
OBJECTIVES: To investigate the impact of flat-detector computed tomography on the clinical assessment of patients with cavopulmonary connections, and to evaluate the obtained diagnostic accuracy and supplementary information, as well as the value of overlaid three-dimensional reconstructions on fluoroscopic images during catheter-based interventions. METHODS: We analysed 31 consecutive patients retrospectively ...
Cheng Claudia - - 2012
INTRODUCTION AND HYPOTHESIS: This study assesses the prevalence of interstitial cystitis (IC)/bladder pain syndrome (BPS) in women with chronic pelvic pain (CPP). METHODS: This was a prospective study of 150 women undergoing laparoscopy as investigation for CPP in an Endometriosis and Pelvic Pain unit. Preoperative questionnaires [demographic details, pelvic pain ...
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