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Ogburn R Matthew - - 2012
Quantification of succulence should ideally convey information about physiological function and yet also be straightforward to measure. While important aspects of succulence and its physiological consequences may be quantified using parameters derived from pressure volume (P-V) curves, this technique applied to succulent tissues is difficult, time-consuming, and generally not suitable ...
Weidmann Anita Elaine - - 2012
Background Obesity has reached pandemic levels, with more than 1.5 billion adults being affected worldwide. In Scotland two-thirds of men and more than half of women are either overweight or obese, placing Scotland overall third behind the United States of America and Mexico. All community pharmacies in Scotland are contracted ...
Shu Ming-Wei - - 2012
Manual shaking-enhanced, ultrasound-assisted emulsification microextraction (MS-USAEME) combined with ultraperformance liquid chromatography (UPLC) with UV detection has been developed for the determination of five endocrine-disrupting phenols (EDPs) in seawater samples and detergent samples: 4-tert-butylphenol (4-t-BP), 4-cumylphenol (4-CP), 4-tert-octylphenol (4-t-OP), 2,4-di-tert-butylphenol (2,4-di-t-BP) and 4-nonylphenol (4-NP). Optimum conditions were found to be: 25 ...
Toi Masakazu - - 2012
BACKGROUND: TSU-68 is a novel multiple tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor-2, platelet-derived growth factor receptor, and fibroblast growth factor receptor. This open-label, non-comparative, multicenter phase II study evaluated TSU-68 in combination with docetaxel in patients with metastatic breast cancer that had relapsed within 1 year despite ...
Abe Satoshi - - 2012
Magnetic bimetallic CoPt nanoparticles are synthesized in the solvent channels of hen egg white lysozyme crystals by the reduction of Co(2+) and Pt(2+) ions pre-organized on the interior surface of the solvent channels. By using different lysozyme crystal systems, the magnetic properties of CoPt nanoparticles can be controlled.
Hu Ying - - 2012
The role of lower esophageal sphincter (LES) in laryngopharyngeal reflux is controversial. In this study, we used an animal model to investigate the association between LES dysfunction and reflux laryngitis. Twelve healthy New Zealand albino rabbits (2.5-3.5 kg) were utilized in this study. The animals were divided into two groups. Eight ...
Liu Hai-Yan - - 2012
Two novel inorganic-organic hybrid compounds based on octamolybdates, namely, [Cu(H(2)L)(2)(γ-Mo(8)O(26))]·(Mo(6)O(19))·2H(2)O (1) and [Cu(H(2)L)(γ-Mo(8)O(26))(H(2)O)(2)]·5H(2)O (2), where L = 1,1'-(1,5-pentanediyl)bis[2-(4-pyridyl)benzimidazole], have been successfully synthesized at different pH values under hydrothermal conditions. Compound 1, which is hydrothermally prepared at pH ≈ 3.5, exhibits an entirely new type of intercalated layer. The nanosized hexamolybdate ...
Njølstad P R - - 2012
To test, or not to test, that is often the question in diabetes genetics. This is why the paper of Shields et al in the current issue of Diabetologia is so warmly welcomed. MODY is the most common form of monogenic diabetes. Nevertheless, the optimal way of identifying MODY families ...
Najafpour Mohammad Mahdi - - 2012
CaMnO(3) and Ca(2)Mn(3)O(8) were synthesized and characterized by SEM, XRD, FTIR and BET. Both oxides showed oxygen evolution activity in the presence of oxone, cerium(iv) ammonium nitrate and H(2)O(2). Oxygen evolution from water during irradiation with visible light (λ > 400 nm) was also observed upon adding these manganese oxides ...
Briceño R D - - 2012
Orb-weaving spiders construct webs with adhesive silk but are not trapped by it. Previous studies have attributed this defense to an oily coating on their legs that protects against adhesion or, more recently, to behavioral avoidance of sticky lines. The old evidence is very weak, however, and the behavioral avoidance ...
Aagesen Alisha M - - 2012
Bacterial surface structures called pili have been studied extensively for their role as possible colonization factors. Most sequenced Vibrio genomes predict a variety of pili genes in these organisms, including several types of type IV pili. In particular, the mannose-sensitive hemagglutinin (MSHA) and the PilA pili, also known as the ...
Baiyewu Olusegun - - 2012
Few studies have examined the neuropsychiatric status of patients with dementia and cognitive impairment in the developing world despite the fact that current demographic trends suggest an urgent need for such studies. To assess the level of neuropsychiatric symptoms in community-dwelling individuals with dementia, cognitive impairment no dementia and normal ...
Shohag Hasanuzzaman - - 2012
The purpose of the present study was to evaluate the status of serum trace elements: zinc, copper, manganese, iron, calcium, and magnesium concentrations in obsessive-compulsive disorder patients. Forty-eight obsessive-compulsive disorder patients and 48 healthy volunteers were included in this study. Patients were recruited from Bangabandhu Sheikh Mujib Medical University by ...
Son Nari - - 2012
We used UPLC-Q-TOF MS to analyze hepatic metabolites of rats aged 6, 12, 18, and 24 months; the MS data were processed by partial least-squares discriminant analysis (PLS-DA) to investigate the discrimination among sample groups. Rats were significantly separated with increasing age, except those aged between 6 and 12 months. ...
Ramezani Tehrani Fahimeh - - 2012
Aim:  Women with gestational diabetes (GDM) are at increased risk of developing type 2 diabetes mellitus (T2DM), but there is disagreement regarding this conversion rate or its cardiovascular consequences. We investigated the metabolic and cardiovascular consequences of women with GDM in a population-based cohort study. Material and Methods:  Three groups ...
Li Xiaoxun X School of Pharmacy and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, United - - 2012
Functionalized cyclopentenones were synthesized by a Rh-catalyzed carbonylation of 3-acyloxy-1,4-enynes, derived from alkynes and α,β-unsaturated aldehydes. The reaction involved a Saucy-Marbet 1,3-acyloxy migration of propargyl esters and a [4 + 1] cycloaddition of the resulting acyloxy substituted vinylallene with CO.
Li Ming - - 2012
To meet the requirement of Raman probes (labels) for biocompatible applications, a synthetic approach has been developed to sandwich the Raman-probe (malachite green isothiocyanate, MGITC) molecules between the gold core and the silica shell in gold-SiO(2) composite nanoparticles. The gold-MGITC-SiO(2) sandwiched structure not only prevents the Raman probe from leaking ...
Takata Kazuyuki - - 2012
Pathological hallmarks of Alzheimer's disease (AD) include senile plaques, neurofibrillary tangles (NFTs), synaptic loss, and neurodegeneration. Senile plaques are composed of amyloid-β (Aβ) and are surrounded by microglia, a primary immune effector cell in the central nervous system. NFTs are formed by the intraneuronal accumulation of hyperphosphorylated tau, and progressive ...
Desouza Ruth-Mary - - 2012
Over recent years, hip resurfacing has been performed in young, active patients, including women in their child bearing years. Current work investigating the transplacental passage of metal ions (cobalt and chromium) suggests significant passage of ions across the placenta in mothers with metal on metal hip resurfacing. In vitro studies ...
Diskin E - - 2012
To date, phenological research has provided evidence that climate warming is impacting both animals and plants, evidenced by the altered timing of phenophases. Much of the evidence supporting these findings has been provided by analysis of historic records and present-day fieldwork; herbaria have been identified recently as an alternative source ...
Parejko James A - - 2012
Certain strains of the rhizosphere bacterium Pseudomonas fluorescens contain the phenazine biosynthesis operon (phzABCDEFG) and produce redox-active phenazine antibiotics that suppress a wide variety of soilborne plant pathogens. In 2007 and 2008, we isolated 412 phenazine-producing (Phz(+)) fluorescent Pseudomonas strains from roots of dryland wheat and barley grown in the ...
Bartram David J - - 2012
PURPOSE: To examine the psychometric properties of the 14-item Warwick-Edinburgh Mental Well-being Scale (WEMWBS) in the UK veterinary profession by the application of Rasch analysis, and to assess the external construct validity of the derived interval scale measurements. METHODS: Data sets were derived from two independent cross-sectional surveys of the ...
Shah Manish N - - 2012
Object This study describes the pediatric experience with a dual-multifunction-room IMRIS 1.5-T intraoperative magnetic resonance imaging (iMRI) suite and analyzes its impact on clinical variables associated with neurosurgical resection of intracranial lesions, including safety and efficacy. Methods Since the inception of the iMRI-guided resection program in April 2008 at both ...
García López Oscar - - 2012
There is some evidence about the low relationship between physical prowess and cognitive function (Posthuma, Mulder, Boomsma & de Geus, 2002). The aim of this paper is to investigate the relationship between cognitive variables (spatial ability, reasoning, numerical ability, inductive reasoning, and reasoning and verbal comprehension) and physical prowess in ...
Fountos G P - - 2012
Purpose: To evaluate modulation transfer function (MTF) in single photon emission computed tomography (SPECT) systems using the line spread function (LSF) method and a novel flood source which can be easily fabricated with materials accessible in hospital facilities.Methods: A Tc-99m-based flood source (E(γ) = 140 keV) consisting of a radiopharmaceutical bound to ...
Garcia Guillermo Garcia - - 2012
World Kidney Day on March 8 th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost effectiveness. Anything that is ...
Wannamethee S Goya - - 2012
BACKGROUND AND PURPOSE: Abnormalities in blood coagulation and the fibrinolytic system have been associated with increased risk of stroke, but few prospective studies have studied the associations in older adults. We have examined the associations between fibrin D-dimer, tissue-type plasminogen activator, and von Willebrand factor (vWF) and risk of stroke ...
Doré Louis C - - 2012
There are many examples of transcription factor families whose members control gene expression profiles of diverse cell types. However, the mechanism by which closely related factors occupy distinct regulatory elements and impart lineage specificity is largely undefined. Here we demonstrate on a genome wide scale that the hematopoietic GATA factors ...
Zorzoli Alessia - - 2012
PURPOSE: Acute myeloid leukemia (AML) accounts for more than half of fatal cases in all pediatric leukemia patients; this observation highlights the need of more effective therapies. Thus, we investigated whether interleukin (IL)-27, an immunomodulatory cytokine, functions as an antitumor agent against pediatric AML cells.EXPERIMENTAL DESIGN: Expression of WSX-1 and ...
Cheng Zhaokang - - 2012
OBJECTIVE: We previously reported that cardiac-restricted deletion of focal adhesion kinase (FAK) exacerbated myocyte death following ischemia/reperfusion (I/R). Here, we interrogated whether targeted elevation of myocardial FAK activity could protect the heart from I/R injury. METHODS AND RESULTS: Transgenic mice were generated with myocyte-specific expression of a FAK variant (termed ...
Domínguez-Punaro M C - - 2012
Hearing impairment is a common and frequently permanent sequel of Streptococcus suis meningitis in humans. Nevertheless, mechanisms underlying the development of cochlear damage have not been addressed so far. In the present work, we characterized a mouse model of suppurative labyrinthitis and meningitis induced by a systemic infection with S. ...
Paris Christophe - - 2012
ObjectiveKnowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001-2009.MethodData were collected from the French national network of occupational health surveillance and prevention ...
Okazaki Yasumasa Y Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, - - 2012
The divalent metal transporter 1 (DMT1) is essential for cellular uptake of iron, mediating iron absorption across the duodenal brush border membrane. We have previously shown that with iron feeding DMT1 in the brush border membrane undergoes endocytosis into the subapical compartment of enterocytes. To understand the mechanisms of iron-induced ...
Ravesh M Salehi - - 2012
Tissue microcirculation can be quantified by a deconvolution analysis of concentration-time curves measured by dynamic contrast-enhanced magnetic resonance imaging. However, deconvolution is an ill-posed problem, which requires regularization of the solutions. In this work, four algebraic deconvolution/regularization methods were evaluated: truncated singular value decomposition and generalized Tikhonov regularization (GTR) in ...
Gurovich Alvaro N - - 2012
Blood flow-induced endothelial shear stress (ESS) during aerobic (AX) and resistance (RX) exercise can regulate endothelial function. However, non-invasive in vivo ESS estimation is normally obtained only according to Poiseuille's laws for streamline flow, rather than using Womersley's approximation for pulsatile flows. Here, we sought to determine brachial and femoral ...
Kim Kyoungmok - - 2012
Herein, we report a [NiRu] biomimetic system for O(2) -tolerant [NiFe]hydrogenases and demonstrate that electron donation to the [NiRu] center can switch the system between the activation of H(2) and O(2) through simple ligand effects by using hexamethylbenzene and pentamethylcyclopentadienyl ligands, respectively. Furthermore, we present the synthesis and direct observations ...
Klein-Júnior Luiz C - - 2012
Polygala cyparissias, used in folk medicine as an anaesthetic, has already demonstrated anti-nociceptive activity against acute pain. In this study, we investigated the anti-hyperalgesic activity of the P. cyparissias methanol extract (PCME) from which the following compounds were isolated: α-spinasterol (PC1), 1,3-dihydroxy-7-methoxyxanthone (PC2), 1,7-dihydroxy-2,3-methylenedioxyxanthone (PC3) and 1,3,6,8-tetrahydroxy-2,7-dimethoxyxanthone (PC4). The anti-hyperalgesic ...
Chi Wei-Jie - - 2012
A series of polynitroprismanes, C(6)H(6-n )(NO(2))(n) (n = 1-6) intended for use as high energy density compounds (HEDCs) were designed computationally. Their electronic structures, heats of formation, interactions between nitro groups, specific enthalpies of combustion, bond dissociation energies, and explosive performances (detonation velocities and detonation pressures) were calculated using density functional theory ...
Pfeifer Christian - - 2012
This research note analyzes differences in the number of absent working days and doctor visits and in their cyclicality between private sector, public sector and self-employed workers. For this purpose, I used large-scale German survey data for the years 1995 to 2007 to estimate random effects negative binomial (count data) ...
Zhang Xiaoguang - - 2012
We have systematically investigated the effect of alcohols (ethanol, propanol, butanol and pentanol) on the structure of water/AOT/IPM system using conductivity, dynamic light scattering (DLS) and small angle X-ray scattering (SAXS) techniques. The results show that no percolation phenomenon is observed in water/AOT/IPM system, whereas the addition of ethanol (propanol ...
Petruzzi Massimo - - 2012
OBJECTIVES: Implant rehabilitation in oral lichen planus (OLP) is a major challenge for clinicians and patients. There is limited scientific evidence, primarily case reports and small case series. We conducted a literature review of data on the effectiveness and safety of implant rehabilitation in OLP patients. MATERIAL AND METHODS: We ...
Baillot J - - 2012
The implementation of the social security system in 2005 in Mayotte has resulted in the end of free healthcare for all non-affiliated residents, primarily Comorians, due to the absence of the State Medical Aid (AME) in this department. Doctors of the World France opened a paediatric clinic in December 2009. ...
Feng Xiang - - 2012
Aortic valve calcification (AVC) is an active process characterized by osteoblastic differentiation of the aortic valve interstitial cells (AVICs). Taurine is a free β-amino acid and plays important physiological roles including protective effect of cardiovascular events. To evaluate the possible role of taurine in AVC, we isolated human AVICs from ...
Fiorbianco Valentina - - 2012
OBJECTIVE: To evaluate right intercostal Veress needle (VN) insertion for laparoscopy in dogs. STUDY DESIGN: Longitudinal cohort study. ANIMALS: Female dogs (n = 56). METHODS: The VN was inserted in the last palpable right intercostal space, either 1/3 (Group T; 28 dogs) or mid distance (Group H; 28 dogs) from ...
- - 2012
Metabolic network modeling and simulation present an effective approach for drug targeting and discovery. The cover image shows a bacterial cell in the center of its metabolic network in a circular layout. Surrounding molecules are possible target drugs. Read the article by Kim et al. http://dx.doi.org/10.1002/biot.201100159. Image by: Hyun Uk ...
Kodal Troels - - 2012
A reform of educational postgraduate medical training was launched in Denmark in 2004. The reform was based on a report by the Danish Medical Specialist Commission and consisted of a number of initiatives that were all aimed at improving the quality of medical training. Since 1998, all junior doctors in ...
Paramasivam Srinivasan - - 2012
The authors present a rare case of arteriovenous fistula (AVF) of the basal vein of Rosenthal draining into a dilated vein of Galen managed by transarterial endovascular embolization. A male infant born at full term following a normal pregnancy and delivery with congestive heart failure, on investigation with MR imaging ...
Moreno-Murcia Juan Antonio - - 2012
The purpose of this study, based on the self-determination theory (Ryan & Deci, 2000) was to test the prediction power of student's responsibility, psychological mediators, intrinsic motivation and the importance attached to physical education in the intention to continue to practice some form of physical activity and/or sport, and the ...
Boada-Grau Joan - - 2012
In this article, we study the psychometric properties of a short scale (TRANS-18) which was designed to detect safe behaviors (personal and vehicle-related) and psychophysiological disorders. 244 drivers participated in the study, including drivers of freight transport vehicles (regular, dangerous and special), cranes, and passenger transport (regular transport and chartered ...
Cho Daniel S - - 2012
Purpose: Although robot-assisted coronary artery bypass grafting (RA-CABG) has gained more acceptance worldwide, its success still depends on the surgeon's experience and expertise, and the conversion rate to full sternotomy is in the order of 15%-25%. One of the reasons for conversion is poor pre-operative planning, which is based solely ...
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