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Results 301 - 350 of 2173
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Köllner V - - 2012
Psychosomatic disease patterns are a common differential diagnosis for orthopedic symptoms. Furthermore, mental factors, such as the method of disease processing or mental comorbidities, such as depression or somatization disorders have a great influence on the chronification of orthopedic complaints and the outcome following orthopedic interventions. The aim of this ...
Räuchle M - - 2012
Osteoarthritis is the most common joint disease in adults. With higher life expectancy and a growing proportion of elderly people in society, the relevance of osteoarthritis is becoming higher, especially in terms of socioeconomic effects and burdens for the healthcare system. In this review the pathogenesis and risk factors of ...
Dong Jin-Run - - 2012
To investigate the characteristics of rhesus monkey embryonic stem cells and to promote their clinical application, the differentiation and proliferation of rosettes neural stem cells from GFP marked rhesus monkey embryonic stem cells were studied The results showed that: 1) A stable and high-efficient neural differentiation system was established. More ...
Parisi L - - 2012
Hypomelanosis of Ito (HOI) is a multisystem neurocutaneous disorder. In the described cases, cutaneous manifestations (unilateral or bilateral streaks and swirls of hypomelanosis with regular and confluent borders) and extracutaneous abnormalities are often associated. Extracutaneous abnormalities involve the musculoskeletal system (scoliosis, vertebral anomalies, cranial-facial malformations) and other organs, as well ...
Noachtar S - - 2012
Advances in diagnostic and therapeutic options require a revision of the current classification of seizures and epilepsies. Recently, a classification proposal was introduced which reflects the ambivalence of the Internationalen Liga gegen Epilepsie (ILAE). We suggest that epileptology should utilize the same established systematic approach used in clinical neurology.
Gekeler F - - 2012
Stimulation with weak electrical currents as a potential therapy for ophthalmic diseases has been propagated for a long time and encountered mixed acceptance but has recently regained interest due to observations in retinal implant projects. In these projects involving patients with retinitis pigmentosa a neuroprotective effect of weak, even subthreshold, ...
Li Gang - - 2012
To study the clinical anatomy of the transversalis fascia (TF) and to explore the intertransversalis fascia approach in urologic laparoscopic operations (ULOs). Prospective study. Two academic hospitals. Data from 1217 urologic laparoscopic or open operations and 10 laparoscopic hernia repairs were analyzed between January 1, 2009, and April 30, 2011. ...
Zabelin A A - - 2012
Photochemical oxidation of the primary electron donor P in reaction centers (RCs) of the filamentous anoxygenic phototrophic bacterium Chloroflexus (C.) aurantiacus was examined by light-induced Fourier transform infrared (FTIR) difference spectroscopy at 95 K in the spectral range of 4000-1200 cm(-1). The light-induced P(+)Q(A)(-)/PQ(A) IR spectrum of C. aurantiacus RCs is ...
Li Sheng-An - - 2012
Animal models are essential for the development of new anti-infectious drugs. Although some bacterial infection models have been established in rodents, small primate models are rare. Here, we report on two bacterial infection models established in tree shrew (Tupaia belangeri chinensis). A burnt skin infection model was induced by dropping ...
Champier Jacques - - 2012
Folate is essential for purine and thymidylate biosynthesis and in methyl transfer for DNA methylation. Folate deficiency alters the secretion of melatonin, a hormone involved in circadian rhythm entrainment, and causes hyperhomocysteinemia because of disruption of homocysteine metabolism. Adverse effects of homocysteine include the generation of free radicals, activation of ...
Marroquin Jose L - - 2012
A new method for detecting activations in random fields, which may be useful for addressing the issue of multiple comparisons in neuroimaging, is presented. This method is based on some constructs of mathematical morphology--specifically, morphological erosions and dilations--that enable the detection of active regions in random fields possessing moderate activation ...
Van Abel Kathryn M - - 2012
To compare thulium:YAG laser-assisted transoral robotic surgery (TY:TORS) and conventional electrocautery-equipped TORS (EC:TORS) in patients undergoing transoral resection of upper aerodigestive tract malignant neoplasms. Prospective matched cohort study. Tertiary academic referral center. Fifteen patients undergoing TY:TORS were matched on the basis of tumor site, clinical T stage, sex, and age ...
Szántó Zoltán - - 2012
Introduction: persistent air leak is one of the major complications following pulmonary resections and, in combination with immobilization, it increases the cost of treatment significantly. Methods: Authors analyzed retrospectively data of 40 consecutive patients of a thoracic surgical unit between 01. March 2011 and 30. October 2011. The mean age ...
Robinson Prema - - 2012
Neurocysticercosis (NCC), a helminth infection of the brain, is a major cause of seizures. The mediators responsible for seizures in NCC are unknown, and their management remains controversial. Substance P (SP) is a neuropeptide produced by neurons, endothelial cells and immunocytes. The current studies examined the hypothesis that SP mediates ...
West Kelly L - - 2012
Multicentric reticulohistiocytosis (MRH) is a rare disease of uncertain etiology that most commonly presents as a papulonodular cutaneous eruption accompanied by erosive polyarthritis. Although MRH is considered a systemic disorder in that it targets skin and joints, involvement of thoracic and visceral organs is uncommon. A woman presented with diffuse ...
Drofdf Wlodzimierz - - 2012
To compare epidemiological analysis concerning sex, age, location of blockage, and frequency of occurrence of etiological factors in 2 groups of patients treated for mechanical bowel obstruction 100 years apart. Epidemiological analysis of patients undergoing an operation for small-bowel obstruction (SBO) or large-bowel obstruction (LBO) from 1868 to 1898 (group ...
Oswald P - - 2012
In a recent letter (EPL 97, 36006 (2012)), we have shown that the Leslie thermomechanical coupling cannot alone explain the Lehmann effect (namely the rotation of cholesteric droplets when they are subjected to a temperature gradient). This result was obtained by measuring in a compensated cholesteric mixture the "Lehmann coefficient" ...
Vollmar C - - 2012
Neuroimaging is crucial for the diagnosis of epilepsy, in particular for syndromic diagnosis of focal epilepsies and for presurgical evaluation. We give recommendations on the optimized acquisition of MRI and discuss the principle and role of additional neuroimaging methods including nuclear medicine and image processing.
Kerl Katrin - - 2012
BACKGROUND: Transepidermal melanocytic migration (TEM) is an important diagnostic criterion for malignancy, especially in association with cytologic atypia. However, TEM may also be observed in benign melanocytic tumors, such as Spitz nevus, acral nevi, or nevi in infancy. We discuss the value of TEM for the diagnosis of melanocytic tumors ...
Werhahn K J - - 2012
Epilepsies frequently only start in old age and given the current demographic trend the prevalence of epilepsy in the elderly population will increase. This article summarizes the most relevant aspects of diagnosis and therapy in elderly patients with epilepsy. Guidelines, systematic reviews or meta-analyses are lacking and there are only ...
Szentmáry N - - 2012
Photodynamic therapy (PDT) has been used in ophthalmology for the last 10 years particularly for disorders of the posterior pole. In recent years PDT has been increasingly applied for corneal cross-linking in progressive keratoconus. The classical PDT is performed with porphyrins as photosensitizers and illumination with visible light of 630-635 nm ...
Semin B K - - 2012
A "decoupling effect" (light-induced electron transport without O2 evolution) was observed in Ca-depleted photosystem II (PSII(-Ca)) membranes, which lack PsbP and PsbQ (Semin et al. (2008) Photosynth. Res., 98, 235-249). Here PsbO-depleted PSII (PSII(-PsbO)) membranes (which also lack PsbP and PsbQ) were used to examine effects of PsbO on the ...
Osler Turner - - 2012
Complications are common in the care of trauma patients and contribute to morbidity, mortality, and cost. However, no comprehensive list of surgical complications is widely accepted. To create an empirical list of complications based on the International Classification of Diseases, Ninth Revision (ICD-9) lexicon and estimate the contribution of these ...
Kong Ling-An - - 2012
Chitin is a major component of fungal cell wall and is synthesized by chitin synthases (Chs). Plant pathogenic fungi normally have multiple chitin synthase genes. To determine their roles in development and pathogenesis, we functionally characterized all seven CHS genes in Magnaporthe oryzae. Three of them, CHS1, CHS6, and CHS7, ...
Armin Bob B - - 2012
To assess clinical and radiologic findings from targeted radiotherapy to the rat maxilla and to compare findings with a recently developed rat model of mandibular osteoradionecrosis (ORN). A prospective, controlled animal study. Ten male Sprague-Dawley rats were divided into an experimental group receiving catheter-assisted high-dose-rate brachytherapy (n = 6) and a control ...
Choi Sae Byeol - - 2012
Most morbidity and mortality are caused by a pancreatic fistula after pancreaticoduodenectomy (PD), and its prevention is the major concern. We applied the omental roll-up technique around pancreaticojejunostomy and investigated the effectiveness of this technique to prevent a pancreatic fistula. Retrospective study. Tertiary hepatobiliary and pancreas surgery clinic, Korea University ...
Choi Hanui - - 2012
The traditional Asian diet, which is characterized as being high in carbohydrate with an abundance of vegetables, may be beneficial for preventing metabolic syndrome abnormalities within the Asian population. However, the prevalence of metabolic syndrome is increasing in Asian countries. This study explored the association between dietary carbohydrates and low ...
Soanes Darren M - - 2012
The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using next generation sequencing (NGS). We performed ...
Wang Wen-Guang - - 2012
Tupaia belangeri are small mammals with a squirrel-like appearance; they were formerly classified under the primates order despite the lack of derived features characteristic of primates. Given that T. belangeri are easy to raise, cheap to maintain, and have a small body size, a high reproductive rate, and close affinity ...
Meyer A-K - - 2012
One third of the population above 70 has a diabetic-like metabolic status. Diabetes-induced diseases as well as acute blood sugar imbalances have great impact on quality of life. Transferring the known disease management regimes from adults to the elderly is only possible to a limited extent. For patients needing short-term ...
Gruber Jonathan D - - 2012
Genetic variation within and between species can be shaped by population-level processes and mutation; however, the relative impact of "survival of the fittest" and "arrival of the fittest" on phenotypic evolution remains unclear. Assessing the influence of mutation on evolution requires understanding the relative rates of different types of mutations ...
Lomonosova Yu N - - 2012
Gravitational unloading causes atrophy of muscle fibers and can lead to destruction of cytoskeletal and contractile proteins. Along with the atrophic changes, unloaded muscle frequently demonstrates significant shifts in the ratio of muscle fibers expressing fast and slow myosin heavy chain isoforms. Stretching of the m. soleus during hindlimb suspension ...
Ji Fang - - 2012
To explore pathological alteration of T2DM in cynomolgus monkeys, gene expression profiles of peripheral blood leukocytes from spontaneous and diet-induced T2DM models was analyzed using quantitative real-time PCR. Among 36 T2DM associated genes tested, 19 genes (including G6PC, CCR2B, CTLA4) displayed a similar expression pattern in both spontaneous and diet-induced ...
Li Ming-Li - - 2012
Interferons (IFNs) represent proteins with antiviral activities that are secreted from cells in response to a variety of stimuli. In addition to antiviral, antibacterial and anti-parasitic host-defense functions they are now also recognized as crucial regulators of cell proliferation, differentiation, survival and death as well as activators of specialized cell ...
Reeves Paul H - - 2012
For self-pollinating plants to reproduce, male and female organ development must be coordinated as flowers mature. The Arabidopsis transcription factors AUXIN RESPONSE FACTOR 6 (ARF6) and ARF8 regulate this complex process by promoting petal expansion, stamen filament elongation, anther dehiscence, and gynoecium maturation, thereby ensuring that pollen released from the ...
Werber A - - 2012
Poor efficiency in terms of treatment of unspecific back pain and related chronic pain syndromes has led to the necessity of general care guidelines addressing evidence-based strategies for treatment of lower back pain (LBP). Systematically validated and reviewed algorithms have been established for all kinds of unspecific back pain, covering ...
Wanat Karolyn A - - 2012
Viral-associated trichodysplasia of immunosuppression is a rare cutaneous eruption that is characterized by follicularly based shiny papules and alopecia with characteristic histopathologic findings of abnormally anagen follicules with excessive inner root sheath differentiation. Prior reports have described the histopathologic characteristics on vertical sections; however, to our knowledge, immunohistochemical analysis of ...
Ackermann Marit - - 2012
Epistatic genetic interactions are key for understanding the genetic contribution to complex traits. Epistasis is always defined with respect to some trait such as growth rate or fitness. Whereas most existing epistasis screens explicitly test for a trait, it is also possible to implicitly test for fitness traits by searching ...
Simm A - - 2012
The incidence of diabetes has increased in the recent years. Diabetes is characterized by increased sugar concentrations in the blood. Due to this dysregulation, more carbohydrate-induced modification of proteins - so-called advanced glycation end products (AGEs) - are formed endogenously by non-enzymatic reactions. These are discussed to be at least ...
Danesh-Meyer Helen V - - 2012
Connexin43 gap junction protein is expressed in astrocytes and the vascular endothelium in the central nervous system. It is upregulated following central nervous system injury and is recognized as playing an important role in modulating the extent of damage. Studies that have transiently blocked connexin43 in spinal cord injury and ...
Kulagina T P - - 2012
The fatty acid composition of thymus cells, liver, blood plasma, muscle tissue, and tumor focus has been studied in mice with solid Ehrlich carcinoma. The tumor growth in the mice was associated with an increase in the total content of monounsaturated fatty acids in all organs and tissues studied and ...
Dill-Müller D - - 2012
The vast majority of dermatologic surgery is performed with local anesthesia. The different methods provide safe and effective analgesia in circumscribed areas of skin and subcutaneous tissue and allow patients to tolerate otherwise painful diagnostic or therapeutic procedures while remaining conscious. Some forms of local anesthesia are unique, such as ...
Fukuda Tomoyuki - - 2012
Meiotic recombination and chromosome synapsis between homologous chromosomes are essential for proper chromosome segregation at the first meiotic division. While recombination and synapsis, as well as checkpoints that monitor these two events, take place in the context of a prophase I-specific axial chromosome structure, it remains unclear how chromosome axis ...
Stingl K - - 2012
The subretinal visual implant is a scientific research approach to restore partial vision in end-stage hereditary retinal diseases by replacing the function of the degenerated photoreceptors by microelectronic chips. In a clinical trial in Tübingen these implants were tested on voluntary blind patients. By using the implants in daily living ...
Jämsen J - - 2012
We earlier described CBS-pyrophosphatase of Moorella thermoacetica (mtCBS-PPase) as a novel phosphohydrolase that acquired a pair of nucleotide-binding CBS domains during evolution, thus endowing the protein with the capacity to be allosterically regulated by adenine nucleotides (Jämsen, J., Tuominen, H., Salminen, A., Belogurov, G. A., Magretova, N. N., Baykov, A. ...
Sun Yong-Mei - - 2012
The clinical use of morphine to reduce pain is limited because of its drug tolerance, dependence and addiction. In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 ...
Sun Wei - - 2012
The crystal structure of the title compound, Ce[B(4)O(6)(OH)(2)]Cl, is built from polyborate sheets parallel to the (001) plane. These sheets stack along the [001] direction and are linked by Ce atoms exhibiting an CeO(8)Cl(2) coordination sphere. O-H⋯O and O-H⋯Cl hydrogen bonds additionally stabilize the structural set-up. The polyborate sheet is ...
Al-Abdullah Ebtehal S - - 2012
The title mol-ecule, C(26)H(35)N(5)O(2)S, displays a chair-shaped piperazine ring, as well as a planar triazole ring whose phenyl substituent is perpendicular to the mean plane of the five-membered ring [dihedral angle = 90.00 (13)°]. The methyl-ene substituent on the piperazine ring occupies an equatorial site. Weak inter-molecular C-H⋯O hydrogen bonding is ...
Praveen A S - - 2012
In the title compound, C(17)H(13)BrClNO, the dihedral angle between the naphthol ring system and the chloro-benzene ring is 76.59 (11)°. This twisted conformation is supported by an intra-molecular O-H⋯N hydrogen bond. In the crystal, [100] chains arise, with adjacent mol-ecules linked by an N-H⋯O hydrogen bond, a C-H⋯π inter-action and an ...
Vafaee Marzieh - - 2012
The asymmetric unit of the title cocrystal, [Sn(CH(3))(C(6)H(5))Cl(2)(H(2)O)(2)]·C(10)H(20)O(5), contains two independent for-mula units. The organotin molecules exhibit a six-coordinate metal atom and are linked to the crown ether molecules by water-crown ether O-H⋯O hydrogen bonds into a linear chain running along [101]. Each coordinated water mol-ecule forms a pair of ...
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