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Pifferi F - - 2012
Converging evidence shows that the non-human primate gray mouse lemur (Microcebus murinus) is ideal for the study of the aging process and for testing the effects of new therapies and dietary interventions on age-associated pathologies. One such dietary supplement is resveratrol (RSV), a dietary polyphenolic compound with several positive effects ...
Zhou Yufeng - - 2012
This study investigated the characteristics of the secondary bubble cluster produced by an electrohydraulic lithotripter using high-speed imaging and passive cavitation detection techniques. The results showed that (i) the discrepancy of the collapse time between near a flat rigid boundary and in a free field of the secondary bubble cluster ...
Wahner-Roedler Dietlind L - - 2012
To report our findings from a prospective pilot study evaluating the accuracy of molecular breast imaging (MBI) in assessing tumor response to neoadjuvant therapy (NT) for breast cancer. Twenty patients with newly diagnosed invasive breast cancer who were scheduled to receive NT underwent MBI before beginning and after completing NT ...
Choo Esther K - - 2012
There is little information about which intimate partner violence (IPV) policies and services assist in the identification of IPV in the emergency department (ED). The objective of this study was to examine the association between a variety of resources and documented IPV diagnoses. Using billing data assembled from 21 Oregon ...
Green Geoff - - 2012
The article reviews the evolution and process of city health development planning (CHDP) in municipalities participating in the European Network of Healthy Cities organized by the European Region of the World Health Organization. The concept of CHDP combines elements from three theoretical domains: (a) health development, (b) city governance, and ...
Coffin Phillip O - - 2012
Injection drug use (IDU) into central veins, most common among long-term IDUs with no other options, can lead to severe infectious, vascular, and traumatic medical consequences. To follow-up on anecdotal reports of femoral vein injection and related medical problems in Seattle, we analyzed data from the annual survey of a ...
Cooper Philip J PJ Centro de Investigaciones FEPIS, Quinindé, Esmeraldas Province, Ecuador. - - 2012
Asthma in Latin America is a growing public health problem and seems to be most prevalent and cause most morbidity among poor urban populations. This article will review the findings of recent human studies of the associations of asthma prevalence in Latin America with factors associated with poverty and inequality ...
Chavez Juan D - - 2012
Protein interactions are critical determinants of insect transmission for viruses in the family Luteoviridae. Two luteovirid structural proteins, the capsid protein (CP) and the readthrough protein (RTP), contain multiple functional domains that regulate virus transmission. There is no structural information available for these economically important viruses. We used Protein Interaction ...
Zhang Yalong - - 2012
Glycopeptides are extremely useful for basic research and clinical applications, but access to structurally defined glycopeptides is limited by the difficulties in synthesizing this class of compounds. In this study, we demonstrate that many common peptide coupling conditions used to prepare O-linked glycopeptides result in substantial amounts of epimerization at ...
Yonemoto Isaac T - - 2012
Pursuit of the actinomycete pyrrolobenzodiazepine natural product sibiromycin as a chemotherapeutic agent has been limited by its cardiotoxicity. Among pyrrolobenzodiazepines, cardiotoxicity is associated with hydroxylation at position 9. Deletion of the methyltransferase gene sibL abolishes the production of sibiromycin. Supplementation of growth media with 4-methylanthranilic acid can substitute for its ...
Braun Doris E - - 2012
Hydrate formation is of great importance as the inclusion of water molecules affects many solid state properties and hence determines the required chemical processing, handling, and storage. Phloroglucinol is industrially important, and the observed differences in the morphology and diffuse scattering effects with growth conditions have been scientifically controversial. We ...
Foster Matthew W - - 2012
The S-nitrosoglutathione-metabolizing enzyme, GSNO reductase (GSNOR), has emerged as an important regulator of protein S-nitrosylation. GSNOR ablation is protective in models of asthma and heart failure, raising the idea that GSNOR inhibitors might hold therapeutic value. Here, we investigated the effects of a small molecule inhibitor of GSNOR (GSNORi) in ...
Goldstein Rebecca - - 2012
Staphylococcus aureus secretes a phosphatidylinositol-specific phospholipase C (PI-PLC) as a virulence factor that is unusual in exhibiting higher activity at acidic pH values than other enzymes in this class. We have determined the crystal structure of this enzyme at pH 4.6 and pH 7.5. Under slightly basic conditions, the S. ...
Takáts Alajos - - 2012
Raynaud's phenomenon is characterized by intense vasospasm of the digital arteries on cold exposure or emotional stress, leading to well-defined colour changes in the skin of the fingers. Behind the clinical manifestations, there is an imbalance between vasoconstrictor and vasodilator factors. It may be primary or secondary to an underlying ...
Ramadan Kristijan - - 2012
RNF8/RNF168-dependent Lys63- linked polyubiquitination at sites of DNA double-strand breaks (DSBs) was originally regarded as the sole ubiquitin-signaling pathway involved in the DNA damage response (DDR). However, ubiquitin-dependent p97/VCP segregase activity and RNF8-dependent Lys48-linked polyubiquitin chains at DSB sites have recently been identified as components of an additional and parallel ...
Blazek Dalibor - - 2012
Comment on: Blazek D, et al. Genes Dev 2011; 25:2158-72.
Varanasi Lakshman - - 2012
The E2F family of transcription factors responds to a variety of intracellular and extracellular signals and, as such, are key regulators of cell growth, differentiation and cell death. The cellular response to DNA damage is a multistep process generally involving the initial detection of DNA damage, propagation of signals via ...
Sal István - - 2012
Being aware of the worldwide spread of diabetes and obesity as well as its economic effects, the authors discuss the complex, behavior remediational methods of the treatment and its current questions. They ephasize the role of chronic stress in the etiopatogenesis of insulin resistance, metabolic syndrome, and type 2 diabetes. ...
Shin Sejeong - - 2012
Comment on: Shin S, et al. Proc Natl Acad Sci USA 2011; 108:1204-13.
Zhang Shi-Meng - - 2012
HIV-1 Tat triggers intrinsic and extrinsic apoptosis pathways in both infected and uninfected cells and plays an important role in the pathogenesis of AIDS. Knocking down Tip60, an interactive protein of Tat, leads to the impairment of cell cycle progression, indicating a key role of Tip60 in cell cycle control. ...
Lampé Rudolf - - 2012
Data on respiratory burst activity of granulocytes from healthy and preeclamptic pregnant women are contradictory. To further investigate a possible role of reactive oxygen species in the etiology of preeclampsia, the induced superoxide-anion generation by granulocytes from non-pregnant, healthy pregnant and preeclamptic pregnant women were measured. The reciprocal effects of ...
Jopling Chris - - 2012
Although adult mammals are unable to significantly regenerate their heart, this is not the case for a number of other vertebrate species. In particular, zebrafish are able to fully regenerate their heart following amputation of up to 20% of the ventricle. Soon after amputation, cardiomyocytes dedifferentiate and proliferate to regenerate ...
Kumar Sanjay - - 2012
TopBP1 is critical for both DNA replication and checkpoint regulation in vertebrate cells. In this study, we have identified Rif1 as a binding partner of TopBP1 in Xenopus egg extracts. In addition, Rif1 also interacts with both ATM and the Mre11-Rad50-Nbs1 (MRN) complex, which are key regulators of checkpoint responses ...
Potluri Lakshmi-Prasad - - 2012
Escherichia coli cells lacking low-molecular-weight penicillin-binding proteins (LMW PBPs) exhibit morphological alterations that also appear when the septal protein FtsZ is mislocalized, suggesting that peptidoglycan modification and division may work together to produce cell shape. We found that in strains lacking PBP5 and other LMW PBPs, higher FtsZ concentrations increased ...
Caracciolo Valentina V Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, - - 2012
Cdk9 and Cdk7 are cdc2-like serine/threonine kinases that stabilize RNA transcript elongation through RNA polII carboxyl terminal domain (CTD) phosphorylation and are considered suitable targets for cancer therapy. The effects of flavopiridol and of siRNA-mediated inhibition of Cdk9 and/or Cdk7 were analyzed in human glioblastoma and human prostate cancer cell ...
Senutovitch Nina - - 2012
Novel fluorescent tools such as green fluorescent protein analogues and fluorogen activating proteins (FAPs) are useful in biological imaging for tracking protein dynamics in real time with a low fluorescence background. FAPs are single-chain variable fragments (scFvs) selected from a yeast surface display library that produce fluorescence upon binding a ...
DeRose Eugene F - - 2012
Ribonucleotides are frequently incorporated into DNA during replication. They are recognized and processed by several cellular enzymes, and their continued presence in the yeast nuclear genome results in replicative stress and genome instability. Thus, it is important to understand the effects of isolated ribonucleotide incorporation on DNA structure. With this ...
Motea Edward A - - 2012
Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer, presenting with approximately 5,000 new cases each year in the United States. An interesting enzyme implicated in this disease is terminal deoxynucleotidyl transferase (TdT), a specialized DNA polymerase involved in V(D)J recombination. TdT is an excellent biomarker for ...
Zhang Yinan - - 2012
The direct amination of α-haloacetoacetates with anilines is described. Compared to existing methods, this simple protocol provides an attractive strategy to prepare diverse γ-anilino-β-ketoesters in one step. Good to excellent yields of the amination products were obtained under robust conditions, providing versatile and useful scaffolds.
Zhang Chuan-Ling - - 2012
The image shows controlled assemblies of gold nanorods in a poly(vinyl alcohol) (PVA) nanofiber matrix with tunable optical properties. They are produced using an electrospinning technique that easily enables the controlled alignment of anisotropic nanostructures in a polymer nanofiber matrix. The assemblies shown here can be applied as substrates for ...
Biswas Sanchita - - 2012
The image features the concept of a millifluidic platform for the controlled synthesis of nanomaterials-an alternative to difficult-to-fabricate, expensive, and complex microfluidic reactors. The millifluidic platform offers a transformative approach, which should jump-start the commercialization of lab-on-a-chip devices for the large-scale production of nanomaterials; it enables better control over size ...
Daack-Hirsch Sandra - - 2012
We conducted a systematic literature review to identify tools that could be used to measure faculty and undergraduate nursing students' genetic literacy, and we assessed the utility of one of those tools, the Genetic Literacy Assessment Instrument (GLAI), with faculty and students at a college of nursing in a large ...
Mossey Sharolyn - - 2012
Undergraduate nursing students, as members of the health care team, must uphold patient safety as a professional and moral obligation during their clinical learning experiences. To address this imperative, in a humanistic paradigm, students engage in critical appraisal of self as a developing practitioner. Using Q-methodology, this study describes undergraduate ...
Doyle Kerrie Esme - - 2012
The World Health Organization (WHO) has recognized that errors in communication are one of the leading causes of adverse patient outcomes. Consequently, the WHO developed the High 5s Project to review, among other variables, handover of patients between shifts, professionals, and organizations. Seven countries were involved in the initial project. ...
Samedy Ketly - - 2012
BACKGROUND:Although there has been previous research linking perceptions of empowerment to specialty certification among critical care nurses, no research in this area has been conducted among nationally certified perinatal nurses. METHODS:A comparative quantitative survey design was used. Participants included 80 perinatal registered nurses from one community hospital in New York. ...
Gorgun Ebru - - 2012
BACKGROUND AND OBJECTIVE:To examine the exact position of implanted Keraring (Mediphacos, Belo Horizonte, Brazil) segments by high-resolution anterior segment optical coherence tomography (AS-OCT). PATIENTS AND METHODS:This study included 17 eyes of 13 patients with keratoconus who underwent uneventful intracorneal ring segment implantation with the aid of femtosecond laser. Eyes were ...
Huang Su - - 2012
This first ever Advanced Optical Materials cover design shows a silicon-polymer hybrid slot waveguide ring-resonator modulator being poled by two pyroelectric crystals. Each of the three images, from top to bottom, indicates one stage of the poling-before, during, and after-with the device configuration in the front and the dipole alignment ...
Xu Guowei - - 2012
Plasmonic graphene has been fabricated by G. Xu et al. using thermally assisted self-assembly of Ag nanoparticles on graphene. The localized surface-plasmonic effect is demonstrated with the resonance frequency shifting from 446 to 495 nm when the lateral dimension of the Ag nanopar-ticles increases from about 50 to 150 nm. ...
Sievers Beth - - 2012
The medical patient population presents with various types of wounds when admitted to the hospital. A clinical nurse specialist (CNS) is often consulted to help nurses to assess wounds and dress them appropriately. Because CNS consultation is available only during business hours, staff identified a need for a core group ...
Banthí Juan Carlos - - 2012
The internal architecture of metal-dielectric Au/Co/Au-SiO(2) magnetoplasmonic nanodisks provides control over the internal electromagnetic field distribu on by varying the relative contributions of the magneto-optically active layers and the optically lossy layers. This allows simultaneous tuning of the magneto-optical activity and the absorption. On page OP36, A. Cebollada and co-workers ...
Valev Ventsislav K - - 2012
When a droplet hits the surface of water, it is often observed that a water column, or 'back-jet', surges upwards. Counterintuitive though it might be, a similar phenomenon can occur when ultrafast light pulses shine on a nanostructured metal surface. These sub-wavelength 'nanojets' occur in the regions of highest local ...
Lee Won-Mo - - 2012
On page OP49, M.-H. Jo and co-workers describe a method of control over photocurrent detection by manipulating ferroelectric domain configurations. The magnitude is spectrally centered around charged domain walls that are associated with oxygen vacancy migration in BiFeO(3) , where potential gradients caused by spontaneous polarization yield asymmetric and nonlinear ...
Schmidt Michael Stenbaek - - 2012
M. S. Schmidt et al. describe on page OP11 a simple, two-step fabrication process to as-semble flexible, freestanding nanopillars into large-area substrates. These substrates can be made using readily available silicon-processing equipment and are suitable for SERS, having a large, uniform Raman enhancement.
Xu Guowei - - 2012
Plasmonic graphene is fabricated using thermally assisted self-assembly of silver nanoparticles on graphene. The localized surface-plasmonic effect is demonstrated with the resonance frequency shifting from 446 to 495 nm when the lateral dimension of the Ag nanoparticles increases from about 50 to 150 nm. Finite-difference time-domain simulations are employed to ...
Laza Simona C - - 2012
Polymeric fibers and helical and bow-tie particles are generated by A. Camposeo, D. Pisignano and co-workers on page 1304, using the combination of two-photon lithog-raphy and microfluidics. The two-photon continuous flow lithography enables the creation of polymeric micro-objects with 3D features and sub-diffraction resolution. The particle synthesis throughput is improved, ...
Xu Jing - - 2012
A concise, protecting group-free total synthesis of (-)-fusarisetin A (1) was efficiently achieved in nine steps from commercially available (S)-(-)-citronellal. The synthetic approach was inspired by our proposed biosynthesis of 1. Key transformations of our strategy include a facile construction of the decalin moiety that is produced via a stereoselective ...
Fogaça M V MV Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, - - 2012
This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal ...
Brenes J C JC Experimental and Physiological Psychology, Philipps-University of Marburg, - - 2012
Electrical stimulation of midbrain tectum structures, particularly the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), produces defensive responses, such as freezing and escape behavior. Freezing also ensues after termination of dPAG stimulation (post-stimulation freezing). These defensive reaction responses are critically mediated by γ-aminobutyric acid and 5-hydroxytryptamine mechanisms in the ...
Landa-Solís Carlos - - 2012
Several ocular diseases affect the corneal surface; the development of effective technologies for the treatment of corneal lesions has brought about an improvement in the quality of life of affected patients. The aim of this study is to culture and characterize limbal stem cells cultured on gamma ((60)Co) radiosterilized human ...
Kochel J - - 2012
The goal of this retrospective study was to examine the effectiveness of isolated bionator therapy in Class II patients both longitudinally and over the long term. We aimed to determine whether skeletal and/or dentoalveolar reactions differ in relationship to the Angle Class (II, Division 1 vs. II, Division 2). A ...
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