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Watanabe Mika - - 2012
This study aimed to elucidate groups at high risk of developing cancer among patients with serologically identified Helicobacter pylori infection and nonatrophic stomach. Annual endoscopy was performed for a mean of 5.4 years in 496 asymptomatic middle-aged men who were H. pylori antibody-positive and pepsinogen (PG) test-negative. Subjects were stratified ...
Härtig Cornelia - - 2012
Thioarsenates dominate arsenic speciation in sulfidic geothermal waters, yet little is known about their fate in the environment. At Conch Spring, an alkaline hot spring in Yellowstone National Park, trithioarsenate transforms to arsenate under increasingly oxidizing conditions along the drainage channel, accompanied by an initial increase, then decrease of monothioarsenate ...
Mossalam Mohanad M Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84108, United - - 2012
Targeting the tumor suppressor p53 to the mitochondria triggers a rapid apoptotic response as efficiently as transcription-dependent p53. (1, 2) p53 forms a complex with the antiapoptotic Bcl-XL, which leads to Bak and Bax oligomerization resulting in apoptosis via mitochondrial outer membrane permeabilization. (3, 4) Although p53 performs its main ...
Robustelli Paul P Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, - - 2012
In this investigation, semiempirical NMR chemical shift prediction methods are used to evaluate the dynamically averaged values of backbone chemical shifts obtained from unbiased molecular dynamics (MD) simulations of proteins. MD-averaged chemical shift predictions generally improve agreement with experimental values when compared to predictions made from static X-ray structures. Improved ...
Law H T HT Simon Fraser University, Department of Biological Sciences, Shrum Science Centre, Room B8276, Burnaby, BC, V5A 1S6, - - 2012
The bacterial pathogens Listeria monocytogenes and enteropathogenic Escherichia coli (EPEC) generate motile actin-rich structures (comet tails and pedestals) as part of their infectious processes. Nexilin, an actin-associated protein and a component of focal adhesions, has been suggested to be involved in actin-based motility. To determine whether nexilin is commandeered during ...
Li Ying - - 2012
The NR2B subunit of NMDA receptor in the anterior cingulate cortex (ACC) is up-regulated in viscerally hypersensitive (VH) rats induced by colonic anaphylaxis. It plays a critical role in modulation of ACC sensitization and visceral pain responses. Given the key role of calcium/calmodulin-dependent protein kinase II (CaMKII) in synaptic plasticity ...
Sharma Raman - - 2012
Malaria is responsible for approximately 1 million deaths annually; thus, continued efforts to discover new antimalarials are required. A HTS screen was established to identify novel inhibitors of the parasite's mitochondrial enzyme NADH:quinone oxidoreductase (PfNDH2). On the basis of only one known inhibitor of this enzyme, the challenge was to ...
Meyer Dieter K - - 2012
J. Neurochem. (2012) 121, 597-606. In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca(2+) -permeable AMPA (GluA) receptors located on the interneurons decreased the response of ...
Nörenberg Wolfgang - - 2012
Changes in the density of NMDA (GluN) receptors in the neuronal membrane are critical for plasticity, whereas malfunction of precisely regulated GluN receptor activity may be involved in neurotoxicity. In cultured rat neocortical interneurons, we have studied the regulation of the surface density of GluN1, GluN2A and GluN2B subunits. Application ...
Scholze Petra - - 2012
Gene association studies in humans have linked the α5 subunit gene CHRNA5 to an increased risk for nicotine dependence. In the CNS, nicotinic acetylcholine receptors (nAChRs) that contain the α5 subunit are expressed at relatively high levels in the habenulo-interpeduncular system. Recent experimental evidence furthermore suggests that α5-containing receptors in ...
Treweek Jennifer B JB Departments of Chemistry and Immunology of The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, - - 2012
Not only has immunopharmacotherapy grown into a field that addresses the abuse of numerous illicit substances, but also the treatment methodologies within immunopharmacotherapy have expanded from traditional active vaccination to passive immunization with anti-drug monoclonal antibodies, optimized mAb formats, and catalytic drug-degrading antibodies. Many laboratories have focused on transitioning distinct ...
Wang Zhuo Z Department of Biochemistry and Molecular Biology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, - - 2012
Initiation of DNA replication in eukaryotes is an evolutionarily conserved process that involves two distinct steps: the formation of prereplication complexes at replication origins in G1 and the assembly of preinitiation complexes (pre-ICs) in S phase, which leads to activation of the replication helicase. For the assembly of pre-ICs in ...
Sager Georg G Medical Pharmacology and Toxicology, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, - - 2012
Elevated intracellular levels of cyclic guanosine monophosphate (cGMP) may induce apoptosis, and at least some cancer cells seem to escape this effect by increased efflux of cGMP, as clinical studies have shown that extracellular cGMP levels are elevated in various types of cancer. The human ATP binding cassette (ABC) transporter ...
Petersen L K - - 2012
Advancements toward an improved vaccine against Bacillus anthracis, the causative agent of anthrax, have focused on formulations composed of the protective antigen (PA) adsorbed to aluminum hydroxide. However, due to the labile nature of PA, antigen stability is a primary concern for vaccine development. Thus, there is a need for ...
Ghimire Harishchandra H Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United - - 2012
A membrane alignment technique has been used to measure the distance between two TOAC nitroxide spin labels on the membrane-spanning M2δ, peptide of the nicotinic acetylcholine receptor (AChR), via CW-EPR spectroscopy. The TOAC-labeled M2δ peptides were mechanically aligned using DMPC lipids on a planar quartz support, and CW-EPR spectra were ...
Wang Sichao - - 2012
Inhibition of the human ether-a-go-go related gene (hERG) potassium channel may result in QT interval prolongation, which causes severe cardiac side effects and is a major problem in clinical studies of drug candidates. The development of in silico tools to filter out potential hERG potassium channel blockers in early stages ...
Covert Wendy M WM Division of Pharmacy, University of Texas MD Anderson Cancer Center, Houston, 77030, USA. - - 2012
The postsurgical use of N-acetylcysteine, octreotide, and other agents to reduce mucus accumulation after urinary diversion procedures is described. Patients undergoing continence-sparing bladder resection are at risk for infection and stone formation due to mucus accumulation. In addition to N-acetylcysteine, agents studied for mucoregulatory control in such patients include aspirin, ...
Butterworth Kelly A - - 2012
Case Description-Primary hypoaldosteronism without concurrent hypoadrenocorticism was diagnosed in an 8-year-old female alpaca with acute onset of weakness progressing to recumbency within 6 hours after onset. Clinical Findings-Hematologic testing at admission revealed profound hyponatremia, hypochloremia, and acidemia with a normal blood potassium concentration. Further diagnostic testing, including an ACTH stimulation ...
Poppe Lindsey B - - 2012
Purpose A multidisciplinary initiative to promote more cost-effective use of blood factor derivatives and increase pharmacist involvement in associated order verification, dispensing, and monitoring activities is described. Summary After an evaluation of a hospital's procedures for the use of blood factor derivatives identified inconsistencies and opportunities for cost savings, a ...
Berent Allyson C - - 2012
Objective-To describe and evaluate the short- and long-term outcomes in female dogs after cystoscopic-guided laser ablation of ectopic ureters (CLA-EU). Design-Prospective case series. Animals-32 incontinent female dogs with intramural ectopic ureters. Procedures-A diagnosis of intramural ectopic ureters was made via cystoscopy and fluoroscopy in all patients. Transurethral CLA-EU (via diode ...
Bragg Ryan F - - 2012
Objective-To evaluate the efficacy of administration of a single 12-mL dose of canine parvovirus (CPV)-immune plasma for treatment of CPV enteritis. Design-Prospective, randomized, double-blinded, placebo-controlled clinical trial. Animals-14 dogs with naturally occurring CPV enteritis. Procedures-Dogs were assigned to treatment groups on the basis of randomization tables and were administered a ...
Hellwig Thaddaus R - - 2012
Purpose A case report describing high-dose argatroban for the treatment of heparin-induced thrombocytopenia (HIT) with thrombosis and associated considerations in interpreting laboratory monitoring data are presented. Summary A 51-year-old woman with an extensive history of coronary artery disease arrived at the emergency department with complaints of chest pain. The patient ...
Hartnack Amanda K AK Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, - - 2012
To evaluate the potential association between Salmonella enterica shedding in hospitalized horses and the risk of diarrhea among stablemates, and to characterize gastrointestinal-related illness and death following discharge among horses that shed S. enterica while hospitalized. Retrospective cohort study [corrected]. 221 horses (59 that shed S. enterica during hospitalization and ...
Hudson David M DM Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195-6500, United - - 2012
Proline residues in collagens are extensively hydroxylated post-translationally. A rare form of this modification, (3S,2S)-l-hydroxyproline (3Hyp), remains without a clear function. Disruption of the enzyme complex responsible for prolyl 3-hydroxylation results in severe forms of recessive osteogenesis imperfecta (OI). These OI types exhibit a loss of or reduction in the ...
Brown Alexandra - - 2012
Purpose The use of anticoagulants for the prevention of venous thromboembolism (VTE) in hospitalized medical and surgical oncology patients is discussed. Summary Hospitalized patients are often at risk for developing VTE, and risk is increased in patients who have cancer. Moreover, the incidence of VTE appears to be rising in ...
Norman Tracy E - - 2012
Objective-To characterize the associations between clinical signs of nasopharyngeal cicatrix syndrome (NCS) and endoscopic findings in horses. Design-Retrospective, case-control study. Animals-239 horses (118 case horses and 121 control horses). Procedures-Medical records of horses that had an endoscopic evaluation of the upper airway performed between January 2003 and December 2008 were ...
Baird-Heinz Hope E - - 2012
Objective-To critically evaluate and summarize available information on the safety of potassium bromide in dogs. Design-Systematic review. Sample-111 references reporting safety information relevant to potassium bromide published between 1938 and 2011. Procedures-PubMed searches without date limitations were conducted with the terms "potassium bromide" and "sodium bromide" in December 2009 and ...
Reeves David J - - 2012
Two cases of successful desensitization to docetaxel after severe hypersensitivity reactions are reported. Two patients with gynecological malignancies (uterine leiomyosarcoma and ovarian adenocarcinoma) experienced severe hypersensitivity reactions with docetaxel, including flushing, numbness, sharp radiating pain, severe nausea and vomiting, apnea, and unresponsiveness. Both patients received ondansetron before docetaxel. One patient ...
Moenster Ryan P - - 2012
Purpose A case of progressive multifocal leukoencephalopathy (PML) in a patient infected with human immunodeficiency virus (HIV) treated with mirtazapine and mefloquine is reported. Summary A 49-year-old African-American man who was recently diagnosed with HIV infection was admitted to the hospital for progressive ataxia, dysarthria, and unsteady gait. Upon initial ...
Bertoni Lélia - - 2012
Objective-To characterize the clinical features, diagnostic procedures, treatment, and outcome for horses with an exostosis on the palmar or plantar cortex of the third metacarpal bone (MC3) or third metatarsal bone (MT3). Design-Retrospective case series. Animals-16 horses. Procedures-Records from 2001 through 2010 were evaluated to identify horses with radiographic and ...
Pashos Chris L - - 2012
Purpose The results of a study assessing the effectiveness of a manufacturer-sponsored assistance program for patients prescribed oral cancer therapies are presented. Methods Rates of dispensing success were evaluated in a random sample of patients (n = 1000) who enrolled in the Celgene Patient Support (CPS) program for assistance obtaining ...
Heilmann Rachel M F - - 2012
Purpose The impact of decentralized clinical pharmacy services on the implementation of appropriate care in postmenopausal women with a recent history of a fracture was assessed. Methods Women 67 years of age or older with a documented fracture between January 1 and December 31, 2007, were identified in two geographic ...
Poon Linda H - - 2012
Purpose The expanding role of a clinical pharmacist at a Veterans Affairs (VA) out-patient clinic for patients with Parkinson's disease (PD) and movement disorders is described. Summary San Francisco VA Medical Center added a clinical pharmacist to the multi-disciplinary team serving patients at an outpatient clinic operated by its Parkinson's ...
Baranczak Aleksandra - - 2012
A benzo[a]anthraquinone ring system, common to a group of angucycline antibiotics, has been prepared by a unique cascade of reactions. The reaction sequence was initiated by a Suzuki-Miyaura cross-coupling between a bromoquinone and vinyl boronic anhdyride. The reaction product is proposed to undergo a 6π-electron cyclization triggered by reductive activation ...
Klaić Lada L Department of Chemistry, Northwestern University, Evanston, IL 60208, - - 2012
The natural product celastrol (1) possesses numerous beneficial therapeutic properties and affects numerous cellular pathways. The mechanism of action and cellular target(s) of celastrol, however, remain unresolved. While a number of studies have proposed that the activity of celastrol is mediated through reaction with cysteine residues, these observations have been ...
Guofeng Shen S Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, - - 2012
Published emission factors (EFs) often vary significantly, leading to high uncertainties in emission estimations. There are few reliable EFs from field measurements of residential wood combustion in China. In this study, 17 wood fuels and one bamboo were combusted in a typical residential stove in rural China to measure realistic ...
Wood Sharla S Department of Chemistry, Wayne State University, Detroit, MI, - - 2012
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger important for physiologic adaptation and virulence. Class-I c-di-GMP riboswitches are phylogenetically widespread and thought to mediate pleiotropic genetic responses to the second messenger. Previous studies suggest that the RNA aptamer domain switches from an extended free state to a compact, c-di-GMP-bound conformation ...
Brandt Mathias C - - 2012
This study investigated the effect of catheter-based renal sympathetic denervation (RD) on left ventricular hypertrophy (LVH) and systolic and diastolic function in patients with resistant hypertension. LVH and diastolic dysfunction are associated with elevated sympathetic activity and increased morbidity and mortality. The effect of RD on LVH and LV function ...
Wang Tracy Y - - 2012
Women are underrepresented in cardiovascular studies, even as their preponderance in the aging population steadily increases. Although concerns have been raised about the differential benefit of antiplatelet medications for women, the propensity for increased bleeding among women has also been recognized. A better understanding of the factors contributing to the ...
Zhang Lei - - 2012
The aim of this meta-analysis was to evaluate the effects of additional trimetazidine (TMZ) treatment on patients with chronic heart failure (CHF). Conflicting results currently exist on the clinical use of TMZ in CHF patients. PubMed, MEDLINE, EMBASE, and EBM Reviews databases were searched through November 2010 for randomized controlled ...
Kowalski Marcin - - 2012
This study describes the histopathologic and electrophysiological findings in patients with recurrence of atrial fibrillation (AF) after pulmonary vein (PV) isolation who underwent a subsequent surgical maze procedure. The recovery of PV conduction is commonly responsible for recurrence of AF after catheter-based PV isolation. Twelve patients with recurrent AF after ...
Li Tao-Sheng TS Cedars-Sinai Heart Institute, Los Angeles, California, - - 2012
The goal of this study was to conduct a direct head-to-head comparison of different stem cell types in vitro for various assays of potency and in vivo for functional myocardial repair in the same mouse model of myocardial infarction. Adult stem cells of diverse origins (e.g., bone marrow, fat, heart) ...
Viles-Gonzalez Juan F - - 2012
The purpose of this study was to investigate the frequency and clinical impact of incomplete left atrial appendage (LAA) sealing and consequent peri-device residual blood flow in patients undergoing percutaneous LAA closure with the Watchman device (Atritech, Inc., Plymouth, Minnesota). During percutaneous LAA closure for stroke prophylaxis, the geometric variability ...
Han Seongwook S Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University, School of Medicine, Indianapolis, Indiana, - - 2012
The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI). Whether MI results in remodeling of extracardiac nerve activity remains unclear. We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram ...
Ermis Fatih - - 2012
INTRODUCTION: Gastroenterology units have faced a major increase in referrals for PEG insertion over the last decade. For this reason we decided to review our PEG insertion procedures with regard to indications, complications and follow-up. MATERIALS AND METHODS: The indications, success of procedure, complications, long-term results of PEG in patients ...
- - 2012
A good work day begins with a chat with my secretary telling me that there are no administrative phone calls waiting! My favorite piece of research is Kurt Gödel's incompleteness theorem (1931), because it is one of the very rare cases that a scientist has proven a statement over his ...
Kari Osmo - - 2012
About 30% of people suffer from allergic symptoms, and 40% to 80% of them have eye symptoms. Atopic conjunctivitis is divided into seasonal allergic conjunctivitis and perennial allergic conjunctivitis. The treatment of seasonal allergic conjunctivitis is simple: antihistamines, anti-inflammatory agents, or cromoglycate. Perennial allergic conjunctivitis needs longer therapy with mast ...
Lochmatter D - - 2012
OBJECTIVE: Since their introduction in 1945, tooth positioners have been used to treat a range of malpositions. Although the original appliance was made of natural rubber, today's tooth positioners are fabricated from various elastic, transparent materials. It was the aim of this study to evaluate the forces and moments produced ...
Kaphzan Hanoch H Center for Neural Science, New York University, New York, New York, - - 2012
Angelman syndrome (AS) is a human neuropsychiatric disorder associated with autism, mental retardation, motor abnormalities, and epilepsy. In most cases, AS is caused by the deletion of the maternal copy of UBE3A gene, which encodes the enzyme ubiquitin ligase E3A, also termed E6-AP. A mouse model of AS has been ...
Burns Kevin A KA Division of Developmental Biology, Cincinnati Children's Hospital, 3333 Burnet Ave, MLC 7007, Cincinnati, OH 45229, - - 2012
Oenocytes are a specialized cell type required for lipid processing, pheromone secretion, and developmental signaling. Their development has been well characterized in Drosophila melanogaster, but it remains unknown whether the developmental program is conserved in other insect species. In this study, we compare and contrast the specification and development of ...
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