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Kraan J - - 2012
Background: Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage/dysfunction. A lack of standardized assays and consensus on CEC phenotype has resulted in a wide variation of reported CEC numbers (4 to 1,300 per mL).Objectives: Given the need for a quick, reliable, robust and validated CEC assay at an affordable ...
Zhang Lulu - - 2012
Major earthquakes often result in incalculable environmental damage, loss of life, and threats to health. Tremendous progress has been made in response to many medical challenges resulting from earthquakes. However, emergency medical rescue is complicated, and great emphasis should be placed on its organisation to achieve the best results. The ...
Katz-Salamon M - - 2012
Objective:  to evaluate the effects of GH treatment on control of breathing, heart rate and blood pressure during sleep in Prader-Willi Syndrome (PWS). Study design:  in a prospective clinical case series study sixteen consecutive PWS patients (median age 16 months at enrolment) were followed-up 6 months (2-32 months) after commencing ...
Moore Melisa - - 2012
Sleep problems in children and adolescents are common, and they impact multiple domains of child and family functioning. Psychologists have a critical role in the assessment and treatment of sleep problems and are integral to interdisciplinary sleep teams. Certain sleep problems may be related to co-morbid psychological or developmental conditions, ...
Jin Mingwu M Department of Physics, University of Texas at Arlington, Arlington, TX 76019, USA. - - 2012
Functional magnetic resonance imaging (fMRI) is an important imaging modality to understand the neurodegenerative course of mild cognitive impairment (MCI) and early Alzheimer's disease (AD), because the memory dysfunction may occur before structural degeneration is obvious. In this research, we investigated the functional abnormalities of subjects with amnestic MCI (aMCI) ...
Ji J-H - - 2012
Paralabral ganglion cysts of the shoulder are rare, and their pathogenesis is similar to that of meniscal cysts. The paralabral cysts are most frequently reported along the posterior, superior, and anterior aspects of the glenohumeral joint and are uncommon inferiorly to the joint. These cysts rarely become evident clinically, unless ...
Gilbert H M HM Research Department of Primary Care and Population Health, University College London Medical Division, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK. - - 2012
To describe the characteristics of a sample of smokers recruited proactively into a smoking cessation trial, and to compare these characteristics with the wider population using data from the General Household Survey (GHS) and National Statistics Omnibus Survey. Sample recruited for a randomized controlled trial. Between August 2007 and October ...
Bodei Lisa - - 2012
Peptide receptor radionuclide therapy (PRRT) consists in the systemic administration of a synthetic peptide, labelled with a suitable beta-emitting radionuclide, able to irradiate tumours and their metastases via the internalization through a specific receptor, overexpressed on the cell membrane. After 15 years of experience, we can state that PRRT with (90)Y-labelled ...
Zheng Fei - - 2012
whi genes, named after the mutations turning Streptomyces coelicolor colonies into white, exist largely in Actinomyces and Mycobacterium. whiB genes, a subclass of whi, involve in wide range of events, such as cell division, spore formation, nutrient starvation, pathogenesis, antibiotic resistance, and stress sense. To better understand the role of ...
Tsai Chu-Lin - - 2012
Little is known about the effect of age on acute asthma outcomes. We sought to investigate age-related differences in the emergency department (ED) presentation and clinical outcomes for patients with acute asthma. We analyzed the 2006-2008 Nationwide Emergency Department Sample, the largest, all-payer, US ED and inpatient database. ED visits ...
Chang Kevin - - 2012
A healthy 30-year-old woman presented to the emergency department with a pulsatile right forearm mass and numbness of her fourth and fifth fingers. Duplex scan imaging revealed an ulnar artery aneurysm with intramural thrombus. After resection, histopathology revealed intravascular papillary endothelial hyperplasia, also known as Masson's tumor, a rare but ...
Sugita Michiko - - 2012
Resistance to thyroid hormone (RTH) is a rare, predominantly inherited syndrome that involves impaired tissue responsiveness to thyroid hormones. We describe the perioperative management of a patient with RTH who underwent total thyroidectomy. Although surgery performed under general anesthesia was uneventful, after the surgery the patient developed difficult-to-treat hypocalcemia that ...
More Swati Sudhakar - - 2012
Diacetyl (DA), a natural butter flavoring agent, is a causative agent for the lung disease, obliterative bronchiolitis. Mutagenic properties of 1,2-dicarbonyls have previously been empirically linked to their possible interaction with DNA nucleobases. In this study, we have for the first time identified chemically the adduct of DA with 2-deoxyguanosine. ...
Falcone Mary - - 2012
The perception that smoking relieves negative affect contributes to smoking persistence. Endogenous opioid neurotransmission, and the μ-opioid receptor (MOR) in particular, plays a role in affective regulation and is modulated by nicotine. We examined the relationship of MOR binding availability in the amygdala to the motivation to smoke for negative ...
Dickinson Laura E LE Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, - - 2012
In the vascular niche, the extracellular matrix (ECM) provides a structural scaffold with a rich ligand landscape of essential matrix proteins that supports the organization and stabilization of endothelial cells (ECs) into functional blood vessels. Many of the physical interactions between ECs and macromolecular components of the ECM occur at ...
Cho Yang Hyun - - 2012
Recurrent right-side heart failure after operation for constrictive pericarditis (CP) may be caused by incomplete pericardiectomy, recurrent constriction due to exuberant scar tissue, or diastolic dysfunction. Because the risks and benefits of reoperation are not well defined, we reviewed the outcome of completion pericardiectomy. From 1993 to December 2010, 41 ...
Fozza Claudio C Hematology Section, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 12, 07100 Sassari, Italy. - - 2012
Almost 10 years have passed since the first experiments specifically addressing the role of regulatory T cells (Treg) in stem cell transplantation (SCT). It is now time to try to dissect what is their actual impact in such a therapeutic context. In the present review we will initially remind the ...
Nijhof Sanne L SL Department of Paediatrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Netherlands. - - 2012
Chronic fatigue syndrome is characterised by persistent fatigue and severe disability. Cognitive behavioural therapy seems to be a promising treatment, but its availability is restricted. We developed Fatigue In Teenagers on the interNET (FITNET), the first dedicated internet-based therapeutic program for adolescents with this disorder, and compared its effectiveness with ...
Toman Blaza - - 2012
Several recent international comparison studies used a relatively novel experimental design to evaluate the measurement capabilities of participating organizations. These studies compared the values assigned by each participant to one or more qualitatively similar materials with measurements made on all of the materials by one laboratory under repeatability conditions. A ...
Kowalska Irina - - 2012
CONTEXT: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. It has recently been shown that the FTO gene modifies weight, fat mass and insulin sensitivity in women with PCOS, where its role might be larger than ...
Lebel B - - 2012
Thirty-five to 40 days' thromboprophylaxis is recommended following total hip replacement (THR). Low molecular weight heparin (LMWH) injected by a health professional ensures good compliance. Compliance with recent oral anticoagulants has not been precisely assessed. Oral self-administration, without coagulation monitoring tests, may be a worrying issue in the management of ...
Alves Ae - - 2012
This study was undertaken to compare cryotolerance, in terms of viability and resumption of meiosis after warming and culture (24 and 48 h), of ex situ (isolated) and in situ (enclosed in the ovarian tissue) feline cumulus-oocyte complexes (COCs) vitrified with DAP 213 (2 m DMSO, 1 m acetamide, 3 m propylene glycol) in ...
Reid-Searl Kerry - - 2012
Aims.  To explore the attitudes, experiences and opinions of registered nurses regarding supervision of undergraduate nursing students while administering medication in the healthcare setting. Background.  Medication errors present a considerable risk to safety in the healthcare setting. By virtue of their role in the administration of medication, registered nurses are ...
Gupta P K - - 2012
Multiple randomised trials have demonstrated lower perioperative mortality after endovascular aneurysm repair (EVAR) compared to open surgical repair for infrarenal abdominal aortic aneurysms (AAAs). However, in these trials the mortality advantage for EVAR is being lost within 2 years of repair and the patients evaluated are relatively older with no ...
Gao Fei F Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. - - 2013
Docosahexaenoic acid (DHA, 22:6n-3), an n-3 polyunsaturated fatty acid (PUFA) found at high concentrations in brain and retina and critical to their function, can be obtained from fish products or be synthesized from circulating α-linolenic acid (α-LNA, 18:3n-3) mainly in the liver. With aging, liver synthetic enzymes are reported reduced ...
Schnegg Caroline I CI Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, - - 2012
Partial or whole-brain irradiation is often required to treat both primary and metastatic brain cancer. Radiation-induced normal tissue injury, including progressive cognitive impairment, however, can significantly affect the well-being of the approximately 200,000 patients who receive these treatments each year in the United States. Although the exact mechanisms underlying radiation-induced ...
Tourlaki Athanasia - - 2012
Abstract Background: Melasma is a common melanosis often difficult to treat. Objective: The aim of our paper is to report on the safety and efficacy of non-ablative fractional photothermolysis combined with the use of triple-combination cream (TCC) on a large population with melasma resistant (i.e. with no complete/near-complete clearing) to ...
Zaccardi Francesco - - 2012
We describe a case report of a patient who developed transient type 2 diabetes after a drug-induced (esomeprazole) sub-acute hepatitis. This case evidences the pathophysiological relevance, also in humans, of liver inflammation in the pathogenesis of type 2 diabetes.
Andersen Mads Hald - - 2012
Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme that is implicated in suppressing T-cell immunity in many settings including cancer. In recent years, we have described spontaneous CD8(+) as well as CD4(+) T-cell reactivity against IDO in the tumor microenvironment of different cancer patients as well as in the peripheral blood ...
Phabphal Kanitpong - - 2012
Epilepsia partialis continua (EPC) is clinically defined as a syndrome of continuous focal jerking of a body part. EPC has various etiologies and outcomes depending on its cause. Most studies on EPC have been conducted in Western countries and no study on the long-term outcome in adult onset epilepsia partialis ...
Taslimi Amir A Department of Biochemistry and Biophysics, P.O. Box 712, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, - - 2012
We have developed a procedure in which disulfide cross-links are used to identify regions of proteins that undergo functionally important intramolecular motion. The approach was applied to the identification of disulfide bonds that stabilize the active state of the yeast α-mating pheromone receptor Ste2p, a member of the superfamily of ...
Naji Meeran - - 2012
Neuroectodermal tumours arise from chromaffin cells and possess the ability to secrete catecholamines. They are generally rare and may occur in association with a variety of hereditary syndromes such as MEN-2A and 2B, neurofibromatosis type 1 and von Hippel-Lindau disease. The most common types are phaeochromocytoma arising from the adrenal ...
Colasanti Alessandro A Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College, London, United Kingdom. - - 2012
We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET). Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a ...
Park S C H - - 2012
The aim of this study was to determine the efficacy and safety of docetaxel-based systemic chemotherapy in elderly patients with castration-resistant prostate cancer (CRPC). We retrospectively reviewed the clinical records of 36 patients with CRPC who were treated with docetaxel-based systemic chemotherapy at a single institution between May 2005 and ...
Meng Qun - - 2012
In the past decade, the Government of China initiated health-care reforms to achieve universal access to health care by 2020. We assessed trends in health-care access and financial protection between 2003, and 2011, nationwide. We used data from the 2003, 2008, and 2011 National Health Services Survey (NHSS), which used ...
Goudar Chetan T - - 2012
The logistic modeling approach was used to describe experimental viable cell density (X) and product concentration (P) data from two industrial fed-batch mammalian cell culture processes with maximum product concentrations in the 3.0-9.4 g/l range. In both cases, experimental data were well described by the logistic equations and the resulting specific ...
Khorana Alok A - - 2012
Thromboembolism, including both venous and arterial events, occurs commonly amongst patients with cancer. The occurrence of thromboembolism has significant consequences for cancer patients, including direct and indirect associations with mortality, morbidity, requirement for long-term anticoagulant therapy and consumption of healthcare resources. Recent studies have resulted in a better understanding of ...
Al-Niaimi F - - 2012
Introduction:  Skin disorders are a common problem for ostomates resulting in more than a third of visits to a stoma nurse. . Irritant reactions, particularly irritant contact dermatitis are the most frequently seen accounting for more than 50% of problems in some studies. We report our experience in patch testing ...
Stechemesser B - - 2012
PURPOSE: Despite the high frequency of hernia surgery procedures and continuous improvements, thanks to new hernia meshes and fixation techniques, in Germany, for example, the recurrence rate and rate of chronic inguinal pain after inguinal surgery are more than 10% far too high. Introduction of a hernia register in Denmark ...
Brennan Michael J - - 2012
In this review, published peer-reviewed preclinical studies using prime-boost tuberculosis (TB) vaccine regimens in animal challenge models for tuberculosis have been evaluated. These studies have been divided into groups that describe prime-boost vaccine combinations that performed better than, equivalent to, or worse than the currently used BCG vaccine. Review of ...
Kumar Seema - - 2012
Overall it is clear that bariatric surgical intervention in appropriately selected adolescents is effective at both adequate weight loss and resolution of weight related co-morbidities in the short and medium term. Long-term results are being conducted currently to assess durability of bariatric surgical interventions. We believe that adolescents undergoing bariatric ...
Napoli Nicola N Division of Bone and Mineral Diseases at Washington University School of Medicine, St. Louis, MO, - - 2012
Menopause is associated with changes in bone, muscle and fat mass. The importance of postmenopausal estrogen metabolism in bone health has been established. However, its relationship to body composition in postmenopausal women remains undetermined. The objective of this study is to determine the association between estrogen metabolism and body composition ...
Maksimainen Mirko - - 2012
Crystal structures of native and α-D-galactose -bound Bacillus circulans sp. alkalophilusβ-galactosidase (Bca-β-gal) were determined at 2.40 Å and 2.25 Å resolutions, respectively. Bca-β-gal is a member of family 42 of glycoside hydrolases and it forms a 460 kDa hexameric structure in crystal. The protein consists of three domains in which ...
Gong Peng - - 2012
China has seen the largest human migration in history, and the country's rapid urbanisation has important consequences for public health. A provincial analysis of its urbanisation trends shows shifting and accelerating rural-to-urban migration across the country and accompanying rapid increases in city size and population. The growing disease burden in ...
Sato Hiroki - - 2012
Decreased activity has been reported in both nocturnal and diurnal primates during the prolonged dry season in western Madagascar, and this has been interpreted as a reaction to the severe environment, with its food scarcity and/or thermal stress. Several day-active lemurs rest more as trees defoliate, although the reason for ...
Bilbao Ainhoa - - 2012
During the past two decades, the use of genetically manipulated animal models in alcohol research has greatly improved the understanding of the mechanisms underlying alcohol addiction. In this chapter, we present an overview of the progress made in this field by summarizing findings obtained from studies of mice harboring global ...
Ramkalawan Hhoonisha - - 2012
Recent advances demonstrate peroxisome proliferator-activated receptors gamma (PPARγ) agonist, pioglitazone, as an anti-inflammatory drug. We investigated the effect of pioglitazone on experimental autoimmune neuritis (EAN) rats. Pioglitazone was given once daily (10 mg/kg) by oral gavage feeding from day 1-24 (suppressive group) and day 11-24 (therapeutic group). Pioglitazone ameliorated the clinical ...
Saxena R R Department of Anaesthesia, Massachusetts General Hospital, Boston, MA 02114, - - 2013
Polycystic ovary syndrome (PCOS) is a disorder of irregular menses, hyperandrogenism and/or polycystic ovary morphology. A large proportion of women with PCOS also exhibit insulin resistance, β-cell dysfunction, impaired glucose tolerance and/or type 2 diabetes (T2D). We therefore hypothesized that genetic variants that predispose to risk of T2D also result ...
Parent Kristin N KN University of California, San Diego, Department of Chemistry & Biochemistry, La Jolla, CA 92093, - - 2012
Coat proteins of tailed, dsDNA phages and in herpesviruses include a conserved core similar to the bacteriophage HK97 subunit. This core is often embellished with other domains such as the telokin Ig-like domain of phage P22. Eighty-six P22-like phages and prophages with sequenced genomes share a similar set of virion ...
Feng Rung-Fen - - 2012
Aims.  The aim of this study was to explore the socialisation experiences of new graduate baccalaureate nurses to practising nurses. Background.  How nurses contend with the stress of their professional role has been of interest to both researchers and healthcare administrators over the past 30 years. Work stress of clinical nurses ...
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