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Results 501 - 550 of 1428
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Colyer Ryan A - - 2012
Fluorescence lifetime can be used as a contrast mechanism to distinguish fluorophores for localization or tracking, for studying molecular interactions, binding, assembly, and aggregation, or for observing conformational changes via FoĢˆrster resonance energy transfer (FRET) between donor and acceptor molecules. Fluorescence lifetime imaging microscopy (FLIM) is thus a powerful technique ...
Jiménez-Ibáñez Enrique O - - 2012
A common finding in patients admitted to an Intensive Care Unit (ICU) is hyperglycemia without prior history of diabetes. This increase in blood glucose is considered a negative prognostic factor for patients in the ICU. Hence, we performed a retrospective cohort study in patients admitted at the ICU of the ...
Moriguchi Hisashi - - 2012
Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may ...
Motlagh Mohammad Esmail - - 2012
In Iran, diarrheal disease is the fourth cause of under five-year mortality. Proper care-seeking behavior and system-based disease management in the national field will have a great effect in reducing morbidity and mortality. This nationwide study was performed on a target population of rural and urban communities; in all 31 ...
Caglià Pietro - - 2012
To assess the suitability of laparoscopic cholecystectomy in elderly patients, although early reports have questioned the efficacy of this procedure in that patient group. Retrospective study evaluating the medical records of the elderly patients who underwent laparoscopic cholecystectomy in our surgical unit. Data included age and gender, American Society of ...
Matsuki Tohru T Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York, United States of - - 2012
Hyperphosphorylation of the microtubule binding protein Tau is a feature of a number of neurodegenerative diseases, including Alzheimer's disease. Tau is hyperphosphorylated in the hippocampus of dab1-null mice in a strain-dependent manner; however, it has not been clear if the Tau phosphorylation phenotype is a secondary effect of the morbidity ...
Shome Saurav - - 2012
Angiogenesis is an important step in the complex biological and molecular events leading to successful healing of dermal wounds. Among the different cellular effectors of wound angiogenesis, the role of mesenchymal stem cells (MSCs) is of current interest due to their transdifferentiation and proangiogenic potentials. Skin is richly innervated by ...
Agrillo Christian - - 2012
Humans and non-human animals share an approximate non-verbal system for representing and comparing numerosities that has no upper limit and for which accuracy is dependent on the numerical ratio. Current evidence indicates that the mechanism for keeping track of individual objects can also be used for numerical purposes; if so, ...
Han Rui-Min - - 2012
Flavonoids and carotenoids with rich structural diversity are ubiquitously present in the plant kingdom. Flavonoids, and especially their glycosides, are more hydrophilic than most carotenoids. The interaction of flavonoids with carotenoids occurs accordingly at water/lipid interfaces and has been found important for the functions of flavonoids as antioxidants in the ...
Tan Hongliang - - 2012
Great efforts have been devoted to the development of sensitive and specific analysis methods for biothiols because of their important roles in biological systems. We present a new detection system for biothiols that is based on the reversible quenching and restoration of fluorescence of terbium chelate caused by Hg(2+) and ...
Nakano Masako - - 2012
A 48-year-old woman presented with a 2-week history of headache. The headache was so severe in the standing position that she could hardly stand up. The results of general and neurological examination were unremarkable. MRI studies of the brain showed diffuse pachymeningeal gadolinium enhancement on the T(1) weighted images. The ...
Haruta Mitsutaka - - 2012
The structural analysis of crystal defects in organic thin films provides fundamental insights into their electronic properties for applications such as field effect transistors. Observation of crystal defects in organic thin films has previously been performed at rather low resolution by conventional transmission electron microscopy based on phase-contrast imaging. Herein, ...
Yamashita Toshiya - - 2012
Guidelines for the diagnosis of reading disorders in elementary school students were published recently in Japan. On the basis of these guidelines, we administrated reading test batteries to 43 Japanese junior high-school students from grade two. The reading test consisted of single sounds, single words, and single sentences. We evaluated ...
Chen Grace Megumi - - 2012
Rigorous, quantitative examination of therapeutic techniques anecdotally reported to have been successful in people with autism who lack communicative speech will help guide basic science toward a more complete characterisation of the cognitive profile in this underserved subpopulation, and show the extent to which theories and results developed with the ...
Jadi Salsabeel - - 2012
To determine the impact of incubation solution composition on protein deposition to silicone hydrogel (SH) contact lenses using a simplistic and a complex model of the tear film. Three SH materials--senofilcon A (SA), lotrafilcon B (LB), and balafilcon A (BA)--were incubated in two different solutions; Solution A was a simplistic ...
Krill Austen L AL Georgia Gwinnett College, School of Liberal Arts, Lawrenceville, Georgia, United States of America. - - 2012
Humans use theory of mind when predicting the thoughts and feelings and actions of others. There is accumulating evidence that cooperation with a computerized game correlates with a unique pattern of brain activation. To investigate the neural correlates of cooperation in real-time we conducted an fMRI hyperscanning study. We hypothesized ...
Bourlier Virginie - - 2012
The present study was undertaken to characterize the remodeling phenotype of human adipose tissue (AT) macrophages (ATM) and to analyze their paracrine effects on AT progenitor cells. The phenotype of ATM, immunoselected from subcutaneous (Sc) AT originating from subjects with wide range of body mass index and from paired biopsies ...
Rantala Markus J - - 2012
Secondary sexual traits that develop under the action of testosterone, such as masculine human male facial characteristics, have been proposed to signal the strength of the immune system due to the sex hormone's immunosuppressive action. Recent work has suggested that glucocorticoid stress hormones may also influence expression of such sexual ...
Simanjuntak Gilbert W S - - 2012
Background: To describe the technique for the removal of bulky fibrin in persistent traumatic full hyphema by using anterior chamber maintainer (ACM). Methods: The ACM was used to reform and maintain the anterior chamber, and to flush out the clotted blood. The ACM cannula was inserted at the 6 o'clock ...
Harrison Neil - - 2012
The phenomenon of crossmodal dynamic visual capture occurs when the direction of motion of a visual cue causes a weakening or reversal of the perceived direction of motion of a concurrently presented auditory stimulus. It is known that there is a perceptual bias towards looming compared to receding stimuli, and ...
Andres-Enguix Isabelle - - 2012
A loss of function mutation in the TRESK K2P potassium channel (KCNK18), has recently been linked with typical familial migraine with aura. We now report the functional characterisation of additional TRESK channel missense variants identified in unrelated patients. Several variants either had no apparent functional effect, or they caused a ...
Soudry Daniel - - 2012
In recent experiments, synaptically isolated neurons from rat cortical culture, were stimulated with periodic extracellular fixed-amplitude current pulses for extended durations of days. The neuron's response depended on its own history, as well as on the history of the input, and was classified into several modes. Interestingly, in one of ...
Lagoe Ronald J - - 2012
As the urgency of healthcare cost containment in the United States increases, this study concerns the impact of this process at the community level in the metropolitan area of Syracuse, New York. It suggests that the responses of the Syracuse hospitals to cost containment have resulted in greater numbers of ...
Adams Jean J Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom. - - 2012
In 2007, new scheduling restrictions on television food advertising to children in the UK were announced. The aim of the restrictions was to "reduce significantly the exposure of children under 16 to high fat, salt or sugar (HFSS) advertising". We explored the impact of the restrictions on relative exposure to ...
Glowacki David R - - 2012
The role of protein dynamics in enzyme catalysis is a matter of intense current debate. Enzyme-catalysed reactions that involve significant quantum tunnelling can give rise to experimental kinetic isotope effects with complex temperature dependences, and it has been suggested that standard statistical rate theories, such as transition-state theory, are inadequate ...
Miller Elizabeth K - - 2012
Early loss of immature permanent teeth due to pulpal necrosis secondary to trauma can have dire consequences for a child's growth and development. The treatment alternatives include surgical endodontics, traditional calcium hydroxide apexification, and mineral trioxide aggregate (MTA) apexification. These options pose potential complications, including: arrest of root development; weakened ...
Unoda Ki-Ichi - - 2012
A 40-year-old man presented with sudden onset of severe left buttock pain that radiated down the thigh to the leg. On examination, he showed moderate weakness and atrophy in the left quadriceps and tibialis anterior muscles, and absence of a left patellar tendon reflex. Needle electromyography revealed an active denervation ...
Shimshek Derya R - - 2012
Mutations in α-synuclein (αSN) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) have been linked to familial Parkinson's disease (PD). Physical and functional interactions between these two proteins have been described. Whether they act additively in vivo to influence disease has remained controversial. αSN is a presynaptic protein and the major constituent ...
Yan Sheng - - 2012
Pancreas transplantation is the definite treatment for type 1 diabetes that enables the achievement of long-term normoglycemia and insulin independence. However Post-Transplantation Pancreatitis (PTP) due to ischemia reperfusion (IR) injury and preservation is a major complication in pancreas transplantation. Owning the potential anti-inflammatory effect of Cisplatin (Cis) in liver IR ...
Farnsworth Tracy J - - 2012
This paper presents a narrative summary of an increasingly important trend in medical education by addressing the merits of community-based distributive medical education (CBDME). This is a relatively new and compelling model for teaching and training physicians in a manner that may better meet societal needs and expectations. Issues and ...
Lin Ying - - 2012
The purposed of this study was to investigate the fibroblast growth factor receptor 2 (FGFR2) gene in one Chinese family with Crouzon syndrome and to characterize the related clinical features. One family underwent complete ophthalmic examinations, and two patients were diagnosed with Crouzon syndrome. Genomic DNA was extracted from leukocytes ...
Baryshyan Amanda L - - 2012
Skeletal muscle tissue engineering has the potential to treat tissue loss and degenerative diseases. However, these systems are also applicable for a variety of devices where actuation is needed, such as microelectromechanical systems (MEMS) and robotics. Most current efforts to generate muscle bioactuators are focused on using mammalian cells, which ...
Çakir Bilal - - 2012
Insulin-degrading enzyme (IDE) is an allosteric Zn(+2) metalloprotease involved in the degradation of many peptides including amyloid-β, and insulin that play key roles in Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), respectively. Therefore, the use of therapeutic agents that regulate the activity of IDE would be a viable ...
Huang Pi-Chun - - 2012
The detection threshold of a Gabor target can be reduced by the presence of collinear flanking Gabors but is disrupted when the target and the flankers have different disparity. Here, we further investigated whether it is the depth or surface difference between the target and the flanker that causes the ...
Shaik Sason - - 2012
Triple bonding is conventionally considered to be the limit for multiply bonded main group elements, despite higher metal-metal bond orders being frequently observed for transition metals and lanthanides/actinides. Here, using high-level theoretical methods, we show that C(2) and its isoelectronic molecules CN(+), BN and CB(-) (each having eight valence electrons) ...
Ramane Deepa V - - 2012
Multicolor multielement LED luminaries have wide applications in decorative, display, and medical domain etc. It can provide light with variable intensity and spectral content. One such application of designing of multispectral reading light for patients having low visual acuities is reported here. Paper describes microcontroller based reading light system for ...
de Jong Joan H - - 2012
The epithelial lining of the intestine is characterized by an immense cellular turn-over ascertaining an extensive regenerative capacity. Multiple reports suggest that besides the local intestinal stem cell pool, circulating cells of bone marrow origin (BMDCs) contribute to this process by fusing with the epithelial lineage. However, the functional relevance ...
Hasan Eman - - 2012
Rituximab, a monoclonal antibody that selectively targets CD20-positive B-lymphocytes, is used for the treatment of patients with rheumatoid arthritis (RA) with an inadequate response or tolerance to tumor necrosis factor inhibitors. The objective of this study was to investigate the effects of rituximab treatment on the serum concentrations of vitamin ...
Yamagata Masahito - - 2012
In the "GFP reconstitution across synaptic partners" (GRASP) method, non-fluorescent fragments of GFP are expressed in two different neurons; the fragments self-assemble at synapses between the two to form a fluorophore. GRASP has proven useful for light microscopic identification of synapses in two invertebrate species, Caenorhabditis elegans and Drosophila melanogaster, ...
Sobhani Rohollah - - 2012
The aim of this study was to evaluate the protective effect of melatonin on ischemia-reperfusion syndrome. Thirty-three adult male Wistar albino rats were randomized into three experimental groups of 11: Group C --control group with no ischemia or reperfusion. Groups I/R and I/R + M had 2.5 hours of ischemia ...
Carlisle Aaron B - - 2012
The white shark (Carcharodon carcharias) is a wide-ranging apex predator in the northeastern Pacific (NEP). Electronic tagging has demonstrated that white sharks exhibit a regular migratory pattern, occurring at coastal sites during the late summer, autumn and early winter and moving offshore to oceanic habitats during the remainder of the ...
Soares Siomar C - - 2012
The adaptability of pathogenic bacteria to hosts is influenced by the genomic plasticity of the bacteria, which can be increased by such mechanisms as horizontal gene transfer. Pathogenicity islands play a major role in this type of gene transfer because they are large, horizontally acquired regions that harbor clusters of ...
Fitzgerald Anthony J - - 2012
We investigate the efficacy of using data reduction techniques to aid classification of terahertz (THz) pulse data obtained from tumor and normal breast tissue. Fifty-one samples were studied from patients undergoing breast surgery at Addenbrooke's Hospital in Cambridge and Guy's Hospital in London. Three methods of data reduction were used: ...
Agarwal Pankaj Kumar - - 2012
Horner's syndrome is well documented in multiple sclerosis (MS). However, alternating Horner's syndrome in MS had not been described before. Here, we report a possible first case of alternating Horner's syndrome in MS.
Hashizume Masahiro - - 2012
Malaria resurgence in African highlands in the 1990s has raised questions about the underlying drivers of the increase in disease incidence including the role of El-Niño-Southern Oscillation (ENSO). However, climatic anomalies other than the ENSO are clearly associated with malaria outbreaks in the highlands. Here we show that the Indian ...
Biron Alain D - - 2012
Healthcare is currently in the midst of a construction boom. An increasing number of hospitals are being constructed using the principles of evidence-based design to improve the quality and safety of patient care while at the same maximizing efficiency. As the McGill University Health Centre embarks on a redevelopment journey, ...
Boncoraglio Giuseppe - - 2012
Sexual conflict drives the coevolution of sexually antagonistic traits, such that an adaptation in one sex selects an opposing coevolutionary response from the other. Although many adaptations and counteradaptations have been identified in sexual conflict over mating interactions, few are known for sexual conflict over parental investment. Here we investigate ...
Gill J Brent - - 2012
The purpose of this study was to report the epidemiology and clinical history of oral piercing injuries presenting to US hospital emergency departments (EDs). A retrospective analysis of oral piercing injuries was performed using patient injury data collected from 2002 through 2008 using the National Electronic Injury Surveillance System (NEISS) ...
Tarafdar Sonali - - 2012
Tamoxifen is a triphenylethylene non-steroidal oestrogen antagonist widely used in oestrogen receptor-positive breast cancer, with well-documented ocular side-effects. Here we report a corneal confocal microscopy finding of a patient on low-dose tamoxifen. We believe that this is the first case report of a patient on low-dose tamoxifen with demonstrable corneal ...
Valente André X C N - - 2012
An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The ...
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