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Results 451 - 500 of 4161
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Ichijima Yosuke - - 2012
Sex chromosome inactivation in male germ cells is a paradigm of epigenetic programming during sexual reproduction. Recent progress has revealed the underlying mechanisms of sex chromosome inactivation in male meiosis. The trigger of chromosome-wide silencing is activation of the DNA damage response (DDR) pathway, which is centered on the mediator ...
Calka O - - 2013
Toxic epidermal necrolysis (TEN) is rare, life-threatening skin disorder that usually is caused by an adverse drug reaction. The exact pathogenesis of TEN is still unknown. Many treatments including prednisolone, cyclosporine and intravenous immunoglobulin (IVIG) can be used to halt the disease process. We present a 12-year-old girl with epilepsy ...
Puterman M M - - 2012
A variety of surgical methods have been developed to reduce the volume of the inferior turbinates, in order to create a more patent nasal airway. We describe a technique used in our department since February 2002 for all patients undergoing inferior turbinectomy. We resect with endoscopic assistance the lateral mucosa ...
Rao Rameshwar R - - 2012
Co-cultures of endothelial cells (EC) and mesenchymal stem cells (MSC) in three-dimensional (3D) protein hydrogels can be used to recapitulate aspects of vasculogenesis in vitro. MSC provide paracrine signals that stimulate EC to form vessel-like structures, which mature as the MSC transition to the role of mural cells. In this ...
Baiyewu Olusegun - - 2012
Few studies have examined the neuropsychiatric status of patients with dementia and cognitive impairment in the developing world despite the fact that current demographic trends suggest an urgent need for such studies. To assess the level of neuropsychiatric symptoms in community-dwelling individuals with dementia, cognitive impairment no dementia and normal ...
Frawley Geoff - - 2012
To document the incidence of difficult airway management and difficult intubation in the era of replacement therapy for Australian children with mucopolysaccharidosis (MPS). Medical treatment for MPS has developed significantly since 1980's with a large number of patients now being offered either bone marrow transplant or enzyme replacement. The impact ...
Katlama Christine - - 2012
Development of new antiretroviral drugs which are highly potent, tolerable over the long term and with a high genetic barrier to resistance is essential for the treatment of a chronic viral disease that requires life-long therapy with near-perfect medication adherence. Integrase inhibitors (INI) are a new class of antiretroviral drugs ...
Gagnon Marilou M School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. - - 2013
Treatment adherence issues in the context of chronic illnesses have become an important concern worldwide and a top priority in the field of health-care. The development of devices that will allow healthcare providers to track treatment adherence and monitor physiological parameters with exact precision raises important questions and concerns. The ...
Chishimba Livingstone L Manchester Academic Health Science Centre, The University of Manchester, Manchester, - - 2012
Rationale and objectives. Severe asthma with fungal sensitization (SAFS) and allergic bronchopulmonary aspergillosis (ABPA) are progressive allergic fungal lung diseases whose effective treatment remains to be established. Current treatment with itraconazole is associated with a 40% failure rate and adverse events (AEs). We assessed the effect of voriconazole or posaconazole ...
Parks R M RM The Centre for Spinal Studies and Surgery, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham, NG7 2UH, UK. - - 2013
Odontoid fractures are the most common upper cervical spine fracture. There are two mechanisms in which odontoid fractures occur, most commonly hyperflexion of the neck resulting in displacement of the dens anteriorly and hyperextension resulting in posterior dens displacement. Type 2 fractures are the most common and are associated with ...
Watson Caroline C Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, Georgia 30602, - - 2012
Unlike small molecule drugs, therapeutic protein pharmaceuticals must not only have the correct amino acid sequence and modifications, but also the correct conformation to ensure safety and efficacy. Here, we describe a method for comparison of therapeutic protein conformations by hydroxyl radical protein footprinting using liquid chromatography-mass spectrometry (LC-MS) as ...
McGregor A H AH Surgery and Cancer, Faculty of Medicine, Imperial College London, Charing Cross Hospital Campus, London, UK. - - 2012
This study evaluated an evidence-based education booklet developed for patients undergoing spinal surgery which was used as a treatment intervention in a multi-centre, factorial, randomised controlled trial (FASTER: Function after spinal treatment, exercise and rehabilitation) investigating the post-operative management of spinal surgery patients. This study sought to determine the acceptability ...
Burton E J EJ Institute for Ageing and Health, Newcastle University, UK. - - 2012
The purpose of this study was to investigate the neuropathological substrates underlying in vivo hippocampal atrophy on magnetic resonance imaging (MRI) in autopsy confirmed neurodegenerative dementia cases. Thirty-one neuropathologically verified cases (23 with Lewy body dementia (LBD) and eight with Alzheimer's disease (AD)) were included who had undergone an MRI ...
Wolke Dieter D Department of Psychology, University of Warwick, Coventry, UK. - - 2012
Abuse by adults has been reported as a potent predictor of borderline personality disorder (BPD). Unclear is whether victimisation by peers increases the risk of borderline personality symptoms. The Avon Longitudinal Study of Parents and Children (ALSPAC) prospective, longitudinal observation study of 6050 mothers and their children. Child bullying was ...
Gardner B B Health Behaviour Research Centre, University College London, London, UK. - - 2012
Consuming a healthy diet in pregnancy has the potential to improve obstetric outcome, including minimising the risk of macrosomia. Effective promotion of dietary change depends on identifying and targeting determinants of gestational diet. The present study aimed to model psychological predictors of intentions to reduce intake of high-fat and high-sugar ...
Youngblut Matthew M Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, 3210 N. Cramer St, Milwaukee, WI 53211, - - 2012
The high-yield expression and purification of Shewanella oneidensis cytochrome c nitrite reductase (ccNiR) and its characterization by a variety of methods, notably Laue crystallography, are reported. A key component of the expression system is an artificial ccNiR gene in which the N-terminal signal peptide from the highly expressed S. oneidensis ...
Bonfanti Paola P Diabetes Research Center, Vrije Universiteit Brussel, Brussels, - - 2012
More than a decade ago, 'plasticity' suddenly became a 'fashionable' topic with overemphasized implications for regenerative medicine. The concept of 'plasticity' is supported by old transplantation work, at least for embryonic cells, and metaplasia is a classic example of plasticity observed in patients. Nevertheless, the publication of a series of ...
Flammer Andreas J AJ Division of Cardiovascular Diseases, Mayo Clinic and College of Medicine, 200 1st Street SW, Rochester, MN 55905, - - 2013
Cranberry juice (CJ) contains a remarkably high concentration of polyphenols, considered to be beneficial for cardiovascular and bone health. The current double-blind, randomized study was designed to test whether daily consumption of double-strength Ocean Spray light CJ (2 × 230 ml) over 4 months has beneficial effects on vascular function ...
Liu Qian Q Threshold Pharmaceuticals, 170 Harbor Way, Suite 300, South San Francisco, CA 94080, - - 2012
Subregional hypoxia is a common feature of tumors and is recognized as a limiting factor for the success of radiotherapy and chemotherapy. TH-302, a hypoxia-activated prodrug selectively targeting hypoxic regions of solid tumors, delivers a cytotoxic warhead to the tumor, while maintaining relatively low systemic toxicity. The antitumor activity, different ...
Dean L G LG Centre for Social Learning and Cognitive Evolution, School of Biology, University of St. Andrews, Queen's Terrace, St. Andrews, Fife, - - 2012
The remarkable ecological and demographic success of humanity is largely attributed to our capacity for cumulative culture, with knowledge and technology accumulating over time, yet the social and cognitive capabilities that have enabled cumulative culture remain unclear. In a comparative study of sequential problem solving, we provided groups of capuchin ...
Fang Carolyn Y CY Cancer Prevention and Control Program, Fox Chase Cancer Center, Robert C. Young Pavilion, 4th Floor, 333 Cottman Avenue, Philadelphia, PA 19111, USA. - - 2013
Accumulating data suggest that depression is associated with risk factors for cardiovascular disease, but few studies have investigated potential behavioral mediators of such associations, particularly among women. In this study of healthy young adult women (n = 225), we examined associations among depressive symptoms, health behaviors, and serum lipid levels. Depressive symptoms ...
Morihara Daisuke D Department of Gastroenterology Division of Advanced Clinical Research for Viral Hepatitis and Liver Cancer, Fukuoka University Faculty of Medicine Department of Internal Medicine, Fukuseikai Hospital Department of Gastroenterology, Fukuoka City Medical Association Hospital Department of Medicine, Hakujyuji Hospital Department of Hepatology, Japanese Red Cross Fukuoka Hospital, Fukuoka, - - 2012
  This prospective study was designed to examine whether consumption of a branched-chain amino acid (BCAA)-enriched nutrient mixture as a late-evening snack (LES) helps maintain and/or improve liver functioning in liver cirrhosis (LC) patients who have undergone radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC).   An equal number (10) of ...
Hren Darko - - 2012
In medicine, professional behavior and ethics are often rule-based. We assessed whether instruction on formal criteria of authorship affected the decision of students about authorship dilemmas and whether they perceive authorship as a conventional or moral concept. A prospective non-randomized intervention study involved 203s year medical students who did (n = 107) or ...
Shearn Andrew I U - - 2012
OBJECTIVE: Bcl-x is the most abundantly expressed member of the Bcl-2 gene family in macrophages but its role in macrophage apoptosis during atherogenesis is unknown. METHODS AND RESULTS: We previously reported dual pro- and antiatherogenic effects of macrophage survival in early versus advanced atherosclerotic lesions, respectively, potentially reflecting growing impairment ...
Origoni M - - 2012
Human papillomavirus (HPV) testing is more sensitive and has higher negative predictive value (NPV) than the Pap test for the detection of cervical intraepithelial neoplasia (CIN) in patients with atypical squamous cells of undetermined significance (ASCUS) cytology, but has low specificity, leading to high referral rates to second-level triage. Our ...
Shokeir Ahmed A - - 2012
What's known on the subject? and What does the study add? It is known that the kidney damage continues even after release of ureteric obstruction. This study found that giving ferulic acid, antioxidant, after release of ureteric obstruction enhanced the recovery of kidney functions in solitary kidney. OBJECTIVE: •  To ...
Larson Theodore C - - 2012
BackgroundAmong asbestos-exposed individuals, abnormal spirometry is usually associated with parenchymal abnormalities or diffuse pleural thickening. Localised pleural thickening (LPT), the most common abnormality associated with asbestos exposure, is typically thought to be a marker of exposure with little clinical consequence. Our objective was to determine if abnormal spirometry is associated ...
Rodríguez Fernando - - 2012
The design of mimic molecules that resemble natural products can be a useful tool to help understand the key aspects in molecular recognition processes that are difficult to access by using natural derivatives. We present the synthesis and the conformational analysis of different glucosylated diamide amino acids that simulate glycopeptides ...
Dietrich Hartmut - - 2012
Objective: This study was conducted to evaluate the safety, tolerability and pharmacokinetics of different doses of a long-acting release (LAR) formulation of pasireotide in healthy subjects.Design: Single-center, open-label, randomized Phase I study.Methods: Twelve healthy male subjects received a single subcutaneous (sc) dose of pasireotide 300 µg, followed by a washout ...
Kawahara Kazuki - - 2012
We have characterized various structures of (Pro-Hyp<sup><i>R</i></sup>-Gly)<sub>3</sub>-Pro-fPro<sup><i>R</i></sup>-Gly-(Pro-Hyp<sup><i>R</i></sup>-Gly)<sub>3</sub> in the process of cis-trans isomerization and helix-coil transition by exploiting the sole <sup>19</sup>F NMR probe in 4(<i>R</i>)-fluoroproline (fPro<sup><i>R</i></sup>). Around the transition temperature (<i>T</i><sub>m</sub>), we detected a species with triple helical structure distinct from the ordinary one concerning the alignment of three strands. ...
Denadai Rafael - - 2012
Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH) are rare, autosomal recessive disorders of the connective tissue caused by mutations in the gene encoding the anthrax toxin receptor 2 protein (ANTXR2) located on chromosome 4q21. Characteristically, these conditions present with overlapping clinical features, such as nodules and/or pearly papules, ...
Cottenceau Hélène - - 2012
Relationships are of great importance during adolescence. Because of their social, communication and behavioral impairments, adolescents with Asperger's syndrome (AS) or high functioning autism (HFA) probably suffer from considerable impairment of their quality of life when facing their peers in school. Nevertheless, only one recent study has been published on ...
Sørensen Karina Meden - - 2012
Recurrent copy number variants (CNVs) are found in a significant proportion of patients with congenital heart disease (CHD) and some of these CNVs are associated with other developmental defects. In some syndromic patients, CHD may be the first presenting symptom, thus screening of patients with CHD for CNVs in specific ...
Pittayapat P - - 2012
OBJECTIVES: The objective of this study is to compare subjective image quality and diagnostic validity of cone-beam CT (CBCT) panoramic reformatting with digital panoramic radiographs. MATERIALS AND METHODS: Four dry human skulls and two formalin-fixed human heads were scanned using nine different CBCTs, one multi-slice CT (MSCT) and one standard ...
Merrill Loren - - 2012
There is some discrepancy in the literature regarding whether acute stress is immunostimulatory or immunosuppressive. Studies of domesticated (laboratory and food) animals and humans typically indicate that acute stress is immunostimulatory, whereas studies of non-domesticated species document both immunostimulatory and immunosuppressive results. Few studies have examined the mechanisms responsible for ...
Weatherall Mark W - - 2012
This article discusses the leading 19th century British contributions to theories of migraine pathogenesis: Edward Liveing's theory of nerve storms and Peter Wallwork Latham's vasomotor theory, providing a detailed accounts of their origin, and their rise and fall in the latter decades of the century, emphasizing the central role of ...
Fehrenbacher Jill C - - 2012
Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. This unit details methods to elicit and measure carrageenan- and complete ...
Van Mellaert Lieve - - 2012
Previously considered a human commensal, Staphylococcus epidermidis is a frequent cause of nosocomial infections and the most common cause of device-related infections. Because the expression of toxins and other obvious virulence factors is less in S. epidermidis, the biofilm-forming capacity is its major virulence factor. Biofilm growth is characterized by ...
Cossu Massimo - - 2012
Object The authors report on the use of stereoelectroencephalography (stereo-EEG) in the presurgical electroclinical evaluation of infants and very young children with focal drug-resistant epilepsy. Methods Fifteen patients (9 girls and 6 boys, mean age 34.1 ± 7.3 months, range 21-45 months), potentially candidates to receive surgical treatment for their ...
Miñano Pérez Pablo - - 2012
As a result of studies examining factors involved in the learning process, various structural models have been developed to explain the direct and indirect effects that occur between the variables in these models. The objective was to evaluate a structural model of cognitive and motivational variables predicting academic achievement, including ...
Fernández Juan - - 2012
Sexual attraction was considered a component of sexual orientation from the beginning of the second half of the 20th century to present times. However, some recent researchers have studied sexual attraction as an independent field measuring it by the Sexual Attraction Questionnaire (SAQ). This study analyzes sexual attraction through the ...
Giordano Marco - - 2012
Purpose: Periprocedural assessment of tissue perfusion by imaging methods could improve outcome control during treatment of peripheral vascular disease. Currently, endovascular revascularization treatments are assessed by planar angiography which only allows for qualitative inspection of blood flow in vessels. In this paper, we present a method for periprocedural perfusion estimation ...
Lebonvallet Nicolas - - 2012
Adult stem cells could be small sources of neurons or other cellular types for regenerative medicine and tissue engineering. Recently, pluripotent stem cells have been extracted from skin tissue, which opened a new accessible source for research. To routinely obtain a high yield of functional neurons from adult human skin ...
Silva Leila S V - - 2012
Cardiovascular disease is the main cause of death among patients with end-stage renal disease (ESRD). The present study was undertaken to identify the main cardiovascular diseases and their risk factors in 160 patients with ESRD on hemodialysis (HD) in Brazil. Their mean age was 47 ± 39 years. The main ...
Shang Weilong - - 2012
Virus-like particles (VLPs) are shell-like viruses that lack virus-specific genetic materials. Many viral-structured proteins can assemble into VLPs, which mimic the overall structure of virus particles and can elicit strong immune responses in a host. Dengue viruses (DENVs), from the genus Flavivirus, are transmitted to humans through the bites of ...
Wolkerstorfer Silviya Velichkova - - 2012
The vulnerability of the xylem to cavitation is an important trait in plant drought resistance and has been quantified by several methods. We present a modified method for the simultaneous measurement of cavitations, recorded as ultrasound acoustic emissions (UAEs), and the water potential, measured with a thermocouple psychrometer, in small ...
Conway Ben - - 2012
As the aluminate base [LiAl(TMP)(2)(iBu)(2)] 1 displays halogen tolerance towards substituted aromatics, 4-halo-anisoles have been ortho-aluminated and electrophilically quenched to form synthetically useful multi-heterohalogenated anisoles, with the Al intermediates along the route structurally defined.
Musnier Astrid - - 2012
FSH is a key hormonal regulator of Sertoli cell secretory activity, required to optimize sperm production. To fulfil its biological function, FSH binds a G protein-coupled receptor, the FSH-R. The FSH-R-transduced signaling network ultimately leads to the transcription or down-regulation of numerous genes. In addition, recent evidence has suggested that ...
Qu Jingya - - 2012
An on-line solid phase extraction device combined with flow-through chemiluminescence monitoring was presented for the enrichment and determination of humic acid (HA) in water samples. The chemiluminescence principle was based on the enhancement effect of HA on the Ce(iv)/H(2)SO(4)-rhodamine 6G chemiluminescence system. For sample pretreatment, the on-line solid-phase extraction (SPE) ...
Phosrithong Narumol - - 2012
Forty-eight chromone derivatives were evaluated for their antioxidant activity using DPPH free radical scavenging assay, ferrous ions (Fe(2+) ) chelating activity test, total antioxidant activity test (FTC and TBA methods) and total reductive capability (potassium ferricyanide reduction). 7,8-Dihydroxy-2-(3'-trifluoromethylphenyl)-3-(3''-trifluoromethylbenzoyl) chromone 32 showed stronger radical scavenging and metal chelating activities than butylated ...
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